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The map label for this gene is hslU [H]

Identifier: 57236972

GI number: 57236972

Start: 697910

End: 699229

Strand: Reverse

Name: hslU [H]

Synonym: CJE0764

Alternate gene names: 57236972

Gene position: 699229-697910 (Counterclockwise)

Preceding gene: 57236973

Following gene: 57236971

Centisome position: 39.33

GC content: 32.95

Gene sequence:

>1320_bases
ATGAATCTAACTCCAAAAGAAATCGTTAAATTTTTAGATGATTATGTTATAGGACAAAAAAAAGCTAAAAAAATCATAGC
TATAGCTTTAAGAAATCGCTACCGCAGAATGCAACTTAGCCCTGAGTTGCAAGATGATATAGTGCCAAAAAATATCTTGA
TGATAGGTTCTACAGGTGTAGGAAAAACAGAAATCGCTAGGCGTTTAGCTAAAATGATGGGCTTTCCTTTCATCAAAATC
GAGGCGAGTAAATATACTGAAGTAGGTTTTGTAGGTCGTGATGTAGAAAGCATGGTAAGAGATCTTGCCAATGCAGCTTT
AAATTTGGTAAAAAATGAGCAAAGAGAAAAAAACAAAGATAAAATCGATGAATTTATAGAAAATAAAATTTTAGAAAAAC
TTTTGCCACCTTTGCCAAAGGGTATCAGCGATGAAAAACAAGAAGAATATAAAAACAGTCTTGAAAAAATGAGAACTAAA
CTAAGAAATGGCAATCTTGATGAAAGCACCATAGAAATAGAAATTTCACAAAATATGTTCGATACCAATCCTAACCTACC
TCCTGAAATGGGTGCAATGCAAGATATAGTTAAGGTTATAGGCGTTGGCAGTAAAAAAGTCAAAAAAGAAATGAAAATCA
AAGACGCTAAAAATGCTTTAAAAAACGAAGCAGGAGAAAAAATCCTAGACCAAGAAAGCATCAAAAGCGAAGCCTTAAAA
AGAGCAGAAAATGAAGGGATTATTTTTATTGATGAAATTGATAAAATCGCTGTTTCAAGCGGAAATTCAAACCGCCAAGA
TCCAAGTAAAGAAGGGGTACAAAGAGACTTACTTCCTATAGTCGAGGGATCAAATGTACAAACAAAAATAGGTACTTTAA
AAACCGATCATATTCTTTTTATCGCTGCAGGGGCTTTTCACCTTAGCAAACCAAGTGATCTTATCCCTGAACTGCAAGGA
CGCTTTCCTTTAAGAGTGGAATTAGATAGTCTTGATGATAAAGCTCTTTATGAAATTTTAACACGCCCTAAAAATTCACT
TTTAAAACAATACTCTCAGCTTTTAAAAACTGAAAATTTAGAACTTGAATTTAATGATGAAGCTATTAAAGAAATAGCAA
AAATAGCTTCAAGAGCCAATGAAGAAATGCAAGATATAGGTGCTAGACGCTTACATACTGTGATAGAAAAATTACTTGAA
GATCTAAGCTTTGAAGCTGATGAGTATGCGGGTAAAAAATTCGTAGTGGATAAAAAAATGGTAGAAGAAAAACTCGGAGA
TATCATAGAAAATAAAGATCTTGCAAGGTATATTTTGTGA

Upstream 100 bases:

>100_bases
TAGATGAAGAAGAACTTGTAAAATCAAGCCTTCAAATCGCAGGTGAAATTTGCATTTATACCAATACCAATATCAAAACT
TATGTAATCGAGGATGAGAA

Downstream 100 bases:

>100_bases
AAAGTGGCTTTGTTAGTATCATAGGGCGTACTAATGCAGGAAAAAGTACTTTAATCAATTCCTTATTAGAAGAAAAAATC
GCCCTAGTTTCTCACAAACA

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MNLTPKEIVKFLDDYVIGQKKAKKIIAIALRNRYRRMQLSPELQDDIVPKNILMIGSTGVGKTEIARRLAKMMGFPFIKI
EASKYTEVGFVGRDVESMVRDLANAALNLVKNEQREKNKDKIDEFIENKILEKLLPPLPKGISDEKQEEYKNSLEKMRTK
LRNGNLDESTIEIEISQNMFDTNPNLPPEMGAMQDIVKVIGVGSKKVKKEMKIKDAKNALKNEAGEKILDQESIKSEALK
RAENEGIIFIDEIDKIAVSSGNSNRQDPSKEGVQRDLLPIVEGSNVQTKIGTLKTDHILFIAAGAFHLSKPSDLIPELQG
RFPLRVELDSLDDKALYEILTRPKNSLLKQYSQLLKTENLELEFNDEAIKEIAKIASRANEEMQDIGARRLHTVIEKLLE
DLSFEADEYAGKKFVVDKKMVEEKLGDIIENKDLARYIL

Sequences:

>Translated_439_residues
MNLTPKEIVKFLDDYVIGQKKAKKIIAIALRNRYRRMQLSPELQDDIVPKNILMIGSTGVGKTEIARRLAKMMGFPFIKI
EASKYTEVGFVGRDVESMVRDLANAALNLVKNEQREKNKDKIDEFIENKILEKLLPPLPKGISDEKQEEYKNSLEKMRTK
LRNGNLDESTIEIEISQNMFDTNPNLPPEMGAMQDIVKVIGVGSKKVKKEMKIKDAKNALKNEAGEKILDQESIKSEALK
RAENEGIIFIDEIDKIAVSSGNSNRQDPSKEGVQRDLLPIVEGSNVQTKIGTLKTDHILFIAAGAFHLSKPSDLIPELQG
RFPLRVELDSLDDKALYEILTRPKNSLLKQYSQLLKTENLELEFNDEAIKEIAKIASRANEEMQDIGARRLHTVIEKLLE
DLSFEADEYAGKKFVVDKKMVEEKLGDIIENKDLARYIL
>Mature_439_residues
MNLTPKEIVKFLDDYVIGQKKAKKIIAIALRNRYRRMQLSPELQDDIVPKNILMIGSTGVGKTEIARRLAKMMGFPFIKI
EASKYTEVGFVGRDVESMVRDLANAALNLVKNEQREKNKDKIDEFIENKILEKLLPPLPKGISDEKQEEYKNSLEKMRTK
LRNGNLDESTIEIEISQNMFDTNPNLPPEMGAMQDIVKVIGVGSKKVKKEMKIKDAKNALKNEAGEKILDQESIKSEALK
RAENEGIIFIDEIDKIAVSSGNSNRQDPSKEGVQRDLLPIVEGSNVQTKIGTLKTDHILFIAAGAFHLSKPSDLIPELQG
RFPLRVELDSLDDKALYEILTRPKNSLLKQYSQLLKTENLELEFNDEAIKEIAKIASRANEEMQDIGARRLHTVIEKLLE
DLSFEADEYAGKKFVVDKKMVEEKLGDIIENKDLARYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=111, Percent_Identity=39.6396396396396, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1790366, Length=442, Percent_Identity=48.6425339366516, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1786642, Length=243, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71982908, Length=222, Percent_Identity=32.4324324324324, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71982905, Length=222, Percent_Identity=32.4324324324324, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71988663, Length=257, Percent_Identity=28.0155642023346, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319704, Length=463, Percent_Identity=25.7019438444924, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24648291, Length=254, Percent_Identity=28.3464566929134, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24648289, Length=254, Percent_Identity=28.3464566929134, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 49778; Mature: 49778

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTPKEIVKFLDDYVIGQKKAKKIIAIALRNRYRRMQLSPELQDDIVPKNILMIGSTGV
CCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCEEEEECCCC
GKTEIARRLAKMMGFPFIKIEASKYTEVGFVGRDVESMVRDLANAALNLVKNEQREKNKD
CHHHHHHHHHHHHCCCEEEEECCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
KIDEFIENKILEKLLPPLPKGISDEKQEEYKNSLEKMRTKLRNGNLDESTIEIEISQNMF
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEE
DTNPNLPPEMGAMQDIVKVIGVGSKKVKKEMKIKDAKNALKNEAGEKILDQESIKSEALK
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAENEGIIFIDEIDKIAVSSGNSNRQDPSKEGVQRDLLPIVEGSNVQTKIGTLKTDHILF
HCCCCCEEEEECCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEHHCCEECCCEEE
IAAGAFHLSKPSDLIPELQGRFPLRVELDSLDDKALYEILTRPKNSLLKQYSQLLKTENL
EEECCHHCCCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCC
ELEFNDEAIKEIAKIASRANEEMQDIGARRLHTVIEKLLEDLSFEADEYAGKKFVVDKKM
CEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEHHHHH
VEEKLGDIIENKDLARYIL
HHHHHHHHHCCCHHHHHCC
>Mature Secondary Structure
MNLTPKEIVKFLDDYVIGQKKAKKIIAIALRNRYRRMQLSPELQDDIVPKNILMIGSTGV
CCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCEEEEECCCC
GKTEIARRLAKMMGFPFIKIEASKYTEVGFVGRDVESMVRDLANAALNLVKNEQREKNKD
CHHHHHHHHHHHHCCCEEEEECCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
KIDEFIENKILEKLLPPLPKGISDEKQEEYKNSLEKMRTKLRNGNLDESTIEIEISQNMF
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEE
DTNPNLPPEMGAMQDIVKVIGVGSKKVKKEMKIKDAKNALKNEAGEKILDQESIKSEALK
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAENEGIIFIDEIDKIAVSSGNSNRQDPSKEGVQRDLLPIVEGSNVQTKIGTLKTDHILF
HCCCCCEEEEECCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEHHCCEECCCEEE
IAAGAFHLSKPSDLIPELQGRFPLRVELDSLDDKALYEILTRPKNSLLKQYSQLLKTENL
EEECCHHCCCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCC
ELEFNDEAIKEIAKIASRANEEMQDIGARRLHTVIEKLLEDLSFEADEYAGKKFVVDKKM
CEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEHHHHH
VEEKLGDIIENKDLARYIL
HHHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA