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The map label for this gene is pepQ [H]

Identifier: 57236966

GI number: 57236966

Start: 690232

End: 692022

Strand: Reverse

Name: pepQ [H]

Synonym: CJE0756

Alternate gene names: 57236966

Gene position: 692022-690232 (Counterclockwise)

Preceding gene: 57236967

Following gene: 57236953

Centisome position: 38.93

GC content: 32.16

Gene sequence:

>1791_bases
ATGAGTATTTACAAACAAAGAGTATTAGAACTTAGAAGATTAATGAAAGAAAATAATATTGACGCCTATCTCATCTTAAG
CGCGGATCCGCATTTGAGCGAATATTTACCAGAATATTACAAAAACAGAGTCTTTATCAGTGGCTTTAAGGGTTCTGTTG
GAACAGTTCTTATCACACAAGAAGAGGGCTTTTTGTGGGTAGATGGAAGATATTGGCTTCAAGCACAAAAGGAATTAGAA
GGTAGTGGCATACTTTTACAAAAGCAAGATGCTAAAAATACTTTTACCAAATGGTTGGAAAAAAATTTAAGCGAAGATCA
AATTTTAGGCATCGATTTTGCACTTTTACCTTTATCTTTGCAAAAAGATTTAAAGATTAATTGCAAGGCAAATTTAAAAC
ATATAGATTTGATAAGTCCGCTTTGGAAAGATCGTCCCACTTTACCACAAGAAAAAATTTATGAACACGAACTAGAATAC
TGCTCTTACTCAAGAAAAGAAAAATTAGCATTAGTGCGTCAAAAAATGAAAAATTTAAATGTTACCTCTCATTTAATCTC
CAGCCTTGATGATATAGCTTGGCTTACAAATTTAAGAGGGAATGATGTAAATTATAATCCTGTATTTTTAAGTCATTTGC
TAATCTTGGAGGACAAAGCCTTGCTTTTTGTTGATCAGAAAAAAGTAAATTCAGAACTTGAAAAAAAATTAAATTTAGAT
GGGTTTTGGCTTAAAAATTATGATGAAATCATCATGGAGCTTGAAAAACTTGCAAATACAAATTTGCTTATTGAACCTTC
AAAAATGACCGCTTTACTCATAAATTCTTTAGATAAAAGCGTAAAAATCATTCAAGAAATTAATCCAAGCACTCACTTAA
AAGCAGCTAAAAATACAAAAGAAATAGCGCATATACAAGATGCTATGATAGAAGATGGAGTGGCTTTATGTAAATTTTTT
GCCTGGCTTGAAGAAGCGATAGAAAATAAAGAACTAATAAGCGAATTAGACATAGATGTTAAAGCAAGCGAATTTAGAGC
ACAAAGCAAGTACTACATAAGTGATAGTTTTGCCACTATAGCAGGCTTTAACGAAAATGCAGCATATCCACATTATAAAG
CCACAAAAGAGAGTTTTGCTTATCTTAAAAAAGATGGGCTTTTACTTATTGATTCTGGTGGACAATATAAAAACGGCACA
ACAGATATTACACGCGTTGTACCAATAGGAAAGGCTAATGCAGAACAAATTCATGACTATACCTTGGTTTTAAAAGCACA
TATTGCCATTTCCAGTGCAATTTTTCCAAAAGATATAGCTATGCCCTTACTTGATGCAATCACACGCGCACCTTTATGGA
AAGAACAAATTGACTATATACACGGCACAGGACATGGCGTGGGATATTTTTTAAATGTCCATGAAGGTCCACAAGTTTTA
TCTTATCTATCCCCTGTGCTTGAAAAAACAAAAGCCAAAGAAGGTATGCTAACCTCCATAGAACCAGGTATTTATAAAGT
AGGTAAATGGGGTATAAGACTTGAAAATTTAGTTATTCATACCAAAGTAGAAAATCCTAAAAATAAAGATTTTGGAGAGT
TTTTATACTTTAAACCTGTTACTCTTTGTCCTTTTGAAATATCTTGTATTGATACAAAAATGTTAGATGAAAAAGAAAAA
GAGTGGTTAAACAATTACCACAAAGAAGTATTTGAAAAACTTTCTCCTAAGCTAGGTGATTATCCAAAAGCTCTAGTTTG
GCTTGAAAAAAGAACAAAAGCCATCTTTTAA

Upstream 100 bases:

>100_bases
TTACCAATGTATGTGGATATTACTTGGTGCTGTTATAATTTTACTTATACTCAAAAAACCTATCAATAAAATACTAAAAA
ATTAATATTAAGGAGAAAAT

Downstream 100 bases:

>100_bases
GATACTTTTGTTAATATAGATAAATTTTCCTTGTATTAAACTTATAATTTATTTAATACAAGGTTTTTAAACCAATTGCT
AAAAAAGTTTTTTTTGAAAA

Product: M24 family peptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 596; Mature: 595

Protein sequence:

>596_residues
MSIYKQRVLELRRLMKENNIDAYLILSADPHLSEYLPEYYKNRVFISGFKGSVGTVLITQEEGFLWVDGRYWLQAQKELE
GSGILLQKQDAKNTFTKWLEKNLSEDQILGIDFALLPLSLQKDLKINCKANLKHIDLISPLWKDRPTLPQEKIYEHELEY
CSYSRKEKLALVRQKMKNLNVTSHLISSLDDIAWLTNLRGNDVNYNPVFLSHLLILEDKALLFVDQKKVNSELEKKLNLD
GFWLKNYDEIIMELEKLANTNLLIEPSKMTALLINSLDKSVKIIQEINPSTHLKAAKNTKEIAHIQDAMIEDGVALCKFF
AWLEEAIENKELISELDIDVKASEFRAQSKYYISDSFATIAGFNENAAYPHYKATKESFAYLKKDGLLLIDSGGQYKNGT
TDITRVVPIGKANAEQIHDYTLVLKAHIAISSAIFPKDIAMPLLDAITRAPLWKEQIDYIHGTGHGVGYFLNVHEGPQVL
SYLSPVLEKTKAKEGMLTSIEPGIYKVGKWGIRLENLVIHTKVENPKNKDFGEFLYFKPVTLCPFEISCIDTKMLDEKEK
EWLNNYHKEVFEKLSPKLGDYPKALVWLEKRTKAIF

Sequences:

>Translated_596_residues
MSIYKQRVLELRRLMKENNIDAYLILSADPHLSEYLPEYYKNRVFISGFKGSVGTVLITQEEGFLWVDGRYWLQAQKELE
GSGILLQKQDAKNTFTKWLEKNLSEDQILGIDFALLPLSLQKDLKINCKANLKHIDLISPLWKDRPTLPQEKIYEHELEY
CSYSRKEKLALVRQKMKNLNVTSHLISSLDDIAWLTNLRGNDVNYNPVFLSHLLILEDKALLFVDQKKVNSELEKKLNLD
GFWLKNYDEIIMELEKLANTNLLIEPSKMTALLINSLDKSVKIIQEINPSTHLKAAKNTKEIAHIQDAMIEDGVALCKFF
AWLEEAIENKELISELDIDVKASEFRAQSKYYISDSFATIAGFNENAAYPHYKATKESFAYLKKDGLLLIDSGGQYKNGT
TDITRVVPIGKANAEQIHDYTLVLKAHIAISSAIFPKDIAMPLLDAITRAPLWKEQIDYIHGTGHGVGYFLNVHEGPQVL
SYLSPVLEKTKAKEGMLTSIEPGIYKVGKWGIRLENLVIHTKVENPKNKDFGEFLYFKPVTLCPFEISCIDTKMLDEKEK
EWLNNYHKEVFEKLSPKLGDYPKALVWLEKRTKAIF
>Mature_595_residues
SIYKQRVLELRRLMKENNIDAYLILSADPHLSEYLPEYYKNRVFISGFKGSVGTVLITQEEGFLWVDGRYWLQAQKELEG
SGILLQKQDAKNTFTKWLEKNLSEDQILGIDFALLPLSLQKDLKINCKANLKHIDLISPLWKDRPTLPQEKIYEHELEYC
SYSRKEKLALVRQKMKNLNVTSHLISSLDDIAWLTNLRGNDVNYNPVFLSHLLILEDKALLFVDQKKVNSELEKKLNLDG
FWLKNYDEIIMELEKLANTNLLIEPSKMTALLINSLDKSVKIIQEINPSTHLKAAKNTKEIAHIQDAMIEDGVALCKFFA
WLEEAIENKELISELDIDVKASEFRAQSKYYISDSFATIAGFNENAAYPHYKATKESFAYLKKDGLLLIDSGGQYKNGTT
DITRVVPIGKANAEQIHDYTLVLKAHIAISSAIFPKDIAMPLLDAITRAPLWKEQIDYIHGTGHGVGYFLNVHEGPQVLS
YLSPVLEKTKAKEGMLTSIEPGIYKVGKWGIRLENLVIHTKVENPKNKDFGEFLYFKPVTLCPFEISCIDTKMLDEKEKE
WLNNYHKEVFEKLSPKLGDYPKALVWLEKRTKAIF

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=613, Percent_Identity=37.6835236541599, Blast_Score=378, Evalue=1e-104,
Organism=Homo sapiens, GI264681565, Length=613, Percent_Identity=35.8890701468189, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI93141226, Length=585, Percent_Identity=32.3076923076923, Blast_Score=317, Evalue=2e-86,
Organism=Escherichia coli, GI1788728, Length=193, Percent_Identity=33.160621761658, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=615, Percent_Identity=32.1951219512195, Blast_Score=307, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI25149105, Length=576, Percent_Identity=27.9513888888889, Blast_Score=231, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6322999, Length=650, Percent_Identity=32.7692307692308, Blast_Score=308, Evalue=2e-84,
Organism=Drosophila melanogaster, GI17137632, Length=609, Percent_Identity=36.6174055829228, Blast_Score=346, Evalue=3e-95,
Organism=Drosophila melanogaster, GI161078230, Length=626, Percent_Identity=28.2747603833866, Blast_Score=253, Evalue=3e-67,
Organism=Drosophila melanogaster, GI21357287, Length=626, Percent_Identity=28.2747603833866, Blast_Score=253, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 68382; Mature: 68251

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIYKQRVLELRRLMKENNIDAYLILSADPHLSEYLPEYYKNRVFISGFKGSVGTVLITQ
CCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCEEEEECCCCCEEEEEEE
EEGFLWVDGRYWLQAQKELEGSGILLQKQDAKNTFTKWLEKNLSEDQILGIDFALLPLSL
CCCEEEECCCEEEEEHHCCCCCCEEEECCCCHHHHHHHHHCCCCCCCEEECCCEEECCCC
QKDLKINCKANLKHIDLISPLWKDRPTLPQEKIYEHELEYCSYSRKEKLALVRQKMKNLN
CCCCEEEEECCCCEEHHHCHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
VTSHLISSLDDIAWLTNLRGNDVNYNPVFLSHLLILEDKALLFVDQKKVNSELEKKLNLD
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCC
GFWLKNYDEIIMELEKLANTNLLIEPSKMTALLINSLDKSVKIIQEINPSTHLKAAKNTK
CEEECCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHCCHH
EIAHIQDAMIEDGVALCKFFAWLEEAIENKELISELDIDVKASEFRAQSKYYISDSFATI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEECCCEEE
AGFNENAAYPHYKATKESFAYLKKDGLLLIDSGGQYKNGTTDITRVVPIGKANAEQIHDY
ECCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHE
TLVLKAHIAISSAIFPKDIAMPLLDAITRAPLWKEQIDYIHGTGHGVGYFLNVHEGPQVL
EEEEEHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEEECCCHHHH
SYLSPVLEKTKAKEGMLTSIEPGIYKVGKWGIRLENLVIHTKVENPKNKDFGEFLYFKPV
HHHHHHHHHHHHCCCCCCCCCCCCEECCCCCEEEEEEEEEEECCCCCCCCCCCEEEECCC
TLCPFEISCIDTKMLDEKEKEWLNNYHKEVFEKLSPKLGDYPKALVWLEKRTKAIF
EECCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIYKQRVLELRRLMKENNIDAYLILSADPHLSEYLPEYYKNRVFISGFKGSVGTVLITQ
CHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCEEEEECCCCCEEEEEEE
EEGFLWVDGRYWLQAQKELEGSGILLQKQDAKNTFTKWLEKNLSEDQILGIDFALLPLSL
CCCEEEECCCEEEEEHHCCCCCCEEEECCCCHHHHHHHHHCCCCCCCEEECCCEEECCCC
QKDLKINCKANLKHIDLISPLWKDRPTLPQEKIYEHELEYCSYSRKEKLALVRQKMKNLN
CCCCEEEEECCCCEEHHHCHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
VTSHLISSLDDIAWLTNLRGNDVNYNPVFLSHLLILEDKALLFVDQKKVNSELEKKLNLD
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCC
GFWLKNYDEIIMELEKLANTNLLIEPSKMTALLINSLDKSVKIIQEINPSTHLKAAKNTK
CEEECCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHCCHH
EIAHIQDAMIEDGVALCKFFAWLEEAIENKELISELDIDVKASEFRAQSKYYISDSFATI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEECCCEEE
AGFNENAAYPHYKATKESFAYLKKDGLLLIDSGGQYKNGTTDITRVVPIGKANAEQIHDY
ECCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHE
TLVLKAHIAISSAIFPKDIAMPLLDAITRAPLWKEQIDYIHGTGHGVGYFLNVHEGPQVL
EEEEEHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEEECCCHHHH
SYLSPVLEKTKAKEGMLTSIEPGIYKVGKWGIRLENLVIHTKVENPKNKDFGEFLYFKPV
HHHHHHHHHHHHCCCCCCCCCCCCEECCCCCEEEEEEEEEEECCCCCCCCCCCEEEECCC
TLCPFEISCIDTKMLDEKEKEWLNNYHKEVFEKLSPKLGDYPKALVWLEKRTKAIF
EECCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]