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The map label for this gene is dapL [H]

Identifier: 21228751

GI number: 21228751

Start: 3164334

End: 3165503

Strand: Reverse

Name: dapL [H]

Synonym: MM_2649

Alternate gene names: 21228751

Gene position: 3165503-3164334 (Counterclockwise)

Preceding gene: 21228754

Following gene: 21228750

Centisome position: 77.28

GC content: 48.89

Gene sequence:

>1170_bases
GTGACTTTTCCAATGTATTCAGACCGCATAAACGCATTACCCCCATACCTTTTTGCAGCTATCGATGAAGCAAGAGACGA
ATTAATTGCTAAGGGAGTGGACGTAATAGACCTTGGCGTGGGAGATCCCGACCTACCGACACACCCGCATATTGTTGAAG
CCATGCAGAAGGCTGTCTGCGACCCCGGGACGCACCAGTACCCTTCTTATGCCGGGATGCCCGAATTCAGGAAGGCTGCG
GCTGAATGGTGCAGGAAATATAAAGGAATTGAGATCGACCCCGCAACTGAAGTCCTTTCCCTGATAGGGTCAAAAGAAGC
TGTGGCTCACATCCCGCTGGCTTTCGTCAATCCCGGAGATGTTGTGCTCTATACTGAGCCAGGGTATCCCGTATATAAGA
TCGGGACTCTTTTTGCAGGTGGAGAACCGTATCCTCTGCCCCTCAAGGCTGAAAATAGTTTCCTGCCTGACCTGGACTCA
ATCCCTGAAGATGTTCTGAAGAAATCCAGACTCTTCTTCTTTAATTACCCGAATAACCCAACTGCAGCAACTGCTGATAT
GGCGTTCTTTGAGAAAGTAGTAAAGTTCTGTAAAAAGCATGACATCATTGCCGTCCATGACAACGCGTACTGCCAGATGG
CTTACGACGGCTACGAAGCACCTTCTTTCCTTGCAGCAGAAGGGGCTATGGACATCGGCATGGAACTCTATTCCCACTCG
AAAACCTATAATATGACAGGCTGGAGACTAGGTTTTGCGGTAGGAAATAAAGACCTGATAAAAGGGCTCGGGAAAGTCAA
ATCCAATGTGGACTCAGGCGTCTTTGATGCAATCCAGATCGCAGGCATCGCAGCCCTCTCATCCCCCCAGGACTGCGTTA
ATGAAACAAACAAAATCTACGAAGAAAGGCGGAATGCTCTTATAGAGGGGCTAACTGCCATGGGCCTTGAAGTAAAGCCC
CCTAAAGCCACATTTTATATCTGGGCTCCGGTCCCGAAAGGCTTCACTTCGATCAGTTTTGCAAAACTCCTGCTCGAAGA
AGCCGGAATTGTAGCTACTCCGGGAGTGGGCTTTGGAGATGCCGGCGAAGGCTATATCAGGTTTGCACTCACAAAGCCGG
TTGAAAGGATCAAAGAAGCTGTGGAAAGGATGAAAAAGCTACAGCTCTAA

Upstream 100 bases:

>100_bases
AAAATAACTTATCAAGGATAAAGAAGGATCCCTTAACCATACCTTTTAATAGCCCCACTGCAGTAATTATGCAGAATTAT
ACACTGTAAATCATATTCAG

Downstream 100 bases:

>100_bases
CTTACATTTTGATCCAGACAATAATTGAACCGGGATCAAAGTGAATCAAAAATCATATGAGAAAAAAATCAGTCCGGCGG
CACGATTGAAAAAGCCGCCA

Product: LL-diaminopimelate aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MTFPMYSDRINALPPYLFAAIDEARDELIAKGVDVIDLGVGDPDLPTHPHIVEAMQKAVCDPGTHQYPSYAGMPEFRKAA
AEWCRKYKGIEIDPATEVLSLIGSKEAVAHIPLAFVNPGDVVLYTEPGYPVYKIGTLFAGGEPYPLPLKAENSFLPDLDS
IPEDVLKKSRLFFFNYPNNPTAATADMAFFEKVVKFCKKHDIIAVHDNAYCQMAYDGYEAPSFLAAEGAMDIGMELYSHS
KTYNMTGWRLGFAVGNKDLIKGLGKVKSNVDSGVFDAIQIAGIAALSSPQDCVNETNKIYEERRNALIEGLTAMGLEVKP
PKATFYIWAPVPKGFTSISFAKLLLEEAGIVATPGVGFGDAGEGYIRFALTKPVERIKEAVERMKKLQL

Sequences:

>Translated_389_residues
MTFPMYSDRINALPPYLFAAIDEARDELIAKGVDVIDLGVGDPDLPTHPHIVEAMQKAVCDPGTHQYPSYAGMPEFRKAA
AEWCRKYKGIEIDPATEVLSLIGSKEAVAHIPLAFVNPGDVVLYTEPGYPVYKIGTLFAGGEPYPLPLKAENSFLPDLDS
IPEDVLKKSRLFFFNYPNNPTAATADMAFFEKVVKFCKKHDIIAVHDNAYCQMAYDGYEAPSFLAAEGAMDIGMELYSHS
KTYNMTGWRLGFAVGNKDLIKGLGKVKSNVDSGVFDAIQIAGIAALSSPQDCVNETNKIYEERRNALIEGLTAMGLEVKP
PKATFYIWAPVPKGFTSISFAKLLLEEAGIVATPGVGFGDAGEGYIRFALTKPVERIKEAVERMKKLQL
>Mature_388_residues
TFPMYSDRINALPPYLFAAIDEARDELIAKGVDVIDLGVGDPDLPTHPHIVEAMQKAVCDPGTHQYPSYAGMPEFRKAAA
EWCRKYKGIEIDPATEVLSLIGSKEAVAHIPLAFVNPGDVVLYTEPGYPVYKIGTLFAGGEPYPLPLKAENSFLPDLDSI
PEDVLKKSRLFFFNYPNNPTAATADMAFFEKVVKFCKKHDIIAVHDNAYCQMAYDGYEAPSFLAAEGAMDIGMELYSHSK
TYNMTGWRLGFAVGNKDLIKGLGKVKSNVDSGVFDAIQIAGIAALSSPQDCVNETNKIYEERRNALIEGLTAMGLEVKPP
KATFYIWAPVPKGFTSISFAKLLLEEAGIVATPGVGFGDAGEGYIRFALTKPVERIKEAVERMKKLQL

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=397, Percent_Identity=25.1889168765743, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI169881279, Length=397, Percent_Identity=25.1889168765743, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI56713256, Length=383, Percent_Identity=23.2375979112272, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI56713254, Length=383, Percent_Identity=23.2375979112272, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI169881281, Length=303, Percent_Identity=21.4521452145215, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4507369, Length=375, Percent_Identity=23.4666666666667, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1788722, Length=382, Percent_Identity=40.5759162303665, Blast_Score=328, Evalue=4e-91,
Organism=Escherichia coli, GI1786816, Length=363, Percent_Identity=24.5179063360882, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1788627, Length=383, Percent_Identity=22.976501305483, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71994476, Length=395, Percent_Identity=24.8101265822785, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71994472, Length=395, Percent_Identity=24.8101265822785, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17567369, Length=328, Percent_Identity=22.8658536585366, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17567663, Length=378, Percent_Identity=24.3386243386243, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322401, Length=399, Percent_Identity=21.8045112781955, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28573069, Length=413, Percent_Identity=23.4866828087167, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646114, Length=413, Percent_Identity=23.4866828087167, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28573067, Length=413, Percent_Identity=23.4866828087167, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28573065, Length=413, Percent_Identity=23.4866828087167, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI18859735, Length=370, Percent_Identity=23.7837837837838, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 42635; Mature: 42504

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFPMYSDRINALPPYLFAAIDEARDELIAKGVDVIDLGVGDPDLPTHPHIVEAMQKAVC
CCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHC
DPGTHQYPSYAGMPEFRKAAAEWCRKYKGIEIDPATEVLSLIGSKEAVAHIPLAFVNPGD
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHEECCEEEECCCC
VVLYTEPGYPVYKIGTLFAGGEPYPLPLKAENSFLPDLDSIPEDVLKKSRLFFFNYPNNP
EEEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCHHCCHHHHHHCCCEEEEECCCCC
TAATADMAFFEKVVKFCKKHDIIAVHDNAYCQMAYDGYEAPSFLAAEGAMDIGMELYSHS
CCHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEECCCCCCCHHHHCCCHHHHHHHHHCC
KTYNMTGWRLGFAVGNKDLIKGLGKVKSNVDSGVFDAIQIAGIAALSSPQDCVNETNKIY
CCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
EERRNALIEGLTAMGLEVKPPKATFYIWAPVPKGFTSISFAKLLLEEAGIVATPGVGFGD
HHHHHHHHHHHHHCCCEECCCCEEEEEEECCCCCCHHHHHHHHHHHHCCEEECCCCCCCC
AGEGYIRFALTKPVERIKEAVERMKKLQL
CCCCEEEEEEHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TFPMYSDRINALPPYLFAAIDEARDELIAKGVDVIDLGVGDPDLPTHPHIVEAMQKAVC
CCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHC
DPGTHQYPSYAGMPEFRKAAAEWCRKYKGIEIDPATEVLSLIGSKEAVAHIPLAFVNPGD
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHEECCEEEECCCC
VVLYTEPGYPVYKIGTLFAGGEPYPLPLKAENSFLPDLDSIPEDVLKKSRLFFFNYPNNP
EEEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCHHCCHHHHHHCCCEEEEECCCCC
TAATADMAFFEKVVKFCKKHDIIAVHDNAYCQMAYDGYEAPSFLAAEGAMDIGMELYSHS
CCHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEECCCCCCCHHHHCCCHHHHHHHHHCC
KTYNMTGWRLGFAVGNKDLIKGLGKVKSNVDSGVFDAIQIAGIAALSSPQDCVNETNKIY
CCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
EERRNALIEGLTAMGLEVKPPKATFYIWAPVPKGFTSISFAKLLLEEAGIVATPGVGFGD
HHHHHHHHHHHHHCCCEECCCCEEEEEEECCCCCCHHHHHHHHHHHHCCEEECCCCCCCC
AGEGYIRFALTKPVERIKEAVERMKKLQL
CCCCEEEEEEHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA