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The map label for this gene is fpoD [H]

Identifier: 21228590

GI number: 21228590

Start: 2966672

End: 2967796

Strand: Reverse

Name: fpoD [H]

Synonym: MM_2488

Alternate gene names: 21228590

Gene position: 2967796-2966672 (Counterclockwise)

Preceding gene: 21228591

Following gene: 21228589

Centisome position: 72.45

GC content: 48.18

Gene sequence:

>1125_bases
ATGGAAGAAATGCTTGAATCAAATGAAATGATCGTACACCTGGGCCCTCAGCATCCCATGCAGCCCGGACCATTCAGATT
GAACCTGAAATTAAAAGGGGAAACAATCATGGATGCTGAAGTGGAAATGGGCTATATCCACAAAGGCATTGAAAAAATCC
TGGAGAACAGGACCTACCTTCAGGGCATCACCATAGTTGACAGGATCTGTTACCTTGTAGCTCTTACAAATGAAGAATGC
TATGTTGGATGCGTTGAAAAGCTTCTTGATATCGAACCCCCTGAGAGAGCTCAGTATATTAGAGTTATTCTGGAAGAGCT
TTCAAGACTCCAGAGCCATCTGCTTGGCCTGGGAGAGTATGGGGAGTTCATCGGCTTCGTTTCCATGTTCATGTACACTA
TCAAGGAAAGGGAAGACATTCTTACTCTTATCGACATGGTCACAGGGGCAAGGGTTACCCACAGCTACCTGAGGTTCGGT
GGGGTTCGTGACGACCTCCCGGAAGGATTTAAAGAAAAAACCATCCCGGTACTGAACAAGCTCAAGAAAGTCATCCGTGA
TTATGAGGAAATGTTCTACTCAGATACAATTTACAGGGAGAGAACTATCGGAATAGGTGTCCTGACAGCAGACGAAGCAA
AAAGCCTTGGGGTTTCCGGGCCTGTCCTGAGGGCAACCGGAGTTCCTTTCGATATCCGGAAGAATGAACCCTACCTTGTG
TACAGGGACCTGGACTTTAAAGTCTGCACTGAAACTGCAGGGGACTGTTTTGCAAGGGTTCAGGTCAGGCTTAACGAGAT
GCGTGAAAGCATTTACATCATAGAACAGTGCCTTGACATGATCCCGAACGGGCCTATCTTTCCGGAAGGAACTCCTTACG
GCAAAAGGACTCCAGTAATGAGAGTTCCGGCAGGCGAGGTATTCCACAGGGTCGAAGACCCGAGAGGAGAAATGGGAATG
TATATGGTTTCCGACGGCTCGGACAGGCCTTACAGGGTAAAAGTCAGAGGACCCTATTACCCGACTCTGCAGGCTCTCCC
CCCTCTTATCATAGGCACAACGGTTGCAGACATGGTATCAATTTCGGGAAGCATGGACGGCTGTACCAGTGAAGTGGACA
GGTGA

Upstream 100 bases:

>100_bases
CTTGTTCTCCCTGATGACATGCTGGGTGAGTGGCCTCTCAGAAAAGACTATGAGGGTTTTCCGAACAGGACAGCAAGAAA
CCTGGTGTGAGGGGTGAAAA

Downstream 100 bases:

>100_bases
CTTTTATGGCTATAGAAATTCCAGAATTCATAGTTCCCTTTGTCCCCTGGATCCGCGGTACTGTAGGCCTGGTTCTCGTA
GGAGCCATCTTCCTTGGCGG

Product: F420H2 dehydrogenase subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D 1; NDH-1 subunit D 1 [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MEEMLESNEMIVHLGPQHPMQPGPFRLNLKLKGETIMDAEVEMGYIHKGIEKILENRTYLQGITIVDRICYLVALTNEEC
YVGCVEKLLDIEPPERAQYIRVILEELSRLQSHLLGLGEYGEFIGFVSMFMYTIKEREDILTLIDMVTGARVTHSYLRFG
GVRDDLPEGFKEKTIPVLNKLKKVIRDYEEMFYSDTIYRERTIGIGVLTADEAKSLGVSGPVLRATGVPFDIRKNEPYLV
YRDLDFKVCTETAGDCFARVQVRLNEMRESIYIIEQCLDMIPNGPIFPEGTPYGKRTPVMRVPAGEVFHRVEDPRGEMGM
YMVSDGSDRPYRVKVRGPYYPTLQALPPLIIGTTVADMVSISGSMDGCTSEVDR

Sequences:

>Translated_374_residues
MEEMLESNEMIVHLGPQHPMQPGPFRLNLKLKGETIMDAEVEMGYIHKGIEKILENRTYLQGITIVDRICYLVALTNEEC
YVGCVEKLLDIEPPERAQYIRVILEELSRLQSHLLGLGEYGEFIGFVSMFMYTIKEREDILTLIDMVTGARVTHSYLRFG
GVRDDLPEGFKEKTIPVLNKLKKVIRDYEEMFYSDTIYRERTIGIGVLTADEAKSLGVSGPVLRATGVPFDIRKNEPYLV
YRDLDFKVCTETAGDCFARVQVRLNEMRESIYIIEQCLDMIPNGPIFPEGTPYGKRTPVMRVPAGEVFHRVEDPRGEMGM
YMVSDGSDRPYRVKVRGPYYPTLQALPPLIIGTTVADMVSISGSMDGCTSEVDR
>Mature_374_residues
MEEMLESNEMIVHLGPQHPMQPGPFRLNLKLKGETIMDAEVEMGYIHKGIEKILENRTYLQGITIVDRICYLVALTNEEC
YVGCVEKLLDIEPPERAQYIRVILEELSRLQSHLLGLGEYGEFIGFVSMFMYTIKEREDILTLIDMVTGARVTHSYLRFG
GVRDDLPEGFKEKTIPVLNKLKKVIRDYEEMFYSDTIYRERTIGIGVLTADEAKSLGVSGPVLRATGVPFDIRKNEPYLV
YRDLDFKVCTETAGDCFARVQVRLNEMRESIYIIEQCLDMIPNGPIFPEGTPYGKRTPVMRVPAGEVFHRVEDPRGEMGM
YMVSDGSDRPYRVKVRGPYYPTLQALPPLIIGTTVADMVSISGSMDGCTSEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=386, Percent_Identity=37.5647668393782, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI260898743, Length=379, Percent_Identity=36.9393139841689, Blast_Score=263, Evalue=3e-70,
Organism=Escherichia coli, GI145693162, Length=387, Percent_Identity=37.7260981912145, Blast_Score=254, Evalue=9e-69,
Organism=Escherichia coli, GI1789076, Length=375, Percent_Identity=32.2666666666667, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1788832, Length=370, Percent_Identity=31.6216216216216, Blast_Score=188, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17555284, Length=392, Percent_Identity=35.969387755102, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17568379, Length=392, Percent_Identity=36.9897959183673, Blast_Score=271, Evalue=3e-73,
Organism=Drosophila melanogaster, GI221459469, Length=383, Percent_Identity=37.3368146214099, Blast_Score=281, Evalue=4e-76,
Organism=Drosophila melanogaster, GI24638644, Length=388, Percent_Identity=36.5979381443299, Blast_Score=277, Evalue=7e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 42493; Mature: 42493

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEMLESNEMIVHLGPQHPMQPGPFRLNLKLKGETIMDAEVEMGYIHKGIEKILENRTYL
CCCHHCCCCEEEEECCCCCCCCCCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHCCHHH
QGITIVDRICYLVALTNEECYVGCVEKLLDIEPPERAQYIRVILEELSRLQSHLLGLGEY
HHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
GEFIGFVSMFMYTIKEREDILTLIDMVTGARVTHSYLRFGGVRDDLPEGFKEKTIPVLNK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHH
LKKVIRDYEEMFYSDTIYRERTIGIGVLTADEAKSLGVSGPVLRATGVPFDIRKNEPYLV
HHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHCCCCCCEEEECCCCEEEECCCCEEE
YRDLDFKVCTETAGDCFARVQVRLNEMRESIYIIEQCLDMIPNGPIFPEGTPYGKRTPVM
EECCCCEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
RVPAGEVFHRVEDPRGEMGMYMVSDGSDRPYRVKVRGPYYPTLQALPPLIIGTTVADMVS
ECCHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEECCCCCCCHHHCCCHHHHHHHHHHHH
ISGSMDGCTSEVDR
HCCCCCCCHHHCCC
>Mature Secondary Structure
MEEMLESNEMIVHLGPQHPMQPGPFRLNLKLKGETIMDAEVEMGYIHKGIEKILENRTYL
CCCHHCCCCEEEEECCCCCCCCCCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHCCHHH
QGITIVDRICYLVALTNEECYVGCVEKLLDIEPPERAQYIRVILEELSRLQSHLLGLGEY
HHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
GEFIGFVSMFMYTIKEREDILTLIDMVTGARVTHSYLRFGGVRDDLPEGFKEKTIPVLNK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHH
LKKVIRDYEEMFYSDTIYRERTIGIGVLTADEAKSLGVSGPVLRATGVPFDIRKNEPYLV
HHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHCCCCCCEEEECCCCEEEECCCCEEE
YRDLDFKVCTETAGDCFARVQVRLNEMRESIYIIEQCLDMIPNGPIFPEGTPYGKRTPVM
EECCCCEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
RVPAGEVFHRVEDPRGEMGMYMVSDGSDRPYRVKVRGPYYPTLQALPPLIIGTTVADMVS
ECCHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEECCCCCCCHHHCCCHHHHHHHHHHHH
ISGSMDGCTSEVDR
HCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA