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The map label for this gene is top6B [H]

Identifier: 21228519

GI number: 21228519

Start: 2877339

End: 2879204

Strand: Direct

Name: top6B [H]

Synonym: MM_2417

Alternate gene names: 21228519

Gene position: 2877339-2879204 (Clockwise)

Preceding gene: 21228518

Following gene: 21228520

Centisome position: 70.24

GC content: 47.75

Gene sequence:

>1866_bases
ATGGAAACCCCCATTGCAGAAGAACTCGCCAAAAAACAAAAATCGATAAGTGTAGCAGAATTTTTTGAAAAGAACAGGCA
GATCCTGGGTTTTGATTCTGCGCCTCGAAGCCTTATAACAACCGTAAAAGAAGCAGTGGACAATGCTCTCGATGCCTGTG
AGGAAGCAGGAATTCTGCCTGATATCCTTGTCCAGGTCGAGAGGACAGGACCGGACTATGTAACTGTTATTATCGAAGAC
AACGGTCCGGGAATTGTAAGAGAGCAGATCCCCAAAGTCTTTGCAAAACTGCTCTACGGCTCAAGGTTCCATGCCCTCAA
ACAGAGCAGGGGGCAGCAGGGGATAGGAATCTCGGCAGCTGTCCTCTATGCCCAGATGACAGCAGGCAGGCACACTAAAA
TTCTCTCAAAAACCAGCCCGACTGCTCCTGCACATTATTATGAGCTCATGATCAACACCAGCACAAATGAACCTGATATC
CTTGTAGACGAGGTCAGGGACTGGTTCCGCCCGCATGGGACGCAGATTGAGCTTGAGATGAGGGCTGCATATGTAAAAGG
GAGAAGGCAGTCCATTTACGAATACCTTAAAGCAACTGCAATTGTAAACCCCCATGCCAGGATAACTCTTATCGACCCTG
ATGGCAACGAAGAAGTTTTTGAAAGGGCTACGGATAAAATGCCTGAGCCTGCGGAAGAAATCCTGCCCCATCCTGAAGGC
ATTGAGCTCGGAACCCTCATGAAAATGCTCCACTACACTGAGCGCCAGAAACTTGCTCCGTTCCTGCGTTACTCTTTTTG
TAAAATAGGGCTGCTTACTGCGGAGGAAATCTGTAAAGCCGCAGGGCTTGACCCGGAAATCGACCCTCATGCACTGGGCC
GCCATGAGGCAAGAAAGCTGATCGAGGCTTTTGAGAAGGTAAAGATCATGGCTCCTCCGACGGACTGTCTTTCTCCTATC
GGTGAAGACCTTATCTATCGGGGGCTTGAGAAAGAGACTACTGTTGATTTCATTGCTACAAGCACAAGGAAACCGGCTGT
GTATTCGGGAAATCCCTTTGTGGTGGAAGTCGGGATGGCTTACGGGGGCAACCTTCCGAAAGAAGAAAAAATAAGCATCA
TGCGTTTTGCAAACCGTGTGCCTCTACTTTACCAGCAGGGTGGCTGTGTGACCACACATGCTGTGGAGGACATTAAGTGG
AAGCAGTACGGCTTAAACCAGCCAGGAGGGGGAATTCCTGTTGGTCCTGTTATCCTCCTTATCCACGTTGCTTCCATTAA
CGTGCCCTTTACTTCGGAATCAAAGGACGCGATTGCAGATATTCCTGTGATTAAAGAGGAAATCGACCTTGCAATCAAAG
AAGTTGCAAGGAAACTCAAGCACTACCTGAGCAAGCAGAGCAACCTCAAGAAGCGCCGGGAAAAAGAGATCATCATTACA
AAGGTTCTTCCGAAATTAGCAGCAAAGGTTGCACATGTTCTGGAAAAAGACGTCCCTGACATAAATCCCGTTGTTGCAAA
GATCATGGGAAACCTGCTTGTGCACAGGGTAATTAAAAACAACGGAGACGGGACTGTAGATGTGGCAATTAAGGTCAAGA
ACTTCGGGACTTCTGCTTATTCTTTCAGGGTACACGAAATGCTCCCCTGTAAAGTTAGCGGGGCAAAGCCAGAGCCAAAG
GTTGTGACCATGGGCAATGATTACGATTATGTCTGGGACATCTCAGCGTCTGCAGGGTCTTCCAAAGTACTGAGCTATAA
AATAGAATCTGCAAGCGAAGAAGAACTCCAGAAGCTTCCTCAATTGATTGTAGAAGGGATTGAAGAAGAACTGGTAACCG
GGGCAAAAGCTTTCAAGGGTGTTTGA

Upstream 100 bases:

>100_bases
TCTGTTTCAAATATTAGACTTGTTTCAAACATTAGATTTATTTTTATATCAAATTCATTCTAAACATCGGATCAATTTTT
CAGCCCTGAGGTAAAAGTTC

Downstream 100 bases:

>100_bases
AATGGAAGGAGAAAAAGGCAGCAAAACAAGAAAGGGAGACGCCCTTGCCAGGGAAAAACTCCTTGAGATTGCAGAAAAGA
TCTATAACCAGTTTGAAGAG

Product: DNA topoisomerase VI subunit B

Products: NA

Alternate protein names: Type II DNA topoisomerase VI subunit B; TopoVI-B [H]

Number of amino acids: Translated: 621; Mature: 621

Protein sequence:

>621_residues
METPIAEELAKKQKSISVAEFFEKNRQILGFDSAPRSLITTVKEAVDNALDACEEAGILPDILVQVERTGPDYVTVIIED
NGPGIVREQIPKVFAKLLYGSRFHALKQSRGQQGIGISAAVLYAQMTAGRHTKILSKTSPTAPAHYYELMINTSTNEPDI
LVDEVRDWFRPHGTQIELEMRAAYVKGRRQSIYEYLKATAIVNPHARITLIDPDGNEEVFERATDKMPEPAEEILPHPEG
IELGTLMKMLHYTERQKLAPFLRYSFCKIGLLTAEEICKAAGLDPEIDPHALGRHEARKLIEAFEKVKIMAPPTDCLSPI
GEDLIYRGLEKETTVDFIATSTRKPAVYSGNPFVVEVGMAYGGNLPKEEKISIMRFANRVPLLYQQGGCVTTHAVEDIKW
KQYGLNQPGGGIPVGPVILLIHVASINVPFTSESKDAIADIPVIKEEIDLAIKEVARKLKHYLSKQSNLKKRREKEIIIT
KVLPKLAAKVAHVLEKDVPDINPVVAKIMGNLLVHRVIKNNGDGTVDVAIKVKNFGTSAYSFRVHEMLPCKVSGAKPEPK
VVTMGNDYDYVWDISASAGSSKVLSYKIESASEEELQKLPQLIVEGIEEELVTGAKAFKGV

Sequences:

>Translated_621_residues
METPIAEELAKKQKSISVAEFFEKNRQILGFDSAPRSLITTVKEAVDNALDACEEAGILPDILVQVERTGPDYVTVIIED
NGPGIVREQIPKVFAKLLYGSRFHALKQSRGQQGIGISAAVLYAQMTAGRHTKILSKTSPTAPAHYYELMINTSTNEPDI
LVDEVRDWFRPHGTQIELEMRAAYVKGRRQSIYEYLKATAIVNPHARITLIDPDGNEEVFERATDKMPEPAEEILPHPEG
IELGTLMKMLHYTERQKLAPFLRYSFCKIGLLTAEEICKAAGLDPEIDPHALGRHEARKLIEAFEKVKIMAPPTDCLSPI
GEDLIYRGLEKETTVDFIATSTRKPAVYSGNPFVVEVGMAYGGNLPKEEKISIMRFANRVPLLYQQGGCVTTHAVEDIKW
KQYGLNQPGGGIPVGPVILLIHVASINVPFTSESKDAIADIPVIKEEIDLAIKEVARKLKHYLSKQSNLKKRREKEIIIT
KVLPKLAAKVAHVLEKDVPDINPVVAKIMGNLLVHRVIKNNGDGTVDVAIKVKNFGTSAYSFRVHEMLPCKVSGAKPEPK
VVTMGNDYDYVWDISASAGSSKVLSYKIESASEEELQKLPQLIVEGIEEELVTGAKAFKGV
>Mature_621_residues
METPIAEELAKKQKSISVAEFFEKNRQILGFDSAPRSLITTVKEAVDNALDACEEAGILPDILVQVERTGPDYVTVIIED
NGPGIVREQIPKVFAKLLYGSRFHALKQSRGQQGIGISAAVLYAQMTAGRHTKILSKTSPTAPAHYYELMINTSTNEPDI
LVDEVRDWFRPHGTQIELEMRAAYVKGRRQSIYEYLKATAIVNPHARITLIDPDGNEEVFERATDKMPEPAEEILPHPEG
IELGTLMKMLHYTERQKLAPFLRYSFCKIGLLTAEEICKAAGLDPEIDPHALGRHEARKLIEAFEKVKIMAPPTDCLSPI
GEDLIYRGLEKETTVDFIATSTRKPAVYSGNPFVVEVGMAYGGNLPKEEKISIMRFANRVPLLYQQGGCVTTHAVEDIKW
KQYGLNQPGGGIPVGPVILLIHVASINVPFTSESKDAIADIPVIKEEIDLAIKEVARKLKHYLSKQSNLKKRREKEIIIT
KVLPKLAAKVAHVLEKDVPDINPVVAKIMGNLLVHRVIKNNGDGTVDVAIKVKNFGTSAYSFRVHEMLPCKVSGAKPEPK
VVTMGNDYDYVWDISASAGSSKVLSYKIESASEEELQKLPQLIVEGIEEELVTGAKAFKGV

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP [H]

COG id: COG1389

COG function: function code L; DNA topoisomerase VI, subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR010979
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005734
- InterPro:   IPR015320
- ProDom:   PD013790 [H]

Pfam domain/function: PF02518 HATPase_c; PF09239 Topo-VIb_trans [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 68761; Mature: 68761

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METPIAEELAKKQKSISVAEFFEKNRQILGFDSAPRSLITTVKEAVDNALDACEEAGILP
CCCCHHHHHHHHHHCCHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
DILVQVERTGPDYVTVIIEDNGPGIVREQIPKVFAKLLYGSRFHALKQSRGQQGIGISAA
HHHHEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHH
VLYAQMTAGRHTKILSKTSPTAPAHYYELMINTSTNEPDILVDEVRDWFRPHGTQIELEM
HHHHHHHCCCCHHHCCCCCCCCCCEEEEEEEECCCCCCCEEHHHHHHHHCCCCCEEEEEH
RAAYVKGRRQSIYEYLKATAIVNPHARITLIDPDGNEEVFERATDKMPEPAEEILPHPEG
HHHHHHHHHHHHHHHHHHHHEECCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHCCCCCC
IELGTLMKMLHYTERQKLAPFLRYSFCKIGLLTAEEICKAAGLDPEIDPHALGRHEARKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHH
IEAFEKVKIMAPPTDCLSPIGEDLIYRGLEKETTVDFIATSTRKPAVYSGNPFVVEVGMA
HHHHHHCEEECCCHHHHHHHHHHHHHCCCCCCCCCHHEEECCCCCEEECCCCEEEEEEHH
YGGNLPKEEKISIMRFANRVPLLYQQGGCVTTHAVEDIKWKQYGLNQPGGGIPVGPVILL
HCCCCCHHHHHHHHHHHCCCCEEEECCCEEEEHHHHHCCHHHCCCCCCCCCCCHHHHHHH
IHVASINVPFTSESKDAIADIPVIKEEIDLAIKEVARKLKHYLSKQSNLKKRREKEIIIT
HHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVLPKLAAKVAHVLEKDVPDINPVVAKIMGNLLVHRVIKNNGDGTVDVAIKVKNFGTSAY
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEE
SFRVHEMLPCKVSGAKPEPKVVTMGNDYDYVWDISASAGSSKVLSYKIESASEEELQKLP
EEEEHHCCCEEECCCCCCCCEEEECCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHH
QLIVEGIEEELVTGAKAFKGV
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
METPIAEELAKKQKSISVAEFFEKNRQILGFDSAPRSLITTVKEAVDNALDACEEAGILP
CCCCHHHHHHHHHHCCHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
DILVQVERTGPDYVTVIIEDNGPGIVREQIPKVFAKLLYGSRFHALKQSRGQQGIGISAA
HHHHEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHH
VLYAQMTAGRHTKILSKTSPTAPAHYYELMINTSTNEPDILVDEVRDWFRPHGTQIELEM
HHHHHHHCCCCHHHCCCCCCCCCCEEEEEEEECCCCCCCEEHHHHHHHHCCCCCEEEEEH
RAAYVKGRRQSIYEYLKATAIVNPHARITLIDPDGNEEVFERATDKMPEPAEEILPHPEG
HHHHHHHHHHHHHHHHHHHHEECCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHCCCCCC
IELGTLMKMLHYTERQKLAPFLRYSFCKIGLLTAEEICKAAGLDPEIDPHALGRHEARKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHH
IEAFEKVKIMAPPTDCLSPIGEDLIYRGLEKETTVDFIATSTRKPAVYSGNPFVVEVGMA
HHHHHHCEEECCCHHHHHHHHHHHHHCCCCCCCCCHHEEECCCCCEEECCCCEEEEEEHH
YGGNLPKEEKISIMRFANRVPLLYQQGGCVTTHAVEDIKWKQYGLNQPGGGIPVGPVILL
HCCCCCHHHHHHHHHHHCCCCEEEECCCEEEEHHHHHCCHHHCCCCCCCCCCCHHHHHHH
IHVASINVPFTSESKDAIADIPVIKEEIDLAIKEVARKLKHYLSKQSNLKKRREKEIIIT
HHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVLPKLAAKVAHVLEKDVPDINPVVAKIMGNLLVHRVIKNNGDGTVDVAIKVKNFGTSAY
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEE
SFRVHEMLPCKVSGAKPEPKVVTMGNDYDYVWDISASAGSSKVLSYKIESASEEELQKLP
EEEEHHCCCEEECCCCCCCCEEEECCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHH
QLIVEGIEEELVTGAKAFKGV
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]