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The map label for this gene is top6A [H]

Identifier: 21228520

GI number: 21228520

Start: 2879206

End: 2880315

Strand: Direct

Name: top6A [H]

Synonym: MM_2418

Alternate gene names: 21228520

Gene position: 2879206-2880315 (Clockwise)

Preceding gene: 21228519

Following gene: 21228521

Centisome position: 70.29

GC content: 48.74

Gene sequence:

>1110_bases
ATGGAAGGAGAAAAAGGCAGCAAAACAAGAAAGGGAGACGCCCTTGCCAGGGAAAAACTCCTTGAGATTGCAGAAAAGAT
CTATAACCAGTTTGAAGAGGAGGTTGTCCCGAGTGTCAGCCTTCCAAGCCGGACAAAAGCAAACCTGGAATATTCCGACG
AGAGCGATGTCTGGGTCTACGGAGACAGGGAAAGCGAAAGAAGCGCAAAAACCGTAAAAGGTGCATTCCAGCTCCTGAAG
ACTACATATGCAACTGATTTTCTTATAAACGAGCATCTTGCCCGTAACCGTGGCTCAACACTTCGAGAACTTTATTATAT
TTCCGAAGGCTGGGACTATGCCAAATTCAAAGAACAGGGTGAAAGCGACCGCCTGATAGAGGACCTGGAAATCCTGACCA
GCCTCCAGAGAGAGTATTTCCATATGCGCCCTGAAGAAGACGGAGCCACGATGTTCGGGCCGATTGAGATTACGGAACAG
ACAAAGCGCGGAGAGCGGAATATCCACTGCCAGAAGGATGTGGGAGAAGGTGGGTACCAGATCCCTTTCAATGTGGAAAA
CATAGAGTTTCAAAAGCACGATGCGAGCATGATTATTGCCATAGAAACCGGTGGTATGTATGCGCGTTTAATGGAAAACG
GGTTTGATGAGGCTTATAACGCAATCCTTGTCCACCTGAAAGGTCAGCCTGCACGGTCAACCCGCAGGATAATCAAGCGC
ATGAACGAAGAACTCGGGATTCCCGTGGCAGTTTTTACTGACGGTGACCCTTGGTCTTACAGGATCTATGCCTCTGTTGC
TTACGGAGCCATAAAAAGTGCTCACCTTTCGGAATTCATGGCAACACCGGCAGCCAAATTCCTGGGGCTTCAGCCTTCTG
ATATCGTGGAATACGAACTTTCAACCGATAAGCTCACAGAGCAGGACGTAAGCGCTCTCCGGAGTGAGCTTTCCGACCCG
CGTTTTGAGTCCGATTACTGGAAAGAACAGATCCAGCTCCAGCTCGATATAGGGAAGAAGGCTGAACAGCAGGCTTTTGC
AGGAAAAGGGCTTGACTTCGTAACCGAGGTTTATCTTCCGAACAGACTGAAAGAGATGGGCATGATTTGA

Upstream 100 bases:

>100_bases
TCTGCAAGCGAAGAAGAACTCCAGAAGCTTCCTCAATTGATTGTAGAAGGGATTGAAGAAGAACTGGTAACCGGGGCAAA
AGCTTTCAAGGGTGTTTGAA

Downstream 100 bases:

>100_bases
TGTCTCAGACTGAAATAAAATTACGGTAAACCAGTAATGACAAAACTGATGGATACCCGATGAATACCTGAAGGGTAACT
GTAGATACCTGATGGATACC

Product: DNA topoisomerase VI subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MEGEKGSKTRKGDALAREKLLEIAEKIYNQFEEEVVPSVSLPSRTKANLEYSDESDVWVYGDRESERSAKTVKGAFQLLK
TTYATDFLINEHLARNRGSTLRELYYISEGWDYAKFKEQGESDRLIEDLEILTSLQREYFHMRPEEDGATMFGPIEITEQ
TKRGERNIHCQKDVGEGGYQIPFNVENIEFQKHDASMIIAIETGGMYARLMENGFDEAYNAILVHLKGQPARSTRRIIKR
MNEELGIPVAVFTDGDPWSYRIYASVAYGAIKSAHLSEFMATPAAKFLGLQPSDIVEYELSTDKLTEQDVSALRSELSDP
RFESDYWKEQIQLQLDIGKKAEQQAFAGKGLDFVTEVYLPNRLKEMGMI

Sequences:

>Translated_369_residues
MEGEKGSKTRKGDALAREKLLEIAEKIYNQFEEEVVPSVSLPSRTKANLEYSDESDVWVYGDRESERSAKTVKGAFQLLK
TTYATDFLINEHLARNRGSTLRELYYISEGWDYAKFKEQGESDRLIEDLEILTSLQREYFHMRPEEDGATMFGPIEITEQ
TKRGERNIHCQKDVGEGGYQIPFNVENIEFQKHDASMIIAIETGGMYARLMENGFDEAYNAILVHLKGQPARSTRRIIKR
MNEELGIPVAVFTDGDPWSYRIYASVAYGAIKSAHLSEFMATPAAKFLGLQPSDIVEYELSTDKLTEQDVSALRSELSDP
RFESDYWKEQIQLQLDIGKKAEQQAFAGKGLDFVTEVYLPNRLKEMGMI
>Mature_369_residues
MEGEKGSKTRKGDALAREKLLEIAEKIYNQFEEEVVPSVSLPSRTKANLEYSDESDVWVYGDRESERSAKTVKGAFQLLK
TTYATDFLINEHLARNRGSTLRELYYISEGWDYAKFKEQGESDRLIEDLEILTSLQREYFHMRPEEDGATMFGPIEITEQ
TKRGERNIHCQKDVGEGGYQIPFNVENIEFQKHDASMIIAIETGGMYARLMENGFDEAYNAILVHLKGQPARSTRRIIKR
MNEELGIPVAVFTDGDPWSYRIYASVAYGAIKSAHLSEFMATPAAKFLGLQPSDIVEYELSTDKLTEQDVSALRSELSDP
RFESDYWKEQIQLQLDIGKKAEQQAFAGKGLDFVTEVYLPNRLKEMGMI

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity [H]

COG id: COG1697

COG function: function code L; DNA topoisomerase VI, subunit A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6A family [H]

Homologues:

Organism=Homo sapiens, GI6912680, Length=311, Percent_Identity=26.0450160771704, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI38201680, Length=311, Percent_Identity=26.0450160771704, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45552753, Length=190, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002815
- InterPro:   IPR013049
- InterPro:   IPR004085
- InterPro:   IPR022904
- InterPro:   IPR011991 [H]

Pfam domain/function: PF04406 TP6A_N [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 42128; Mature: 42128

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGEKGSKTRKGDALAREKLLEIAEKIYNQFEEEVVPSVSLPSRTKANLEYSDESDVWVY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCEEEE
GDRESERSAKTVKGAFQLLKTTYATDFLINEHLARNRGSTLRELYYISEGWDYAKFKEQG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEECCCCCHHHHHHCC
ESDRLIEDLEILTSLQREYFHMRPEEDGATMFGPIEITEQTKRGERNIHCQKDVGEGGYQ
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECEEECHHHCCCCCCCEECCCCCCCCCC
IPFNVENIEFQKHDASMIIAIETGGMYARLMENGFDEAYNAILVHLKGQPARSTRRIIKR
CCEECCCCEEEECCCEEEEEEECCCHHHHHHHCCHHHHCEEEEEEECCCCCHHHHHHHHH
MNEELGIPVAVFTDGDPWSYRIYASVAYGAIKSAHLSEFMATPAAKFLGLQPSDIVEYEL
HHHHHCCCEEEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHEEEEC
STDKLTEQDVSALRSELSDPRFESDYWKEQIQLQLDIGKKAEQQAFAGKGLDFVTEVYLP
CCHHCCHHHHHHHHHHHCCCCCCHHHHHHHEEEEEECCCCHHHHHHHCCCHHHHHHHHCC
NRLKEMGMI
HHHHHHCCC
>Mature Secondary Structure
MEGEKGSKTRKGDALAREKLLEIAEKIYNQFEEEVVPSVSLPSRTKANLEYSDESDVWVY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCEEEE
GDRESERSAKTVKGAFQLLKTTYATDFLINEHLARNRGSTLRELYYISEGWDYAKFKEQG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEECCCCCHHHHHHCC
ESDRLIEDLEILTSLQREYFHMRPEEDGATMFGPIEITEQTKRGERNIHCQKDVGEGGYQ
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECEEECHHHCCCCCCCEECCCCCCCCCC
IPFNVENIEFQKHDASMIIAIETGGMYARLMENGFDEAYNAILVHLKGQPARSTRRIIKR
CCEECCCCEEEECCCEEEEEEECCCHHHHHHHCCHHHHCEEEEEEECCCCCHHHHHHHHH
MNEELGIPVAVFTDGDPWSYRIYASVAYGAIKSAHLSEFMATPAAKFLGLQPSDIVEYEL
HHHHHCCCEEEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHEEEEC
STDKLTEQDVSALRSELSDPRFESDYWKEQIQLQLDIGKKAEQQAFAGKGLDFVTEVYLP
CCHHCCHHHHHHHHHHHCCCCCCHHHHHHHEEEEEECCCCHHHHHHHCCCHHHHHHHHCC
NRLKEMGMI
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]