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The map label for this gene is hisE [H]

Identifier: 21228474

GI number: 21228474

Start: 2829197

End: 2829520

Strand: Reverse

Name: hisE [H]

Synonym: MM_2372

Alternate gene names: 21228474

Gene position: 2829520-2829197 (Counterclockwise)

Preceding gene: 21228475

Following gene: 21228472

Centisome position: 69.07

GC content: 42.59

Gene sequence:

>324_bases
GTGTTAAAAATGCCGGAGGCTGACTTATCCATTTTAAACAGGGTGTATGATATCATCCTGGACAGGAAAGAGAACTATGA
CGAAAATTCATATGTCTGTAAACTTTTGAACCACCGAAAGGGAATGAACAAAATCCTTGAGAAAGTGGGAGAGGAATCCA
TTGAAACCATACTTGCAGTCAGGAACGAAGACCATAGAGAGATCGTCTCTGAGAGCTCGGACCTGATCTTCCACCTGCTG
GTGCTGCTTGCCGCAAACAACATTACTCTTGAGGAAATAGCAGATGAGTTAAGTACCAGGCACGAAAAAATGAGAAGAGA
TTGA

Upstream 100 bases:

>100_bases
GAGAAATCACGGATCCCAGGAAGGTTTAAAGACCCTCCTGTTTACTTCTTCCTAATTTTTTCTACTTATTATTTAATGAT
GTATTATTTATCTTGAACAG

Downstream 100 bases:

>100_bases
ATAAGAAACGCTCATGATATTCTTGGAATAACATGCCCAAAAAATGAAAGTATCTGGAAGTACTTTCATGCCAAAAAAAC
GACTAATGCTGAAGAGATAC

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH [H]

Number of amino acids: Translated: 107; Mature: 107

Protein sequence:

>107_residues
MLKMPEADLSILNRVYDIILDRKENYDENSYVCKLLNHRKGMNKILEKVGEESIETILAVRNEDHREIVSESSDLIFHLL
VLLAANNITLEEIADELSTRHEKMRRD

Sequences:

>Translated_107_residues
MLKMPEADLSILNRVYDIILDRKENYDENSYVCKLLNHRKGMNKILEKVGEESIETILAVRNEDHREIVSESSDLIFHLL
VLLAANNITLEEIADELSTRHEKMRRD
>Mature_107_residues
MLKMPEADLSILNRVYDIILDRKENYDENSYVCKLLNHRKGMNKILEKVGEESIETILAVRNEDHREIVSESSDLIFHLL
VLLAANNITLEEIADELSTRHEKMRRD

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=92, Percent_Identity=38.0434782608696, Blast_Score=65, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008179
- InterPro:   IPR021130 [H]

Pfam domain/function: PF01503 PRA-PH [H]

EC number: =3.6.1.31 [H]

Molecular weight: Translated: 12523; Mature: 12523

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKMPEADLSILNRVYDIILDRKENYDENSYVCKLLNHRKGMNKILEKVGEESIETILAV
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RNEDHREIVSESSDLIFHLLVLLAANNITLEEIADELSTRHEKMRRD
CCCHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLKMPEADLSILNRVYDIILDRKENYDENSYVCKLLNHRKGMNKILEKVGEESIETILAV
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RNEDHREIVSESSDLIFHLLVLLAANNITLEEIADELSTRHEKMRRD
CCCHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]