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The map label for this gene is trmE [C]

Identifier: 21228472

GI number: 21228472

Start: 2826593

End: 2827609

Strand: Reverse

Name: trmE [C]

Synonym: MM_2370

Alternate gene names: 21228472

Gene position: 2827609-2826593 (Counterclockwise)

Preceding gene: 21228474

Following gene: 21228464

Centisome position: 69.03

GC content: 45.82

Gene sequence:

>1017_bases
ATGATGATTTTTGAGAAAATTCACACAGTTCCCACTTCCGAGGAGTTAACCAATAAAGCATTTAAACGGGCAGCCAGGGC
AATGTCCGGGAAAACTATTGATGGGAGAGACAGCCGTTTCAAGGCCAATGAATCCATGCTTCTTACGGCTGCAAATATTT
TCACGGATAACCTTGCAAATATAGTCAGAAGATTCCCGAGCTTCGAACAGCTTCCCAGATTCTATTATGAACTTACAGAC
ATCCTTGTAGGAGTGGAAAAACTCAAGATGTCCCTTGCGTCCGTGGACTGGGCTAGCAGGAAAATTCATGAGGTTGCAAG
GAGTTACGTGGGAAAAATCCGTGAATCGGATATTCCAGAGCCTGTAAGAAAAGAAGCTTTCGGCAGGCTTGCATCAATAA
TTAATTCAATAAATAAGGACCTCCTCTTCCTGAACGAAGCCAGAAACATCCTGAGAAAACTCCCTGATGTCCAGGACGAG
CCAACGATTGTAATAGCTGGATATCCCAATGTAGGGAAATCAAGCTTTGTTTCAAAGATTACCGGTGCGACCCCAGAAAT
TGCTCCATACCCATTCACAACAAAAGGAGTAACCATAGGTCACTTTACACGGGACGGAGTCCGTTATCAGGTGATGGACA
CTCCAGGGCTCCTTGACCGCCCAATGGCCGAAAGAAACGACATTGAACGGCAGGCGATCACTGCAATTCACTACCTGGAT
GCAGTTGTAATGGTCGTTATTGACCCCAGTGAAAGCTGCGGGTATGAACTTCAAGATCAGAGGCGCCTGCTTGCTGAAAT
CAGAGAGAATTTTAACCTTCCCCTGCTTGTGGTCGCTAATAAAGCTGACAGGCCTGAGTTCATGAAAATGGATGAGGTTG
AGCTGAACATGTCCACAATAACAGGAGAAGGAATTGAACAGGTAATGGACAGGCTCCTGGAAATGATAGAAGAAAAACGC
CTCAGGTCTCTCGAAGAGGCACCTTCAGAAGAGTCGGATGACGAATCCGCTCTCTAA

Upstream 100 bases:

>100_bases
TCTTGCAGAACTTTTGCCTGCGGACTTTAGATTTTTCTGATAAACTTCTTCGCTCAGAAAACCTTTATATAGATTAAATG
AGCCCCCAGAGGGTTAGAAA

Downstream 100 bases:

>100_bases
TTCTTTTTCCCCTGCGTTCAGAGCATCATGTTATTCAGATATCATGAGATGTTCAGAGTATCCTGAAATGTTCAGAATAT
CCTGAAATGTTCAGAATATC

Product: GTP-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MMIFEKIHTVPTSEELTNKAFKRAARAMSGKTIDGRDSRFKANESMLLTAANIFTDNLANIVRRFPSFEQLPRFYYELTD
ILVGVEKLKMSLASVDWASRKIHEVARSYVGKIRESDIPEPVRKEAFGRLASIINSINKDLLFLNEARNILRKLPDVQDE
PTIVIAGYPNVGKSSFVSKITGATPEIAPYPFTTKGVTIGHFTRDGVRYQVMDTPGLLDRPMAERNDIERQAITAIHYLD
AVVMVVIDPSESCGYELQDQRRLLAEIRENFNLPLLVVANKADRPEFMKMDEVELNMSTITGEGIEQVMDRLLEMIEEKR
LRSLEEAPSEESDDESAL

Sequences:

>Translated_338_residues
MMIFEKIHTVPTSEELTNKAFKRAARAMSGKTIDGRDSRFKANESMLLTAANIFTDNLANIVRRFPSFEQLPRFYYELTD
ILVGVEKLKMSLASVDWASRKIHEVARSYVGKIRESDIPEPVRKEAFGRLASIINSINKDLLFLNEARNILRKLPDVQDE
PTIVIAGYPNVGKSSFVSKITGATPEIAPYPFTTKGVTIGHFTRDGVRYQVMDTPGLLDRPMAERNDIERQAITAIHYLD
AVVMVVIDPSESCGYELQDQRRLLAEIRENFNLPLLVVANKADRPEFMKMDEVELNMSTITGEGIEQVMDRLLEMIEEKR
LRSLEEAPSEESDDESAL
>Mature_338_residues
MMIFEKIHTVPTSEELTNKAFKRAARAMSGKTIDGRDSRFKANESMLLTAANIFTDNLANIVRRFPSFEQLPRFYYELTD
ILVGVEKLKMSLASVDWASRKIHEVARSYVGKIRESDIPEPVRKEAFGRLASIINSINKDLLFLNEARNILRKLPDVQDE
PTIVIAGYPNVGKSSFVSKITGATPEIAPYPFTTKGVTIGHFTRDGVRYQVMDTPGLLDRPMAERNDIERQAITAIHYLD
AVVMVVIDPSESCGYELQDQRRLLAEIRENFNLPLLVVANKADRPEFMKMDEVELNMSTITGEGIEQVMDRLLEMIEEKR
LRSLEEAPSEESDDESAL

Specific function: Exhibits A Very High Intrinsic Gtpase Hydrolysis Rate. Involved In The Biosynthesis Of The Hypermodified Nucleoside 5- Methylaminomethyl-2-Thiouridine, Which Is Found In The Wobble Position Of Some Trnas. [C]

COG id: COG1084

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasmic; may also be associated with the inner membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP1/OBG family. NOG subfamily [H]

Homologues:

Organism=Homo sapiens, GI55953087, Length=336, Percent_Identity=34.5238095238095, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI25145602, Length=346, Percent_Identity=31.7919075144509, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI25145600, Length=346, Percent_Identity=31.7919075144509, Blast_Score=175, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6325164, Length=260, Percent_Identity=35.7692307692308, Blast_Score=168, Evalue=1e-42,
Organism=Drosophila melanogaster, GI19921908, Length=349, Percent_Identity=34.0974212034384, Blast_Score=185, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006073
- InterPro:   IPR010674
- InterPro:   IPR005225 [H]

Pfam domain/function: PF06858 NOG1 [H]

EC number: NA

Molecular weight: Translated: 38289; Mature: 38289

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIFEKIHTVPTSEELTNKAFKRAARAMSGKTIDGRDSRFKANESMLLTAANIFTDNLAN
CCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHH
IVRRFPSFEQLPRFYYELTDILVGVEKLKMSLASVDWASRKIHEVARSYVGKIRESDIPE
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PVRKEAFGRLASIINSINKDLLFLNEARNILRKLPDVQDEPTIVIAGYPNVGKSSFVSKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHH
TGATPEIAPYPFTTKGVTIGHFTRDGVRYQVMDTPGLLDRPMAERNDIERQAITAIHYLD
CCCCCCCCCCCCCCCCEEEECEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
AVVMVVIDPSESCGYELQDQRRLLAEIRENFNLPLLVVANKADRPEFMKMDEVELNMSTI
HEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHCCCHHEEEHHHH
TGEGIEQVMDRLLEMIEEKRLRSLEEAPSEESDDESAL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MMIFEKIHTVPTSEELTNKAFKRAARAMSGKTIDGRDSRFKANESMLLTAANIFTDNLAN
CCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHH
IVRRFPSFEQLPRFYYELTDILVGVEKLKMSLASVDWASRKIHEVARSYVGKIRESDIPE
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PVRKEAFGRLASIINSINKDLLFLNEARNILRKLPDVQDEPTIVIAGYPNVGKSSFVSKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHH
TGATPEIAPYPFTTKGVTIGHFTRDGVRYQVMDTPGLLDRPMAERNDIERQAITAIHYLD
CCCCCCCCCCCCCCCCEEEECEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
AVVMVVIDPSESCGYELQDQRRLLAEIRENFNLPLLVVANKADRPEFMKMDEVELNMSTI
HEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHCCCHHEEEHHHH
TGEGIEQVMDRLLEMIEEKRLRSLEEAPSEESDDESAL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]