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The map label for this gene is echB [H]

Identifier: 21228423

GI number: 21228423

Start: 2780327

End: 2781199

Strand: Direct

Name: echB [H]

Synonym: MM_2321

Alternate gene names: 21228423

Gene position: 2780327-2781199 (Clockwise)

Preceding gene: 21228422

Following gene: 21228424

Centisome position: 67.87

GC content: 41.12

Gene sequence:

>873_bases
ATGGTAGCTATGAACGATGTTTTGCTAGCTATTCTTGTTCTGATTGGTGCTCCTATCATAGGCTGTTTAGCTTCGGGGAT
TGACAGGAAAATCACTGCAAGACTGCAGGGTAGAGTCGGTCCACCTCTTTTACAGCCGTACTATGATGTCAGGAAGCTCA
TGAGTAAAGAAAACATGATCGTAAACGGCTCTCAGAACTTTTACGTAGTCGTGTACCTGGTCTTTATCATTCTGAGCCTC
TTGATGTTAATATTCAGGGCAGACATGCTGATGATAATATTCGTATATACTGTAGCTTCTCTGGCTCTTATTGTAGGAGG
TATGAGCACCGGTTCTCCATATGCCAGAGTAGGAAGTTCAAGGGAGATCATGGCTATACTTTCTTATGAGCCGGTTTTGA
TTTTATATGCCCTTGCAATCTACCTGGTCACCGGCACTTTCAAAGTATCCGCGCTGTTAGAAGCATCCACTCCTCTGCTG
ATATATACGCCTCTTTTATTCATAGCAATGATAGTTGTTCTGAATATAAAATTGAAAAAATCGCCCTTTGATTATTCAAC
CTCTCACCACGGTCACCAGGAACTGGTTAAAGGTATGACAACCGAATATTCAGGGCCAGGATTTGCCACAATTGAGATTG
CTCACTTCTATGAATACGTGTTCTTAACCGGACTAATATTCTTATTCTGGGCATCAACTCCAATAATAGGTTTGCTTCTG
GGTATCATTGCTTTCTTGCTGGTAATCGTAATAGACAATATTACTGCAAGAGTTTACTGGCAATGGATGCTCAAATTGAG
CTGGACATTCCTGTTAGCAATTTCACTTGTGAACATAGTGTACCTGTACGTAAGTGGAGTAAAATTAGTGTGA

Upstream 100 bases:

>100_bases
TATATCTCCAGAACACTTTTGGAGAAAATAAACTTACAACGCTTGGATATGCAATTTCCATAATTCTTATTGTAATTGCA
TTGGCAGGAGGGGTACTATA

Downstream 100 bases:

>100_bases
AAGAGGGCTATTTATGAGTTTAGCAAAATCACCATGGATCATACATGTGAATTGTAACAGCTGCAATGGCTGTGACATTG
AGGTAGTAGCCTGTCTTACC

Product: ech hydrogenase subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MVAMNDVLLAILVLIGAPIIGCLASGIDRKITARLQGRVGPPLLQPYYDVRKLMSKENMIVNGSQNFYVVVYLVFIILSL
LMLIFRADMLMIIFVYTVASLALIVGGMSTGSPYARVGSSREIMAILSYEPVLILYALAIYLVTGTFKVSALLEASTPLL
IYTPLLFIAMIVVLNIKLKKSPFDYSTSHHGHQELVKGMTTEYSGPGFATIEIAHFYEYVFLTGLIFLFWASTPIIGLLL
GIIAFLLVIVIDNITARVYWQWMLKLSWTFLLAISLVNIVYLYVSGVKLV

Sequences:

>Translated_290_residues
MVAMNDVLLAILVLIGAPIIGCLASGIDRKITARLQGRVGPPLLQPYYDVRKLMSKENMIVNGSQNFYVVVYLVFIILSL
LMLIFRADMLMIIFVYTVASLALIVGGMSTGSPYARVGSSREIMAILSYEPVLILYALAIYLVTGTFKVSALLEASTPLL
IYTPLLFIAMIVVLNIKLKKSPFDYSTSHHGHQELVKGMTTEYSGPGFATIEIAHFYEYVFLTGLIFLFWASTPIIGLLL
GIIAFLLVIVIDNITARVYWQWMLKLSWTFLLAISLVNIVYLYVSGVKLV
>Mature_290_residues
MVAMNDVLLAILVLIGAPIIGCLASGIDRKITARLQGRVGPPLLQPYYDVRKLMSKENMIVNGSQNFYVVVYLVFIILSL
LMLIFRADMLMIIFVYTVASLALIVGGMSTGSPYARVGSSREIMAILSYEPVLILYALAIYLVTGTFKVSALLEASTPLL
IYTPLLFIAMIVVLNIKLKKSPFDYSTSHHGHQELVKGMTTEYSGPGFATIEIAHFYEYVFLTGLIFLFWASTPIIGLLL
GIIAFLLVIVIDNITARVYWQWMLKLSWTFLLAISLVNIVYLYVSGVKLV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0650

COG function: function code C; Formate hydrogenlyase subunit 4

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Escherichia coli, GI1789077, Length=206, Percent_Identity=30.0970873786408, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87082115, Length=202, Percent_Identity=30.1980198019802, Blast_Score=78, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 32235; Mature: 32235

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAMNDVLLAILVLIGAPIIGCLASGIDRKITARLQGRVGPPLLQPYYDVRKLMSKENMI
CCCHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEE
VNGSQNFYVVVYLVFIILSLLMLIFRADMLMIIFVYTVASLALIVGGMSTGSPYARVGSS
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCC
REIMAILSYEPVLILYALAIYLVTGTFKVSALLEASTPLLIYTPLLFIAMIVVLNIKLKK
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEC
SPFDYSTSHHGHQELVKGMTTEYSGPGFATIEIAHFYEYVFLTGLIFLFWASTPIIGLLL
CCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
GIIAFLLVIVIDNITARVYWQWMLKLSWTFLLAISLVNIVYLYVSGVKLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVAMNDVLLAILVLIGAPIIGCLASGIDRKITARLQGRVGPPLLQPYYDVRKLMSKENMI
CCCHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEE
VNGSQNFYVVVYLVFIILSLLMLIFRADMLMIIFVYTVASLALIVGGMSTGSPYARVGSS
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCC
REIMAILSYEPVLILYALAIYLVTGTFKVSALLEASTPLLIYTPLLFIAMIVVLNIKLKK
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEC
SPFDYSTSHHGHQELVKGMTTEYSGPGFATIEIAHFYEYVFLTGLIFLFWASTPIIGLLL
CCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
GIIAFLLVIVIDNITARVYWQWMLKLSWTFLLAISLVNIVYLYVSGVKLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA