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The map label for this gene is htpX [H]

Identifier: 21228217

GI number: 21228217

Start: 2526897

End: 2528087

Strand: Reverse

Name: htpX [H]

Synonym: MM_2115

Alternate gene names: 21228217

Gene position: 2528087-2526897 (Counterclockwise)

Preceding gene: 21228253

Following gene: 21228215

Centisome position: 61.72

GC content: 43.16

Gene sequence:

>1191_bases
TTGATTGTTGCAATAATTGCAATTTCAGGGTTCCTGCTGTATGCTTACATATATTTCTCAGGCAGCAAATGGATCCTCAG
ATGGTATGGAGCACATAAGGTCCAGAGGAGCGAAAAACCTCTTCTTTACTCACTCCTTGAGGACCTTTCTTCCAGAGCAA
AAATTAATCCCCCCGAAATATACAGTTTTGAGTCCAGAATTCCCTCAATATTTACAGTCGGCAACACAGGTAAATCTTCA
ATCACTATTTCGACATCCATGCTGGAGATGTTTGGAGAACTGGAACTGGAAGCCCTGATGGCGCATGAGATCGGACACAT
ACAAAATGGAGATGTGGGCAAAAATACGTTTATAGCACTTATTGCAGGCACAATAATGTCGTTTCCTAACTTTGCAATGT
GGTGCTCCATGCTCTCCGGTTTCGGACAGCCGGAGGACCCTGCACCCAGGTTCTTCAGATATATAGGAACTGCTATTGCC
GCTCCGCCTGCAGCACTTCTAATACACCTCACAAACCCGGCCAGAAGAGAACTCGAAGCCGATGAAATAGCAGTGAAATT
AACAAAAAATCCCCAGGTCCTGGCAAAGACGATAGAGTACCTTGAAAACTACATCCCCCTCCAGCCTGTATCCACCAAGT
TTAACCCGGGCCATTTCCACCTTTTCAGCACACATACCCAGCAGGTGAGAGGATACCTGTCTATATTCATATCCCTGTTC
GACACTCACCCTGAAACCGGAAACAGAGTCTCACGCATCCTGAGCCATACAACTTACTCGAAAAACGAGAATATCAGCAA
TAACCGCTCAAGGGTCCCAGGCTTTTTTGATGTGAAAAACTGGAGGCTTTCACTTGGTATAAGCTTTGCATCTTATATGG
CTTTCCTGTTTGTGGTTATCGTAGGGGTCACGTTTGCAATCAAAGATTTCAATTTCCTTGTTAACGGAGGAATTGCTGCA
ATATACACATGCACAGTCGTACTTCTTATCGGAGCTACTGCGAAACTCTCCAGAAGGAAGACTTATTTTAAAAGTCCTTC
ACTGATACAAAATAGAGTTGTTTCAAAACCGGTACAGGCTTTCAAGCATTTGATGAAGAAAGGATTAAAGTCTATTCACT
TCAACTCTAACCACCTGATCCATAGAAAAAAATCGGATAAGAAGGAAGAGAAGAAAAGCGAGATATTATAA

Upstream 100 bases:

>100_bases
AAACAAAAAGCAGGGGGACATATAAATGACCGGATCCGAAATGCCTGAATCTTTTAATTTTTCATCAGCCCTCTCAGGCG
GGGTTGCAATAGAAATTATT

Downstream 100 bases:

>100_bases
GAAAAAAATATCTCGAGATAATCTTCTCAAGTAATATATGTCAAATAATCAAGTAATATAATTATCAAATAAGAAAGAAT
GAATAAAACAAATAAGAAAG

Product: protease HTPX-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MIVAIIAISGFLLYAYIYFSGSKWILRWYGAHKVQRSEKPLLYSLLEDLSSRAKINPPEIYSFESRIPSIFTVGNTGKSS
ITISTSMLEMFGELELEALMAHEIGHIQNGDVGKNTFIALIAGTIMSFPNFAMWCSMLSGFGQPEDPAPRFFRYIGTAIA
APPAALLIHLTNPARRELEADEIAVKLTKNPQVLAKTIEYLENYIPLQPVSTKFNPGHFHLFSTHTQQVRGYLSIFISLF
DTHPETGNRVSRILSHTTYSKNENISNNRSRVPGFFDVKNWRLSLGISFASYMAFLFVVIVGVTFAIKDFNFLVNGGIAA
IYTCTVVLLIGATAKLSRRKTYFKSPSLIQNRVVSKPVQAFKHLMKKGLKSIHFNSNHLIHRKKSDKKEEKKSEIL

Sequences:

>Translated_396_residues
MIVAIIAISGFLLYAYIYFSGSKWILRWYGAHKVQRSEKPLLYSLLEDLSSRAKINPPEIYSFESRIPSIFTVGNTGKSS
ITISTSMLEMFGELELEALMAHEIGHIQNGDVGKNTFIALIAGTIMSFPNFAMWCSMLSGFGQPEDPAPRFFRYIGTAIA
APPAALLIHLTNPARRELEADEIAVKLTKNPQVLAKTIEYLENYIPLQPVSTKFNPGHFHLFSTHTQQVRGYLSIFISLF
DTHPETGNRVSRILSHTTYSKNENISNNRSRVPGFFDVKNWRLSLGISFASYMAFLFVVIVGVTFAIKDFNFLVNGGIAA
IYTCTVVLLIGATAKLSRRKTYFKSPSLIQNRVVSKPVQAFKHLMKKGLKSIHFNSNHLIHRKKSDKKEEKKSEIL
>Mature_396_residues
MIVAIIAISGFLLYAYIYFSGSKWILRWYGAHKVQRSEKPLLYSLLEDLSSRAKINPPEIYSFESRIPSIFTVGNTGKSS
ITISTSMLEMFGELELEALMAHEIGHIQNGDVGKNTFIALIAGTIMSFPNFAMWCSMLSGFGQPEDPAPRFFRYIGTAIA
APPAALLIHLTNPARRELEADEIAVKLTKNPQVLAKTIEYLENYIPLQPVSTKFNPGHFHLFSTHTQQVRGYLSIFISLF
DTHPETGNRVSRILSHTTYSKNENISNNRSRVPGFFDVKNWRLSLGISFASYMAFLFVVIVGVTFAIKDFNFLVNGGIAA
IYTCTVVLLIGATAKLSRRKTYFKSPSLIQNRVVSKPVQAFKHLMKKGLKSIHFNSNHLIHRKKSDKKEEKKSEIL

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022919
- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 44564; Mature: 44564

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVAIIAISGFLLYAYIYFSGSKWILRWYGAHKVQRSEKPLLYSLLEDLSSRAKINPPEI
CEEEEEHHHHHHHHHHHHHCCCCEEEEECCHHHHCCCCCCHHHHHHHHHHHCCCCCCCCC
YSFESRIPSIFTVGNTGKSSITISTSMLEMFGELELEALMAHEIGHIQNGDVGKNTFIAL
EEHHHCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
IAGTIMSFPNFAMWCSMLSGFGQPEDPAPRFFRYIGTAIAAPPAALLIHLTNPARRELEA
HHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCHHHHCCCC
DEIAVKLTKNPQVLAKTIEYLENYIPLQPVSTKFNPGHFHLFSTHTQQVRGYLSIFISLF
CCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHH
DTHPETGNRVSRILSHTTYSKNENISNNRSRVPGFFDVKNWRLSLGISFASYMAFLFVVI
HCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCEEEEECCCHHHHHHHHHHHH
VGVTFAIKDFNFLVNGGIAAIYTCTVVLLIGATAKLSRRKTYFKSPSLIQNRVVSKPVQA
HHHHHHHHHHHHEECCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FKHLMKKGLKSIHFNSNHLIHRKKSDKKEEKKSEIL
HHHHHHHHHHHEECCCCCEEECCCCCHHHHHHHCCC
>Mature Secondary Structure
MIVAIIAISGFLLYAYIYFSGSKWILRWYGAHKVQRSEKPLLYSLLEDLSSRAKINPPEI
CEEEEEHHHHHHHHHHHHHCCCCEEEEECCHHHHCCCCCCHHHHHHHHHHHCCCCCCCCC
YSFESRIPSIFTVGNTGKSSITISTSMLEMFGELELEALMAHEIGHIQNGDVGKNTFIAL
EEHHHCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
IAGTIMSFPNFAMWCSMLSGFGQPEDPAPRFFRYIGTAIAAPPAALLIHLTNPARRELEA
HHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCHHHHCCCC
DEIAVKLTKNPQVLAKTIEYLENYIPLQPVSTKFNPGHFHLFSTHTQQVRGYLSIFISLF
CCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHH
DTHPETGNRVSRILSHTTYSKNENISNNRSRVPGFFDVKNWRLSLGISFASYMAFLFVVI
HCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCEEEEECCCHHHHHHHHHHHH
VGVTFAIKDFNFLVNGGIAAIYTCTVVLLIGATAKLSRRKTYFKSPSLIQNRVVSKPVQA
HHHHHHHHHHHHEECCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FKHLMKKGLKSIHFNSNHLIHRKKSDKKEEKKSEIL
HHHHHHHHHHHEECCCCCEEECCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA