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The map label for this gene is trxA [H]

Identifier: 21228181

GI number: 21228181

Start: 2479613

End: 2480005

Strand: Direct

Name: trxA [H]

Synonym: MM_2079

Alternate gene names: 21228181

Gene position: 2479613-2480005 (Clockwise)

Preceding gene: 21228180

Following gene: 21228184

Centisome position: 60.53

GC content: 44.78

Gene sequence:

>393_bases
TTGAACGGAAGCAGTATAATCGAATTTGAGGACATGACCTGGAGCCAGCAGGTTGAGGATTCCAAAAAGCCCGTTGTTGT
GATGTTTTACAGCCCTGCATGCCCATATTGCAAAGCTATGGAACCATATTTTGAGGAATATGCTAAGGAATACGGTTCTT
CGGCAGTTTTTGGCAGAATAAATATAGCAACAAACCCGTGGACTGCAGAAAAATACGGGGTTCAGGGCACTCCTACCTTC
AAGTTTTTCTGCCATGGAAGACCTGTATGGGAACAGGTAGGCCAGATCTATCCTTCAATACTGAAAAATGCTGTCCGGGA
TATGCTTCAGCACGGTGAGGAATGCATAAGAAAAAGCACCCCTGTAGGGCAGGACATTACAGGATACGTATAA

Upstream 100 bases:

>100_bases
TACTATGAAAATTCATGTTTTATGAACCTTCATGTTTTATGGATCTGGAGCAAATTAACTCCTGAATTTACTCTATTTAT
AGTTTTAAGGGGGAAGTTGA

Downstream 100 bases:

>100_bases
TTCATGTTTACTGTGACGATTCATGTTTACTGTGACGATTCAGACCCACTGTGATGATTCGGGTTTACTGTAATGATTCA
GGCTCACTGTGACCTCTTCT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 130; Mature: 130

Protein sequence:

>130_residues
MNGSSIIEFEDMTWSQQVEDSKKPVVVMFYSPACPYCKAMEPYFEEYAKEYGSSAVFGRINIATNPWTAEKYGVQGTPTF
KFFCHGRPVWEQVGQIYPSILKNAVRDMLQHGEECIRKSTPVGQDITGYV

Sequences:

>Translated_130_residues
MNGSSIIEFEDMTWSQQVEDSKKPVVVMFYSPACPYCKAMEPYFEEYAKEYGSSAVFGRINIATNPWTAEKYGVQGTPTF
KFFCHGRPVWEQVGQIYPSILKNAVRDMLQHGEECIRKSTPVGQDITGYV
>Mature_130_residues
MNGSSIIEFEDMTWSQQVEDSKKPVVVMFYSPACPYCKAMEPYFEEYAKEYGSSAVFGRINIATNPWTAEKYGVQGTPTF
KFFCHGRPVWEQVGQIYPSILKNAVRDMLQHGEECIRKSTPVGQDITGYV

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI87082331, Length=99, Percent_Identity=32.3232323232323, Blast_Score=66, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=81, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 14795; Mature: 14795

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGSSIIEFEDMTWSQQVEDSKKPVVVMFYSPACPYCKAMEPYFEEYAKEYGSSAVFGRI
CCCCCEEEECCCCCHHHHCCCCCCEEEEEECCCCCHHHHCCHHHHHHHHHHCCCEEEEEE
NIATNPWTAEKYGVQGTPTFKFFCHGRPVWEQVGQIYPSILKNAVRDMLQHGEECIRKST
EECCCCCCCHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PVGQDITGYV
CCCCCCCCCC
>Mature Secondary Structure
MNGSSIIEFEDMTWSQQVEDSKKPVVVMFYSPACPYCKAMEPYFEEYAKEYGSSAVFGRI
CCCCCEEEECCCCCHHHHCCCCCCEEEEEECCCCCHHHHCCHHHHHHHHHHCCCEEEEEE
NIATNPWTAEKYGVQGTPTFKFFCHGRPVWEQVGQIYPSILKNAVRDMLQHGEECIRKST
EECCCCCCCHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PVGQDITGYV
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]