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The map label for this gene is dys1 [H]

Identifier: 21228184

GI number: 21228184

Start: 2482032

End: 2482985

Strand: Direct

Name: dys1 [H]

Synonym: MM_2082

Alternate gene names: 21228184

Gene position: 2482032-2482985 (Clockwise)

Preceding gene: 21228181

Following gene: 21228185

Centisome position: 60.59

GC content: 49.27

Gene sequence:

>954_bases
ATGGATTTTGGAGCTTCTGCTAAAAATCTCAGTACTCCGGTCAAAGGGGCAAAAATAGTCCCGAATATGACTGTAGACGA
ACTTGTAAAAGAGTACGCCGGCTGTGCCTTTGGAGCAGGCAGGCTGGCTGAAGCTGTGGACATTTATTATGAAATGCTGG
CTTCCGGGAAAACTACGAAATTTTTCGGGCTTGCAGGAGCAATGACACCTGCTGGCATGAGGAATATCATCGCAGACCTG
ATCCGGGACGGATATATAGACGTGCTTGTTACAACAGGCGCCAATATGGTTCACGATACCGTCGAAGCCCTCGGACTTCA
CCATTATAAAGGTTCGGACTGCGCAAACGATATTCAGCTCAGGCATGAATGTATTGACAGGATCTATGATGTTTATCTCC
CTGACCAGCATTTTACTGATCTTGAAGAGTTCCTTCAGGGCGTTTATTCCGGGCTTCCGCAGGAAAACCTCTCTATCAGG
CAGGTCCTTACCGAAATAGGAAAAAATCTGGACGATGACTCTTCTATCCTGAAAACAGCTGCCGAAATGGGAGTTCCGGT
GTACTGTCCCGCCCTTCAGGACTCCGTAATAGGGCTTCAGGCCTGGCTGTACAAAGAAGGAAACCCTCTTCATGTGGATG
CTTTTGCGGACATGCATGAATTCATGGATATCTGCTATGGGGCTGAAAGCGCGGGGACGATGCTGCTGGGAGGAGGAGTT
CCCAAGAACTATATCCTGCAGTCCATGCTTGTAACTCCCAGGTCCTTTGATTATGCAATCCAGCTGACAATGGACCGCCC
GGAAACAGGAGGCTTGAGCGGGGCAACTCTTGACGAAGCCCAGTCCTGGGGGAAGGTCGGGGAAGATGCAAAATCAGTTA
CCGTATATGCAGATTCAACAATTACTCTCCCGCTTATAGTCTCTGCTGTGAGGACGCGCCTTTCAAAGAGGTGA

Upstream 100 bases:

>100_bases
TCCGTGACAGGCTGCAATGTATGCTTATATCCTGCACATTTTATTCATTACAGTTTAACACGATTACATTTAATAATCTT
GTAATTTCTGAGGAACAAAA

Downstream 100 bases:

>100_bases
GCTTATGGAACGAAATACATGTATGATCCTTGCCCTTGATGTGACTGAGAGGGAAGAAGCGCTGAAGATTGCAGAAAATG
TCCGGGAATTTGTGGATGCA

Product: putative deoxyhypusine synthase

Products: NA

Alternate protein names: DHS 1 [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MDFGASAKNLSTPVKGAKIVPNMTVDELVKEYAGCAFGAGRLAEAVDIYYEMLASGKTTKFFGLAGAMTPAGMRNIIADL
IRDGYIDVLVTTGANMVHDTVEALGLHHYKGSDCANDIQLRHECIDRIYDVYLPDQHFTDLEEFLQGVYSGLPQENLSIR
QVLTEIGKNLDDDSSILKTAAEMGVPVYCPALQDSVIGLQAWLYKEGNPLHVDAFADMHEFMDICYGAESAGTMLLGGGV
PKNYILQSMLVTPRSFDYAIQLTMDRPETGGLSGATLDEAQSWGKVGEDAKSVTVYADSTITLPLIVSAVRTRLSKR

Sequences:

>Translated_317_residues
MDFGASAKNLSTPVKGAKIVPNMTVDELVKEYAGCAFGAGRLAEAVDIYYEMLASGKTTKFFGLAGAMTPAGMRNIIADL
IRDGYIDVLVTTGANMVHDTVEALGLHHYKGSDCANDIQLRHECIDRIYDVYLPDQHFTDLEEFLQGVYSGLPQENLSIR
QVLTEIGKNLDDDSSILKTAAEMGVPVYCPALQDSVIGLQAWLYKEGNPLHVDAFADMHEFMDICYGAESAGTMLLGGGV
PKNYILQSMLVTPRSFDYAIQLTMDRPETGGLSGATLDEAQSWGKVGEDAKSVTVYADSTITLPLIVSAVRTRLSKR
>Mature_317_residues
MDFGASAKNLSTPVKGAKIVPNMTVDELVKEYAGCAFGAGRLAEAVDIYYEMLASGKTTKFFGLAGAMTPAGMRNIIADL
IRDGYIDVLVTTGANMVHDTVEALGLHHYKGSDCANDIQLRHECIDRIYDVYLPDQHFTDLEEFLQGVYSGLPQENLSIR
QVLTEIGKNLDDDSSILKTAAEMGVPVYCPALQDSVIGLQAWLYKEGNPLHVDAFADMHEFMDICYGAESAGTMLLGGGV
PKNYILQSMLVTPRSFDYAIQLTMDRPETGGLSGATLDEAQSWGKVGEDAKSVTVYADSTITLPLIVSAVRTRLSKR

Specific function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine

COG id: COG1899

COG function: function code O; Deoxyhypusine synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoxyhypusine synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503325, Length=257, Percent_Identity=29.5719844357977, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI7108338, Length=256, Percent_Identity=25.78125, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17536927, Length=332, Percent_Identity=26.2048192771084, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6321859, Length=278, Percent_Identity=28.0575539568345, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45550569, Length=258, Percent_Identity=30.2325581395349, Blast_Score=121, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002773
- InterPro:   IPR022899 [H]

Pfam domain/function: PF01916 DS [H]

EC number: =2.5.1.46 [H]

Molecular weight: Translated: 34423; Mature: 34423

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFGASAKNLSTPVKGAKIVPNMTVDELVKEYAGCAFGAGRLAEAVDIYYEMLASGKTTK
CCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCE
FFGLAGAMTPAGMRNIIADLIRDGYIDVLVTTGANMVHDTVEALGLHHYKGSDCANDIQL
EEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHH
RHECIDRIYDVYLPDQHFTDLEEFLQGVYSGLPQENLSIRQVLTEIGKNLDDDSSILKTA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
AEMGVPVYCPALQDSVIGLQAWLYKEGNPLHVDAFADMHEFMDICYGAESAGTMLLGGGV
HHCCCCEECCHHHHHHHHHHHHEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCEEECCCC
PKNYILQSMLVTPRSFDYAIQLTMDRPETGGLSGATLDEAQSWGKVGEDAKSVTVYADST
CHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCC
ITLPLIVSAVRTRLSKR
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFGASAKNLSTPVKGAKIVPNMTVDELVKEYAGCAFGAGRLAEAVDIYYEMLASGKTTK
CCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCE
FFGLAGAMTPAGMRNIIADLIRDGYIDVLVTTGANMVHDTVEALGLHHYKGSDCANDIQL
EEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHH
RHECIDRIYDVYLPDQHFTDLEEFLQGVYSGLPQENLSIRQVLTEIGKNLDDDSSILKTA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
AEMGVPVYCPALQDSVIGLQAWLYKEGNPLHVDAFADMHEFMDICYGAESAGTMLLGGGV
HHCCCCEECCHHHHHHHHHHHHEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCEEECCCC
PKNYILQSMLVTPRSFDYAIQLTMDRPETGGLSGATLDEAQSWGKVGEDAKSVTVYADST
CHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCC
ITLPLIVSAVRTRLSKR
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]