Click here to switch to the map view.

The map label for this gene is mtbB

Identifier: 21228153

GI number: 21228153

Start: 2446618

End: 2447685

Strand: Reverse

Name: mtbB

Synonym: MM_2051

Alternate gene names: 21228153

Gene position: 2447685-2446618 (Counterclockwise)

Preceding gene: 21228154

Following gene: 21228152

Centisome position: 59.75

GC content: 51.12

Gene sequence:

>1068_bases
ATGGCAACTGAATATGCTTTGAGAATGGGAGACGGAAAGAGGGTTTTCCTTGCCAGGGAAAAAATTATGGAGGAGATTGA
GGCAGGTACTGCAAATGCTGCAGATCTTGGTGAGATCCCTGCCCTCAGTGCTGATGAAATGAATAAGCTTGCAGAAATCC
TTATGATGCCCGGCAAAGCCGTCAGTGTCGAGCATGGTATGGAAATCCCTGTGACTCATGACATCGGTACAATCCGGCTT
GACGGTGACCAGGGCAACAGCGGTGTGGGGATCCCTTCCAGCCGTCTTGTCGGGTGCATGATGCACGAAAGGGCATTTGG
CGCTGACACAATGGAACTCGGCCACATTGACTACAGTTTCAAGCCGGTAAAACCAGTTGTTGCAAACGAGTGCCAGGCAA
TGGAAGTCTGCCAGCAGAACATGATCATTCCGCTCTTTTACGGTGCAATGCCGAACATGGGGCTGTACTACACTCCTGAC
GGACCTTTCGAAAACCCCGGCGACCTCATGAAGGCTTTCAAGATCCAGGAAGCCTGGGACTCCATGGAGCACGCAGCCGA
GCACCTTACAAGGGATACGATCTGGATAATGCAGAAGCTCTTTGCTTCAGGCGCAGACGGCGTTAACTTTGACACAACTG
CTGCCGCAGGGGATGGAGATTTCTATGGGACTCTTCACGCAATTGAGGCTCTGAGAAAAGAGTTCCCTGAGATGTACATC
GAAGCCGGAATGGCAGGCGAGATGGTGCTTGGAATGCATGGAAACCTTCAGTATGATGGAGTTACCCTTGCAGGGCTCTG
GCCACACCAGCAGGCTCCACTTGTTGCGAAAGCGGGTGCAAATGTTTTCGGGCCTGTTGTCAATACAAACACAAGCAAGA
CCTCTCCATGGAACCTTGCACGCGCAGTAACTTTCATAAAAGAAGCTGTAAAAGTGTCTTCCCTGCCCTGCCATGTTGAC
ATGGGTATGGGAGTAGGCGGGATACCAATGCTTGAAACTCCTCCGATTGATGCAGTTACAAGGGCAAGCAAGGCAATGGT
TGAGATTGCAGGAGTAGACGGCATATAG

Upstream 100 bases:

>100_bases
CCAGGCGTGGGCTGACAAGATAGGTGCGGACTGCTACGCTGAGAATGCAAGCGAAGCTGTAGCAAAGGCAAAAGAACTGC
TTGTGGGGAAGTGAAAAGAA

Downstream 100 bases:

>100_bases
ATCGGGGTCGGCGACCCTCTGGGTATGCCGATCTCCCACATAATGGCTTCAGGTATGACAGGAATGAGAGCAGCAGGAGA
CCTTGTTGCAAGGATGCAGT

Product: dimethylamine:corrinoid methyltransferase

Products: NA

Alternate protein names: DMA methyltransferase 1; DMAMT 1

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MATEYALRMGDGKRVFLAREKIMEEIEAGTANAADLGEIPALSADEMNKLAEILMMPGKAVSVEHGMEIPVTHDIGTIRL
DGDQGNSGVGIPSSRLVGCMMHERAFGADTMELGHIDYSFKPVKPVVANECQAMEVCQQNMIIPLFYGAMPNMGLYYTPD
GPFENPGDLMKAFKIQEAWDSMEHAAEHLTRDTIWIMQKLFASGADGVNFDTTAAAGDGDFYGTLHAIEALRKEFPEMYI
EAGMAGEMVLGMHGNLQYDGVTLAGLWPHQQAPLVAKAGANVFGPVVNTNTSKTSPWNLARAVTFIKEAVKVSSLPCHVD
MGMGVGGIPMLETPPIDAVTRASKAMVEIAGVDGI

Sequences:

>Translated_355_residues
MATEYALRMGDGKRVFLAREKIMEEIEAGTANAADLGEIPALSADEMNKLAEILMMPGKAVSVEHGMEIPVTHDIGTIRL
DGDQGNSGVGIPSSRLVGCMMHERAFGADTMELGHIDYSFKPVKPVVANECQAMEVCQQNMIIPLFYGAMPNMGLYYTPD
GPFENPGDLMKAFKIQEAWDSMEHAAEHLTRDTIWIMQKLFASGADGVNFDTTAAAGDGDFYGTLHAIEALRKEFPEMYI
EAGMAGEMVLGMHGNLQYDGVTLAGLWPHQQAPLVAKAGANVFGPVVNTNTSKTSPWNLARAVTFIKEAVKVSSLPCHVD
MGMGVGGIPMLETPPIDAVTRASKAMVEIAGVDGI
>Mature_354_residues
ATEYALRMGDGKRVFLAREKIMEEIEAGTANAADLGEIPALSADEMNKLAEILMMPGKAVSVEHGMEIPVTHDIGTIRLD
GDQGNSGVGIPSSRLVGCMMHERAFGADTMELGHIDYSFKPVKPVVANECQAMEVCQQNMIIPLFYGAMPNMGLYYTPDG
PFENPGDLMKAFKIQEAWDSMEHAAEHLTRDTIWIMQKLFASGADGVNFDTTAAAGDGDFYGTLHAIEALRKEFPEMYIE
AGMAGEMVLGMHGNLQYDGVTLAGLWPHQQAPLVAKAGANVFGPVVNTNTSKTSPWNLARAVTFIKEAVKVSSLPCHVDM
GMGVGGIPMLETPPIDAVTRASKAMVEIAGVDGI

Specific function: Catalyzes the transfer of a methyl group from dimethylamine to the corrinoid cofactor of mtbC

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dimethylamine methyltransferase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTBB1_METMA (P58970)

Other databases:

- EMBL:   AE008384
- EMBL:   AE008384
- RefSeq:   NP_634074.1
- RefSeq:   NP_634075.1
- GeneID:   1480392
- GeneID:   1480393
- BioCyc:   MMAZ192952:MM2050-MONOMER
- BioCyc:   MMAZ192952:MM2051-MONOMER
- GO:   GO:0015948
- InterPro:   IPR012653
- TIGRFAMs:   TIGR02368

Pfam domain/function: PF09505 Dimeth_Pyl

EC number: NA

Molecular weight: Translated: 38168; Mature: 38037

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
7.0 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
6.8 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATEYALRMGDGKRVFLAREKIMEEIEAGTANAADLGEIPALSADEMNKLAEILMMPGKA
CCCCEEEEECCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCE
VSVEHGMEIPVTHDIGTIRLDGDQGNSGVGIPSSRLVGCMMHERAFGADTMELGHIDYSF
EECCCCCCCCEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCC
KPVKPVVANECQAMEVCQQNMIIPLFYGAMPNMGLYYTPDGPFENPGDLMKAFKIQEAWD
CCCCHHHHCCHHHHHHHHHCCEEEEEECCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHH
SMEHAAEHLTRDTIWIMQKLFASGADGVNFDTTAAAGDGDFYGTLHAIEALRKEFPEMYI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EAGMAGEMVLGMHGNLQYDGVTLAGLWPHQQAPLVAKAGANVFGPVVNTNTSKTSPWNLA
HCCCCCCEEEECCCCEEECCEEEEEECCCCCCCEEECCCCCCCCCEECCCCCCCCCHHHH
RAVTFIKEAVKVSSLPCHVDMGMGVGGIPMLETPPIDAVTRASKAMVEIAGVDGI
HHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHEEEEECCCCC
>Mature Secondary Structure 
ATEYALRMGDGKRVFLAREKIMEEIEAGTANAADLGEIPALSADEMNKLAEILMMPGKA
CCCEEEEECCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCE
VSVEHGMEIPVTHDIGTIRLDGDQGNSGVGIPSSRLVGCMMHERAFGADTMELGHIDYSF
EECCCCCCCCEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCC
KPVKPVVANECQAMEVCQQNMIIPLFYGAMPNMGLYYTPDGPFENPGDLMKAFKIQEAWD
CCCCHHHHCCHHHHHHHHHCCEEEEEECCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHH
SMEHAAEHLTRDTIWIMQKLFASGADGVNFDTTAAAGDGDFYGTLHAIEALRKEFPEMYI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EAGMAGEMVLGMHGNLQYDGVTLAGLWPHQQAPLVAKAGANVFGPVVNTNTSKTSPWNLA
HCCCCCCEEEECCCCEEECCEEEEEECCCCCCCEEECCCCCCCCCEECCCCCCCCCHHHH
RAVTFIKEAVKVSSLPCHVDMGMGVGGIPMLETPPIDAVTRASKAMVEIAGVDGI
HHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824