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The map label for this gene is dph2

Identifier: 21227979

GI number: 21227979

Start: 2231427

End: 2232449

Strand: Direct

Name: dph2

Synonym: MM_1877

Alternate gene names: NA

Gene position: 2231427-2232449 (Clockwise)

Preceding gene: 21227978

Following gene: 21227980

Centisome position: 54.47

GC content: 49.36

Gene sequence:

>1023_bases
GTGTGGAGATTAAGGATGTCTTTGGGAATCAGTGAAGCATTCGACCTCAGGCCTGATTACATAATCAGCGTAATAAAGGA
TACCAGAGCAAAGCTTGTGGGCTTTCAGTTTCCTGAAGGGTTAAAACGTAAGGGTCCGGAGCTGGCAAAGAAGGTCGAAA
AAGCTACCGGAGCTGAAATTATTATCTCGGGGGACCCGTGTTTCGGAGCATGTGACCTGGACAGGACTCTCCTCGACCAC
GTTGACATACTTTTCCATTTCGGGCATGCTGAACTGGAAGACATTAGGCTTTCGAATAAAGTCTATTTTATCGAAACCCG
GTCTTCGGTGGACGTCCTGCATGTTATTGAAAAGGCTGTCCCTGAGCTTAAAGGGCAAAAAATAGGGCTGATCACTACTG
TTCAGCACGTCCATAAACTTCCTGATGTATGTGGCGTGCTGGAGAGAATGGGAAAGACCTGCGTAATCGGGCGTGGTGAC
TCCAGAATTGCTTATGCTGGACAGGTTCTCGGCTGCAATTTCTCTGCAGCCCGGGATGAAGACTGTGACGAGTACCTCTA
TATCGGAAGCGGAGATTTCCACCCCCTGGGGGTAGCTCTTTCCACAAAGAAACGTGTCCTTGCAGCCGATCCTTTTTCCG
GAGAGGTCCGCGAGGTTGACCCTTCAAGGATTCTGCGCCAGAGGAGTGCGGTAATCGCAAAGTCCCTGGATGCACAGGTC
TTCGGGATTATTGTCTCAAGCAAAAACGGGCAGAAGAGGATGGAGCTTGCTTCTTCCTTAAAGGAACTTGCAAAGAAGCA
TGGAAAAGAGTCACACCTTATACTGATCGACCTCGTAACTCCGGACCAGCTGCTCCAGTTCAAAGTAGACGCTTTCGTAA
ATACAGCCTGCCCGAGGCTTGCTATTGATGAAGTGGGACGTTTTCCTGCCCCTATGCTGACACCCCAGGAGTTTGAAATA
GTGCTTGGGGAACGCGAATGGGAAAAGCTTGTGCTGGACGAAATCACTGAAGAACCTGTATGA

Upstream 100 bases:

>100_bases
GATGTGATTTCCGTTATCGGACGCGGCGATGGTTACCTGAAGCTGAGGGAGCTCGGAGTTGAACCCAAGATTCTCGTCAC
AATTGATGTGGGCGAGAAAG

Downstream 100 bases:

>100_bases
TTGGGAGTAAATGGCTGCATAATCATACATTCGTGGTCGAGCAATTCTAAAATTAAATCTAATAATACTAAAAGACAAAG
GATATGAAACAGAGAAAACT

Product: diphthamide synthase subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MWRLRMSLGISEAFDLRPDYIISVIKDTRAKLVGFQFPEGLKRKGPELAKKVEKATGAEIIISGDPCFGACDLDRTLLDH
VDILFHFGHAELEDIRLSNKVYFIETRSSVDVLHVIEKAVPELKGQKIGLITTVQHVHKLPDVCGVLERMGKTCVIGRGD
SRIAYAGQVLGCNFSAARDEDCDEYLYIGSGDFHPLGVALSTKKRVLAADPFSGEVREVDPSRILRQRSAVIAKSLDAQV
FGIIVSSKNGQKRMELASSLKELAKKHGKESHLILIDLVTPDQLLQFKVDAFVNTACPRLAIDEVGRFPAPMLTPQEFEI
VLGEREWEKLVLDEITEEPV

Sequences:

>Translated_340_residues
MWRLRMSLGISEAFDLRPDYIISVIKDTRAKLVGFQFPEGLKRKGPELAKKVEKATGAEIIISGDPCFGACDLDRTLLDH
VDILFHFGHAELEDIRLSNKVYFIETRSSVDVLHVIEKAVPELKGQKIGLITTVQHVHKLPDVCGVLERMGKTCVIGRGD
SRIAYAGQVLGCNFSAARDEDCDEYLYIGSGDFHPLGVALSTKKRVLAADPFSGEVREVDPSRILRQRSAVIAKSLDAQV
FGIIVSSKNGQKRMELASSLKELAKKHGKESHLILIDLVTPDQLLQFKVDAFVNTACPRLAIDEVGRFPAPMLTPQEFEI
VLGEREWEKLVLDEITEEPV
>Mature_340_residues
MWRLRMSLGISEAFDLRPDYIISVIKDTRAKLVGFQFPEGLKRKGPELAKKVEKATGAEIIISGDPCFGACDLDRTLLDH
VDILFHFGHAELEDIRLSNKVYFIETRSSVDVLHVIEKAVPELKGQKIGLITTVQHVHKLPDVCGVLERMGKTCVIGRGD
SRIAYAGQVLGCNFSAARDEDCDEYLYIGSGDFHPLGVALSTKKRVLAADPFSGEVREVDPSRILRQRSAVIAKSLDAQV
FGIIVSSKNGQKRMELASSLKELAKKHGKESHLILIDLVTPDQLLQFKVDAFVNTACPRLAIDEVGRFPAPMLTPQEFEI
VLGEREWEKLVLDEITEEPV

Specific function: Unknown

COG id: COG1736

COG function: function code J; Diphthamide synthase subunit DPH2

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI116686106, Length=319, Percent_Identity=27.8996865203762, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17552166, Length=306, Percent_Identity=27.4509803921569, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322088, Length=313, Percent_Identity=29.3929712460064, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24662841, Length=313, Percent_Identity=28.7539936102236, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21356957, Length=313, Percent_Identity=28.7539936102236, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016435
- InterPro:   IPR002728
- InterPro:   IPR022428 [H]

Pfam domain/function: PF01866 Diphthamide_syn [H]

EC number: NA

Molecular weight: Translated: 37803; Mature: 37803

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWRLRMSLGISEAFDLRPDYIISVIKDTRAKLVGFQFPEGLKRKGPELAKKVEKATGAEI
CEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHCCCCEE
IISGDPCFGACDLDRTLLDHVDILFHFGHAELEDIRLSNKVYFIETRSSVDVLHVIEKAV
EEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHEEECCEEEEEEECCCHHHHHHHHHHH
PELKGQKIGLITTVQHVHKLPDVCGVLERMGKTCVIGRGDSRIAYAGQVLGCNFSAARDE
HHHCCCEEEHHHHHHHHHHCHHHHHHHHHCCCEEEEECCCCCEEEECEEEECCCCCCCCC
DCDEYLYIGSGDFHPLGVALSTKKRVLAADPFSGEVREVDPSRILRQRSAVIAKSLDAQV
CCCCEEEECCCCCCEEEEEECCCCEEEEECCCCCCCEECCHHHHHHHHHHHHHHHCCCEE
FGIIVSSKNGQKRMELASSLKELAKKHGKESHLILIDLVTPDQLLQFKVDAFVNTACPRL
EEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCH
AIDEVGRFPAPMLTPQEFEIVLGEREWEKLVLDEITEEPV
HHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MWRLRMSLGISEAFDLRPDYIISVIKDTRAKLVGFQFPEGLKRKGPELAKKVEKATGAEI
CEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHCCCCEE
IISGDPCFGACDLDRTLLDHVDILFHFGHAELEDIRLSNKVYFIETRSSVDVLHVIEKAV
EEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHEEECCEEEEEEECCCHHHHHHHHHHH
PELKGQKIGLITTVQHVHKLPDVCGVLERMGKTCVIGRGDSRIAYAGQVLGCNFSAARDE
HHHCCCEEEHHHHHHHHHHCHHHHHHHHHCCCEEEEECCCCCEEEECEEEECCCCCCCCC
DCDEYLYIGSGDFHPLGVALSTKKRVLAADPFSGEVREVDPSRILRQRSAVIAKSLDAQV
CCCCEEEECCCCCCEEEEEECCCCEEEEECCCCCCCEECCHHHHHHHHHHHHHHHCCCEE
FGIIVSSKNGQKRMELASSLKELAKKHGKESHLILIDLVTPDQLLQFKVDAFVNTACPRL
EEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCH
AIDEVGRFPAPMLTPQEFEIVLGEREWEKLVLDEITEEPV
HHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]