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The map label for this gene is apt [H]

Identifier: 21227978

GI number: 21227978

Start: 2230892

End: 2231461

Strand: Direct

Name: apt [H]

Synonym: MM_1876

Alternate gene names: 21227978

Gene position: 2230892-2231461 (Clockwise)

Preceding gene: 21227977

Following gene: 21227979

Centisome position: 54.46

GC content: 47.54

Gene sequence:

>570_bases
ATGCTTGAAAGACTGAAAGATTCACTGATCAGGTCCCCTATAATCAAGCGAGGGGAGTATAACTATTTTATCCATCCTAT
TTCTGATGGGGTACCTTCCATCGACCCTCACCTGGTAGAAGAGATTTCCGATTACATCTCAGAGATCGCAGATATGAACG
TTGACACTATCCTGACCGTGGAAGCTATGGGCATTCCGGTTGCAAATGCGCTCTCCCTGAAAACCGGGATTCCTCTTACC
ATTGTCCGGAAGCGGCCTTATTTCCTTGAAGGGGAAGTTGAACTCTCCCAGAGCACAGGGTATTCGAAGGGCGTCCTCTA
CATAAACGGGCTAAAAAAAGGGGACAGAATAATTATTGTCGATGACGTTATCAGTACAGGAGGTACGCTCCTTGCCCTTG
TAAGAGCGCTGCAGACAATAGGTGTAGAGGTAATGGATGTGATTTCCGTTATCGGACGCGGCGATGGTTACCTGAAGCTG
AGGGAGCTCGGAGTTGAACCCAAGATTCTCGTCACAATTGATGTGGGCGAGAAAGGTGTGGAGATTAAGGATGTCTTTGG
GAATCAGTGA

Upstream 100 bases:

>100_bases
TTTATATTCCTAGCTTCGGGAAACGGTATTAAAAGGAGCAGGCTTAATTTCAGGATTTTTTACTTCCCGGAATATTGAGA
CAGCCAGAAAGGTTAAAACC

Downstream 100 bases:

>100_bases
AGCATTCGACCTCAGGCCTGATTACATAATCAGCGTAATAAAGGATACCAGAGCAAAGCTTGTGGGCTTTCAGTTTCCTG
AAGGGTTAAAACGTAAGGGT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MLERLKDSLIRSPIIKRGEYNYFIHPISDGVPSIDPHLVEEISDYISEIADMNVDTILTVEAMGIPVANALSLKTGIPLT
IVRKRPYFLEGEVELSQSTGYSKGVLYINGLKKGDRIIIVDDVISTGGTLLALVRALQTIGVEVMDVISVIGRGDGYLKL
RELGVEPKILVTIDVGEKGVEIKDVFGNQ

Sequences:

>Translated_189_residues
MLERLKDSLIRSPIIKRGEYNYFIHPISDGVPSIDPHLVEEISDYISEIADMNVDTILTVEAMGIPVANALSLKTGIPLT
IVRKRPYFLEGEVELSQSTGYSKGVLYINGLKKGDRIIIVDDVISTGGTLLALVRALQTIGVEVMDVISVIGRGDGYLKL
RELGVEPKILVTIDVGEKGVEIKDVFGNQ
>Mature_189_residues
MLERLKDSLIRSPIIKRGEYNYFIHPISDGVPSIDPHLVEEISDYISEIADMNVDTILTVEAMGIPVANALSLKTGIPLT
IVRKRPYFLEGEVELSQSTGYSKGVLYINGLKKGDRIIIVDDVISTGGTLLALVRALQTIGVEVMDVISVIGRGDGYLKL
RELGVEPKILVTIDVGEKGVEIKDVFGNQ

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20679; Mature: 20679

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERLKDSLIRSPIIKRGEYNYFIHPISDGVPSIDPHLVEEISDYISEIADMNVDTILTV
CHHHHHHHHHHCHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEE
EAMGIPVANALSLKTGIPLTIVRKRPYFLEGEVELSQSTGYSKGVLYINGLKKGDRIIIV
EECCCCCCHHEECCCCCCEEEEECCCEEEECEEEECCCCCCCCCEEEEECCCCCCEEEEE
DDVISTGGTLLALVRALQTIGVEVMDVISVIGRGDGYLKLRELGVEPKILVTIDVGEKGV
ECCHHCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCC
EIKDVFGNQ
EEECCCCCC
>Mature Secondary Structure
MLERLKDSLIRSPIIKRGEYNYFIHPISDGVPSIDPHLVEEISDYISEIADMNVDTILTV
CHHHHHHHHHHCHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEE
EAMGIPVANALSLKTGIPLTIVRKRPYFLEGEVELSQSTGYSKGVLYINGLKKGDRIIIV
EECCCCCCHHEECCCCCCEEEEECCCEEEECEEEECCCCCCCCCEEEEECCCCCCEEEEE
DDVISTGGTLLALVRALQTIGVEVMDVISVIGRGDGYLKLRELGVEPKILVTIDVGEKGV
ECCHHCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCC
EIKDVFGNQ
EEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA