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The map label for this gene is hemA [H]

Identifier: 21227843

GI number: 21227843

Start: 2081770

End: 2083116

Strand: Direct

Name: hemA [H]

Synonym: MM_1741

Alternate gene names: 21227843

Gene position: 2081770-2083116 (Clockwise)

Preceding gene: 21227842

Following gene: 21227844

Centisome position: 50.82

GC content: 46.03

Gene sequence:

>1347_bases
GTGACAGAAATCTCAAGTATGGTTATATCCCATAAAAAAGCAAAAGTTGAGGAAATGGAGTCCGCCTGGCACGGAGACCT
GGACGGTCTGCTCCGTAACCTTTACAAGCATGAGTATGTGTATGAGTGCGTCGTTTTAAAAACCTGCAACCGTGTTGAAA
TCTACGTTGTTTCCCCCAAGAGCAGCAGTGTACTTTTCTCTTTTGCAAAAGAAATGGGAGCTTCCACCCATATTATTGAC
TTTTACGGGCATGACGAGTCCCTGGAACACCTGCTGAGGCTTGCAGGAGGCCTCGAATCCATGATTGTGGGGGAAGACCA
GATCCTCGGGCAGATTAAGGACCTCTACGCTTATTCGAAGAAAGCCGGGACAACCGGTAAAATCCTTGAAACGGCATTTG
AAAAAGCCATTCAGGTAGGAAAAAGGATAAGGAATGAGACCCGGATCAATAAAGGTTCGGTCTCCATAGGCTCTGCTGCC
GTGGACCTTGCTGAAGATATCTTCGGGGGGCTTACAGGAAAAAACGTGCTTGTTATTGGGGCAGGAGAGATTGGAGTCCT
TGTCGCAAAAGCCCTTGCCGAAAAGGATATTGAGGCTATCTATATTGCAAACCGCACTTATAAGAAAGCTGAAGAAATCG
CCTACGAACTCGGTGGGCACGCGGTCAGGCTTGATGATATCAGGGATTACCTACCTGGTGCTGATGTAGTTATAAGCGGT
ACGGGAGCTCCTCATTATATCCTTACGCGGGAAATTGTTGAAGAAGCCATAAAGTGCAGGGAAAGGAAACTCCTTCTTAT
CGATATCGCAAATCCCAGGGACATTGAGGAATCCGTTGTGGAGCTTGAAAATGTCGAACTCTGCAATATCGACAACCTTA
GAGTCATAAGTGAAAGGACTCTCAGGATGAGGAAAGAAGAAGCAAAAAAAGCCGAAGCCATCATTCAGGAAGAGATCCGG
CTTTTAAACCTCCAGTACAAACGCCAGAAAGCCGACAGGTTGATTTCCGAGCTTTACAAGCAGGTATATGATGTCCGGCT
AAGAGAGAGGCAAAAAGCTGTCAACCGTTTAAGTTCCTATCATACCATCGGGGATATAGAAACCGAGGTTCTTGACGACC
TGACCCGTTCTATTGTTAACAAGATCCTGGGAGAACCTACCAAAGTCCTCCGCCAGGCTGCAGAACTCGGGAACGAAGAG
TTTCTTGATGTGGTTTCAAGGGTCTTCTGCCTCGACAAGGAGAAGGTGAGATTTGAAAAAATAAAACAGGCAAAGTTTGA
CCAGATAAAACCCGGCTGTACAAAAGAACAGGCAGAGGTCAAAGAAGAATATGCTGTAAAAGATTAA

Upstream 100 bases:

>100_bases
CTTTAGTGAAAAACGGCTGAGGATTTCCGGACAAAGTTTAATTTATAATTCCTTATATTATTCATTCTATTCCCTTATTC
ATTCTATCCGGAGGCTCTCT

Downstream 100 bases:

>100_bases
ACTCGGGGTACAGGAAAATAAAAAACGGAATAATTCAAGGGTTGAAACAAAAATACTAATCCAGTTCACAGTAATAAATA
ATCAAATAAATTTACAGATA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTEISSMVISHKKAKVEEMESAWHGDLDGLLRNLYKHEYVYECVVLKTCNRVEIYVVSPKSSSVLFSFAKEMGASTHIID
FYGHDESLEHLLRLAGGLESMIVGEDQILGQIKDLYAYSKKAGTTGKILETAFEKAIQVGKRIRNETRINKGSVSIGSAA
VDLAEDIFGGLTGKNVLVIGAGEIGVLVAKALAEKDIEAIYIANRTYKKAEEIAYELGGHAVRLDDIRDYLPGADVVISG
TGAPHYILTREIVEEAIKCRERKLLLIDIANPRDIEESVVELENVELCNIDNLRVISERTLRMRKEEAKKAEAIIQEEIR
LLNLQYKRQKADRLISELYKQVYDVRLRERQKAVNRLSSYHTIGDIETEVLDDLTRSIVNKILGEPTKVLRQAAELGNEE
FLDVVSRVFCLDKEKVRFEKIKQAKFDQIKPGCTKEQAEVKEEYAVKD

Sequences:

>Translated_448_residues
MTEISSMVISHKKAKVEEMESAWHGDLDGLLRNLYKHEYVYECVVLKTCNRVEIYVVSPKSSSVLFSFAKEMGASTHIID
FYGHDESLEHLLRLAGGLESMIVGEDQILGQIKDLYAYSKKAGTTGKILETAFEKAIQVGKRIRNETRINKGSVSIGSAA
VDLAEDIFGGLTGKNVLVIGAGEIGVLVAKALAEKDIEAIYIANRTYKKAEEIAYELGGHAVRLDDIRDYLPGADVVISG
TGAPHYILTREIVEEAIKCRERKLLLIDIANPRDIEESVVELENVELCNIDNLRVISERTLRMRKEEAKKAEAIIQEEIR
LLNLQYKRQKADRLISELYKQVYDVRLRERQKAVNRLSSYHTIGDIETEVLDDLTRSIVNKILGEPTKVLRQAAELGNEE
FLDVVSRVFCLDKEKVRFEKIKQAKFDQIKPGCTKEQAEVKEEYAVKD
>Mature_447_residues
TEISSMVISHKKAKVEEMESAWHGDLDGLLRNLYKHEYVYECVVLKTCNRVEIYVVSPKSSSVLFSFAKEMGASTHIIDF
YGHDESLEHLLRLAGGLESMIVGEDQILGQIKDLYAYSKKAGTTGKILETAFEKAIQVGKRIRNETRINKGSVSIGSAAV
DLAEDIFGGLTGKNVLVIGAGEIGVLVAKALAEKDIEAIYIANRTYKKAEEIAYELGGHAVRLDDIRDYLPGADVVISGT
GAPHYILTREIVEEAIKCRERKLLLIDIANPRDIEESVVELENVELCNIDNLRVISERTLRMRKEEAKKAEAIIQEEIRL
LNLQYKRQKADRLISELYKQVYDVRLRERQKAVNRLSSYHTIGDIETEVLDDLTRSIVNKILGEPTKVLRQAAELGNEEF
LDVVSRVFCLDKEKVRFEKIKQAKFDQIKPGCTKEQAEVKEEYAVKD

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=409, Percent_Identity=35.9413202933985, Blast_Score=211, Evalue=8e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 50563; Mature: 50432

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEISSMVISHKKAKVEEMESAWHGDLDGLLRNLYKHEYVYECVVLKTCNRVEIYVVSPK
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
SSSVLFSFAKEMGASTHIIDFYGHDESLEHLLRLAGGLESMIVGEDQILGQIKDLYAYSK
CCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHH
KAGTTGKILETAFEKAIQVGKRIRNETRINKGSVSIGSAAVDLAEDIFGGLTGKNVLVIG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEE
AGEIGVLVAKALAEKDIEAIYIANRTYKKAEEIAYELGGHAVRLDDIRDYLPGADVVISG
CCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCEEEEHHHHHHCCCCCEEEEC
TGAPHYILTREIVEEAIKCRERKLLLIDIANPRDIEESVVELENVELCNIDNLRVISERT
CCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEECCCCCHHHHHHH
LRMRKEEAKKAEAIIQEEIRLLNLQYKRQKADRLISELYKQVYDVRLRERQKAVNRLSSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HTIGDIETEVLDDLTRSIVNKILGEPTKVLRQAAELGNEEFLDVVSRVFCLDKEKVRFEK
CCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHH
IKQAKFDQIKPGCTKEQAEVKEEYAVKD
HHHHHHHCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
TEISSMVISHKKAKVEEMESAWHGDLDGLLRNLYKHEYVYECVVLKTCNRVEIYVVSPK
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
SSSVLFSFAKEMGASTHIIDFYGHDESLEHLLRLAGGLESMIVGEDQILGQIKDLYAYSK
CCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHH
KAGTTGKILETAFEKAIQVGKRIRNETRINKGSVSIGSAAVDLAEDIFGGLTGKNVLVIG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEE
AGEIGVLVAKALAEKDIEAIYIANRTYKKAEEIAYELGGHAVRLDDIRDYLPGADVVISG
CCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCEEEEHHHHHHCCCCCEEEEC
TGAPHYILTREIVEEAIKCRERKLLLIDIANPRDIEESVVELENVELCNIDNLRVISERT
CCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEECCCCCHHHHHHH
LRMRKEEAKKAEAIIQEEIRLLNLQYKRQKADRLISELYKQVYDVRLRERQKAVNRLSSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HTIGDIETEVLDDLTRSIVNKILGEPTKVLRQAAELGNEEFLDVVSRVFCLDKEKVRFEK
CCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHH
IKQAKFDQIKPGCTKEQAEVKEEYAVKD
HHHHHHHCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]