Click here to switch to the map view.

The map label for this gene is mutL [H]

Identifier: 21227784

GI number: 21227784

Start: 2020241

End: 2022310

Strand: Reverse

Name: mutL [H]

Synonym: MM_1682

Alternate gene names: 21227784

Gene position: 2022310-2020241 (Counterclockwise)

Preceding gene: 21227785

Following gene: 21227783

Centisome position: 49.37

GC content: 46.38

Gene sequence:

>2070_bases
ATGAAGGGAAATAAAATCCGGATTCTTGATAAGGACACGATAAATAAGATTGCAGCCGGAGAAGTAATAGAACGACCGGC
ATCCGTTGTAAAGGAACTTGTGGATAACTCAATCGATGCCGGAGCAACAGAAATCCGAATCGAAGTCGAGAAGGGAGGAA
AACGTTCCATCCTTATCAGGGACAATGGCTGTGGCATGAGCAGAGCCGATGCCCTCCTTGCATATAAAAAACATGCAACA
AGCAAACTCACAAAGATAGAAGACCTGGATAAAATTTCTACAATGGGCTTCAGGGGAGAAGCCCTTGCCTCCATAACCGC
CATTGCAAAGGTGGAAATCCTTACACGCCCTCCGGAAGAGATTGCAGGCACAAAAGTTGTAATCCATGGAGGAAAGGTAG
AGGAAATTTCTGATGCAGGCACGGCTCCGGGGACGTCAGTACACGTAAAAGACCTCTTCTATAATACACCTGCAAGGCGC
AAGTACCTGAAAACCGACCGTACGGAACTTGCCCATATCACTGATACCGTCATGAGACTTGCGCTGGCAAATCCGGGGAT
TTCCTTTACCCTACTTAACGAAGGAAAGCCAGTTCTTAGGAATACGGGGTCAAGTGACCTTTTTAACAGTATGGTAAACC
TTCTGGGGCCCGATACCGCACGCTCGATGCTTCCTCTTGATTACGGGACAGAAGAATTTGATATCAGGGGCTATGTCTCA
AAGCCCGAACTTAACAGGGGAGATAGCGACCAGCTCTTTCTTTTTGTAAATACCCGCCCTGTAACCTCAAGCACGATCAA
TAAAGCTGTCCGCGAAGGGTATTACACAAAAATGCCCAAAGGCCGTTATCCTGTAGCTGTGCTCGCCCTTACCCTCGATC
CGGGAGAAGTGGATGTAAACGTCCATCCGCGCAAAGCTGAAGTCCGTTTCAGCCGCGAAAAGGAGGTAGGGGACGCTGTA
ATCAGTGCGGTTGAAAAGGTACTTTCGGAACACGGTCTGGCCCCTGAGATAAGGGGAAAAGAAGCAAAAAGGTTACAGAA
AACCTTTGATGCCCCGGAATCACCAAAAATTCAGATACCGGATACCAGCAAAGTAGTTCCTGAGAGAGAAAACGCAGAGG
TAACCGGAAAAACAGCCGGAAAAGAAATAGAAAGCGAGCCTGGCGTTTTAACGGTTTCAGAGGAAAAAAAGGTTCTGGAA
GGCGGGAATAGAGTCCTGAGAGATAAGCCCGGTGCTTATACCTATCCTGTAAAGGATACGGAGAGGAGGCTGAAGAAATC
CGAGCGCCTCCTTGAGTTTTCAGGAGAGGGTGAGGAGAAGAAGGCTGTAGAGAATAAAGAAGGGAAAACGGAAGAAAAAA
AGCTACCATCAGAGATACAGCCGGAAAGTAAAAAAGCAGAAGAAAAAATAGAAGAAAAAATAGAAGAAAAAATAGAAGAA
AAAATAGAAGAAAAAAGTCAAACCCGGAAGCCGAAGCAAAAAGCAAATACTGACCTTCTTGAAGATCTGCGGGTTATAGG
CCAGGTTTCCAGGATGTATATTCTTGCTGAAAAAGGTGAAGACCTTGTGATTATTGACCAGCACGCAGCCCACGAGCGCA
TCCTTTACGAGCAGGTCCTGAGAAGTAAAAAATCAAGGGTGCAGGAGCTGATTACGCCGGTGATGATAGAACTTACCCCG
AAAGAAAAGGTTCTCATGGAGGAATACATACCCTACCTTGAGGAATACGGGTTTGGAATTTCGGAATTCGGGGATAATAC
CTATGTGGTTACCTTTGTACCCGAGGTTTTCGGACGTCTCGAGAATACCGATGTAATTCATGATGTTATAGCTGACCTGC
TGGCTGAAGGAAAGGTCAAAAAAGAAACAGGAATATCGGAAAAAGTGAGCAAGACATTTGCCTGCAGGGCAGCAATTAAA
GGTGGGGCAGCCTGCACCCCAGAGCAAATGGAAGATTTGATAGAGCAGCTCAAAACGGCTGAAGCCCCGTACTCCTGCCC
GCATGGGAGACCAACTGTCATAACCATTACGAAAAGTCAACTTGACAGGATGTTTGCCAGAACTCTTTAA

Upstream 100 bases:

>100_bases
GGAAGGACAGATGAAAGAGCAGGTTGAAGATATACCGGAAGAGAAAACAGGAAAGCAAGCTGAAAAAAAGCTTGAAGAAG
AGATGGAAAAGAAGATGGAT

Downstream 100 bases:

>100_bases
ACAGCGTTAACTGAATAAAGAAGATCTTGAGAAAATCCGGAAAAAGCTGATAGCTCAGCAAAGAAATTATGATATGAAAA
ACGTAACTTTTCGATGAAAT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 689; Mature: 689

Protein sequence:

>689_residues
MKGNKIRILDKDTINKIAAGEVIERPASVVKELVDNSIDAGATEIRIEVEKGGKRSILIRDNGCGMSRADALLAYKKHAT
SKLTKIEDLDKISTMGFRGEALASITAIAKVEILTRPPEEIAGTKVVIHGGKVEEISDAGTAPGTSVHVKDLFYNTPARR
KYLKTDRTELAHITDTVMRLALANPGISFTLLNEGKPVLRNTGSSDLFNSMVNLLGPDTARSMLPLDYGTEEFDIRGYVS
KPELNRGDSDQLFLFVNTRPVTSSTINKAVREGYYTKMPKGRYPVAVLALTLDPGEVDVNVHPRKAEVRFSREKEVGDAV
ISAVEKVLSEHGLAPEIRGKEAKRLQKTFDAPESPKIQIPDTSKVVPERENAEVTGKTAGKEIESEPGVLTVSEEKKVLE
GGNRVLRDKPGAYTYPVKDTERRLKKSERLLEFSGEGEEKKAVENKEGKTEEKKLPSEIQPESKKAEEKIEEKIEEKIEE
KIEEKSQTRKPKQKANTDLLEDLRVIGQVSRMYILAEKGEDLVIIDQHAAHERILYEQVLRSKKSRVQELITPVMIELTP
KEKVLMEEYIPYLEEYGFGISEFGDNTYVVTFVPEVFGRLENTDVIHDVIADLLAEGKVKKETGISEKVSKTFACRAAIK
GGAACTPEQMEDLIEQLKTAEAPYSCPHGRPTVITITKSQLDRMFARTL

Sequences:

>Translated_689_residues
MKGNKIRILDKDTINKIAAGEVIERPASVVKELVDNSIDAGATEIRIEVEKGGKRSILIRDNGCGMSRADALLAYKKHAT
SKLTKIEDLDKISTMGFRGEALASITAIAKVEILTRPPEEIAGTKVVIHGGKVEEISDAGTAPGTSVHVKDLFYNTPARR
KYLKTDRTELAHITDTVMRLALANPGISFTLLNEGKPVLRNTGSSDLFNSMVNLLGPDTARSMLPLDYGTEEFDIRGYVS
KPELNRGDSDQLFLFVNTRPVTSSTINKAVREGYYTKMPKGRYPVAVLALTLDPGEVDVNVHPRKAEVRFSREKEVGDAV
ISAVEKVLSEHGLAPEIRGKEAKRLQKTFDAPESPKIQIPDTSKVVPERENAEVTGKTAGKEIESEPGVLTVSEEKKVLE
GGNRVLRDKPGAYTYPVKDTERRLKKSERLLEFSGEGEEKKAVENKEGKTEEKKLPSEIQPESKKAEEKIEEKIEEKIEE
KIEEKSQTRKPKQKANTDLLEDLRVIGQVSRMYILAEKGEDLVIIDQHAAHERILYEQVLRSKKSRVQELITPVMIELTP
KEKVLMEEYIPYLEEYGFGISEFGDNTYVVTFVPEVFGRLENTDVIHDVIADLLAEGKVKKETGISEKVSKTFACRAAIK
GGAACTPEQMEDLIEQLKTAEAPYSCPHGRPTVITITKSQLDRMFARTL
>Mature_689_residues
MKGNKIRILDKDTINKIAAGEVIERPASVVKELVDNSIDAGATEIRIEVEKGGKRSILIRDNGCGMSRADALLAYKKHAT
SKLTKIEDLDKISTMGFRGEALASITAIAKVEILTRPPEEIAGTKVVIHGGKVEEISDAGTAPGTSVHVKDLFYNTPARR
KYLKTDRTELAHITDTVMRLALANPGISFTLLNEGKPVLRNTGSSDLFNSMVNLLGPDTARSMLPLDYGTEEFDIRGYVS
KPELNRGDSDQLFLFVNTRPVTSSTINKAVREGYYTKMPKGRYPVAVLALTLDPGEVDVNVHPRKAEVRFSREKEVGDAV
ISAVEKVLSEHGLAPEIRGKEAKRLQKTFDAPESPKIQIPDTSKVVPERENAEVTGKTAGKEIESEPGVLTVSEEKKVLE
GGNRVLRDKPGAYTYPVKDTERRLKKSERLLEFSGEGEEKKAVENKEGKTEEKKLPSEIQPESKKAEEKIEEKIEEKIEE
KIEEKSQTRKPKQKANTDLLEDLRVIGQVSRMYILAEKGEDLVIIDQHAAHERILYEQVLRSKKSRVQELITPVMIELTP
KEKVLMEEYIPYLEEYGFGISEFGDNTYVVTFVPEVFGRLENTDVIHDVIADLLAEGKVKKETGISEKVSKTFACRAAIK
GGAACTPEQMEDLIEQLKTAEAPYSCPHGRPTVITITKSQLDRMFARTL

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=571, Percent_Identity=28.7215411558669, Blast_Score=210, Evalue=4e-54,
Organism=Homo sapiens, GI4505911, Length=347, Percent_Identity=30.5475504322767, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI189458898, Length=347, Percent_Identity=30.5475504322767, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI310128478, Length=336, Percent_Identity=30.3571428571429, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI4505913, Length=336, Percent_Identity=30.3571428571429, Blast_Score=159, Evalue=1e-38,
Organism=Homo sapiens, GI189458896, Length=340, Percent_Identity=30.2941176470588, Blast_Score=140, Evalue=6e-33,
Organism=Homo sapiens, GI310128480, Length=285, Percent_Identity=29.1228070175439, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI263191589, Length=482, Percent_Identity=24.896265560166, Blast_Score=117, Evalue=5e-26,
Organism=Homo sapiens, GI91992162, Length=381, Percent_Identity=26.7716535433071, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI91992160, Length=381, Percent_Identity=26.7716535433071, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI310128482, Length=219, Percent_Identity=26.027397260274, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI310128484, Length=247, Percent_Identity=25.1012145748988, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI310128486, Length=212, Percent_Identity=25.9433962264151, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI1790612, Length=331, Percent_Identity=38.9728096676737, Blast_Score=239, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI71991825, Length=373, Percent_Identity=35.1206434316354, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17562796, Length=362, Percent_Identity=32.0441988950276, Blast_Score=172, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6323819, Length=334, Percent_Identity=35.0299401197605, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324247, Length=354, Percent_Identity=31.9209039548023, Blast_Score=148, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6325093, Length=426, Percent_Identity=23.2394366197183, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6323063, Length=412, Percent_Identity=25.9708737864078, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17136968, Length=327, Percent_Identity=37.0030581039755, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=28.0112044817927, Blast_Score=137, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 76610; Mature: 76610

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGNKIRILDKDTINKIAAGEVIERPASVVKELVDNSIDAGATEIRIEVEKGGKRSILIR
CCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEEEE
DNGCGMSRADALLAYKKHATSKLTKIEDLDKISTMGFRGEALASITAIAKVEILTRPPEE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEECCCHHH
IAGTKVVIHGGKVEEISDAGTAPGTSVHVKDLFYNTPARRKYLKTDRTELAHITDTVMRL
HCCCEEEEECCCCHHHHCCCCCCCCEEEEHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHH
ALANPGISFTLLNEGKPVLRNTGSSDLFNSMVNLLGPDTARSMLPLDYGTEEFDIRGYVS
HHCCCCCEEEEECCCCHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCEEEEEECC
KPELNRGDSDQLFLFVNTRPVTSSTINKAVREGYYTKMPKGRYPVAVLALTLDPGEVDVN
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCHHCCCCCCCCEEEEEEEECCCEEEEE
VHPRKAEVRFSREKEVGDAVISAVEKVLSEHGLAPEIRGKEAKRLQKTFDAPESPKIQIP
ECCCCHHEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEECC
DTSKVVPERENAEVTGKTAGKEIESEPGVLTVSEEKKVLEGGNRVLRDKPGAYTYPVKDT
CCCCCCCCCCCCEECCCCCCCCCCCCCCEEEECCCHHHHHCCCEEECCCCCCEECCCCHH
ERRLKKSERLLEFSGEGEEKKAVENKEGKTEEKKLPSEIQPESKKAEEKIEEKIEEKIEE
HHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
KIEEKSQTRKPKQKANTDLLEDLRVIGQVSRMYILAEKGEDLVIIDQHAAHERILYEQVL
HHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHEEEEEECCCCEEEECCCCHHHHHHHHHHH
RSKKSRVQELITPVMIELTPKEKVLMEEYIPYLEEYGFGISEFGDNTYVVTFVPEVFGRL
HHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEEHHHHCCC
ENTDVIHDVIADLLAEGKVKKETGISEKVSKTFACRAAIKGGAACTPEQMEDLIEQLKTA
CCCHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
EAPYSCPHGRPTVITITKSQLDRMFARTL
CCCCCCCCCCCEEEEEEHHHHHHHHHHCC
>Mature Secondary Structure
MKGNKIRILDKDTINKIAAGEVIERPASVVKELVDNSIDAGATEIRIEVEKGGKRSILIR
CCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEEEE
DNGCGMSRADALLAYKKHATSKLTKIEDLDKISTMGFRGEALASITAIAKVEILTRPPEE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEECCCHHH
IAGTKVVIHGGKVEEISDAGTAPGTSVHVKDLFYNTPARRKYLKTDRTELAHITDTVMRL
HCCCEEEEECCCCHHHHCCCCCCCCEEEEHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHH
ALANPGISFTLLNEGKPVLRNTGSSDLFNSMVNLLGPDTARSMLPLDYGTEEFDIRGYVS
HHCCCCCEEEEECCCCHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCEEEEEECC
KPELNRGDSDQLFLFVNTRPVTSSTINKAVREGYYTKMPKGRYPVAVLALTLDPGEVDVN
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCHHCCCCCCCCEEEEEEEECCCEEEEE
VHPRKAEVRFSREKEVGDAVISAVEKVLSEHGLAPEIRGKEAKRLQKTFDAPESPKIQIP
ECCCCHHEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEECC
DTSKVVPERENAEVTGKTAGKEIESEPGVLTVSEEKKVLEGGNRVLRDKPGAYTYPVKDT
CCCCCCCCCCCCEECCCCCCCCCCCCCCEEEECCCHHHHHCCCEEECCCCCCEECCCCHH
ERRLKKSERLLEFSGEGEEKKAVENKEGKTEEKKLPSEIQPESKKAEEKIEEKIEEKIEE
HHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
KIEEKSQTRKPKQKANTDLLEDLRVIGQVSRMYILAEKGEDLVIIDQHAAHERILYEQVL
HHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHEEEEEECCCCEEEECCCCHHHHHHHHHHH
RSKKSRVQELITPVMIELTPKEKVLMEEYIPYLEEYGFGISEFGDNTYVVTFVPEVFGRL
HHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEEHHHHCCC
ENTDVIHDVIADLLAEGKVKKETGISEKVSKTFACRAAIKGGAACTPEQMEDLIEQLKTA
CCCHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
EAPYSCPHGRPTVITITKSQLDRMFARTL
CCCCCCCCCCCEEEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA