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The map label for this gene is tlpC [C]

Identifier: 21227760

GI number: 21227760

Start: 1981521

End: 1983518

Strand: Direct

Name: tlpC [C]

Synonym: MM_1658

Alternate gene names: 21227760

Gene position: 1981521-1983518 (Clockwise)

Preceding gene: 21227759

Following gene: 21227761

Centisome position: 48.37

GC content: 44.69

Gene sequence:

>1998_bases
ATGGCTTTACAGAATAGCGATTTAAAACTGAATGAGTCGGCAGACTCTTCGAATAAATTTAATGAAGATGCAGATACTGG
AACCATAGAGACAGGCTGGCTGATAGATAACCTGCCAGTAACTGTTTTCAGAGTCTCAAATGAATCTTCATGGCCTATTT
GTTATATCAGTAAAAGTGTGGAAGTACTCACCGGCTACCCGGCAGCGGAATTTCTTTCCAGGAGACTTTCATGGTCAGAT
ATTGTTTTTCCGGAGGACGTTTCCAGAATCGATGCTGCTATAGAGAACTCAATGAAAACCAGGAGTCCTTATCAGGTCGA
ATACAGGATCCAGAAATCCTGTGGCGATACGGTATTTGTTCAGGAGCAGGCCCGTCTGGTGAATGATGAACATGGCAATA
TAGCTTATATTGACGGCGTGTTTCTGGACGTTACCCCCCAGATAAAACGAAGAGAAGAGTCACAGAGGGCGATTGTCAGC
AGCATACCCAGGCCGTCACTTGCGCTTTATGTGGACGCTTCCGGGAAAATAAAGTACATTAATGAGTATTTTTTGGAAAT
CTGCAGGTTTAAGAGTGCTGACGAAGCCACTGGCAGGTCCCCTTCCGAATTACTGGACACCAGTTCCAGAAGGACGCTTG
CTGAGAAGGTGATGGAAACCGGAGAAGGTATCTATAATGTAGAGAAATCCATCAAATTCAAAGCTCTGGATAAACCTCTA
TTTACCGTGCTTTCAGCAGTGCCTGTAAAAGATGAAACCGGAACTATTGCTGGAAGCCTTATGGTAATAACAGATATGAC
CGAGATGAAAGACCGGGAAACAGAGGTCAAGGAAATTTTAAACTACACCAGCAGTTGCCTGAAAAATCTTGGAGACGGAA
TCCAAAAAATAAGTGAAGGAGCTCTCGACGTTCATCTTGAGAAAATCAAAGACGATGACTTCGGTGATACTTTTGATGAA
TTTAACAGGCTTGTCAATAATTTGAAATCTGTTATTAAGAATGTCCTCGAAGATATGCTTACTACTCTTGAAGAAGCCCG
CCAGTCAGAAGAAGCTGTTAACCAGATGAACATGGGGATGCAGCAGATCTCAACTGCTGCAGAGCAGATCGCAACCGGTT
CCGAAAACCTTTCCAGGCATGCAGGCATAGCAGCTTCTGATATAAAAGCTTCTCAGGAGATCTTTAAAAAGCTGAGCGAA
TCCTCCACGCAGTCTTCCAGTTATGCTTCCCATGCTGGCAAAACCAGCGATGAAGCCCAGGGGCTCAGTAATACGGCGCT
CGAAGAAGTGGAACAGCTTGTTGCGGGAATTTCCCAGCTGGGAGACATCGTCCACTCTCTTGATGACGCTGTTAATAACA
TCGGAGCCGTCACAGGAAAAATCAAGTCCATTGCCGATCAGACCAACCTCCTGGCTTTAAATGCAGCTATCGAAGCAGCA
CGAGCCGGAGAATACGGCAGGGGTTTTGCTGTCGTTGCTGACGAGGTCAGGAAACTTGCCGCAGATTCGAGAAAGAGCAC
TGACGAAATAAATGAGATTGTTACAAACGTCCAGAAAGAGACCAGAAAAGTTACAGACGCCATCAACACAGCAGACAGCC
AGGCGAAAAATGGGAGCAAGAACATTAAACAGGCCCTGAATAAGAGCCATGAGATTGTCGATGCTGTTGCCACTATAAAC
TTCATGCTTGCTGAGCTTGACAGGCTTGCGGAAGAAGGACTTATCAAGATCGAAAATATTGAGAAAAGCATAAGTGAGAC
CGCTTCAACAGCAGAAGAAAATGCTGCAAGTAGTGAAGAGACCTCAGCTGCAATTGAAGAGCAGACAGCTGCAATGCAGC
AGGTCAGTACCTCTGTACAGAATGTCAGCGGGCTTGCCCGGAGGACGGTTGATACCCTTTTTGAGAACTTTAAAGTCTCA
GGAGAACAGAAGAACAGTCAGCCTTCTTTTGATAAAACACACACTTTTAATGAAAAAAGAAATCCAAAATTATATTGA

Upstream 100 bases:

>100_bases
TGCTGAAATCCGGCATCTTTTTATACTTCCCTATATACTTAAATACTCCCTTGATTTATATTATCTGTTAATATATAACT
TCTCAGGGGCTAGATTGGTC

Downstream 100 bases:

>100_bases
AATAGAGCCCTCCAATACTAAGAATACCAGGATATGATACTTTCTCTGTCGTATCCTGGAAATTCTTTTCTGACATCTCC
ACTAAGTTTTCTGATCTCTC

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MALQNSDLKLNESADSSNKFNEDADTGTIETGWLIDNLPVTVFRVSNESSWPICYISKSVEVLTGYPAAEFLSRRLSWSD
IVFPEDVSRIDAAIENSMKTRSPYQVEYRIQKSCGDTVFVQEQARLVNDEHGNIAYIDGVFLDVTPQIKRREESQRAIVS
SIPRPSLALYVDASGKIKYINEYFLEICRFKSADEATGRSPSELLDTSSRRTLAEKVMETGEGIYNVEKSIKFKALDKPL
FTVLSAVPVKDETGTIAGSLMVITDMTEMKDRETEVKEILNYTSSCLKNLGDGIQKISEGALDVHLEKIKDDDFGDTFDE
FNRLVNNLKSVIKNVLEDMLTTLEEARQSEEAVNQMNMGMQQISTAAEQIATGSENLSRHAGIAASDIKASQEIFKKLSE
SSTQSSSYASHAGKTSDEAQGLSNTALEEVEQLVAGISQLGDIVHSLDDAVNNIGAVTGKIKSIADQTNLLALNAAIEAA
RAGEYGRGFAVVADEVRKLAADSRKSTDEINEIVTNVQKETRKVTDAINTADSQAKNGSKNIKQALNKSHEIVDAVATIN
FMLAELDRLAEEGLIKIENIEKSISETASTAEENAASSEETSAAIEEQTAAMQQVSTSVQNVSGLARRTVDTLFENFKVS
GEQKNSQPSFDKTHTFNEKRNPKLY

Sequences:

>Translated_665_residues
MALQNSDLKLNESADSSNKFNEDADTGTIETGWLIDNLPVTVFRVSNESSWPICYISKSVEVLTGYPAAEFLSRRLSWSD
IVFPEDVSRIDAAIENSMKTRSPYQVEYRIQKSCGDTVFVQEQARLVNDEHGNIAYIDGVFLDVTPQIKRREESQRAIVS
SIPRPSLALYVDASGKIKYINEYFLEICRFKSADEATGRSPSELLDTSSRRTLAEKVMETGEGIYNVEKSIKFKALDKPL
FTVLSAVPVKDETGTIAGSLMVITDMTEMKDRETEVKEILNYTSSCLKNLGDGIQKISEGALDVHLEKIKDDDFGDTFDE
FNRLVNNLKSVIKNVLEDMLTTLEEARQSEEAVNQMNMGMQQISTAAEQIATGSENLSRHAGIAASDIKASQEIFKKLSE
SSTQSSSYASHAGKTSDEAQGLSNTALEEVEQLVAGISQLGDIVHSLDDAVNNIGAVTGKIKSIADQTNLLALNAAIEAA
RAGEYGRGFAVVADEVRKLAADSRKSTDEINEIVTNVQKETRKVTDAINTADSQAKNGSKNIKQALNKSHEIVDAVATIN
FMLAELDRLAEEGLIKIENIEKSISETASTAEENAASSEETSAAIEEQTAAMQQVSTSVQNVSGLARRTVDTLFENFKVS
GEQKNSQPSFDKTHTFNEKRNPKLY
>Mature_664_residues
ALQNSDLKLNESADSSNKFNEDADTGTIETGWLIDNLPVTVFRVSNESSWPICYISKSVEVLTGYPAAEFLSRRLSWSDI
VFPEDVSRIDAAIENSMKTRSPYQVEYRIQKSCGDTVFVQEQARLVNDEHGNIAYIDGVFLDVTPQIKRREESQRAIVSS
IPRPSLALYVDASGKIKYINEYFLEICRFKSADEATGRSPSELLDTSSRRTLAEKVMETGEGIYNVEKSIKFKALDKPLF
TVLSAVPVKDETGTIAGSLMVITDMTEMKDRETEVKEILNYTSSCLKNLGDGIQKISEGALDVHLEKIKDDDFGDTFDEF
NRLVNNLKSVIKNVLEDMLTTLEEARQSEEAVNQMNMGMQQISTAAEQIATGSENLSRHAGIAASDIKASQEIFKKLSES
STQSSSYASHAGKTSDEAQGLSNTALEEVEQLVAGISQLGDIVHSLDDAVNNIGAVTGKIKSIADQTNLLALNAAIEAAR
AGEYGRGFAVVADEVRKLAADSRKSTDEINEIVTNVQKETRKVTDAINTADSQAKNGSKNIKQALNKSHEIVDAVATINF
MLAELDRLAEEGLIKIENIEKSISETASTAEENAASSEETSAAIEEQTAAMQQVSTSVQNVSGLARRTVDTLFENFKVSG
EQKNSQPSFDKTHTFNEKRNPKLY

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=355, Percent_Identity=28.7323943661972, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789453, Length=250, Percent_Identity=31.2, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1788194, Length=271, Percent_Identity=28.7822878228782, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788195, Length=250, Percent_Identity=30.8, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI2367378, Length=239, Percent_Identity=30.1255230125523, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 72997; Mature: 72866

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50113 PAC ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALQNSDLKLNESADSSNKFNEDADTGTIETGWLIDNLPVTVFRVSNESSWPICYISKSV
CCCCCCCCEECCCCCCCCCCCCCCCCCCEEECEEEECCCEEEEEECCCCCCCEEEEECCC
EVLTGYPAAEFLSRRLSWSDIVFPEDVSRIDAAIENSMKTRSPYQVEYRIQKSCGDTVFV
HHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEE
QEQARLVNDEHGNIAYIDGVFLDVTPQIKRREESQRAIVSSIPRPSLALYVDASGKIKYI
HHHHHHHCCCCCCEEEECCEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHH
NEYFLEICRFKSADEATGRSPSELLDTSSRRTLAEKVMETGEGIYNVEKSIKFKALDKPL
HHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHH
FTVLSAVPVKDETGTIAGSLMVITDMTEMKDRETEVKEILNYTSSCLKNLGDGIQKISEG
HHHHHHCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ALDVHLEKIKDDDFGDTFDEFNRLVNNLKSVIKNVLEDMLTTLEEARQSEEAVNQMNMGM
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQISTAAEQIATGSENLSRHAGIAASDIKASQEIFKKLSESSTQSSSYASHAGKTSDEAQ
HHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHC
GLSNTALEEVEQLVAGISQLGDIVHSLDDAVNNIGAVTGKIKSIADQTNLLALNAAIEAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHH
RAGEYGRGFAVVADEVRKLAADSRKSTDEINEIVTNVQKETRKVTDAINTADSQAKNGSK
HCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
NIKQALNKSHEIVDAVATINFMLAELDRLAEEGLIKIENIEKSISETASTAEENAASSEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHCCCCHH
TSAAIEEQTAAMQQVSTSVQNVSGLARRTVDTLFENFKVSGEQKNSQPSFDKTHTFNEKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
NPKLY
CCCCC
>Mature Secondary Structure 
ALQNSDLKLNESADSSNKFNEDADTGTIETGWLIDNLPVTVFRVSNESSWPICYISKSV
CCCCCCCEECCCCCCCCCCCCCCCCCCEEECEEEECCCEEEEEECCCCCCCEEEEECCC
EVLTGYPAAEFLSRRLSWSDIVFPEDVSRIDAAIENSMKTRSPYQVEYRIQKSCGDTVFV
HHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEE
QEQARLVNDEHGNIAYIDGVFLDVTPQIKRREESQRAIVSSIPRPSLALYVDASGKIKYI
HHHHHHHCCCCCCEEEECCEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHH
NEYFLEICRFKSADEATGRSPSELLDTSSRRTLAEKVMETGEGIYNVEKSIKFKALDKPL
HHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHH
FTVLSAVPVKDETGTIAGSLMVITDMTEMKDRETEVKEILNYTSSCLKNLGDGIQKISEG
HHHHHHCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ALDVHLEKIKDDDFGDTFDEFNRLVNNLKSVIKNVLEDMLTTLEEARQSEEAVNQMNMGM
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQISTAAEQIATGSENLSRHAGIAASDIKASQEIFKKLSESSTQSSSYASHAGKTSDEAQ
HHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHC
GLSNTALEEVEQLVAGISQLGDIVHSLDDAVNNIGAVTGKIKSIADQTNLLALNAAIEAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHH
RAGEYGRGFAVVADEVRKLAADSRKSTDEINEIVTNVQKETRKVTDAINTADSQAKNGSK
HCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
NIKQALNKSHEIVDAVATINFMLAELDRLAEEGLIKIENIEKSISETASTAEENAASSEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHCCCCHH
TSAAIEEQTAAMQQVSTSVQNVSGLARRTVDTLFENFKVSGEQKNSQPSFDKTHTFNEKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
NPKLY
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA