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The map label for this gene is pyrH

Identifier: 21227713

GI number: 21227713

Start: 1921843

End: 1922544

Strand: Reverse

Name: pyrH

Synonym: MM_1611

Alternate gene names: 21227713

Gene position: 1922544-1921843 (Counterclockwise)

Preceding gene: 21227720

Following gene: 21227712

Centisome position: 46.93

GC content: 46.72

Gene sequence:

>702_bases
ATGCTCATAGTACTCTCATTAGGCGGTTCAATTCTCGCAAAAAACCTTGATCCGGATCGTTTTTTAAAATATGCAAATGC
TCTGCGCGACATATCCAAAAAACATACACTGCTTGTAGTAACTGGAGGAGGAGAAGCAGCAAGGGACTATATAGGTGCTG
CACGGGCTATGGGGGCAGATGAAGTAACCTGCGACTACATAGGCATAGAAATCACTCGCCTGAACGCAAGGCTGCTTATT
TCAGCTCTCGGACACGATGCTTATCCTGAAATCCCTTCAAACTACCCTGAAGCTTCAAAAGCCATGACTTCAGGAAAAGT
CGTGGTAATGGGGGGAGTTACACCTGGTCAGACAACTGACGCTGTTGCTTCAATCCTCGCAGAATACCTGAGGGCAGACC
TGCTGACAATTGCAACGTCAATTGACGGGGTTTATTCCTCAGACCCTAACTGCGACCCCTGTGCAGTCAAATACGAGAAA
ATCTCCCCTGAAAAACTCATAAACATTGTTATGGCTATCGAGATGAAAGCAGGCTCAAAATCCCCTGTTGACCCTGTAGC
TGCAAAGATTATAGAGCGCTGCAAGCTCGACGCTCTTGTAATGGACGCCAGAAACCCTGATCTTCTTGTAGAAGTCATAT
GCGGAGAGGCTGCCAAAAAATCCCCGGTCTCCTGCGGAACCTGGATTACAGCAAAAAAATAA

Upstream 100 bases:

>100_bases
TCCATGCAGCAGCCTGCAAAATAGAGAAGTGTAAAAACTCTGAATAAAAAATACCAGCGATAAATTTAAAAATCCGCATT
GTTAATGTGTAGAGATCATC

Downstream 100 bases:

>100_bases
AAAATCGAAACAATAGAAGTAAAAACAGTTCTTTTCTGGCATATTAAAACCGGAAAAGAAAAAAATCAAAAACTTAAACA
TAGAGGTTCCGACATACATC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MLIVLSLGGSILAKNLDPDRFLKYANALRDISKKHTLLVVTGGGEAARDYIGAARAMGADEVTCDYIGIEITRLNARLLI
SALGHDAYPEIPSNYPEASKAMTSGKVVVMGGVTPGQTTDAVASILAEYLRADLLTIATSIDGVYSSDPNCDPCAVKYEK
ISPEKLINIVMAIEMKAGSKSPVDPVAAKIIERCKLDALVMDARNPDLLVEVICGEAAKKSPVSCGTWITAKK

Sequences:

>Translated_233_residues
MLIVLSLGGSILAKNLDPDRFLKYANALRDISKKHTLLVVTGGGEAARDYIGAARAMGADEVTCDYIGIEITRLNARLLI
SALGHDAYPEIPSNYPEASKAMTSGKVVVMGGVTPGQTTDAVASILAEYLRADLLTIATSIDGVYSSDPNCDPCAVKYEK
ISPEKLINIVMAIEMKAGSKSPVDPVAAKIIERCKLDALVMDARNPDLLVEVICGEAAKKSPVSCGTWITAKK
>Mature_233_residues
MLIVLSLGGSILAKNLDPDRFLKYANALRDISKKHTLLVVTGGGEAARDYIGAARAMGADEVTCDYIGIEITRLNARLLI
SALGHDAYPEIPSNYPEASKAMTSGKVVVMGGVTPGQTTDAVASILAEYLRADLLTIATSIDGVYSSDPNCDPCAVKYEK
ISPEKLINIVMAIEMKAGSKSPVDPVAAKIIERCKLDALVMDARNPDLLVEVICGEAAKKSPVSCGTWITAKK

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=193, Percent_Identity=31.0880829015544, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_METMA (P59010)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_633635.1
- ProteinModelPortal:   P59010
- SMR:   P59010
- GeneID:   1479953
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1611
- NMPDR:   fig|192952.1.peg.1611
- HOGENOM:   HBG497552
- OMA:   TRANAML
- ProtClustDB:   PRK00358
- BioCyc:   MMAZ192952:MM1611-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_A
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR011818
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02076

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 24711; Mature: 24711

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: BINDING 43-43 BINDING 44-44 BINDING 48-48 BINDING 65-65 BINDING 139-139 BINDING 145-145 BINDING 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIVLSLGGSILAKNLDPDRFLKYANALRDISKKHTLLVVTGGGEAARDYIGAARAMGAD
CEEEEECCCCEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCC
EVTCDYIGIEITRLNARLLISALGHDAYPEIPSNYPEASKAMTSGKVVVMGGVTPGQTTD
CCEEEEEEEEEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCHHH
AVASILAEYLRADLLTIATSIDGVYSSDPNCDPCAVKYEKISPEKLINIVMAIEMKAGSK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHEEEECCCCC
SPVDPVAAKIIERCKLDALVMDARNPDLLVEVICGEAAKKSPVSCGTWITAKK
CCCCHHHHHHHHHHCCCEEEECCCCCCEEEEEECCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MLIVLSLGGSILAKNLDPDRFLKYANALRDISKKHTLLVVTGGGEAARDYIGAARAMGAD
CEEEEECCCCEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCC
EVTCDYIGIEITRLNARLLISALGHDAYPEIPSNYPEASKAMTSGKVVVMGGVTPGQTTD
CCEEEEEEEEEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCHHH
AVASILAEYLRADLLTIATSIDGVYSSDPNCDPCAVKYEKISPEKLINIVMAIEMKAGSK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHEEEECCCCC
SPVDPVAAKIIERCKLDALVMDARNPDLLVEVICGEAAKKSPVSCGTWITAKK
CCCCHHHHHHHHHHCCCEEEECCCCCCEEEEEECCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824