Click here to switch to the map view.

The map label for this gene is asd [H]

Identifier: 21227720

GI number: 21227720

Start: 1930096

End: 1931124

Strand: Reverse

Name: asd [H]

Synonym: MM_1618

Alternate gene names: 21227720

Gene position: 1931124-1930096 (Counterclockwise)

Preceding gene: 21227721

Following gene: 21227713

Centisome position: 47.14

GC content: 51.9

Gene sequence:

>1029_bases
ATGGCAGCAGTTAAAGCGGGTATTTTAGGCGCCACTGGCGCTGTAGGGCAGAGATTTGTAGAAGCACTTGCAAACCATCC
ATGGTTTGAGATCACAGCCCTTGCAGCATCCGAAAGGAGCGCCGGCAAAACGTATAGAGAAGCGGCAGGCTGGAGGCTTG
ACACAGCCATGCCGGAAAGTGTCGAAAACATAGAGGTTGTTCCTGTAGACCCAAAAACAGTTGATGCAGATGTGGTCTTT
TCAGCTCTTCCTGCAGACCTTGCCCTTACAGTGGAATCCGAGTTTGCAAAAGCCGGGTTTGCAGTTGCAAGCAATGCATC
TTCCTACAGGATGGAAAAAGACATCCCTCTTGTAATCCCTGAAGTAAACCCCGAACACCTGGGGCTCCTTGAAGTCCAGC
AGGATACAAGGGGCTGGGACGGATACATTATCACTAACCCTAACTGCTCCACAATTGTCATGACAGTTACCCTGAAGCCC
CTGATGCAGTTTGGGCTCGAAACCGTACAGGTCGCCACAATGCAGGCGATTTCCGGAGCAGGTTTCTCCGGAGTTGCAGC
CATGGCAATCTATGACAATGTAATCCCCTATATAGGAAGCGAAGAAAAAAAGATGGAAACTGAAACCTTAAAGCTCCTGG
GAGAATTCAACGGCTCAGAAATCGTGCCTGCAGATATGAAGGTCAGCGCTTCCTGCCACAGGGTGCCTGTAGTTGACGGG
CACACGGAAGCCATCTGGGCAGGCATGAGAGAAAACCCCACGCCTGAAGAAGTAAGGGAAGCCTTCCTGAAATTCGACCC
AAAACTTGGAGAACTCCCCTCAGAGCCGAAAAAAGCTCTCATAGTGCGGGACGAAGTAGATAGACCTCAGCCGCGCCTTG
ACCGCAACATGGGAAAAGGCATGAGTGTCTCAGTGGGGAGGATCAGAGAAGGTATCCGATACATCGCAATGGGGCACAAC
ACGATCCGCGGAGCTGCGGGCGCGAGTGTCCTGAATGCCGAGCTTCTGCATTCGATGGGCAAGCTCTGA

Upstream 100 bases:

>100_bases
ATAAAAAAACAGAGATTGAGATGGAATAACTTTTTATTCCATTCTTTTCTTTTTCTCTTTTATCAAATCATTTCTTATCT
CTCCGGAGGTAGCTTTTTAG

Downstream 100 bases:

>100_bases
GTTGATAAAACTTTTAAAGAGCGATAAAAAGCAAATTATAATCGCATAAATCGAAAGAAATAGCAAAGAATAAGAATGAG
AAGTAAAAAGCCCGAAAACC

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MAAVKAGILGATGAVGQRFVEALANHPWFEITALAASERSAGKTYREAAGWRLDTAMPESVENIEVVPVDPKTVDADVVF
SALPADLALTVESEFAKAGFAVASNASSYRMEKDIPLVIPEVNPEHLGLLEVQQDTRGWDGYIITNPNCSTIVMTVTLKP
LMQFGLETVQVATMQAISGAGFSGVAAMAIYDNVIPYIGSEEKKMETETLKLLGEFNGSEIVPADMKVSASCHRVPVVDG
HTEAIWAGMRENPTPEEVREAFLKFDPKLGELPSEPKKALIVRDEVDRPQPRLDRNMGKGMSVSVGRIREGIRYIAMGHN
TIRGAAGASVLNAELLHSMGKL

Sequences:

>Translated_342_residues
MAAVKAGILGATGAVGQRFVEALANHPWFEITALAASERSAGKTYREAAGWRLDTAMPESVENIEVVPVDPKTVDADVVF
SALPADLALTVESEFAKAGFAVASNASSYRMEKDIPLVIPEVNPEHLGLLEVQQDTRGWDGYIITNPNCSTIVMTVTLKP
LMQFGLETVQVATMQAISGAGFSGVAAMAIYDNVIPYIGSEEKKMETETLKLLGEFNGSEIVPADMKVSASCHRVPVVDG
HTEAIWAGMRENPTPEEVREAFLKFDPKLGELPSEPKKALIVRDEVDRPQPRLDRNMGKGMSVSVGRIREGIRYIAMGHN
TIRGAAGASVLNAELLHSMGKL
>Mature_341_residues
AAVKAGILGATGAVGQRFVEALANHPWFEITALAASERSAGKTYREAAGWRLDTAMPESVENIEVVPVDPKTVDADVVFS
ALPADLALTVESEFAKAGFAVASNASSYRMEKDIPLVIPEVNPEHLGLLEVQQDTRGWDGYIITNPNCSTIVMTVTLKPL
MQFGLETVQVATMQAISGAGFSGVAAMAIYDNVIPYIGSEEKKMETETLKLLGEFNGSEIVPADMKVSASCHRVPVVDGH
TEAIWAGMRENPTPEEVREAFLKFDPKLGELPSEPKKALIVRDEVDRPQPRLDRNMGKGMSVSVGRIREGIRYIAMGHNT
IRGAAGASVLNAELLHSMGKL

Specific function: This enzyme catalyzes the second step in the common metabolic pathway to synthesize Thr and Met from Asp [H]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788658, Length=296, Percent_Identity=28.0405405405405, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320362, Length=354, Percent_Identity=47.1751412429379, Blast_Score=290, Evalue=3e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR005676
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 36861; Mature: 36729

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVKAGILGATGAVGQRFVEALANHPWFEITALAASERSAGKTYREAAGWRLDTAMPES
CCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCEECCCCCCC
VENIEVVPVDPKTVDADVVFSALPADLALTVESEFAKAGFAVASNASSYRMEKDIPLVIP
CCCEEEEECCCCCCCHHHHHHHCCCCEEEEEHHHHHHCCCCEECCCCCEEECCCCCEEEC
EVNPEHLGLLEVQQDTRGWDGYIITNPNCSTIVMTVTLKPLMQFGLETVQVATMQAISGA
CCCCCCCEEEEEECCCCCCCCEEEECCCCCEEEEEEEHHHHHHHCHHHHHHHHHHHHCCC
GFSGVAAMAIYDNVIPYIGSEEKKMETETLKLLGEFNGSEIVPADMKVSASCHRVPVVDG
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCEECCCCCCCEEECC
HTEAIWAGMRENPTPEEVREAFLKFDPKLGELPSEPKKALIVRDEVDRPQPRLDRNMGKG
CHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHCCCC
MSVSVGRIREGIRYIAMGHNTIRGAAGASVLNAELLHSMGKL
CEEEHHHHHHCCEEEEECCCHHCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAVKAGILGATGAVGQRFVEALANHPWFEITALAASERSAGKTYREAAGWRLDTAMPES
CCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCEECCCCCCC
VENIEVVPVDPKTVDADVVFSALPADLALTVESEFAKAGFAVASNASSYRMEKDIPLVIP
CCCEEEEECCCCCCCHHHHHHHCCCCEEEEEHHHHHHCCCCEECCCCCEEECCCCCEEEC
EVNPEHLGLLEVQQDTRGWDGYIITNPNCSTIVMTVTLKPLMQFGLETVQVATMQAISGA
CCCCCCCEEEEEECCCCCCCCEEEECCCCCEEEEEEEHHHHHHHCHHHHHHHHHHHHCCC
GFSGVAAMAIYDNVIPYIGSEEKKMETETLKLLGEFNGSEIVPADMKVSASCHRVPVVDG
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCEECCCCCCCEEECC
HTEAIWAGMRENPTPEEVREAFLKFDPKLGELPSEPKKALIVRDEVDRPQPRLDRNMGKG
CHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHCCCC
MSVSVGRIREGIRYIAMGHNTIRGAAGASVLNAELLHSMGKL
CEEEHHHHHHCCEEEEECCCHHCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]