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The map label for this gene is pepQ [H]

Identifier: 21227602

GI number: 21227602

Start: 1787666

End: 1788847

Strand: Reverse

Name: pepQ [H]

Synonym: MM_1500

Alternate gene names: 21227602

Gene position: 1788847-1787666 (Counterclockwise)

Preceding gene: 21227603

Following gene: 21227601

Centisome position: 43.67

GC content: 44.59

Gene sequence:

>1182_bases
ATGAAAGTTACAGACTTCAGCATAAAAAAATCCCTTGAAGAAGCAAAAGCAGATGCTTACCTGATGACAGGGGATATCCA
TAACGCCGACATTTACTATGTAACCCGTTTCCTGGCATCGGATGAGTTTATGTATCTGCAAACAGGAGCCGGGAAAGAGA
TCCTTTTTATTTCGGAAATGGAGCGCGGGAGAGCTGAAATTGAATCAAGGATTTCAAATATAAAAACAACCCAGGAATTT
GGCTACCGCGAGAAAATCAAAGAGAAAAAGGATGCATCTATTGCTTATGCAGCCTGCATCTCAGAGCTGCTTCTAGGAGA
AGAAGTAAAAAGAATTGCAGTCCCCTATGATTTTCCGGTCTTTTATTCAAGCTATCTTACAGAAGCGGGTTTTACCATTA
TGCCCATAAAAAGCCCTTTCAGAAAAATGAGGAGCGTGAAGAGGCAGGAAGAGCTTGAAGCCATAAGATACTCCCAGATG
GCAGGAGAAAAGGCTATGGAGGCAGCCATTGCCCTGATAGAGGGAGCAGAAGAAAAAGAAGGCATACTTTATGTTGAAGG
GGAAATACTTACCGGGGCTAAAGTGAATTCAGTCATTGACCATACACTGCTTGATTTCGGGTGTGAAGCAGAAGAAACTA
TAGTCTCCTGCGGGGAGGACACCGCAAATCCCCACGGTACTACAGATGGACCTCTCAGGGCAAATGCACCGATTATTCTT
GATATTTTTCCGAGAAGCAAGAAGAAGCGCTATTTTGCAGACATGACGCGCACGGTGCTACGGGGCGAAGCTTCTGAAAA
GCTGAAAGAAATGTATGAGACTGTGTTTGAAGCCCAGAAAAAAGCATTATCCATGGTTAAAGCTGGAGTTCAGGCAGCCG
AAATACACACTGCAGTCTGTGACCTGTTTGAAGCAAGAGGCTATCACACTTACAGAAGCGGATCAAAAGCAGGCTTCACA
CACTCCACAGGGCATGGAGTAGGGCTTGATATCCATGAATTGCCCGGTGTTGGAGAAAGCAGCTTTATCCTTGAGGCAGG
CAACGTAATAACTATCGAACCGGGCCTCTATTACCCGGAGATCGGAGGAATCCGGCTCGAAGATATGGTACTGGTTACTG
AAGAAGGGTGCAAGAACCTTACGCGGCTGGAAAAGAAATTTGTATTAAAATCTTATTTATAA

Upstream 100 bases:

>100_bases
AGATTTGTTACCAGCCGGATTTGAGTTTACACGCAGATCCATACATATGCCTGCCGGCTGACGATAACAACTTTATCTAC
AAACATCAGAATTACCCAGC

Downstream 100 bases:

>100_bases
ATAAAAGAATAAATTGTAACCGGAAATTAACCTGAAATTCTCCTGGCTACGTAAAATAAGCACTAAAAAAGCAAAAAAGA
AAGTAAACCCAGAATTTACA

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKVTDFSIKKSLEEAKADAYLMTGDIHNADIYYVTRFLASDEFMYLQTGAGKEILFISEMERGRAEIESRISNIKTTQEF
GYREKIKEKKDASIAYAACISELLLGEEVKRIAVPYDFPVFYSSYLTEAGFTIMPIKSPFRKMRSVKRQEELEAIRYSQM
AGEKAMEAAIALIEGAEEKEGILYVEGEILTGAKVNSVIDHTLLDFGCEAEETIVSCGEDTANPHGTTDGPLRANAPIIL
DIFPRSKKKRYFADMTRTVLRGEASEKLKEMYETVFEAQKKALSMVKAGVQAAEIHTAVCDLFEARGYHTYRSGSKAGFT
HSTGHGVGLDIHELPGVGESSFILEAGNVITIEPGLYYPEIGGIRLEDMVLVTEEGCKNLTRLEKKFVLKSYL

Sequences:

>Translated_393_residues
MKVTDFSIKKSLEEAKADAYLMTGDIHNADIYYVTRFLASDEFMYLQTGAGKEILFISEMERGRAEIESRISNIKTTQEF
GYREKIKEKKDASIAYAACISELLLGEEVKRIAVPYDFPVFYSSYLTEAGFTIMPIKSPFRKMRSVKRQEELEAIRYSQM
AGEKAMEAAIALIEGAEEKEGILYVEGEILTGAKVNSVIDHTLLDFGCEAEETIVSCGEDTANPHGTTDGPLRANAPIIL
DIFPRSKKKRYFADMTRTVLRGEASEKLKEMYETVFEAQKKALSMVKAGVQAAEIHTAVCDLFEARGYHTYRSGSKAGFT
HSTGHGVGLDIHELPGVGESSFILEAGNVITIEPGLYYPEIGGIRLEDMVLVTEEGCKNLTRLEKKFVLKSYL
>Mature_393_residues
MKVTDFSIKKSLEEAKADAYLMTGDIHNADIYYVTRFLASDEFMYLQTGAGKEILFISEMERGRAEIESRISNIKTTQEF
GYREKIKEKKDASIAYAACISELLLGEEVKRIAVPYDFPVFYSSYLTEAGFTIMPIKSPFRKMRSVKRQEELEAIRYSQM
AGEKAMEAAIALIEGAEEKEGILYVEGEILTGAKVNSVIDHTLLDFGCEAEETIVSCGEDTANPHGTTDGPLRANAPIIL
DIFPRSKKKRYFADMTRTVLRGEASEKLKEMYETVFEAQKKALSMVKAGVQAAEIHTAVCDLFEARGYHTYRSGSKAGFT
HSTGHGVGLDIHELPGVGESSFILEAGNVITIEPGLYYPEIGGIRLEDMVLVTEEGCKNLTRLEKKFVLKSYL

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=412, Percent_Identity=23.3009708737864, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1788728, Length=309, Percent_Identity=26.537216828479, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1789275, Length=284, Percent_Identity=27.8169014084507, Blast_Score=72, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320922, Length=277, Percent_Identity=24.187725631769, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 43816; Mature: 43816

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVTDFSIKKSLEEAKADAYLMTGDIHNADIYYVTRFLASDEFMYLQTGAGKEILFISEM
CCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEECH
ERGRAEIESRISNIKTTQEFGYREKIKEKKDASIAYAACISELLLGEEVKRIAVPYDFPV
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCCCHH
FYSSYLTEAGFTIMPIKSPFRKMRSVKRQEELEAIRYSQMAGEKAMEAAIALIEGAEEKE
HHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GILYVEGEILTGAKVNSVIDHTLLDFGCEAEETIVSCGEDTANPHGTTDGPLRANAPIIL
CEEEEECEEECCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEE
DIFPRSKKKRYFADMTRTVLRGEASEKLKEMYETVFEAQKKALSMVKAGVQAAEIHTAVC
EECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
DLFEARGYHTYRSGSKAGFTHSTGHGVGLDIHELPGVGESSFILEAGNVITIEPGLYYPE
HHHHHCCCCEECCCCCCCCCCCCCCCCCCCHHHCCCCCCCCEEEECCCEEEECCCCCCCC
IGGIRLEDMVLVTEEGCKNLTRLEKKFVLKSYL
CCCEEEEEEEEEECHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVTDFSIKKSLEEAKADAYLMTGDIHNADIYYVTRFLASDEFMYLQTGAGKEILFISEM
CCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEECH
ERGRAEIESRISNIKTTQEFGYREKIKEKKDASIAYAACISELLLGEEVKRIAVPYDFPV
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCCCHH
FYSSYLTEAGFTIMPIKSPFRKMRSVKRQEELEAIRYSQMAGEKAMEAAIALIEGAEEKE
HHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GILYVEGEILTGAKVNSVIDHTLLDFGCEAEETIVSCGEDTANPHGTTDGPLRANAPIIL
CEEEEECEEECCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEE
DIFPRSKKKRYFADMTRTVLRGEASEKLKEMYETVFEAQKKALSMVKAGVQAAEIHTAVC
EECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
DLFEARGYHTYRSGSKAGFTHSTGHGVGLDIHELPGVGESSFILEAGNVITIEPGLYYPE
HHHHHCCCCEECCCCCCCCCCCCCCCCCCCHHHCCCCCCCCEEEECCCEEEECCCCCCCC
IGGIRLEDMVLVTEEGCKNLTRLEKKFVLKSYL
CCCEEEEEEEEEECHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]