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The map label for this gene is map [H]

Identifier: 21227601

GI number: 21227601

Start: 1786558

End: 1787448

Strand: Reverse

Name: map [H]

Synonym: MM_1499

Alternate gene names: 21227601

Gene position: 1787448-1786558 (Counterclockwise)

Preceding gene: 21227602

Following gene: 21227600

Centisome position: 43.64

GC content: 45.68

Gene sequence:

>891_bases
ATGACAGATAATGTTTACAACAGAGAAGATGTTCTTGAAAAGTATAGAGAAGCAGGCAGAATCCTGAAAATTGTCAGGGC
TGAGGCTGCAGATATGATAAAAGTAGGAAACAGCCTGCTTGAAGTTGCCGAATTTGTAGAAAATAAAACCATAGAACTGG
GAGGCAAACCTGCATTTCCCTGCAATATCTCAAGAAACCAGGAGGCTGCCCATGCAACCCCGAAAGCAGGAGATAAGGAC
GTTTTTGGAAAAGATATGGTGAAGCTGGACCTTGGAGTTCATGTTGATGGGTACATAGCAGATTCGGCAATAACTGTGGA
CCTTTCAGGCAATCCTGATATTGTAAAAGCCTCTGAGGATGCCCTGGCAGCAGCTATAGACCTTATTAAGCCCGGAGTCA
GTACAGGAGAGATAGGAACTGCAATAGAAGAAAGTATCCGCAGCTATAGTTTAAGTCCTATTATGAACCTCACAGGCCAC
GGGCTTTCTCAATATGAAGCTCACGACAACCCCTCAGTGCCCAATAAACACGTGGAAGGCGGGGTCATCCTTAAGGAAGG
AGATGTTCTTGCAATCGAACCTTTTGCAACTAACGGGACAGGGCTTGTACACGACGGGAGCTGGGCTGAGATATACAGCA
TCATAAGGAAAAAGCCTGTCCGCATGCCAGCAGTCAGAAACGTTCTTAAACAGGCGGAAGAGTACAGGGAACTCCCCTTC
GCTAAACGCTGGCTCAAATCAGATAAACTCGAATTTTCACTTATCCAGCTTGAAAGGGCAGGAATCCTTCACTCCTATCC
TGTACTTATTGAAAGTGCCGGGGGGCTTGTTTCCCAGGCAGAGCATACTGTCATAATAACCCATGACGGATGTGAGGTAA
CAACTAAATAA

Upstream 100 bases:

>100_bases
GGACTTGCTGGCCTAATAAAGCAATAAAAACAACTATAATATTGTTTATAAACAGAAAATACCCAGGATTTGTATAAACG
CATCCTGAAGCGGGGTTAAT

Downstream 100 bases:

>100_bases
ATTTACGAGGAGATAAGTTACAGAAAAAATGAGAAGTTACCGGGACGGCAGACAAATAAAATGAAAAAAGAGTTGACATT
CTTGAAACTGTATCATCTTT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTDNVYNREDVLEKYREAGRILKIVRAEAADMIKVGNSLLEVAEFVENKTIELGGKPAFPCNISRNQEAAHATPKAGDKD
VFGKDMVKLDLGVHVDGYIADSAITVDLSGNPDIVKASEDALAAAIDLIKPGVSTGEIGTAIEESIRSYSLSPIMNLTGH
GLSQYEAHDNPSVPNKHVEGGVILKEGDVLAIEPFATNGTGLVHDGSWAEIYSIIRKKPVRMPAVRNVLKQAEEYRELPF
AKRWLKSDKLEFSLIQLERAGILHSYPVLIESAGGLVSQAEHTVIITHDGCEVTTK

Sequences:

>Translated_296_residues
MTDNVYNREDVLEKYREAGRILKIVRAEAADMIKVGNSLLEVAEFVENKTIELGGKPAFPCNISRNQEAAHATPKAGDKD
VFGKDMVKLDLGVHVDGYIADSAITVDLSGNPDIVKASEDALAAAIDLIKPGVSTGEIGTAIEESIRSYSLSPIMNLTGH
GLSQYEAHDNPSVPNKHVEGGVILKEGDVLAIEPFATNGTGLVHDGSWAEIYSIIRKKPVRMPAVRNVLKQAEEYRELPF
AKRWLKSDKLEFSLIQLERAGILHSYPVLIESAGGLVSQAEHTVIITHDGCEVTTK
>Mature_295_residues
TDNVYNREDVLEKYREAGRILKIVRAEAADMIKVGNSLLEVAEFVENKTIELGGKPAFPCNISRNQEAAHATPKAGDKDV
FGKDMVKLDLGVHVDGYIADSAITVDLSGNPDIVKASEDALAAAIDLIKPGVSTGEIGTAIEESIRSYSLSPIMNLTGHG
LSQYEAHDNPSVPNKHVEGGVILKEGDVLAIEPFATNGTGLVHDGSWAEIYSIIRKKPVRMPAVRNVLKQAEEYRELPFA
KRWLKSDKLEFSLIQLERAGILHSYPVLIESAGGLVSQAEHTVIITHDGCEVTTK

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI5803092, Length=314, Percent_Identity=33.1210191082803, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI124494254, Length=257, Percent_Identity=27.6264591439689, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI164420681, Length=231, Percent_Identity=26.4069264069264, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786364, Length=215, Percent_Identity=28.3720930232558, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17544396, Length=306, Percent_Identity=31.6993464052288, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17542840, Length=315, Percent_Identity=26.031746031746, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319380, Length=312, Percent_Identity=32.3717948717949, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323273, Length=222, Percent_Identity=29.7297297297297, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17137568, Length=313, Percent_Identity=30.9904153354633, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24658585, Length=320, Percent_Identity=27.5, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24583427, Length=216, Percent_Identity=26.8518518518519, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002468
- InterPro:   IPR018349
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 32166; Mature: 32035

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS01202 MAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDNVYNREDVLEKYREAGRILKIVRAEAADMIKVGNSLLEVAEFVENKTIELGGKPAFP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
CNISRNQEAAHATPKAGDKDVFGKDMVKLDLGVHVDGYIADSAITVDLSGNPDIVKASED
CCCCCCCCHHCCCCCCCCCCCCCCCEEEEEECEEECCEEECCEEEEEECCCCCEEECCHH
ALAAAIDLIKPGVSTGEIGTAIEESIRSYSLSPIMNLTGHGLSQYEAHDNPSVPNKHVEG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GVILKEGDVLAIEPFATNGTGLVHDGSWAEIYSIIRKKPVRMPAVRNVLKQAEEYRELPF
CEEEECCCEEEEECCCCCCCEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHH
AKRWLKSDKLEFSLIQLERAGILHSYPVLIESAGGLVSQAEHTVIITHDGCEVTTK
HHHHHHCCCCEEEEEEEHHHCCCCCCCCEEECCCCCCCCCCCEEEEEECCCEECCC
>Mature Secondary Structure 
TDNVYNREDVLEKYREAGRILKIVRAEAADMIKVGNSLLEVAEFVENKTIELGGKPAFP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
CNISRNQEAAHATPKAGDKDVFGKDMVKLDLGVHVDGYIADSAITVDLSGNPDIVKASED
CCCCCCCCHHCCCCCCCCCCCCCCCEEEEEECEEECCEEECCEEEEEECCCCCEEECCHH
ALAAAIDLIKPGVSTGEIGTAIEESIRSYSLSPIMNLTGHGLSQYEAHDNPSVPNKHVEG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GVILKEGDVLAIEPFATNGTGLVHDGSWAEIYSIIRKKPVRMPAVRNVLKQAEEYRELPF
CEEEECCCEEEEECCCCCCCEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHH
AKRWLKSDKLEFSLIQLERAGILHSYPVLIESAGGLVSQAEHTVIITHDGCEVTTK
HHHHHHCCCCEEEEEEEHHHCCCCCCCCEEECCCCCCCCCCCEEEEEECCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]