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The map label for this gene is hisC

Identifier: 21227507

GI number: 21227507

Start: 1686325

End: 1687431

Strand: Reverse

Name: hisC

Synonym: MM_1405

Alternate gene names: 21227507

Gene position: 1687431-1686325 (Counterclockwise)

Preceding gene: 21227508

Following gene: 21227501

Centisome position: 41.19

GC content: 45.44

Gene sequence:

>1107_bases
TTGTTGATGTCCTTGAGCAGGCGTGAACTGATAAAAAAAGAAATCTTTGACATTGAAGAATACGTTCCCGGAAGATCCAT
AGAAGAGATAGCTTCAACCTACGGGCTTAAGCCAGAATCAATTATTAAACTGGGATCAAATGAAAACCCTCTGGGACCCT
CACCGAAAGCCGTAAAGGCTCTCATAGAGGCAGCTCCCGGAGCAAATATATACCCATCAGCGGATGCACATGAATTAAGA
GAAGCCCTCTCGAAATACACAGGTTTTCCGGTATCAAATATTGTCGCCTCAGGGCCAGGAATGGACGGGCTTCTTGACGG
GCTTTGCAGGATAATTATTGAAAAGGGAGACGAGGTTATAGTGCCCATCCCTACCTTTTCCTATTATGAGCTTCCTGCCA
GAGCCTGCGGCGCAGAACCTGTCTTTATCAGGCGGAACCAGGATTTCTCCCTGAACCCCGAAAAGATTCTTGAAGCCGTG
TCTCCCAGAACCAAAATCATTTTCCTGTGTTCTCCAAATAACCCTTCAGGCAATCTCCTTCCGGAAGCTGACCTGAGGAA
AATTATTGAAAATACCGATGCCCTTGTGTTTGTGGACGAAGCATACGTTGAATTTGCGGACAGGAACCTTGCAGCACTGG
TAAATGAATATGACAATGTTGCGGTTGGAAGGACTTTTTCCAAAGTATTCGGGCTTGCAGGTCTACGCCTGGGATATGGC
ATAATGCCTGAGTGGCTTACAAAAGAATATTTAAGAGCAGCCACCCCGTTCTCGGTAAGTCTTCCGGCATTGCGGGCAGG
ACTGGCTGCGCTTTCGGATACTGAATACCTGAATAAAAGCATAAATCTTGCAAGGGAAGGCAGAGAATACCTGAAAGAAA
AAATTCCTTTTAAGGTTTATCCTTCTCAGGCAAATTTTGTGCTTGTGGATGTTTCTCCCCTGAAAGCAAAAAAGGTCACG
GAAAGCCTTCTGAAGAAAGGAATAATAGTTCGCCCCTGTGATTCTTTCAGGGAGGCAGGAGATTCTTTTATCAGGGTAAC
AGTCGGCACTCCTGAGCAGAATGAAAAGGTTGTCAGGGCTTTTGAGATTTCAAAGAGCGAGGTATAA

Upstream 100 bases:

>100_bases
GATTTTGCAAGGGAACATGGTGTGCTTGTAAACTGCACCTCGGACTCGGTGCTCCGCCTTGTCCCTCCACTTGTGATTAC
GAAAGAACAGATAGACTCGG

Downstream 100 bases:

>100_bases
ACCCTGCTCTTAAAACCCTGCCCCTTTACTTGAATTTAATTTTTAATTCTCAAATTCTAAGTTTTAGATGTCTTTAATTC
TCAAATTCTAAGTTTTAGAT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MLMSLSRRELIKKEIFDIEEYVPGRSIEEIASTYGLKPESIIKLGSNENPLGPSPKAVKALIEAAPGANIYPSADAHELR
EALSKYTGFPVSNIVASGPGMDGLLDGLCRIIIEKGDEVIVPIPTFSYYELPARACGAEPVFIRRNQDFSLNPEKILEAV
SPRTKIIFLCSPNNPSGNLLPEADLRKIIENTDALVFVDEAYVEFADRNLAALVNEYDNVAVGRTFSKVFGLAGLRLGYG
IMPEWLTKEYLRAATPFSVSLPALRAGLAALSDTEYLNKSINLAREGREYLKEKIPFKVYPSQANFVLVDVSPLKAKKVT
ESLLKKGIIVRPCDSFREAGDSFIRVTVGTPEQNEKVVRAFEISKSEV

Sequences:

>Translated_368_residues
MLMSLSRRELIKKEIFDIEEYVPGRSIEEIASTYGLKPESIIKLGSNENPLGPSPKAVKALIEAAPGANIYPSADAHELR
EALSKYTGFPVSNIVASGPGMDGLLDGLCRIIIEKGDEVIVPIPTFSYYELPARACGAEPVFIRRNQDFSLNPEKILEAV
SPRTKIIFLCSPNNPSGNLLPEADLRKIIENTDALVFVDEAYVEFADRNLAALVNEYDNVAVGRTFSKVFGLAGLRLGYG
IMPEWLTKEYLRAATPFSVSLPALRAGLAALSDTEYLNKSINLAREGREYLKEKIPFKVYPSQANFVLVDVSPLKAKKVT
ESLLKKGIIVRPCDSFREAGDSFIRVTVGTPEQNEKVVRAFEISKSEV
>Mature_368_residues
MLMSLSRRELIKKEIFDIEEYVPGRSIEEIASTYGLKPESIIKLGSNENPLGPSPKAVKALIEAAPGANIYPSADAHELR
EALSKYTGFPVSNIVASGPGMDGLLDGLCRIIIEKGDEVIVPIPTFSYYELPARACGAEPVFIRRNQDFSLNPEKILEAV
SPRTKIIFLCSPNNPSGNLLPEADLRKIIENTDALVFVDEAYVEFADRNLAALVNEYDNVAVGRTFSKVFGLAGLRLGYG
IMPEWLTKEYLRAATPFSVSLPALRAGLAALSDTEYLNKSINLAREGREYLKEKIPFKVYPSQANFVLVDVSPLKAKKVT
ESLLKKGIIVRPCDSFREAGDSFIRVTVGTPEQNEKVVRAFEISKSEV

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Homo sapiens, GI56713254, Length=322, Percent_Identity=25.1552795031056, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI56713256, Length=322, Percent_Identity=25.1552795031056, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1788332, Length=305, Percent_Identity=31.1475409836066, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322075, Length=397, Percent_Identity=28.9672544080605, Blast_Score=116, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_METMA (Q8PX17)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_633429.1
- ProteinModelPortal:   Q8PX17
- SMR:   Q8PX17
- GeneID:   1479747
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1405
- NMPDR:   fig|192952.1.peg.1405
- HOGENOM:   HBG646350
- OMA:   MSARYHH
- ProtClustDB:   PRK00950
- BioCyc:   MMAZ192952:MM1405-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40531; Mature: 40531

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMSLSRRELIKKEIFDIEEYVPGRSIEEIASTYGLKPESIIKLGSNENPLGPSPKAVKA
CCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHEEECCCCCCCCCCHHHHHH
LIEAAPGANIYPSADAHELREALSKYTGFPVSNIVASGPGMDGLLDGLCRIIIEKGDEVI
HHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCEEE
VPIPTFSYYELPARACGAEPVFIRRNQDFSLNPEKILEAVSPRTKIIFLCSPNNPSGNLL
EECCCCCHHCCCHHHCCCCCEEEECCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCC
PEADLRKIIENTDALVFVDEAYVEFADRNLAALVNEYDNVAVGRTFSKVFGLAGLRLGYG
CHHHHHHHHCCCCCEEEEEHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
IMPEWLTKEYLRAATPFSVSLPALRAGLAALSDTEYLNKSINLAREGREYLKEKIPFKVY
CCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
PSQANFVLVDVSPLKAKKVTESLLKKGIIVRPCDSFREAGDSFIRVTVGTPEQNEKVVRA
CCCCCEEEEECCCCHHHHHHHHHHHCCCEEECCHHHHHCCCCEEEEEECCCCCCCHHHHH
FEISKSEV
HHCCCCCC
>Mature Secondary Structure
MLMSLSRRELIKKEIFDIEEYVPGRSIEEIASTYGLKPESIIKLGSNENPLGPSPKAVKA
CCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHEEECCCCCCCCCCHHHHHH
LIEAAPGANIYPSADAHELREALSKYTGFPVSNIVASGPGMDGLLDGLCRIIIEKGDEVI
HHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCEEE
VPIPTFSYYELPARACGAEPVFIRRNQDFSLNPEKILEAVSPRTKIIFLCSPNNPSGNLL
EECCCCCHHCCCHHHCCCCCEEEECCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCC
PEADLRKIIENTDALVFVDEAYVEFADRNLAALVNEYDNVAVGRTFSKVFGLAGLRLGYG
CHHHHHHHHCCCCCEEEEEHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
IMPEWLTKEYLRAATPFSVSLPALRAGLAALSDTEYLNKSINLAREGREYLKEKIPFKVY
CCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
PSQANFVLVDVSPLKAKKVTESLLKKGIIVRPCDSFREAGDSFIRVTVGTPEQNEKVVRA
CCCCCEEEEECCCCHHHHHHHHHHHCCCEEECCHHHHHCCCCEEEEEECCCCCCCHHHHH
FEISKSEV
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824