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The map label for this gene is ppx [H]

Identifier: 21227478

GI number: 21227478

Start: 1649935

End: 1651566

Strand: Direct

Name: ppx [H]

Synonym: MM_1376

Alternate gene names: 21227478

Gene position: 1649935-1651566 (Clockwise)

Preceding gene: 21227477

Following gene: 21227480

Centisome position: 40.28

GC content: 46.26

Gene sequence:

>1632_bases
ATGGAACCCGAGAAAATTTCAGAAGGCAGGGTTGTTGCGTTTATTGATATAGGGACCAACTCGGTCCGGCTTCTTCTGGT
CCGGATCAATCCTAATGGGTCTTACCAGCCCCTGACCAAACAGAAGGAAACGGTGAGGCTTGGAGAAAAGGAGTTTATAG
ACAGGATCCTCCAGCCAGAAGCTATGGAGCGGGCAGCCTTTGTCTGTAAGAAGTTTATGGAGCTTTCAAGGGCTTACAGG
GTAGAAGAGATTATAGCCGTGGCTACCTCTGCGACCCGGGACGCAAGCAATAAAGTCCAGCTCCTTGAAATGATTAAAAA
GGAAGCAAACCTCGAGGTCTGCACGATTTCAGGTTCGGAAGAAGCCCGTCTGATTTATCTGGGGGTTTCGAGCGGGCTCA
GACTCGGAAACTCAAAAGCCATTTTTATCGACATCGGGGGCGGAAGCACTGAAGTGTCTGTAGGTGACCAGAACCAGTAT
TATTTTCTTCACTCCCTTAACCTTGGGTCAATTCGCCTGACAAATATGTTCCTTCCGGATGAAACCGGCCCTGTCTCTGA
GGAACGTTATGAACAGATCAAGGCGTACATCCGGCGCAAGAGTGCGGACATAATTAAAGAGCTTTCCAGATATACGGTAA
ATTTTGTAATTGGAAGTTCGGGAACTATTGAAAACCTTGCCAAAATCGCCTTTGTTTACCTGCATAAGACAGCTCATGAA
AGCTTTGAGAAACTTGAGTATGAAGACCTGAAGAAGATTGTCAGGGCAATGTGTGCCCTTTCGCTTGAAGAAAGACGTAA
ATTCCCCGGAATAAACTCACAGAGAGCAGACATAATCCTTGCAGGGGCTGCAATTATAGAGACTTTTATGGAAGAACTCG
GACTTTCCGAGATTACGGTCAGTAAGCGCGGGTTAAGGGAAGGCCTTCTCGTAGACTATATCTCGAAGAGTGAGTTCTCG
TATTTGGTCACTCAGATGTCGGTAAGGAAGCGCAGCATTATGCAGCTCGGCCTTGCCTGCAATTTTGATGAGGAACATGC
CCATACAGTTTCAAGGCTCGCTCTTGAACTCTTTGACAGTATTCAGGCTCTCGGCATCTATGAGTTTGAGGAGAGTGAGA
GAGAGCTTCTCGAATACGGTGCAACCCTGCACGACATAGGAACATTCCTCTCATACGATACTCATCAGGCACATGCCTAT
CACCTTATAAGAGAGAGCAACCTGCCTGGTTTCCAGCCTGAAGAAATCGAAATCATTGCAAATCTTGCCTATTTCCACAG
AAAAAACACTCCTAAAAAGAAACACCCCAACCTTGAAGGGTTGAGCAAAGAATCTGTAAAAAGTATAAGGGCGCTCAGTG
CCCTGCTCCGTATTGCCGAAGGGCTTGACCGCTCCCATACCGGCATAGTGTCCCATGTCCGTTTCTATATAGCCTCCACA
GAGAGCCTTGTGCTTGAGATGCATGCTCAGAAGGAATGTCAGCTCGAAATCTGGGAAGTCGAGAAACATAAAAAGTACTT
TAAGAAAATTTTCGGATATTCTCTCCAGTCCAAGGCAATTATAGAACAGACTGCGGGAACCCCATTAATTTTCAAAGGAA
ATGTTGAAATTGAGGAAATGCCAAGGGACTGA

Upstream 100 bases:

>100_bases
AGTCTCAAATAGAATAAAAATGTGAACGAATATTGTGAAGCTTATGAAGCTCTCGAATCCTTCAAGAAAAACGAAAGGCA
GGGCTTTCAGGTGGTCGTAA

Downstream 100 bases:

>100_bases
AACTTATTCGTGAACGGGACTCTTCCAGAAATGGAACCTTTTCAAAACTGGAACCTTTTCAAAACTGGTTTTTTCGGTTT
AAAGTTGTTTCAAAAATAAA

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 543; Mature: 543

Protein sequence:

>543_residues
MEPEKISEGRVVAFIDIGTNSVRLLLVRINPNGSYQPLTKQKETVRLGEKEFIDRILQPEAMERAAFVCKKFMELSRAYR
VEEIIAVATSATRDASNKVQLLEMIKKEANLEVCTISGSEEARLIYLGVSSGLRLGNSKAIFIDIGGGSTEVSVGDQNQY
YFLHSLNLGSIRLTNMFLPDETGPVSEERYEQIKAYIRRKSADIIKELSRYTVNFVIGSSGTIENLAKIAFVYLHKTAHE
SFEKLEYEDLKKIVRAMCALSLEERRKFPGINSQRADIILAGAAIIETFMEELGLSEITVSKRGLREGLLVDYISKSEFS
YLVTQMSVRKRSIMQLGLACNFDEEHAHTVSRLALELFDSIQALGIYEFEESERELLEYGATLHDIGTFLSYDTHQAHAY
HLIRESNLPGFQPEEIEIIANLAYFHRKNTPKKKHPNLEGLSKESVKSIRALSALLRIAEGLDRSHTGIVSHVRFYIAST
ESLVLEMHAQKECQLEIWEVEKHKKYFKKIFGYSLQSKAIIEQTAGTPLIFKGNVEIEEMPRD

Sequences:

>Translated_543_residues
MEPEKISEGRVVAFIDIGTNSVRLLLVRINPNGSYQPLTKQKETVRLGEKEFIDRILQPEAMERAAFVCKKFMELSRAYR
VEEIIAVATSATRDASNKVQLLEMIKKEANLEVCTISGSEEARLIYLGVSSGLRLGNSKAIFIDIGGGSTEVSVGDQNQY
YFLHSLNLGSIRLTNMFLPDETGPVSEERYEQIKAYIRRKSADIIKELSRYTVNFVIGSSGTIENLAKIAFVYLHKTAHE
SFEKLEYEDLKKIVRAMCALSLEERRKFPGINSQRADIILAGAAIIETFMEELGLSEITVSKRGLREGLLVDYISKSEFS
YLVTQMSVRKRSIMQLGLACNFDEEHAHTVSRLALELFDSIQALGIYEFEESERELLEYGATLHDIGTFLSYDTHQAHAY
HLIRESNLPGFQPEEIEIIANLAYFHRKNTPKKKHPNLEGLSKESVKSIRALSALLRIAEGLDRSHTGIVSHVRFYIAST
ESLVLEMHAQKECQLEIWEVEKHKKYFKKIFGYSLQSKAIIEQTAGTPLIFKGNVEIEEMPRD
>Mature_543_residues
MEPEKISEGRVVAFIDIGTNSVRLLLVRINPNGSYQPLTKQKETVRLGEKEFIDRILQPEAMERAAFVCKKFMELSRAYR
VEEIIAVATSATRDASNKVQLLEMIKKEANLEVCTISGSEEARLIYLGVSSGLRLGNSKAIFIDIGGGSTEVSVGDQNQY
YFLHSLNLGSIRLTNMFLPDETGPVSEERYEQIKAYIRRKSADIIKELSRYTVNFVIGSSGTIENLAKIAFVYLHKTAHE
SFEKLEYEDLKKIVRAMCALSLEERRKFPGINSQRADIILAGAAIIETFMEELGLSEITVSKRGLREGLLVDYISKSEFS
YLVTQMSVRKRSIMQLGLACNFDEEHAHTVSRLALELFDSIQALGIYEFEESERELLEYGATLHDIGTFLSYDTHQAHAY
HLIRESNLPGFQPEEIEIIANLAYFHRKNTPKKKHPNLEGLSKESVKSIRALSALLRIAEGLDRSHTGIVSHVRFYIAST
ESLVLEMHAQKECQLEIWEVEKHKKYFKKIFGYSLQSKAIIEQTAGTPLIFKGNVEIEEMPRD

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=419, Percent_Identity=29.5942720763723, Blast_Score=156, Evalue=4e-39,
Organism=Escherichia coli, GI1788848, Length=510, Percent_Identity=25.0980392156863, Blast_Score=154, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 61549; Mature: 61549

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPEKISEGRVVAFIDIGTNSVRLLLVRINPNGSYQPLTKQKETVRLGEKEFIDRILQPE
CCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCCCHHHHHCCHHHHHHHHHCHH
AMERAAFVCKKFMELSRAYRVEEIIAVATSATRDASNKVQLLEMIKKEANLEVCTISGSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCC
EARLIYLGVSSGLRLGNSKAIFIDIGGGSTEVSVGDQNQYYFLHSLNLGSIRLTNMFLPD
CCEEEEEEECCCCEECCCCEEEEEECCCCEEEEECCCCCEEEEEECCCCCEEEEEEECCC
ETGPVSEERYEQIKAYIRRKSADIIKELSRYTVNFVIGSSGTIENLAKIAFVYLHKTAHE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHH
SFEKLEYEDLKKIVRAMCALSLEERRKFPGINSQRADIILAGAAIIETFMEELGLSEITV
HHHHCCHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCEEEH
SKRGLREGLLVDYISKSEFSYLVTQMSVRKRSIMQLGLACNFDEEHAHTVSRLALELFDS
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
IQALGIYEFEESERELLEYGATLHDIGTFLSYDTHQAHAYHLIRESNLPGFQPEEIEIIA
HHHHEEEEHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHEEECCCCCCCCCCHHHHHH
NLAYFHRKNTPKKKHPNLEGLSKESVKSIRALSALLRIAEGLDRSHTGIVSHVRFYIAST
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
ESLVLEMHAQKECQLEIWEVEKHKKYFKKIFGYSLQSKAIIEQTAGTPLIFKGNVEIEEM
HHHHEEHHCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEECCCCHHCC
PRD
CCC
>Mature Secondary Structure
MEPEKISEGRVVAFIDIGTNSVRLLLVRINPNGSYQPLTKQKETVRLGEKEFIDRILQPE
CCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCCCHHHHHCCHHHHHHHHHCHH
AMERAAFVCKKFMELSRAYRVEEIIAVATSATRDASNKVQLLEMIKKEANLEVCTISGSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCC
EARLIYLGVSSGLRLGNSKAIFIDIGGGSTEVSVGDQNQYYFLHSLNLGSIRLTNMFLPD
CCEEEEEEECCCCEECCCCEEEEEECCCCEEEEECCCCCEEEEEECCCCCEEEEEEECCC
ETGPVSEERYEQIKAYIRRKSADIIKELSRYTVNFVIGSSGTIENLAKIAFVYLHKTAHE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHH
SFEKLEYEDLKKIVRAMCALSLEERRKFPGINSQRADIILAGAAIIETFMEELGLSEITV
HHHHCCHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCEEEH
SKRGLREGLLVDYISKSEFSYLVTQMSVRKRSIMQLGLACNFDEEHAHTVSRLALELFDS
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
IQALGIYEFEESERELLEYGATLHDIGTFLSYDTHQAHAYHLIRESNLPGFQPEEIEIIA
HHHHEEEEHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHEEECCCCCCCCCCHHHHHH
NLAYFHRKNTPKKKHPNLEGLSKESVKSIRALSALLRIAEGLDRSHTGIVSHVRFYIAST
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
ESLVLEMHAQKECQLEIWEVEKHKKYFKKIFGYSLQSKAIIEQTAGTPLIFKGNVEIEEM
HHHHEEHHCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEECCCCHHCC
PRD
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]