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The map label for this gene is mutS [H]

Identifier: 21227476

GI number: 21227476

Start: 1644599

End: 1646728

Strand: Direct

Name: mutS [H]

Synonym: MM_1374

Alternate gene names: 21227476

Gene position: 1644599-1646728 (Clockwise)

Preceding gene: 21227475

Following gene: 21227477

Centisome position: 40.15

GC content: 47.79

Gene sequence:

>2130_bases
TTGAATATGGCAGCTTTTCAGCAACTCTCAGGTCTACGGGAACTTAACGGAATAGGTGAGCGAGTAGCCGGCAGGCTTGT
CGAGCACTTCGGGAGCGAAGATGCAGCTCTCCAGGCAATCCTTGAAGGTGATATAGCTTCGCTTTCCGAGGTAAATGGTG
TCAGCCATACATTTGCTCTTTCCCTGGCCAGGGATGCCAGAGGCAGGGCTGAAGGGTGTGCAATTTCCGATTTTCTGAAG
ACAAAAGAAGCCCTTGACCTGTACTCCCGCCTTCTTGAGCTCATAAAAACTTTTGCTCATACCTCACATGCCAGGGACAG
GATGGACCTCTTTTATCCATTTCCTGCGTCCCGTATGGACCTTATTGAAGAGAGGCGGGCTTTTGTTGCAGATTATCTGA
AAATCGCAGACGTCCTTTCTGCAGATAAGGAGTTTATCGCTCTCCTTTTAAGGGTGAAGAAACTGAAGCCTGTGCCTGGA
AACCTGAGGGCGAGGGACAGGATAATTCTTTCAGGAGACCGGAAAATTCTGGATGCAGCCAGGGAAAGGTTTCAGGCATT
CTTGACTGTTCAGGCGGTAGAGAGTTTTTCCGAGTTTGTGGACCTTGCAAGAGGATACTCCAGTGTTATTGTATTTGATG
ATAATTTTCTCAGCTTTGACCTTCCTGAAGGGCTTGAGCCAGAGCTTTTCCAGGACCCCTCAAAAGCCGAGTTCTGGCAG
ATCCTGCCTGAGGTAGAGCTGGCTTTTTTTGCCAGAAACCTGGACTGCGTCCTTGCCTGTTTGAATATAGTATCCACTCT
CAGGATTGCGGGTTTCAGCTTTTTTGAAGATCTCTCAGACGCCGAGCTCGAAGACCTCAAAACTGCCCTTCTGAAGGTTG
GAGAGGATGGAAAGCCCGTTGAAGGGCTTGACCCCGAACTTGACAGGCTTGAAACCGCACTGAAAAACCTTGATCCCATA
CTCACCTCTACCTTAAACGAGGCAAACCAGCGCATGAACCGGACGCTGGAAGCAAGCTCTCTCACCCTGAGCGGGCAGGA
ACTCATCAAGCTTGTGAGTGGAGGGATGGAGATCAAAGACCTGCTGGCAAAAGAGCTGCAGAGAGTCTATACAGGTGAAA
TCGAAGCACTAAAAGAGGAACTTTCGGAAAAGCTCGATTTCCAGAAGCAGGAAAAGCTGATGCTTGATTCCCTCTTTTCC
GATGAAATATCCTATCCTCTCAGGGCAGAACAGGCTCAACTGCAGCTTTTCAGGCAAAAACTGAGCATGTCCCTTGAAAA
AACAAGGCTTTCCCGCAAAAGGGAGCTTGCAAAAACCCTCTCAGTTTTCCGCCAGCCTGTAGAAAAGCTTGTAAAGGAGA
TTTTAGACTTTGACCTGGGGTTTTCAATAGCATGTTTTGCCTCACAGTTCCGGCTGAAGATGCCGGTAATCGTTCCTGAA
GCCGGAATAGGCTTTGAAGCCGGGGAAAATCTCTTTTTAAAAGCCAGATACGGAGAAATTGATCCTGTAAGCTATTCCGT
TGGAAAAACGAGCTTTTCTCCTGTGGATATGGAAAACCGGGTCGTACTTTTAAGCGGGGTGAACTCAGGAGGAAAAACCT
CCCTGCTCGAACTCCTTGCTCAGTGTGTGGTTCTCGGTCACATGGGCTTTCCTGTCCCGGCAATGAAGCTTGAACTCGGA
CCTGTGGAGGAATTCTATTATTTCGGAAAATCAAAAGGGACTCTTGATGCAGGAGCTTTTGAAACCACCCTTAAACAGTT
CTCAGTGCTTTCCGAAGCTTCCGGGAAACTTGTGCTCGCCGATGAACTGGAATCAATTACCGAACCCGGAGCCTCAGCCC
GGATTATAGCGGGGATACTTGAATATCTTGCCCGGAGTGAAGAGAGCCTCGGGATTTTTGTTTCCCACCTCTCCGAGCTT
ATCCTTGAAAACACAGAGACAGAAATCAGGGTAGACGGGATCGAAGCCGAAGGGCTGGATTCCAGCCTGGAACTTATAGT
AAATAGAAATCCTATATACAATCGTGTTGCAAGGAGTACTCCCGAACTGATTGTGGAAAGGTTGCTGAGGAAGACAACAG
GAAAAGAGCAGGAGTTTTATGCTCATTTAAAGAATAAATTTAAAAATTGA

Upstream 100 bases:

>100_bases
CCATGCAGCCCTATCTTGAAAAAGAACTTTCTCTTTTGTTTAAATAAAAAGATAAAAATAGGGTTTTACCCCTGAACTCA
ACTGATTCGTTTAAAGTGTT

Downstream 100 bases:

>100_bases
AAACTCATTGGCTCTGGAGAAATTAAAAACTATTGAATTTTTCCAATCTTTTTCTACTTCCGGGTTTCTTTTAAAATATT
TTCATTTCGCTTACATGCCA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 709; Mature: 709

Protein sequence:

>709_residues
MNMAAFQQLSGLRELNGIGERVAGRLVEHFGSEDAALQAILEGDIASLSEVNGVSHTFALSLARDARGRAEGCAISDFLK
TKEALDLYSRLLELIKTFAHTSHARDRMDLFYPFPASRMDLIEERRAFVADYLKIADVLSADKEFIALLLRVKKLKPVPG
NLRARDRIILSGDRKILDAARERFQAFLTVQAVESFSEFVDLARGYSSVIVFDDNFLSFDLPEGLEPELFQDPSKAEFWQ
ILPEVELAFFARNLDCVLACLNIVSTLRIAGFSFFEDLSDAELEDLKTALLKVGEDGKPVEGLDPELDRLETALKNLDPI
LTSTLNEANQRMNRTLEASSLTLSGQELIKLVSGGMEIKDLLAKELQRVYTGEIEALKEELSEKLDFQKQEKLMLDSLFS
DEISYPLRAEQAQLQLFRQKLSMSLEKTRLSRKRELAKTLSVFRQPVEKLVKEILDFDLGFSIACFASQFRLKMPVIVPE
AGIGFEAGENLFLKARYGEIDPVSYSVGKTSFSPVDMENRVVLLSGVNSGGKTSLLELLAQCVVLGHMGFPVPAMKLELG
PVEEFYYFGKSKGTLDAGAFETTLKQFSVLSEASGKLVLADELESITEPGASARIIAGILEYLARSEESLGIFVSHLSEL
ILENTETEIRVDGIEAEGLDSSLELIVNRNPIYNRVARSTPELIVERLLRKTTGKEQEFYAHLKNKFKN

Sequences:

>Translated_709_residues
MNMAAFQQLSGLRELNGIGERVAGRLVEHFGSEDAALQAILEGDIASLSEVNGVSHTFALSLARDARGRAEGCAISDFLK
TKEALDLYSRLLELIKTFAHTSHARDRMDLFYPFPASRMDLIEERRAFVADYLKIADVLSADKEFIALLLRVKKLKPVPG
NLRARDRIILSGDRKILDAARERFQAFLTVQAVESFSEFVDLARGYSSVIVFDDNFLSFDLPEGLEPELFQDPSKAEFWQ
ILPEVELAFFARNLDCVLACLNIVSTLRIAGFSFFEDLSDAELEDLKTALLKVGEDGKPVEGLDPELDRLETALKNLDPI
LTSTLNEANQRMNRTLEASSLTLSGQELIKLVSGGMEIKDLLAKELQRVYTGEIEALKEELSEKLDFQKQEKLMLDSLFS
DEISYPLRAEQAQLQLFRQKLSMSLEKTRLSRKRELAKTLSVFRQPVEKLVKEILDFDLGFSIACFASQFRLKMPVIVPE
AGIGFEAGENLFLKARYGEIDPVSYSVGKTSFSPVDMENRVVLLSGVNSGGKTSLLELLAQCVVLGHMGFPVPAMKLELG
PVEEFYYFGKSKGTLDAGAFETTLKQFSVLSEASGKLVLADELESITEPGASARIIAGILEYLARSEESLGIFVSHLSEL
ILENTETEIRVDGIEAEGLDSSLELIVNRNPIYNRVARSTPELIVERLLRKTTGKEQEFYAHLKNKFKN
>Mature_709_residues
MNMAAFQQLSGLRELNGIGERVAGRLVEHFGSEDAALQAILEGDIASLSEVNGVSHTFALSLARDARGRAEGCAISDFLK
TKEALDLYSRLLELIKTFAHTSHARDRMDLFYPFPASRMDLIEERRAFVADYLKIADVLSADKEFIALLLRVKKLKPVPG
NLRARDRIILSGDRKILDAARERFQAFLTVQAVESFSEFVDLARGYSSVIVFDDNFLSFDLPEGLEPELFQDPSKAEFWQ
ILPEVELAFFARNLDCVLACLNIVSTLRIAGFSFFEDLSDAELEDLKTALLKVGEDGKPVEGLDPELDRLETALKNLDPI
LTSTLNEANQRMNRTLEASSLTLSGQELIKLVSGGMEIKDLLAKELQRVYTGEIEALKEELSEKLDFQKQEKLMLDSLFS
DEISYPLRAEQAQLQLFRQKLSMSLEKTRLSRKRELAKTLSVFRQPVEKLVKEILDFDLGFSIACFASQFRLKMPVIVPE
AGIGFEAGENLFLKARYGEIDPVSYSVGKTSFSPVDMENRVVLLSGVNSGGKTSLLELLAQCVVLGHMGFPVPAMKLELG
PVEEFYYFGKSKGTLDAGAFETTLKQFSVLSEASGKLVLADELESITEPGASARIIAGILEYLARSEESLGIFVSHLSEL
ILENTETEIRVDGIEAEGLDSSLELIVNRNPIYNRVARSTPELIVERLLRKTTGKEQEFYAHLKNKFKN

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 79105; Mature: 79105

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMAAFQQLSGLRELNGIGERVAGRLVEHFGSEDAALQAILEGDIASLSEVNGVSHTFAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHCCCHHHHHH
SLARDARGRAEGCAISDFLKTKEALDLYSRLLELIKTFAHTSHARDRMDLFYPFPASRMD
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHH
LIEERRAFVADYLKIADVLSADKEFIALLLRVKKLKPVPGNLRARDRIILSGDRKILDAA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHH
RERFQAFLTVQAVESFSEFVDLARGYSSVIVFDDNFLSFDLPEGLEPELFQDPSKAEFWQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCCCCCHHHCCCCHHHHHH
ILPEVELAFFARNLDCVLACLNIVSTLRIAGFSFFEDLSDAELEDLKTALLKVGEDGKPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
EGLDPELDRLETALKNLDPILTSTLNEANQRMNRTLEASSLTLSGQELIKLVSGGMEIKD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHCCCHHHH
LLAKELQRVYTGEIEALKEELSEKLDFQKQEKLMLDSLFSDEISYPLRAEQAQLQLFRQK
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LSMSLEKTRLSRKRELAKTLSVFRQPVEKLVKEILDFDLGFSIACFASQFRLKMPVIVPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEECCEEECC
AGIGFEAGENLFLKARYGEIDPVSYSVGKTSFSPVDMENRVVLLSGVNSGGKTSLLELLA
CCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHH
QCVVLGHMGFPVPAMKLELGPVEEFYYFGKSKGTLDAGAFETTLKQFSVLSEASGKLVLA
HHHHHHCCCCCCCCCEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEH
DELESITEPGASARIIAGILEYLARSEESLGIFVSHLSELILENTETEIRVDGIEAEGLD
HHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
SSLELIVNRNPIYNRVARSTPELIVERLLRKTTGKEQEFYAHLKNKFKN
CHHHHEECCCHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNMAAFQQLSGLRELNGIGERVAGRLVEHFGSEDAALQAILEGDIASLSEVNGVSHTFAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHCCCHHHHHH
SLARDARGRAEGCAISDFLKTKEALDLYSRLLELIKTFAHTSHARDRMDLFYPFPASRMD
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHH
LIEERRAFVADYLKIADVLSADKEFIALLLRVKKLKPVPGNLRARDRIILSGDRKILDAA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHH
RERFQAFLTVQAVESFSEFVDLARGYSSVIVFDDNFLSFDLPEGLEPELFQDPSKAEFWQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCCCCCHHHCCCCHHHHHH
ILPEVELAFFARNLDCVLACLNIVSTLRIAGFSFFEDLSDAELEDLKTALLKVGEDGKPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
EGLDPELDRLETALKNLDPILTSTLNEANQRMNRTLEASSLTLSGQELIKLVSGGMEIKD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHCCCHHHH
LLAKELQRVYTGEIEALKEELSEKLDFQKQEKLMLDSLFSDEISYPLRAEQAQLQLFRQK
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LSMSLEKTRLSRKRELAKTLSVFRQPVEKLVKEILDFDLGFSIACFASQFRLKMPVIVPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEECCEEECC
AGIGFEAGENLFLKARYGEIDPVSYSVGKTSFSPVDMENRVVLLSGVNSGGKTSLLELLA
CCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHH
QCVVLGHMGFPVPAMKLELGPVEEFYYFGKSKGTLDAGAFETTLKQFSVLSEASGKLVLA
HHHHHHCCCCCCCCCEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEH
DELESITEPGASARIIAGILEYLARSEESLGIFVSHLSELILENTETEIRVDGIEAEGLD
HHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
SSLELIVNRNPIYNRVARSTPELIVERLLRKTTGKEQEFYAHLKNKFKN
CHHHHEECCCHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA