Click here to switch to the map view.

The map label for this gene is 21227455

Identifier: 21227455

GI number: 21227455

Start: 1621804

End: 1622838

Strand: Direct

Name: 21227455

Synonym: MM_1353

Alternate gene names: NA

Gene position: 1621804-1622838 (Clockwise)

Preceding gene: 21227454

Following gene: 21227457

Centisome position: 39.59

GC content: 43.19

Gene sequence:

>1035_bases
ATGAAAGAAATCATCTTTGATGATATAGGAAGCTATCCACTCCCTGAAGGAGTTAGCAGGGAATGGGTGCAGAATGCCTT
TAAAACGAGAGCAGAAGATGAGAAACTTTTTACTGTAATCAATGATGCTTTTCAGCAGAAAATCGATGCAGGCGTAGAAG
TTCCTACCTATCCCCAGTATCAGGACATGAACGAGCAGTTCCTGAAGGTTATCCGGGATTCTAACTGTACAGACAGTCCC
TTTGAGGTAAAACTGGAATGCGCAAGGATTGAAGAGCTTGAGGCTATAGAGACGGTAGCAAAAGCTTATAAAGAAAAATT
CGGGGAGACCTTAAAGGTCCGTATCTGTGTGACCGGCCCAACCGAACTTTACCTGAAAGAGTTCGGAGGCACCAGGTATA
CGGATATATACACTCTTTTTGCAAAGAGCATAAACAGGTTTGTCCGGAACTCGATGAAATCTGCAAAACACTTTAAGATC
GCAACGGTTTCAATTGACGAGCCAAGCATAGGACTCAATCCTGAACTTGCCTTTGATGAAAACGATGTTATCTCCGCCCT
TACAGAAGCTTCTAAGGCTGCAAGCAAATGGGGAGCTGACGTGGAGATCCATCTTCATTCCCCTCTTTATTACAATTATG
CCTGTGAGACCACCACAATCAATGTAATAGGCGTTGAGTCTGCAGGCACTCCTTCTTACCTTGAGCTTATTGACAAAAAG
ATGCTTGAAGACACCGATTCTTTCCTGAGGATTGGAATTGCAAGAACGGATATTTTTTCCCTTGCTGGAATTCTCAATGA
GAAATACTGTACCAACATCTGGAAAGATCAGCAATATATCCCTGAAATCGTTTCGCAGCTGGAAACTCCGGAAGTTATTG
AAAAAAGGTTGAAGCTGGCATACAGGCGTTTTGGCAGTCTGATCAAATATGTGGGTCCTGACTGCGGCCTGGGTTCATGG
CCTAACCAGAGAATAGCTTTTATCCTGCTTTCAAACGTCGCACAGGGTATCAAAAATTTCAGGGAAAATCTTTAA

Upstream 100 bases:

>100_bases
TCTCCTTTGAGAAGATATTCTCATAGTATTTCTCATCTGTTATTTTATAATTTTACTGTCTTTCCAATAATAATAAATTC
TTACAGGTATACTAGAGAGC

Downstream 100 bases:

>100_bases
CCCTGAAAACCTTTCTTTTTAGGTCCTCTTTCTTTTTAAGTCTGAAGATTTTTCTTTCAATAACCCGCCGAAAAATCAGA
AACTTCTCTGATTATATTAT

Product: 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase

Products: tetrahydropteroyltri-L-glutamate; L-methionine

Alternate protein names: Methionine Synthase Vitamin-B12 Independent

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MKEIIFDDIGSYPLPEGVSREWVQNAFKTRAEDEKLFTVINDAFQQKIDAGVEVPTYPQYQDMNEQFLKVIRDSNCTDSP
FEVKLECARIEELEAIETVAKAYKEKFGETLKVRICVTGPTELYLKEFGGTRYTDIYTLFAKSINRFVRNSMKSAKHFKI
ATVSIDEPSIGLNPELAFDENDVISALTEASKAASKWGADVEIHLHSPLYYNYACETTTINVIGVESAGTPSYLELIDKK
MLEDTDSFLRIGIARTDIFSLAGILNEKYCTNIWKDQQYIPEIVSQLETPEVIEKRLKLAYRRFGSLIKYVGPDCGLGSW
PNQRIAFILLSNVAQGIKNFRENL

Sequences:

>Translated_344_residues
MKEIIFDDIGSYPLPEGVSREWVQNAFKTRAEDEKLFTVINDAFQQKIDAGVEVPTYPQYQDMNEQFLKVIRDSNCTDSP
FEVKLECARIEELEAIETVAKAYKEKFGETLKVRICVTGPTELYLKEFGGTRYTDIYTLFAKSINRFVRNSMKSAKHFKI
ATVSIDEPSIGLNPELAFDENDVISALTEASKAASKWGADVEIHLHSPLYYNYACETTTINVIGVESAGTPSYLELIDKK
MLEDTDSFLRIGIARTDIFSLAGILNEKYCTNIWKDQQYIPEIVSQLETPEVIEKRLKLAYRRFGSLIKYVGPDCGLGSW
PNQRIAFILLSNVAQGIKNFRENL
>Mature_344_residues
MKEIIFDDIGSYPLPEGVSREWVQNAFKTRAEDEKLFTVINDAFQQKIDAGVEVPTYPQYQDMNEQFLKVIRDSNCTDSP
FEVKLECARIEELEAIETVAKAYKEKFGETLKVRICVTGPTELYLKEFGGTRYTDIYTLFAKSINRFVRNSMKSAKHFKI
ATVSIDEPSIGLNPELAFDENDVISALTEASKAASKWGADVEIHLHSPLYYNYACETTTINVIGVESAGTPSYLELIDKK
MLEDTDSFLRIGIARTDIFSLAGILNEKYCTNIWKDQQYIPEIVSQLETPEVIEKRLKLAYRRFGSLIKYVGPDCGLGSW
PNQRIAFILLSNVAQGIKNFRENL

Specific function: Unknown

COG id: COG0620

COG function: function code E; Methionine synthase II (cobalamin-independent)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.1.1.14

Molecular weight: Translated: 39072; Mature: 39072

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIIFDDIGSYPLPEGVSREWVQNAFKTRAEDEKLFTVINDAFQQKIDAGVEVPTYPQY
CCCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
QDMNEQFLKVIRDSNCTDSPFEVKLECARIEELEAIETVAKAYKEKFGETLKVRICVTGP
CCHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
TELYLKEFGGTRYTDIYTLFAKSINRFVRNSMKSAKHFKIATVSIDEPSIGLNPELAFDE
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCC
NDVISALTEASKAASKWGADVEIHLHSPLYYNYACETTTINVIGVESAGTPSYLELIDKK
HHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEECCEEEEEEEECCCCCHHHHHHHHHH
MLEDTDSFLRIGIARTDIFSLAGILNEKYCTNIWKDQQYIPEIVSQLETPEVIEKRLKLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHH
YRRFGSLIKYVGPDCGLGSWPNQRIAFILLSNVAQGIKNFRENL
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKEIIFDDIGSYPLPEGVSREWVQNAFKTRAEDEKLFTVINDAFQQKIDAGVEVPTYPQY
CCCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
QDMNEQFLKVIRDSNCTDSPFEVKLECARIEELEAIETVAKAYKEKFGETLKVRICVTGP
CCHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
TELYLKEFGGTRYTDIYTLFAKSINRFVRNSMKSAKHFKIATVSIDEPSIGLNPELAFDE
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCC
NDVISALTEASKAASKWGADVEIHLHSPLYYNYACETTTINVIGVESAGTPSYLELIDKK
HHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEECCEEEEEEEECCCCCHHHHHHHHHH
MLEDTDSFLRIGIARTDIFSLAGILNEKYCTNIWKDQQYIPEIVSQLETPEVIEKRLKLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHH
YRRFGSLIKYVGPDCGLGSWPNQRIAFILLSNVAQGIKNFRENL
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5-methyltetrahydropteroyltri-L-glutamate; L-homocysteine

Specific reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA