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The map label for this gene is adcA [H]

Identifier: 21227435

GI number: 21227435

Start: 1590690

End: 1591676

Strand: Direct

Name: adcA [H]

Synonym: MM_1333

Alternate gene names: 21227435

Gene position: 1590690-1591676 (Clockwise)

Preceding gene: 21227434

Following gene: 21227436

Centisome position: 38.83

GC content: 42.45

Gene sequence:

>987_bases
ATGAAATTAAAAATCATACCTCTGCTGGTAATTCTGATTGTTGGTCTGAGTATTTTCGTAAGTGGATGTACGGATGCCGG
AGATTCAGGGAATAATAGGAGTACAGGACAGGGAGCTGAAATTTCAGGAAACGAAGAACCCATAATAGTTGCCGTAAGCG
TTGTCCCTCAAGCTGAGTTCGTAGAAAAAGTCGGAGGAGACAGGGTAAAAACAGTTGTTATAGTTCCTTCCGGGGCAGAT
CCTCATACTTATGAACCTTCTCCAAAGGAAGTCAAGGAAATCAGCAAAGCCAGCATGTTATTAACAGTAGGGGTTGGGAT
GCCTTTTGAAGAAGTCTGGATTGACAGGTTTGAGTCTATGAATAGCGATACTCTCATTATAAACTGCTCTGAAGGAATCG
AACTGAAAAAGCTTGAAGGATATCACCATCATGAAGGGGAAGAAGGACATGATGAGGAGCTGGAAACCGGGCATGAAAAC
AAAAGTGAGGGGAATCATGAAGAACTGGACCCTCATATATGGACATCCCCTTCAAATGCAAAGATAATGGTCGAAGAGAT
TTATGAAGGGCTTGTAGAGCTCGATCCTGAAAATGAAGCTTATTATGCCCAGAATAGAGATGCTTATCTTGAAGAGCTGG
ATGCTCTGGATACGAGGATCCGGGAAAAACTTGAAGGAAAAGAAGAAAAAAATTTCATGGTTTATCATCCTTCCTGGGGC
TATTTTGCTGCAGATTATGGGCTTAACATGATCTCCGTCGAAATTGAAGGAAAAGAGCCGAGTGCACAGGATCTTACTGA
ACTTGTGGACCTTGCAAAAGAAAAGGATGTCAAAGTTATTTTTGTCCAGGCTCAGTTCAGCACGAGGAGCGCGGAAGTTT
TAGCTCAGGAAATCGGAGGAGAAGTTGTAGCTGTTGATCCTCTGGCAAAGAATTATATTGAGAATATGGACAGCGTCTCT
GATATCTTTGCCAGAAACCTGGTGTAA

Upstream 100 bases:

>100_bases
GGTGCTATCAAATTTATCTTTTATATGTCAGTTCCATCTGATCTTCAAAAAAAATTAACTGCGCCAAAGAACAAAATTGA
AATTATAAAGGAGTTTAACA

Downstream 100 bases:

>100_bases
TATCGTGAACAGGCTTTCACTTAAATTATTGATAAAATCGTCGTTCAGGTTCTACATCTAAATATAAAAAGAACATAATT
CGGGATAAGATAAAAACGAT

Product: Zinc ABC transporter zinc-binding protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MKLKIIPLLVILIVGLSIFVSGCTDAGDSGNNRSTGQGAEISGNEEPIIVAVSVVPQAEFVEKVGGDRVKTVVIVPSGAD
PHTYEPSPKEVKEISKASMLLTVGVGMPFEEVWIDRFESMNSDTLIINCSEGIELKKLEGYHHHEGEEGHDEELETGHEN
KSEGNHEELDPHIWTSPSNAKIMVEEIYEGLVELDPENEAYYAQNRDAYLEELDALDTRIREKLEGKEEKNFMVYHPSWG
YFAADYGLNMISVEIEGKEPSAQDLTELVDLAKEKDVKVIFVQAQFSTRSAEVLAQEIGGEVVAVDPLAKNYIENMDSVS
DIFARNLV

Sequences:

>Translated_328_residues
MKLKIIPLLVILIVGLSIFVSGCTDAGDSGNNRSTGQGAEISGNEEPIIVAVSVVPQAEFVEKVGGDRVKTVVIVPSGAD
PHTYEPSPKEVKEISKASMLLTVGVGMPFEEVWIDRFESMNSDTLIINCSEGIELKKLEGYHHHEGEEGHDEELETGHEN
KSEGNHEELDPHIWTSPSNAKIMVEEIYEGLVELDPENEAYYAQNRDAYLEELDALDTRIREKLEGKEEKNFMVYHPSWG
YFAADYGLNMISVEIEGKEPSAQDLTELVDLAKEKDVKVIFVQAQFSTRSAEVLAQEIGGEVVAVDPLAKNYIENMDSVS
DIFARNLV
>Mature_328_residues
MKLKIIPLLVILIVGLSIFVSGCTDAGDSGNNRSTGQGAEISGNEEPIIVAVSVVPQAEFVEKVGGDRVKTVVIVPSGAD
PHTYEPSPKEVKEISKASMLLTVGVGMPFEEVWIDRFESMNSDTLIINCSEGIELKKLEGYHHHEGEEGHDEELETGHEN
KSEGNHEELDPHIWTSPSNAKIMVEEIYEGLVELDPENEAYYAQNRDAYLEELDALDTRIREKLEGKEEKNFMVYHPSWG
YFAADYGLNMISVEIEGKEPSAQDLTELVDLAKEKDVKVIFVQAQFSTRSAEVLAQEIGGEVVAVDPLAKNYIENMDSVS
DIFARNLV

Specific function: Part of the high-affinity ABC transporter complex AdcABC involved in zinc import (Probable) [H]

COG id: COG0803

COG function: function code P; ABC-type metal ion transport system, periplasmic component/surface adhesin

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 9 family [H]

Homologues:

Organism=Escherichia coli, GI87081990, Length=281, Percent_Identity=24.1992882562278, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006127
- InterPro:   IPR006129
- InterPro:   IPR006128 [H]

Pfam domain/function: PF01297 SBP_bac_9 [H]

EC number: NA

Molecular weight: Translated: 36325; Mature: 36325

Theoretical pI: Translated: 4.16; Mature: 4.16

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKIIPLLVILIVGLSIFVSGCTDAGDSGNNRSTGQGAEISGNEEPIIVAVSVVPQAEF
CCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHH
VEKVGGDRVKTVVIVPSGADPHTYEPSPKEVKEISKASMLLTVGVGMPFEEVWIDRFESM
HHHHCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHCC
NSDTLIINCSEGIELKKLEGYHHHEGEEGHDEELETGHENKSEGNHEELDPHIWTSPSNA
CCCEEEEECCCCCEEEECCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHCCCCEECCCCCC
KIMVEEIYEGLVELDPENEAYYAQNRDAYLEELDALDTRIREKLEGKEEKNFMVYHPSWG
EEEHHHHHHHHHEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCC
YFAADYGLNMISVEIEGKEPSAQDLTELVDLAKEKDVKVIFVQAQFSTRSAEVLAQEIGG
CEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCC
EVVAVDPLAKNYIENMDSVSDIFARNLV
CEEEECHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLKIIPLLVILIVGLSIFVSGCTDAGDSGNNRSTGQGAEISGNEEPIIVAVSVVPQAEF
CCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHH
VEKVGGDRVKTVVIVPSGADPHTYEPSPKEVKEISKASMLLTVGVGMPFEEVWIDRFESM
HHHHCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHCC
NSDTLIINCSEGIELKKLEGYHHHEGEEGHDEELETGHENKSEGNHEELDPHIWTSPSNA
CCCEEEEECCCCCEEEECCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHCCCCEECCCCCC
KIMVEEIYEGLVELDPENEAYYAQNRDAYLEELDALDTRIREKLEGKEEKNFMVYHPSWG
EEEHHHHHHHHHEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCC
YFAADYGLNMISVEIEGKEPSAQDLTELVDLAKEKDVKVIFVQAQFSTRSAEVLAQEIGG
CEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCC
EVVAVDPLAKNYIENMDSVSDIFARNLV
CEEEECHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9811636 [H]