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The map label for this gene is ycgO [H]

Identifier: 21227418

GI number: 21227418

Start: 1566461

End: 1567747

Strand: Direct

Name: ycgO [H]

Synonym: MM_1316

Alternate gene names: 21227418

Gene position: 1566461-1567747 (Clockwise)

Preceding gene: 21227417

Following gene: 21227419

Centisome position: 38.24

GC content: 43.28

Gene sequence:

>1287_bases
ATGGAATCCGTGTGGCTGGGTATAGGGCTGGCTGCAGGAACATATCTGAACTGGAAATTTGTCGCGAAAAAATTACGTCA
ATATACTCAGGTTGCAGGGGATTCAATTACAATACCTGTGTACTTTGAAAACAGGTTCAGGGATAAAAGCCACAGTTTAA
GAATTATCTCATCTATCCTGATTCTGGTCTTTTTCTTGCTTTACACTTCCTCAGGCCTTGTTGCGGGAGGAAAGCTTTTC
AACACTGTTTTTGAAATTCCTTATCAGCAAGCTCTTCTAATCGGTGCATTAGTAATTATCACCTATACTTTCCTCGGAGG
CTTTATGGCCGTCTGCTGGACTGATTTTTTCCAGGGAACGCTGATGGTCTGTGCCATTGCTCTTGTGCCGCTTGCAGCTA
TGAAAGGAATAGGTGGTTATGACTCGACAGTGAGTATTATTGAAAGTATAGATCCGCAGCTGCTCAATCCCTGGACTGCC
CTTGCCGGAGGTGCAATTCCTCTGATCTCCAATCTTGCCTGGGGTCTGGGATACTTCGGGATGCCACATATACTGGTCCG
TTTTATGGCTATAGAATCACCTGAAAAAATAAAGCAGGCCAGGATTATTGCAATGGTCTGGGTCATTATTTCCCTGATTT
TTGCTGTAGTAGTTGGAATTGTCGGAAGAGCCTACCTCTATCCCGAGTTTCTGGGAGAAGCAGGCAGTGAGACTATCTTT
ATGGTAATGATAAATAATATGTTCACACCCATTATCGCTGGAATACTGCTTGCAGCTATCCTTGCGGCTATCATGAGTAC
TGCTGATTCCCAGCTCCTTGTAGCTGCATCTGCCTTCACTGAAGATATTTACAGGATAATCATGAGGAAAAACGCAGGTG
AAAAAGAACTTGTCTGGATGGGCAGGTTTGCAGTTATCATAATTTCAGCAATTGCGTACCTGATAGCTAGAGATCCGAAC
AATTCAGTAATGGGCCTGGTATCATATGCGTGGGCAGGATTTGGAGCTGCCTTTGGACCTGTTATCCTGTTCTCCCTTTT
CTGGAGGAATACAACCAGAAATGGAGCGCTGGGAGGAATGATTGTGGGCGGATTAACAGTTATTATCTGGAAACAACTCT
CAGGAGGGATTTTTGATCTATACGAGATAGTTCCTGGATTCCTGCTCTCATGTATCACAATCTATGCAATCAGTATTCTG
GATAAAGAAGGCCCTGCAGAAGAAATCCTTAGAGAATTCGACCATTTAAAACAGATAACTCTCGGAGGAAAAAATACTCA
TAAATAA

Upstream 100 bases:

>100_bases
TAGAAAGTTAAACAGCTGGGTTACTGCGCTGAGTGCCCAGGCATCGGATATGAGCGGCTGGCTATTGCTGGGGCTACCAT
GATATGCTTACCTTTCAGGG

Downstream 100 bases:

>100_bases
AATATGGGATCTTCAGAAACCTGACCCGAGCAAATTTTCTGCAAAATATTTTTTGGGCACTGAAAGGAACCGAGAAGAAC
CTAAAGGAACCGAGAAGGAA

Product: sodium/proline symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MESVWLGIGLAAGTYLNWKFVAKKLRQYTQVAGDSITIPVYFENRFRDKSHSLRIISSILILVFFLLYTSSGLVAGGKLF
NTVFEIPYQQALLIGALVIITYTFLGGFMAVCWTDFFQGTLMVCAIALVPLAAMKGIGGYDSTVSIIESIDPQLLNPWTA
LAGGAIPLISNLAWGLGYFGMPHILVRFMAIESPEKIKQARIIAMVWVIISLIFAVVVGIVGRAYLYPEFLGEAGSETIF
MVMINNMFTPIIAGILLAAILAAIMSTADSQLLVAASAFTEDIYRIIMRKNAGEKELVWMGRFAVIIISAIAYLIARDPN
NSVMGLVSYAWAGFGAAFGPVILFSLFWRNTTRNGALGGMIVGGLTVIIWKQLSGGIFDLYEIVPGFLLSCITIYAISIL
DKEGPAEEILREFDHLKQITLGGKNTHK

Sequences:

>Translated_428_residues
MESVWLGIGLAAGTYLNWKFVAKKLRQYTQVAGDSITIPVYFENRFRDKSHSLRIISSILILVFFLLYTSSGLVAGGKLF
NTVFEIPYQQALLIGALVIITYTFLGGFMAVCWTDFFQGTLMVCAIALVPLAAMKGIGGYDSTVSIIESIDPQLLNPWTA
LAGGAIPLISNLAWGLGYFGMPHILVRFMAIESPEKIKQARIIAMVWVIISLIFAVVVGIVGRAYLYPEFLGEAGSETIF
MVMINNMFTPIIAGILLAAILAAIMSTADSQLLVAASAFTEDIYRIIMRKNAGEKELVWMGRFAVIIISAIAYLIARDPN
NSVMGLVSYAWAGFGAAFGPVILFSLFWRNTTRNGALGGMIVGGLTVIIWKQLSGGIFDLYEIVPGFLLSCITIYAISIL
DKEGPAEEILREFDHLKQITLGGKNTHK
>Mature_428_residues
MESVWLGIGLAAGTYLNWKFVAKKLRQYTQVAGDSITIPVYFENRFRDKSHSLRIISSILILVFFLLYTSSGLVAGGKLF
NTVFEIPYQQALLIGALVIITYTFLGGFMAVCWTDFFQGTLMVCAIALVPLAAMKGIGGYDSTVSIIESIDPQLLNPWTA
LAGGAIPLISNLAWGLGYFGMPHILVRFMAIESPEKIKQARIIAMVWVIISLIFAVVVGIVGRAYLYPEFLGEAGSETIF
MVMINNMFTPIIAGILLAAILAAIMSTADSQLLVAASAFTEDIYRIIMRKNAGEKELVWMGRFAVIIISAIAYLIARDPN
NSVMGLVSYAWAGFGAAFGPVILFSLFWRNTTRNGALGGMIVGGLTVIIWKQLSGGIFDLYEIVPGFLLSCITIYAISIL
DKEGPAEEILREFDHLKQITLGGKNTHK

Specific function: Catalyzes the sodium-dependent uptake of extracellular amino acids [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=431, Percent_Identity=44.3155452436195, Blast_Score=351, Evalue=6e-97,
Organism=Homo sapiens, GI14140236, Length=370, Percent_Identity=22.972972972973, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI11141885, Length=304, Percent_Identity=25.6578947368421, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI206597487, Length=391, Percent_Identity=23.7851662404092, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI206597483, Length=391, Percent_Identity=23.7851662404092, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI109659836, Length=377, Percent_Identity=23.0769230769231, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787251, Length=413, Percent_Identity=48.18401937046, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI87082237, Length=389, Percent_Identity=28.5347043701799, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1790503, Length=355, Percent_Identity=25.0704225352113, Blast_Score=99, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24648033, Length=249, Percent_Identity=24.4979919678715, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21356865, Length=249, Percent_Identity=24.4979919678715, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221459584, Length=305, Percent_Identity=22.9508196721311, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 46788; Mature: 46788

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESVWLGIGLAAGTYLNWKFVAKKLRQYTQVAGDSITIPVYFENRFRDKSHSLRIISSIL
CCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHH
ILVFFLLYTSSGLVAGGKLFNTVFEIPYQQALLIGALVIITYTFLGGFMAVCWTDFFQGT
HHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMVCAIALVPLAAMKGIGGYDSTVSIIESIDPQLLNPWTALAGGAIPLISNLAWGLGYFG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCCCHHHHHCCHHHHHHHHHHHHHHCC
MPHILVRFMAIESPEKIKQARIIAMVWVIISLIFAVVVGIVGRAYLYPEFLGEAGSETIF
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCEEE
MVMINNMFTPIIAGILLAAILAAIMSTADSQLLVAASAFTEDIYRIIMRKNAGEKELVWM
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
GRFAVIIISAIAYLIARDPNNSVMGLVSYAWAGFGAAFGPVILFSLFWRNTTRNGALGGM
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
IVGGLTVIIWKQLSGGIFDLYEIVPGFLLSCITIYAISILDKEGPAEEILREFDHLKQIT
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LGGKNTHK
CCCCCCCC
>Mature Secondary Structure
MESVWLGIGLAAGTYLNWKFVAKKLRQYTQVAGDSITIPVYFENRFRDKSHSLRIISSIL
CCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHH
ILVFFLLYTSSGLVAGGKLFNTVFEIPYQQALLIGALVIITYTFLGGFMAVCWTDFFQGT
HHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMVCAIALVPLAAMKGIGGYDSTVSIIESIDPQLLNPWTALAGGAIPLISNLAWGLGYFG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCCCHHHHHCCHHHHHHHHHHHHHHCC
MPHILVRFMAIESPEKIKQARIIAMVWVIISLIFAVVVGIVGRAYLYPEFLGEAGSETIF
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCEEE
MVMINNMFTPIIAGILLAAILAAIMSTADSQLLVAASAFTEDIYRIIMRKNAGEKELVWM
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
GRFAVIIISAIAYLIARDPNNSVMGLVSYAWAGFGAAFGPVILFSLFWRNTTRNGALGGM
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
IVGGLTVIIWKQLSGGIFDLYEIVPGFLLSCITIYAISILDKEGPAEEILREFDHLKQIT
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LGGKNTHK
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]