Definition Methanosarcina mazei Go1 chromosome, complete genome.
Accession NC_003901
Length 4,096,345

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The map label for this gene is mfnA

Identifier: 21227419

GI number: 21227419

Start: 1568868

End: 1570064

Strand: Direct

Name: mfnA

Synonym: MM_1317

Alternate gene names: 21227419

Gene position: 1568868-1570064 (Clockwise)

Preceding gene: 21227418

Following gene: 21227420

Centisome position: 38.3

GC content: 44.61

Gene sequence:

>1197_bases
ATGAATGAGCAGGGTCTTTCGGAAAGAGAGATATTTTCCTATCTGGAAAATGCAAAGTCAGAAGATACGGATTATTATCG
GGTTTTTAGTTCAATGTGTACCCGCCCTCATAAGATCGCAATCGAGGCTAACAGGCTCTTTATTGAAGCTAACCTGGGCG
ATCTGGGGCTTTTTGCCGGAGCCCACAAACTAGAGCAGGAGGTTGTCAGAATGCTTGGCAACCTTCTTCACGCCTCTTCA
ATTGACGTTCCTTCAGGCGGTTTATGTCAGAGCTCTGTTTGCGGTTACCTGACCACAGGAGGTACGGAATCCAACATTCA
GGCTGTAAGAGGAATGAAAAACCTGGTAACAGCAGGAAAAAAAGAATTTAAGGGAACTCCAAACATTGTAATTCCCGCAT
CGGCTCATTTTTCTTTTGATAAAGTTGCCGACATGATGGGCATAGAAGTCAGAAGGGCTTCTCTTGATTCGGAGTTCAGG
GTGGATATGGCTTCAGTTGAAAAACTCATAAATGAAAACACGATAGGTCTCGTAGGAATTGCAGGGAATACTGAATTTGG
CCAGATAGATCCGATCGATAAACTCTCGGAAGTAGCTCTTGAAAATGAGCTTTTCCTGCACGTTGATGCGGCTTTCGGAG
GTTTTGTTATTCCTTTCCTGGAAAAGCCCCAGCCTTTTGACTTCAAAGTGCCGGGAGTGACTTCAATTGCCATAGACCCC
CATAAGATGGGTCTTTCCACAATTCCTTCAGGCGCTTTACTTTTCAGGTCCCCTTCTTTCCTGGATTCTCTCAAAGTAAG
TACCCCATATCTTACAACAAAATCCCAGTTCACACTTACAGGCACCCGGAGTGGAGCCTCAGCTGCTGCTACCTGCGCAG
TCATGAAGTATCTCGGATATGAAGGTTACAGAAAAAATGTGCAGTACTGCATGGAGCTTACTTCAAAAATTGTAGAAGAA
GCAAGAAAACTTGGTTTCGAGCCATTGATTGAGCCGGTCATGAACGTCGTTGCTCTTAAAGTCCCGAATCCTGACCTTGT
CAGAGAACGGCTTCTTAAAAAATTCGGCTGGAATGTCTCAATTACCCGCACTCCAAGGGCTCTCCGTCTTGTCCTTATGC
CTCATAACAGTCCCGAAGATATCGAACTATTTTTAGAAGACCTTAAGAAAGTGACAGCAGAAATTAAAAGCCCCTAA

Upstream 100 bases:

>100_bases
CTGGTCTGTTATGATCCCGAAGAAGTCAGTTTTTCTAGAGTCAGTTTTTCTAGTTTGATTCCATAAGTCTTTTAAATAAA
ACTGGTTTTACTTTACCTAT

Downstream 100 bases:

>100_bases
TTATATTTTTTAATTTCAGGCTTTAATTTCAGATTTTTAATTTCAAACTTCTATTGCAGGGTTCTAACTTAAACCCCCAG
TTCAAATCTTCTCATTCAAA

Product: L-tyrosine decarboxylase

Products: NA

Alternate protein names: TDC

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MNEQGLSEREIFSYLENAKSEDTDYYRVFSSMCTRPHKIAIEANRLFIEANLGDLGLFAGAHKLEQEVVRMLGNLLHASS
IDVPSGGLCQSSVCGYLTTGGTESNIQAVRGMKNLVTAGKKEFKGTPNIVIPASAHFSFDKVADMMGIEVRRASLDSEFR
VDMASVEKLINENTIGLVGIAGNTEFGQIDPIDKLSEVALENELFLHVDAAFGGFVIPFLEKPQPFDFKVPGVTSIAIDP
HKMGLSTIPSGALLFRSPSFLDSLKVSTPYLTTKSQFTLTGTRSGASAAATCAVMKYLGYEGYRKNVQYCMELTSKIVEE
ARKLGFEPLIEPVMNVVALKVPNPDLVRERLLKKFGWNVSITRTPRALRLVLMPHNSPEDIELFLEDLKKVTAEIKSP

Sequences:

>Translated_398_residues
MNEQGLSEREIFSYLENAKSEDTDYYRVFSSMCTRPHKIAIEANRLFIEANLGDLGLFAGAHKLEQEVVRMLGNLLHASS
IDVPSGGLCQSSVCGYLTTGGTESNIQAVRGMKNLVTAGKKEFKGTPNIVIPASAHFSFDKVADMMGIEVRRASLDSEFR
VDMASVEKLINENTIGLVGIAGNTEFGQIDPIDKLSEVALENELFLHVDAAFGGFVIPFLEKPQPFDFKVPGVTSIAIDP
HKMGLSTIPSGALLFRSPSFLDSLKVSTPYLTTKSQFTLTGTRSGASAAATCAVMKYLGYEGYRKNVQYCMELTSKIVEE
ARKLGFEPLIEPVMNVVALKVPNPDLVRERLLKKFGWNVSITRTPRALRLVLMPHNSPEDIELFLEDLKKVTAEIKSP
>Mature_398_residues
MNEQGLSEREIFSYLENAKSEDTDYYRVFSSMCTRPHKIAIEANRLFIEANLGDLGLFAGAHKLEQEVVRMLGNLLHASS
IDVPSGGLCQSSVCGYLTTGGTESNIQAVRGMKNLVTAGKKEFKGTPNIVIPASAHFSFDKVADMMGIEVRRASLDSEFR
VDMASVEKLINENTIGLVGIAGNTEFGQIDPIDKLSEVALENELFLHVDAAFGGFVIPFLEKPQPFDFKVPGVTSIAIDP
HKMGLSTIPSGALLFRSPSFLDSLKVSTPYLTTKSQFTLTGTRSGASAAATCAVMKYLGYEGYRKNVQYCMELTSKIVEE
ARKLGFEPLIEPVMNVVALKVPNPDLVRERLLKKFGWNVSITRTPRALRLVLMPHNSPEDIELFLEDLKKVTAEIKSP

Specific function: Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily

Homologues:

Organism=Homo sapiens, GI31982936, Length=418, Percent_Identity=30.1435406698565, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI197383062, Length=343, Percent_Identity=23.6151603498542, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1787769, Length=295, Percent_Identity=27.7966101694915, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789934, Length=295, Percent_Identity=27.7966101694915, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17557272, Length=350, Percent_Identity=31.1428571428571, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17543922, Length=351, Percent_Identity=31.0541310541311, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25148342, Length=357, Percent_Identity=28.8515406162465, Blast_Score=135, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6320500, Length=285, Percent_Identity=32.6315789473684, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323905, Length=306, Percent_Identity=28.7581699346405, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21355963, Length=358, Percent_Identity=34.6368715083799, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24654344, Length=358, Percent_Identity=34.6368715083799, Blast_Score=187, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MFNA_METMA (Q8PXA5)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_633341.1
- ProteinModelPortal:   Q8PXA5
- SMR:   Q8PXA5
- GeneID:   1479659
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1317
- NMPDR:   fig|192952.1.peg.1317
- HOGENOM:   HBG497871
- OMA:   ILGSMCT
- ProtClustDB:   PRK13520
- BioCyc:   MMAZ192952:MM1317-MONOMER
- BRENDA:   4.1.1.25
- HAMAP:   MF_01610
- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR020931
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11999
- TIGRFAMs:   TIGR03812

Pfam domain/function: PF00282 Pyridoxal_deC; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =4.1.1.25

Molecular weight: Translated: 43762; Mature: 43762

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MNEQGLSEREIFSYLENAKSEDTDYYRVFSSMCTRPHKIAIEANRLFIEANLGDLGLFAG
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEEEEEEEEECCCCHHHHHH
AHKLEQEVVRMLGNLLHASSIDVPSGGLCQSSVCGYLTTGGTESNIQAVRGMKNLVTAGK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCEEECCCCCHHHHHHHHHHHHHHCCH
KEFKGTPNIVIPASAHFSFDKVADMMGIEVRRASLDSEFRVDMASVEKLINENTIGLVGI
HHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHCCCCEEEEEE
AGNTEFGQIDPIDKLSEVALENELFLHVDAAFGGFVIPFLEKPQPFDFKVPGVTSIAIDP
CCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCEEECCCCCCCCCCEECCCEEEEEECH
HKMGLSTIPSGALLFRSPSFLDSLKVSTPYLTTKSQFTLTGTRSGASAAATCAVMKYLGY
HHCCCCCCCCCEEEECCCHHHHHHCCCCCEEECCCEEEEEECCCCCHHHHHHHHHHHHCC
EGYRKNVQYCMELTSKIVEEARKLGFEPLIEPVMNVVALKVPNPDLVRERLLKKFGWNVS
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEECCCHHHHHHHHHHHHCCCEE
ITRTPRALRLVLMPHNSPEDIELFLEDLKKVTAEIKSP
EEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNEQGLSEREIFSYLENAKSEDTDYYRVFSSMCTRPHKIAIEANRLFIEANLGDLGLFAG
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEEEEEEEEECCCCHHHHHH
AHKLEQEVVRMLGNLLHASSIDVPSGGLCQSSVCGYLTTGGTESNIQAVRGMKNLVTAGK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCEEECCCCCHHHHHHHHHHHHHHCCH
KEFKGTPNIVIPASAHFSFDKVADMMGIEVRRASLDSEFRVDMASVEKLINENTIGLVGI
HHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHCCCCEEEEEE
AGNTEFGQIDPIDKLSEVALENELFLHVDAAFGGFVIPFLEKPQPFDFKVPGVTSIAIDP
CCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCEEECCCCCCCCCCEECCCEEEEEECH
HKMGLSTIPSGALLFRSPSFLDSLKVSTPYLTTKSQFTLTGTRSGASAAATCAVMKYLGY
HHCCCCCCCCCEEEECCCHHHHHHCCCCCEEECCCEEEEEECCCCCHHHHHHHHHHHHCC
EGYRKNVQYCMELTSKIVEEARKLGFEPLIEPVMNVVALKVPNPDLVRERLLKKFGWNVS
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEECCCHHHHHHHHHHHHCCCEE
ITRTPRALRLVLMPHNSPEDIELFLEDLKKVTAEIKSP
EEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824