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The map label for this gene is tyrA [C]

Identifier: 21227377

GI number: 21227377

Start: 1509626

End: 1511044

Strand: Direct

Name: tyrA [C]

Synonym: MM_1275

Alternate gene names: 21227377

Gene position: 1509626-1511044 (Clockwise)

Preceding gene: 21227376

Following gene: 21227378

Centisome position: 36.85

GC content: 44.05

Gene sequence:

>1419_bases
TTGAATACGGACTACGATGCTGGAAAAACGAAGGTTCTGATCCTTGGCGGGACCGGAGAGATGGGGCAGTGGTTCACACG
TTTTTTCAAAGAAAGAGGCTATGAGGTTACTGTCTGGGGAAAAGGCGGCAAGATAGAAGTCGCGAAAAAACTGGACGTAC
CTTTTGCTTTAGACCTTGAGGCAGTTATCCCTGAAAGTGACATAGTGATAGTTTCCGTCCCGATCAATGCAACAGAAGAA
ACCATCGCAGAAATCGCCCCAAAAATGAAAGCTGGAAGCATTCTTATGGATTTTACCTCAATAAAGGTAGGACCTGTTGA
AGCGATGAGAAAGTTTGCGCCCAAAGATGTTGAAATTCTTGGGACGCACCCCATGTTTGGTCCGACAATTCCCACAATAA
GGGGGCAAACAGTAATCCTTGTTCCGGTAAAAGGGTATTCGGAAAAATGGTTTCCGGTAATCAGACAGCTTTTTGAGGAA
AGCGGCGCGCACGTTGAGATCACAACTGCAGAGGAACACGACAGGCTGGTCTCAGTAGTGCAGGGGCTTACTCATTTTGC
TTATATTGCTATAGGCACAACCATTGACAGGCTTGATTTTGACGTCAAAAAGTCCAGAAAATTCGTAAGCCCGGTTTACA
GTATAATGCTCGACTTTGTGGGCAGGATCCTGGGACAGAATCCCTATCTCTATGCCCTGATTCAGATGGAAAACCCTGGA
GTTCCTGAGGTGCATGAAGCATTTATAAAAGAGTGTGAGGAGCTTTCCAGCCTTGTGAAGGCACACGATGAGGAAGGCTT
TGTAAGAAAGATGAAAGCAGCTGCCCGTAAATATGATGACACATCTCATGCCCTGCGCAGGTCGGACAAACTGATCAACT
CCAGGATAATCGAATATGAAACTATCCTGAATTCTACAGGAAAAGTCTGTGGTTTTTCTCATATTTATTCCGGAAATATC
CACGTGGGCAGACTGGAAAAAGTTAGACCGAACGAGATAGTTCTTATGAAACTTGTCTCAAAAGGTACTGCTCCCAATAT
AAAAAACAGATTTATAACACTAAAGCTTGAAAACCTTCGCCCCCTTTCGGAAGCTGAACTAAGGGAATGGAGAAAAGAAA
ACCTGGAGCATTCGGTAAGGGATATTTCAGTCGTGATCCCTGAAGGAGCCGATCCTGAAGTAGTCCTCAGGGCGGTGAGT
ACAAATAAACATCTTGCAGACTGTAAAATCAGTGACATTTATAAAGGGGTTAATGGGACGTTGCTAGAAAAAAAAGGAAG
TACAGCCGAAAAATTGGGAGTAACTTACAGAATAAGTATATTTGGGGATTGTGACGCAGATTCTGTTGAAACTGAGGTGA
CAGCCCTTCTTTGCGGTCTCGGATGCCGTATAAGAGAGAAAAACCTGAAATTCAGTTAA

Upstream 100 bases:

>100_bases
TAATGCTCGTCTATCAGGGAGCAGAAGCTTTCAGGCTCTGGACAGGGGTTGAGCCTCCGCTGGAGCTTATGAAAAAGACC
GTACTGGAGGCTCTGCAAGC

Downstream 100 bases:

>100_bases
TGAAAAGGTTTTTCTCTCTGCCGGGCTTAATAAACAGAGAAATACATATAAACAATTAATAGATAGAAATTATAATGTCC
CAGGTCAAATGGAAAATTTC

Product: prephenate dehydrogenase

Products: 4-hydroxyphenylpyruvate; CO2; NADH

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MNTDYDAGKTKVLILGGTGEMGQWFTRFFKERGYEVTVWGKGGKIEVAKKLDVPFALDLEAVIPESDIVIVSVPINATEE
TIAEIAPKMKAGSILMDFTSIKVGPVEAMRKFAPKDVEILGTHPMFGPTIPTIRGQTVILVPVKGYSEKWFPVIRQLFEE
SGAHVEITTAEEHDRLVSVVQGLTHFAYIAIGTTIDRLDFDVKKSRKFVSPVYSIMLDFVGRILGQNPYLYALIQMENPG
VPEVHEAFIKECEELSSLVKAHDEEGFVRKMKAAARKYDDTSHALRRSDKLINSRIIEYETILNSTGKVCGFSHIYSGNI
HVGRLEKVRPNEIVLMKLVSKGTAPNIKNRFITLKLENLRPLSEAELREWRKENLEHSVRDISVVIPEGADPEVVLRAVS
TNKHLADCKISDIYKGVNGTLLEKKGSTAEKLGVTYRISIFGDCDADSVETEVTALLCGLGCRIREKNLKFS

Sequences:

>Translated_472_residues
MNTDYDAGKTKVLILGGTGEMGQWFTRFFKERGYEVTVWGKGGKIEVAKKLDVPFALDLEAVIPESDIVIVSVPINATEE
TIAEIAPKMKAGSILMDFTSIKVGPVEAMRKFAPKDVEILGTHPMFGPTIPTIRGQTVILVPVKGYSEKWFPVIRQLFEE
SGAHVEITTAEEHDRLVSVVQGLTHFAYIAIGTTIDRLDFDVKKSRKFVSPVYSIMLDFVGRILGQNPYLYALIQMENPG
VPEVHEAFIKECEELSSLVKAHDEEGFVRKMKAAARKYDDTSHALRRSDKLINSRIIEYETILNSTGKVCGFSHIYSGNI
HVGRLEKVRPNEIVLMKLVSKGTAPNIKNRFITLKLENLRPLSEAELREWRKENLEHSVRDISVVIPEGADPEVVLRAVS
TNKHLADCKISDIYKGVNGTLLEKKGSTAEKLGVTYRISIFGDCDADSVETEVTALLCGLGCRIREKNLKFS
>Mature_472_residues
MNTDYDAGKTKVLILGGTGEMGQWFTRFFKERGYEVTVWGKGGKIEVAKKLDVPFALDLEAVIPESDIVIVSVPINATEE
TIAEIAPKMKAGSILMDFTSIKVGPVEAMRKFAPKDVEILGTHPMFGPTIPTIRGQTVILVPVKGYSEKWFPVIRQLFEE
SGAHVEITTAEEHDRLVSVVQGLTHFAYIAIGTTIDRLDFDVKKSRKFVSPVYSIMLDFVGRILGQNPYLYALIQMENPG
VPEVHEAFIKECEELSSLVKAHDEEGFVRKMKAAARKYDDTSHALRRSDKLINSRIIEYETILNSTGKVCGFSHIYSGNI
HVGRLEKVRPNEIVLMKLVSKGTAPNIKNRFITLKLENLRPLSEAELREWRKENLEHSVRDISVVIPEGADPEVVLRAVS
TNKHLADCKISDIYKGVNGTLLEKKGSTAEKLGVTYRISIFGDCDADSVETEVTALLCGLGCRIREKNLKFS

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=282, Percent_Identity=29.0780141843972, Blast_Score=126, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319643, Length=305, Percent_Identity=22.9508196721311, Blast_Score=85, Evalue=3e-17,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR005121
- InterPro:   IPR008299
- InterPro:   IPR003099 [H]

Pfam domain/function: PF03147 FDX-ACB; PF02153 PDH [H]

EC number: 1.3.1.12

Molecular weight: Translated: 52642; Mature: 52642

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTDYDAGKTKVLILGGTGEMGQWFTRFFKERGYEVTVWGKGGKIEVAKKLDVPFALDLE
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCEEECCH
AVIPESDIVIVSVPINATEETIAEIAPKMKAGSILMDFTSIKVGPVEAMRKFAPKDVEIL
HCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCEEEE
GTHPMFGPTIPTIRGQTVILVPVKGYSEKWFPVIRQLFEESGAHVEITTAEEHDRLVSVV
ECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHH
QGLTHFAYIAIGTTIDRLDFDVKKSRKFVSPVYSIMLDFVGRILGQNPYLYALIQMENPG
HHHHHHHHHEECCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCC
VPEVHEAFIKECEELSSLVKAHDEEGFVRKMKAAARKYDDTSHALRRSDKLINSRIIEYE
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
TILNSTGKVCGFSHIYSGNIHVGRLEKVRPNEIVLMKLVSKGTAPNIKNRFITLKLENLR
HHHCCCCCCCCCEEEEECCEEEECCCCCCCCCEEEEEEHHCCCCCCCCCCEEEEEECCCC
PLSEAELREWRKENLEHSVRDISVVIPEGADPEVVLRAVSTNKHLADCKISDIYKGVNGT
CCCHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHEEEEECCCCCCCCCCHHHHHCCCCCE
LLEKKGSTAEKLGVTYRISIFGDCDADSVETEVTALLCGLGCRIREKNLKFS
EEECCCCCHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCEEECCCCCCC
>Mature Secondary Structure
MNTDYDAGKTKVLILGGTGEMGQWFTRFFKERGYEVTVWGKGGKIEVAKKLDVPFALDLE
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCEEECCH
AVIPESDIVIVSVPINATEETIAEIAPKMKAGSILMDFTSIKVGPVEAMRKFAPKDVEIL
HCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCEEEE
GTHPMFGPTIPTIRGQTVILVPVKGYSEKWFPVIRQLFEESGAHVEITTAEEHDRLVSVV
ECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHH
QGLTHFAYIAIGTTIDRLDFDVKKSRKFVSPVYSIMLDFVGRILGQNPYLYALIQMENPG
HHHHHHHHHEECCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCC
VPEVHEAFIKECEELSSLVKAHDEEGFVRKMKAAARKYDDTSHALRRSDKLINSRIIEYE
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
TILNSTGKVCGFSHIYSGNIHVGRLEKVRPNEIVLMKLVSKGTAPNIKNRFITLKLENLR
HHHCCCCCCCCCEEEEECCEEEECCCCCCCCCEEEEEEHHCCCCCCCCCCEEEEEECCCC
PLSEAELREWRKENLEHSVRDISVVIPEGADPEVVLRAVSTNKHLADCKISDIYKGVNGT
CCCHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHEEEEECCCCCCCCCCHHHHHCCCCCE
LLEKKGSTAEKLGVTYRISIFGDCDADSVETEVTALLCGLGCRIREKNLKFS
EEECCCCCHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: prephenate; NAD+

Specific reaction: prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]