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The map label for this gene is aroE

Identifier: 21227376

GI number: 21227376

Start: 1508787

End: 1509629

Strand: Direct

Name: aroE

Synonym: MM_1274

Alternate gene names: 21227376

Gene position: 1508787-1509629 (Clockwise)

Preceding gene: 21227375

Following gene: 21227377

Centisome position: 36.83

GC content: 48.64

Gene sequence:

>843_bases
ATGAAGCAGGTTTTTGGTGTATTTGGAGACCCTGTAGGTCATTCCCTTTCCCCAGCCATGCATAATGCAGCTTTTTCAGC
ACTTGGCATGGACTGTATCTATCACGCTTTCAGGGTCACTCCAGAAAAGCTGGAAAAAGCGATCCTTGGAGCTGAAGCTA
TGGGATTTGGAGGGATTAACCTTACAGTTCCCTTGAAAGAAAAGGCTTTAAAACTTGACTTCGTCAAGCCTGACCCCCTT
GCAAAGAGAATTGGAGCAGTGAATACTCTGGTATTCGGGAAAAAGGGAGATATCCAGGGATATAACACTGACGGGCCTGG
GGCAAAGCAGGCGCTTCTGGACACTGGAGTGGAAATTAGGGGGTCCAGAATGGTGGTCGCAGGAGCAGGAGGAGCAGCAA
GGGCAGTTGCTTTTCAGCTTGCAGCCGACGGTGCAGATATCACAGTAATAAACAGGACAGAAGAAAGGGCAGTAGGACTT
GCAAGAGAAATCTCGGCTGCAGACCTTCCGGGAAAAATCAGAGGTACCGGGCTTTCAGGATTAAAAGAACTGTTAAGGGA
TGCCGATGTCCTGATAAATACCACAACTCTCGGAATGCACCCGAACACGGACGCAACTATTGTAACAGCAGAAGAGCTTC
ACAGCGGCCTTACAGTTTTTGATATCGTATATAACCCACTTGAGACAAGGCTTTTAAGGGAAGCCAGGACATCAGGAGCA
AAAACGATAAGCGGGGTTTTAATGCTCGTCTATCAGGGAGCAGAAGCTTTCAGGCTCTGGACAGGGGTTGAGCCTCCGCT
GGAGCTTATGAAAAAGACCGTACTGGAGGCTCTGCAAGCTTGA

Upstream 100 bases:

>100_bases
ATGGTTCAGTCCTTACATATGCTTCTATAGAAAGTAATGCGTCTGCAGCTCCTGGCCAGCTTCCGGTAGATGAAGTAAAA
AAAATAATGGAAATGCTAAA

Downstream 100 bases:

>100_bases
ATACGGACTACGATGCTGGAAAAACGAAGGTTCTGATCCTTGGCGGGACCGGAGAGATGGGGCAGTGGTTCACACGTTTT
TTCAAAGAAAGAGGCTATGA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKQVFGVFGDPVGHSLSPAMHNAAFSALGMDCIYHAFRVTPEKLEKAILGAEAMGFGGINLTVPLKEKALKLDFVKPDPL
AKRIGAVNTLVFGKKGDIQGYNTDGPGAKQALLDTGVEIRGSRMVVAGAGGAARAVAFQLAADGADITVINRTEERAVGL
AREISAADLPGKIRGTGLSGLKELLRDADVLINTTTLGMHPNTDATIVTAEELHSGLTVFDIVYNPLETRLLREARTSGA
KTISGVLMLVYQGAEAFRLWTGVEPPLELMKKTVLEALQA

Sequences:

>Translated_280_residues
MKQVFGVFGDPVGHSLSPAMHNAAFSALGMDCIYHAFRVTPEKLEKAILGAEAMGFGGINLTVPLKEKALKLDFVKPDPL
AKRIGAVNTLVFGKKGDIQGYNTDGPGAKQALLDTGVEIRGSRMVVAGAGGAARAVAFQLAADGADITVINRTEERAVGL
AREISAADLPGKIRGTGLSGLKELLRDADVLINTTTLGMHPNTDATIVTAEELHSGLTVFDIVYNPLETRLLREARTSGA
KTISGVLMLVYQGAEAFRLWTGVEPPLELMKKTVLEALQA
>Mature_280_residues
MKQVFGVFGDPVGHSLSPAMHNAAFSALGMDCIYHAFRVTPEKLEKAILGAEAMGFGGINLTVPLKEKALKLDFVKPDPL
AKRIGAVNTLVFGKKGDIQGYNTDGPGAKQALLDTGVEIRGSRMVVAGAGGAARAVAFQLAADGADITVINRTEERAVGL
AREISAADLPGKIRGTGLSGLKELLRDADVLINTTTLGMHPNTDATIVTAEELHSGLTVFDIVYNPLETRLLREARTSGA
KTISGVLMLVYQGAEAFRLWTGVEPPLELMKKTVLEALQA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=281, Percent_Identity=38.0782918149466, Blast_Score=170, Evalue=7e-44,
Organism=Escherichia coli, GI1789675, Length=282, Percent_Identity=32.2695035460993, Blast_Score=118, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6320332, Length=284, Percent_Identity=30.6338028169014, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_METMA (Q8PXE6)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_633298.1
- ProteinModelPortal:   Q8PXE6
- SMR:   Q8PXE6
- GeneID:   1479616
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1274
- NMPDR:   fig|192952.1.peg.1274
- HOGENOM:   HBG553408
- OMA:   AVAFKIW
- ProtClustDB:   CLSK812084
- BioCyc:   MMAZ192952:MM1274-MONOMER
- BRENDA:   1.1.1.25
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29620; Mature: 29620

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: ACT_SITE 66-66

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQVFGVFGDPVGHSLSPAMHNAAFSALGMDCIYHAFRVTPEKLEKAILGAEAMGFGGIN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHCCCCCEE
LTVPLKEKALKLDFVKPDPLAKRIGAVNTLVFGKKGDIQGYNTDGPGAKQALLDTGVEIR
EEEECCCCCEEEECCCCCHHHHHHCHHHEEEECCCCCCCCCCCCCCCHHHHHHHCCCEEC
GSRMVVAGAGGAARAVAFQLAADGADITVINRTEERAVGLAREISAADLPGKIRGTGLSG
CCEEEEEECCCHHHHHEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCHHH
LKELLRDADVLINTTTLGMHPNTDATIVTAEELHSGLTVFDIVYNPLETRLLREARTSGA
HHHHHHCCCEEEEEEEECCCCCCCEEEEEHHHHHCCCEEEHHHHCHHHHHHHHHHHHCCH
KTISGVLMLVYQGAEAFRLWTGVEPPLELMKKTVLEALQA
HHHHHHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQVFGVFGDPVGHSLSPAMHNAAFSALGMDCIYHAFRVTPEKLEKAILGAEAMGFGGIN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHCCCCCEE
LTVPLKEKALKLDFVKPDPLAKRIGAVNTLVFGKKGDIQGYNTDGPGAKQALLDTGVEIR
EEEECCCCCEEEECCCCCHHHHHHCHHHEEEECCCCCCCCCCCCCCCHHHHHHHCCCEEC
GSRMVVAGAGGAARAVAFQLAADGADITVINRTEERAVGLAREISAADLPGKIRGTGLSG
CCEEEEEECCCHHHHHEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCHHH
LKELLRDADVLINTTTLGMHPNTDATIVTAEELHSGLTVFDIVYNPLETRLLREARTSGA
HHHHHHCCCEEEEEEEECCCCCCCEEEEEHHHHHCCCEEEHHHHCHHHHHHHHHHHHCCH
KTISGVLMLVYQGAEAFRLWTGVEPPLELMKKTVLEALQA
HHHHHHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824