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The map label for this gene is aroD

Identifier: 21227375

GI number: 21227375

Start: 1508062

End: 1508790

Strand: Direct

Name: aroD

Synonym: MM_1273

Alternate gene names: 21227375

Gene position: 1508062-1508790 (Clockwise)

Preceding gene: 21227374

Following gene: 21227376

Centisome position: 36.81

GC content: 44.03

Gene sequence:

>729_bases
ATGACTCAAATAGGCTCGTTTGACCTTGAAAAGAAAACTGCAGTTGTTGCAGTCATTCTTGAGAAACCCCTTGAAAATTC
AAAGAAGGCAGCCGAAAAAGGAGCTGATATCCTTGAAATCCGGCTGGACCTGCTTGGGATAAGGACCCCTGAGAGAGCCG
CAGAGGTGATCAGGGAAATAAAAGCCGAAACCGGGATTCCCATAATTGTTACCAGCCGTTCGGGAGCGGAAGGAGGAAAG
TGGGATGGAAAAGAAGAAGATAGAACAGGACTTCTTATAAATCTTCTTTCTTTAAAAGATGGCCCGGATGCGATTGATAT
CGAACTTTCTGCCGGCATGAAAGAAAGAAACAGGGTTATTAAAGCGGCTAAGGACCGGGAAACAGCTGTAATCGTCTCTT
CCCATGACTTTTTGAAAACCCCTCCCCTCCAGAACATGAGGACAATTATTGAAGAAATGTTTCTTGCAGGTGCAGATATT
GCCAAACTTGCAGTTATGCCCCTGTCAGTGGGAGATACCCTTAACCTGCTGAGAGTTACTCTGGACTTTAAAGATGCAGG
AAAATCCGTGTGCACAATTGCAATGGGCAGTCAAGGAAAGCATACAAGAGTTGTTGCCCCTTTTTATGGTTCAGTCCTTA
CATATGCTTCTATAGAAAGTAATGCGTCTGCAGCTCCTGGCCAGCTTCCGGTAGATGAAGTAAAAAAAATAATGGAAATG
CTAAAATGA

Upstream 100 bases:

>100_bases
TTTCGGCAAAAAAATCGAAGAGACGATTATAGAGAAATAAAGCAGGAAAGACTCTGTAAAGTCGATAGCAGCAGATTTCT
ACTCCCGGTTCGGAGAAAGC

Downstream 100 bases:

>100_bases
AGCAGGTTTTTGGTGTATTTGGAGACCCTGTAGGTCATTCCCTTTCCCCAGCCATGCATAATGCAGCTTTTTCAGCACTT
GGCATGGACTGTATCTATCA

Product: 3-dehydroquinate dehydratase

Products: NA

Alternate protein names: 3-dehydroquinase; Type I DHQase

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTQIGSFDLEKKTAVVAVILEKPLENSKKAAEKGADILEIRLDLLGIRTPERAAEVIREIKAETGIPIIVTSRSGAEGGK
WDGKEEDRTGLLINLLSLKDGPDAIDIELSAGMKERNRVIKAAKDRETAVIVSSHDFLKTPPLQNMRTIIEEMFLAGADI
AKLAVMPLSVGDTLNLLRVTLDFKDAGKSVCTIAMGSQGKHTRVVAPFYGSVLTYASIESNASAAPGQLPVDEVKKIMEM
LK

Sequences:

>Translated_242_residues
MTQIGSFDLEKKTAVVAVILEKPLENSKKAAEKGADILEIRLDLLGIRTPERAAEVIREIKAETGIPIIVTSRSGAEGGK
WDGKEEDRTGLLINLLSLKDGPDAIDIELSAGMKERNRVIKAAKDRETAVIVSSHDFLKTPPLQNMRTIIEEMFLAGADI
AKLAVMPLSVGDTLNLLRVTLDFKDAGKSVCTIAMGSQGKHTRVVAPFYGSVLTYASIESNASAAPGQLPVDEVKKIMEM
LK
>Mature_241_residues
TQIGSFDLEKKTAVVAVILEKPLENSKKAAEKGADILEIRLDLLGIRTPERAAEVIREIKAETGIPIIVTSRSGAEGGKW
DGKEEDRTGLLINLLSLKDGPDAIDIELSAGMKERNRVIKAAKDRETAVIVSSHDFLKTPPLQNMRTIIEEMFLAGADIA
KLAVMPLSVGDTLNLLRVTLDFKDAGKSVCTIAMGSQGKHTRVVAPFYGSVLTYASIESNASAAPGQLPVDEVKKIMEML
K

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; third step. [C]

COG id: COG0710

COG function: function code E; 3-dehydroquinate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-I 3-dehydroquinase family

Homologues:

Organism=Escherichia coli, GI1787984, Length=218, Percent_Identity=31.1926605504587, Blast_Score=98, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROD_METMA (Q8PXE7)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_633297.1
- ProteinModelPortal:   Q8PXE7
- SMR:   Q8PXE7
- GeneID:   1479615
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1273
- NMPDR:   fig|192952.1.peg.1273
- HOGENOM:   HBG732926
- OMA:   IAKLAVM
- ProtClustDB:   CLSK450616
- BioCyc:   MMAZ192952:MM1273-MONOMER
- BRENDA:   4.2.1.10
- HAMAP:   MF_00214
- InterPro:   IPR013785
- InterPro:   IPR001381
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01093

Pfam domain/function: PF01487 DHquinase_I

EC number: =4.2.1.10

Molecular weight: Translated: 26153; Mature: 26022

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS01028 DEHYDROQUINASE_I

Important sites: ACT_SITE 135-135 ACT_SITE 162-162

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQIGSFDLEKKTAVVAVILEKPLENSKKAAEKGADILEIRLDLLGIRTPERAAEVIREI
CCCCCCCCCCCHHHEEEEEECCCCCCHHHHHHCCCCEEEEEHHHHCCCCHHHHHHHHHHH
KAETGIPIIVTSRSGAEGGKWDGKEEDRTGLLINLLSLKDGPDAIDIELSAGMKERNRVI
HHHCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCHHHHHHH
KAAKDRETAVIVSSHDFLKTPPLQNMRTIIEEMFLAGADIAKLAVMPLSVGDTLNLLRVT
HHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHEEEECCCCCCEEEEEEE
LDFKDAGKSVCTIAMGSQGKHTRVVAPFYGSVLTYASIESNASAAPGQLPVDEVKKIMEM
EEHHHCCCEEEEEEECCCCCCEEEECCHHCCHHEEEECCCCCCCCCCCCCHHHHHHHHHH
LK
HC
>Mature Secondary Structure 
TQIGSFDLEKKTAVVAVILEKPLENSKKAAEKGADILEIRLDLLGIRTPERAAEVIREI
CCCCCCCCCCHHHEEEEEECCCCCCHHHHHHCCCCEEEEEHHHHCCCCHHHHHHHHHHH
KAETGIPIIVTSRSGAEGGKWDGKEEDRTGLLINLLSLKDGPDAIDIELSAGMKERNRVI
HHHCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCHHHHHHH
KAAKDRETAVIVSSHDFLKTPPLQNMRTIIEEMFLAGADIAKLAVMPLSVGDTLNLLRVT
HHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHEEEECCCCCCEEEEEEE
LDFKDAGKSVCTIAMGSQGKHTRVVAPFYGSVLTYASIESNASAAPGQLPVDEVKKIMEM
EEHHHCCCEEEEEEECCCCCCEEEECCHHCCHHEEEECCCCCCCCCCCCCHHHHHHHHHH
LK
HC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824