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The map label for this gene is 21227374

Identifier: 21227374

GI number: 21227374

Start: 1506859

End: 1508001

Strand: Direct

Name: 21227374

Synonym: MM_1272

Alternate gene names: NA

Gene position: 1506859-1508001 (Clockwise)

Preceding gene: 21227373

Following gene: 21227375

Centisome position: 36.79

GC content: 48.21

Gene sequence:

>1143_bases
TTGAAAAAGAAAAGCGTCTGGATAAAAGCCGATGAAGGCGGATGGGAAGAACAGAAAGAGAGGATCACAACAGGCCTGGA
ATCCGGAGCCGACTGTGTACTTGTAAATCCGGGAGATGTAGAAAAAGTCAGGGAACTCGGAAACATTACAGTTGCAGCCT
TTGCCCGCGACAATAAGTCAGGAGCCGACATCGTGGTCGTGGGAAAGAGAGGAGAAGGTGACGGAACAAAACCCCTGCCT
CAGGAAATTCCGGGTTCTTTTGATGTAAACGCAGCAACCCTGCTCACCGACAAAGGCGTAACCGTAGGCGGATATGTGGT
CATAAAGGACAGAAGCTACGAACGCTTCGCAGCAGAAATGGGAAAAATCTGCGATTACCTGCTTGTTACCGGCACTGACT
GGAAAGTTATCCCTCTCGAAAACCTGATTGCTGACCTCCAGCGTGAGAAAGTAAAGATTATTTTTGGAGTAAAAAGTGCC
GAGGAAGCAAGGCTCGCCTTCCAGACTCTTGAAACAGGAGCTGATGGAGTCCTCCTTGACAGCGGAAACCCGCAGGAAAT
AAAAGACACAATTAAAGCTGCAAGAGAACTTGAAAGCGAAAGCACAGAACTTGAATCCGCAGTTGTAACCAGGGTAGAAC
CTCTTGGAATGGGGGACAGGGTCTGTGTGGATACCTGCAACCTCATGCAGCGCGGAGAAGGAATGCTTATAGGTTCACAG
GCAAGCGGGATGTTCCTGGTAAATTCGGAGTCTGACGACAGTCCTTACGTGGCAGCCCGCCCATTCAGGGTAAATGCAGG
TGCAGTTCATTCTTATATAAAAATTGGAGACAAAACCCGCTATCTTTCAGAACTCCAGGCTGGAGACAGCGTTACTATCA
TAGACTCAAGAGGGAAGCAGAGGGAAGGAATAGTTGGCAGGATAAAGATAGAAAGCCGCCCACTTATGCTAATTGAAGCA
AAAGCCGGAGACCGGACTTTAACCGCAATCCTGCAAAATGCCGAAACCATCAAGCTTGTAGGAAAGGGCGGAACCCCTAT
CTCGGTTGCAAAGCTCAAAAAAGGTGATGAGGTTCTGGTACGCCTCGAAGAAGGAGCCAGGCATTTCGGCAAAAAAATCG
AAGAGACGATTATAGAGAAATAA

Upstream 100 bases:

>100_bases
GAAAAAGACACAGAATGAAGGATTCCCAAGCAGGGTTTCGGAGAATGTACCGGAATAAATCCGGAATAAAAACAGAATTT
ATGAACGGGGTTGAAAGCCT

Downstream 100 bases:

>100_bases
AGCAGGAAAGACTCTGTAAAGTCGATAGCAGCAGATTTCTACTCCCGGTTCGGAGAAAGCATGACTCAAATAGGCTCGTT
TGACCTTGAAAAGAAAACTG

Product: 3-dehydroquinate synthase

Products: 3-dehydroquinate; phosphate

Alternate protein names: DHQ synthase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKKKSVWIKADEGGWEEQKERITTGLESGADCVLVNPGDVEKVRELGNITVAAFARDNKSGADIVVVGKRGEGDGTKPLP
QEIPGSFDVNAATLLTDKGVTVGGYVVIKDRSYERFAAEMGKICDYLLVTGTDWKVIPLENLIADLQREKVKIIFGVKSA
EEARLAFQTLETGADGVLLDSGNPQEIKDTIKAARELESESTELESAVVTRVEPLGMGDRVCVDTCNLMQRGEGMLIGSQ
ASGMFLVNSESDDSPYVAARPFRVNAGAVHSYIKIGDKTRYLSELQAGDSVTIIDSRGKQREGIVGRIKIESRPLMLIEA
KAGDRTLTAILQNAETIKLVGKGGTPISVAKLKKGDEVLVRLEEGARHFGKKIEETIIEK

Sequences:

>Translated_380_residues
MKKKSVWIKADEGGWEEQKERITTGLESGADCVLVNPGDVEKVRELGNITVAAFARDNKSGADIVVVGKRGEGDGTKPLP
QEIPGSFDVNAATLLTDKGVTVGGYVVIKDRSYERFAAEMGKICDYLLVTGTDWKVIPLENLIADLQREKVKIIFGVKSA
EEARLAFQTLETGADGVLLDSGNPQEIKDTIKAARELESESTELESAVVTRVEPLGMGDRVCVDTCNLMQRGEGMLIGSQ
ASGMFLVNSESDDSPYVAARPFRVNAGAVHSYIKIGDKTRYLSELQAGDSVTIIDSRGKQREGIVGRIKIESRPLMLIEA
KAGDRTLTAILQNAETIKLVGKGGTPISVAKLKKGDEVLVRLEEGARHFGKKIEETIIEK
>Mature_380_residues
MKKKSVWIKADEGGWEEQKERITTGLESGADCVLVNPGDVEKVRELGNITVAAFARDNKSGADIVVVGKRGEGDGTKPLP
QEIPGSFDVNAATLLTDKGVTVGGYVVIKDRSYERFAAEMGKICDYLLVTGTDWKVIPLENLIADLQREKVKIIFGVKSA
EEARLAFQTLETGADGVLLDSGNPQEIKDTIKAARELESESTELESAVVTRVEPLGMGDRVCVDTCNLMQRGEGMLIGSQ
ASGMFLVNSESDDSPYVAARPFRVNAGAVHSYIKIGDKTRYLSELQAGDSVTIIDSRGKQREGIVGRIKIESRPLMLIEA
KAGDRTLTAILQNAETIKLVGKGGTPISVAKLKKGDEVLVRLEEGARHFGKKIEETIIEK

Specific function: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis [H]

COG id: COG1465

COG function: function code E; Predicted alternative 3-dehydroquinate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal-type DHQ synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002812
- ProDom:   PD017907 [H]

Pfam domain/function: PF01959 DHQS [H]

EC number: 4.2.3.4

Molecular weight: Translated: 41164; Mature: 41164

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKSVWIKADEGGWEEQKERITTGLESGADCVLVNPGDVEKVRELGNITVAAFARDNKS
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHCCEEEEEEECCCCC
GADIVVVGKRGEGDGTKPLPQEIPGSFDVNAATLLTDKGVTVGGYVVIKDRSYERFAAEM
CCCEEEEECCCCCCCCCCCHHHCCCCCCCCEEEEEECCCCEECCEEEEECCCHHHHHHHH
GKICDYLLVTGTDWKVIPLENLIADLQREKVKIIFGVKSAEEARLAFQTLETGADGVLLD
HHHHCEEEEECCCEEEEEHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEC
SGNPQEIKDTIKAARELESESTELESAVVTRVEPLGMGDRVCVDTCNLMQRGEGMLIGSQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHCCCCEEEECC
ASGMFLVNSESDDSPYVAARPFRVNAGAVHSYIKIGDKTRYLSELQAGDSVTIIDSRGKQ
CCCEEEEECCCCCCCEEEECCEEECCHHHHHEEEECCHHHHHHHHCCCCEEEEEECCCCC
REGIVGRIKIESRPLMLIEAKAGDRTLTAILQNAETIKLVGKGGTPISVAKLKKGDEVLV
CCCCEEEEEECCCCEEEEEECCCCHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCCEEE
RLEEGARHFGKKIEETIIEK
EEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKKSVWIKADEGGWEEQKERITTGLESGADCVLVNPGDVEKVRELGNITVAAFARDNKS
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHCCEEEEEEECCCCC
GADIVVVGKRGEGDGTKPLPQEIPGSFDVNAATLLTDKGVTVGGYVVIKDRSYERFAAEM
CCCEEEEECCCCCCCCCCCHHHCCCCCCCCEEEEEECCCCEECCEEEEECCCHHHHHHHH
GKICDYLLVTGTDWKVIPLENLIADLQREKVKIIFGVKSAEEARLAFQTLETGADGVLLD
HHHHCEEEEECCCEEEEEHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEC
SGNPQEIKDTIKAARELESESTELESAVVTRVEPLGMGDRVCVDTCNLMQRGEGMLIGSQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHCCCCEEEECC
ASGMFLVNSESDDSPYVAARPFRVNAGAVHSYIKIGDKTRYLSELQAGDSVTIIDSRGKQ
CCCEEEEECCCCCCCEEEECCEEECCHHHHHEEEECCHHHHHHHHCCCCEEEEEECCCCC
REGIVGRIKIESRPLMLIEAKAGDRTLTAILQNAETIKLVGKGGTPISVAKLKKGDEVLV
CCCCEEEEEECCCCEEEEEECCCCHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCCEEE
RLEEGARHFGKKIEETIIEK
EEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-deoxy-arabino-heptulonate 7-phosphate

Specific reaction: 3-deoxy-arabino-heptulonate 7-phosphate = 3-dehydroquinate + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]