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The map label for this gene is hpsA [H]

Identifier: 21227317

GI number: 21227317

Start: 1437166

End: 1438395

Strand: Direct

Name: hpsA [H]

Synonym: MM_1215

Alternate gene names: 21227317

Gene position: 1437166-1438395 (Clockwise)

Preceding gene: 21227312

Following gene: 21227318

Centisome position: 35.08

GC content: 47.89

Gene sequence:

>1230_bases
GTGGAGATTGCAAAGGAAGCAGTCGCAGGAGGAGCGGACTGGATAGAAATAGGAACCCCCCTGATCAAGAGCGAGGGCAT
GAATGCAATCCGCACCATGAGAAAAGCTTTTCCGGACAGGACAATTCTAGCTGACATGAAGACTGTGGACACAGGAGCCA
TGGAGGTGGAGATGGCGGCAAAAGCCGGTGCAGATGTGGCTATTGTTCTCGGTAGTGCTGATGATTCCACAATCCTTGAT
GCACTCCGATCAGCCCACAAATATGGAGTCAGGCTGATGGCAGACCTGATCTCGGCTCCTGATCCTGTAAAAAGAGCAGT
TGAACTCGAAGCTCTTGGGGTGGACTATATTAACGTTCACGTAGGCATAGACCAGCAAATGATTGGAAAGGACCCGGTAT
CCATTTTAATGGAAATTTCAGAAAAAGTGGGTGTGCAGCTTGCAGTAGCCGGAGGTCTTGATTCCGAAAGTGCAGCTCAG
GCGGTCAGGGCAGGAGCCAGGATTGTAATAGTGGGAGGAAATATAACCCGTTCTGACAATGTAACCGAAGCCGCAAAAAA
AATAAGAAAGAGTGTTGACTCTCCTGAGTCTGTAGATATCAGGGACAGGGGAACCGTAGACCAGGAGATAAGGGAGATCT
TTAAGGAAGTCTCTACCTCGAATATATCGGACGCAATGCACAGAAAAGGAGCGATGAAAGGTATCCATCCCCTGGTAAGA
GGGAAAATGGTAGGACCTGCGGTTACAGTTCAGTGTTTCCCGGGGGACTGGGCAAAGACAGTAGAAGCCATCGATCTCGC
AAAACCTGGAGATGTAATAGTAATCTATAATGAAAGCAAGGATATTGCATGCTGGGGAGGGCTTGCAACCCTGAGCAGCC
TGAACAAAGGAATTGCAGGCGTGGTAATTGAAGGGGCTGTAAGAGATATTGATGAAGTGGAGAACCTCGGGCTTCCGATT
TATACAAGCAATACCGTGCCAAATGCCGGAGACCCAAAGGGATTTGGAGAAATCAACGCTGAAATCACCTGTGGAAGCCA
GGCTGTAAAGCCAGGAGATTATATAATCGGTGACGAAAGCGGAGTTGTAGTCGTCCCTAAGGAACGCGCCTACGAACTGG
CAAGAAGAGCAAAAGAAGTCAACAAAGAAGAAAAGAGGCTTTTCGATGAAATTCGGAGAGGTGGAACCCTTTCAGAGATT
CTGAAACTCAAAAAGTGGGAAAAAATTTGA

Upstream 100 bases:

>100_bases
AAAAATTAATTTTTCACATTTTTTTCAGTTTCCCGATAGAGGTGATACTATCGTTCCCATAATTCAGGTTGCACTTGATC
TTCTGGAACTTGACCGCTCA

Downstream 100 bases:

>100_bases
GAAAAGCAAAATTCTCTGAAGAATTTTTGAAATTGTAAAAACAAATACAAATACAAATAGAAGTAGAAATAGAAGTAGAA
ATAGAAGCAGAAATAAAAAC

Product: bifunctional hexulose-6-phosphate synthase/ribonuclease regulator

Products: NA

Alternate protein names: HPS; D-arabino-3-hexulose-6-phosphate formaldehyde lyase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MEIAKEAVAGGADWIEIGTPLIKSEGMNAIRTMRKAFPDRTILADMKTVDTGAMEVEMAAKAGADVAIVLGSADDSTILD
ALRSAHKYGVRLMADLISAPDPVKRAVELEALGVDYINVHVGIDQQMIGKDPVSILMEISEKVGVQLAVAGGLDSESAAQ
AVRAGARIVIVGGNITRSDNVTEAAKKIRKSVDSPESVDIRDRGTVDQEIREIFKEVSTSNISDAMHRKGAMKGIHPLVR
GKMVGPAVTVQCFPGDWAKTVEAIDLAKPGDVIVIYNESKDIACWGGLATLSSLNKGIAGVVIEGAVRDIDEVENLGLPI
YTSNTVPNAGDPKGFGEINAEITCGSQAVKPGDYIIGDESGVVVVPKERAYELARRAKEVNKEEKRLFDEIRRGGTLSEI
LKLKKWEKI

Sequences:

>Translated_409_residues
MEIAKEAVAGGADWIEIGTPLIKSEGMNAIRTMRKAFPDRTILADMKTVDTGAMEVEMAAKAGADVAIVLGSADDSTILD
ALRSAHKYGVRLMADLISAPDPVKRAVELEALGVDYINVHVGIDQQMIGKDPVSILMEISEKVGVQLAVAGGLDSESAAQ
AVRAGARIVIVGGNITRSDNVTEAAKKIRKSVDSPESVDIRDRGTVDQEIREIFKEVSTSNISDAMHRKGAMKGIHPLVR
GKMVGPAVTVQCFPGDWAKTVEAIDLAKPGDVIVIYNESKDIACWGGLATLSSLNKGIAGVVIEGAVRDIDEVENLGLPI
YTSNTVPNAGDPKGFGEINAEITCGSQAVKPGDYIIGDESGVVVVPKERAYELARRAKEVNKEEKRLFDEIRRGGTLSEI
LKLKKWEKI
>Mature_409_residues
MEIAKEAVAGGADWIEIGTPLIKSEGMNAIRTMRKAFPDRTILADMKTVDTGAMEVEMAAKAGADVAIVLGSADDSTILD
ALRSAHKYGVRLMADLISAPDPVKRAVELEALGVDYINVHVGIDQQMIGKDPVSILMEISEKVGVQLAVAGGLDSESAAQ
AVRAGARIVIVGGNITRSDNVTEAAKKIRKSVDSPESVDIRDRGTVDQEIREIFKEVSTSNISDAMHRKGAMKGIHPLVR
GKMVGPAVTVQCFPGDWAKTVEAIDLAKPGDVIVIYNESKDIACWGGLATLSSLNKGIAGVVIEGAVRDIDEVENLGLPI
YTSNTVPNAGDPKGFGEINAEITCGSQAVKPGDYIIGDESGVVVVPKERAYELARRAKEVNKEEKRLFDEIRRGGTLSEI
LKLKKWEKI

Specific function: Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate [H]

COG id: COG0684

COG function: function code H; Demethylmenaquinone methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPS/KGPDC family. HPS subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR017120
- InterPro:   IPR001754
- InterPro:   IPR011060
- InterPro:   IPR005493 [H]

Pfam domain/function: PF03737 Methyltransf_6; PF00215 OMPdecase [H]

EC number: =4.1.2.43 [H]

Molecular weight: Translated: 43725; Mature: 43725

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIAKEAVAGGADWIEIGTPLIKSEGMNAIRTMRKAFPDRTILADMKTVDTGAMEVEMAA
CCCHHHHHCCCCCEEHHCCCHHHHCCHHHHHHHHHHCCCCEEEHHHHHCCCCCEEEEEHH
KAGADVAIVLGSADDSTILDALRSAHKYGVRLMADLISAPDPVKRAVELEALGVDYINVH
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEECCEEEEEE
VGIDQQMIGKDPVSILMEISEKVGVQLAVAGGLDSESAAQAVRAGARIVIVGGNITRSDN
ECCCHHHHCCCHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCCCCC
VTEAAKKIRKSVDSPESVDIRDRGTVDQEIREIFKEVSTSNISDAMHRKGAMKGIHPLVR
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHH
GKMVGPAVTVQCFPGDWAKTVEAIDLAKPGDVIVIYNESKDIACWGGLATLSSLNKGIAG
CCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEECHHHHHHHHCCCCEE
VVIEGAVRDIDEVENLGLPIYTSNTVPNAGDPKGFGEINAEITCGSQAVKPGDYIIGDES
EEEHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCC
GVVVVPKERAYELARRAKEVNKEEKRLFDEIRRGGTLSEILKLKKWEKI
CEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MEIAKEAVAGGADWIEIGTPLIKSEGMNAIRTMRKAFPDRTILADMKTVDTGAMEVEMAA
CCCHHHHHCCCCCEEHHCCCHHHHCCHHHHHHHHHHCCCCEEEHHHHHCCCCCEEEEEHH
KAGADVAIVLGSADDSTILDALRSAHKYGVRLMADLISAPDPVKRAVELEALGVDYINVH
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEECCEEEEEE
VGIDQQMIGKDPVSILMEISEKVGVQLAVAGGLDSESAAQAVRAGARIVIVGGNITRSDN
ECCCHHHHCCCHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCCCCC
VTEAAKKIRKSVDSPESVDIRDRGTVDQEIREIFKEVSTSNISDAMHRKGAMKGIHPLVR
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHH
GKMVGPAVTVQCFPGDWAKTVEAIDLAKPGDVIVIYNESKDIACWGGLATLSSLNKGIAG
CCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEECHHHHHHHHCCCCEE
VVIEGAVRDIDEVENLGLPIYTSNTVPNAGDPKGFGEINAEITCGSQAVKPGDYIIGDES
EEEHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCC
GVVVVPKERAYELARRAKEVNKEEKRLFDEIRRGGTLSEILKLKKWEKI
CEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA