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The map label for this gene is galE [C]

Identifier: 21227295

GI number: 21227295

Start: 1418443

End: 1419207

Strand: Reverse

Name: galE [C]

Synonym: MM_1193

Alternate gene names: 21227295

Gene position: 1419207-1418443 (Counterclockwise)

Preceding gene: 21227300

Following gene: 21227294

Centisome position: 34.65

GC content: 43.01

Gene sequence:

>765_bases
ATGAAAGTGCTGATTACAGGAGGAGCAGGTTTCATAGGCTCCCATATAGCTGAGTATTTTGCAGAAGCAGGCCATAGTGT
AAGAATTCTTGACAATTTCGCTACCGGTTTTTCTAAAAATATCCCTCAGCACAAAAATGTCGAATTTATTCAGGGGGATA
TATGTGATCCTTCTTCGGTCGAAAAGGCTATCTCAGGTATGGACTGCGTTTTTAATGAAGCTGCCCTTGTATCAGTGCCG
CTTAGCTGTGAAAAACCAGTCGAGGCTTTTCGGATAAATACTTTGGGAACGCTTAATGTATTGCAGGCATGCGTGAGGGA
AGGAGTCGAAAAGTTTGTAACAGCATCTTCAGCTGCAGTTTACGGGAACAATCCTGTCCTCCCTAAAAGTGAAGGCATGT
ATCCGGAGCCAGCTTCACCTTACGCGATCTCCAAACTTGACGGGGAATTCCTGGCAAAGATGTTTTACGAAGAACATGGG
CTCAGGACTACCTGTTTACGTTACTTTAATGTCTATGGGCCTCGCCAGGACCCAAAGTCTCCATATGCAGCTGTAATCCC
CATTTTCCTTGAAAAGGCAAAAGCAGGAAAAGACCTTGTTATTCATGGCGACGGACTTCAGAGCAGGGATTTTGTACATG
TCAGGGATGTTGTCAGGGCAAATGTAGCAGCTCTTGAAAATGGAGACGGCCAGGTATTCAACCTACTTTCCGCAGTAAAA
TTTCTGAATTTTATATTTTTTAAATTATGCAAGTACTTTTTATAA

Upstream 100 bases:

>100_bases
GATTACTATCCGTTTTTTCTATTTCTATTAATATTTTTTAATTCTATTTTTCAGGCCTGCATAGAAAATTTTATTTTATA
CTTTTCCCTTTTCTCGAAGC

Downstream 100 bases:

>100_bases
AATTTCTTCCTATTTTACCGTGATGACTCTCTCTCCCAGCTCTGAATCCACTACCCATCTTGGTCATTATGGCCTTATTG
CTGGCGTATTTGACGAACTT

Product: dTDP-glucose 4,6-dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MKVLITGGAGFIGSHIAEYFAEAGHSVRILDNFATGFSKNIPQHKNVEFIQGDICDPSSVEKAISGMDCVFNEAALVSVP
LSCEKPVEAFRINTLGTLNVLQACVREGVEKFVTASSAAVYGNNPVLPKSEGMYPEPASPYAISKLDGEFLAKMFYEEHG
LRTTCLRYFNVYGPRQDPKSPYAAVIPIFLEKAKAGKDLVIHGDGLQSRDFVHVRDVVRANVAALENGDGQVFNLLSAVK
FLNFIFFKLCKYFL

Sequences:

>Translated_254_residues
MKVLITGGAGFIGSHIAEYFAEAGHSVRILDNFATGFSKNIPQHKNVEFIQGDICDPSSVEKAISGMDCVFNEAALVSVP
LSCEKPVEAFRINTLGTLNVLQACVREGVEKFVTASSAAVYGNNPVLPKSEGMYPEPASPYAISKLDGEFLAKMFYEEHG
LRTTCLRYFNVYGPRQDPKSPYAAVIPIFLEKAKAGKDLVIHGDGLQSRDFVHVRDVVRANVAALENGDGQVFNLLSAVK
FLNFIFFKLCKYFL
>Mature_254_residues
MKVLITGGAGFIGSHIAEYFAEAGHSVRILDNFATGFSKNIPQHKNVEFIQGDICDPSSVEKAISGMDCVFNEAALVSVP
LSCEKPVEAFRINTLGTLNVLQACVREGVEKFVTASSAAVYGNNPVLPKSEGMYPEPASPYAISKLDGEFLAKMFYEEHG
LRTTCLRYFNVYGPRQDPKSPYAAVIPIFLEKAKAGKDLVIHGDGLQSRDFVHVRDVVRANVAALENGDGQVFNLLSAVK
FLNFIFFKLCKYFL

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=258, Percent_Identity=31.3953488372093, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI7657641, Length=243, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI56237023, Length=277, Percent_Identity=30.6859205776173, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI56118217, Length=277, Percent_Identity=30.6859205776173, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI189083684, Length=277, Percent_Identity=30.6859205776173, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI193211614, Length=236, Percent_Identity=30.5084745762712, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI8393516, Length=236, Percent_Identity=30.5084745762712, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI239745448, Length=241, Percent_Identity=29.045643153527, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI310132178, Length=241, Percent_Identity=29.045643153527, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI310113012, Length=241, Percent_Identity=29.045643153527, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI116268111, Length=270, Percent_Identity=29.2592592592593, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786974, Length=266, Percent_Identity=33.0827067669173, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI48994969, Length=258, Percent_Identity=29.8449612403101, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788353, Length=262, Percent_Identity=29.0076335877863, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788366, Length=252, Percent_Identity=25.7936507936508, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790049, Length=244, Percent_Identity=28.6885245901639, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788589, Length=256, Percent_Identity=26.171875, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17539532, Length=225, Percent_Identity=32.8888888888889, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71982035, Length=277, Percent_Identity=31.0469314079422, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71982038, Length=279, Percent_Identity=30.8243727598566, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17568069, Length=266, Percent_Identity=30.0751879699248, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI115532424, Length=249, Percent_Identity=26.9076305220884, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI133901788, Length=255, Percent_Identity=27.843137254902, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI133901790, Length=255, Percent_Identity=27.843137254902, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539422, Length=255, Percent_Identity=27.843137254902, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI133901786, Length=255, Percent_Identity=27.843137254902, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539424, Length=255, Percent_Identity=27.843137254902, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=250, Percent_Identity=29.6, Blast_Score=96, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321437, Length=243, Percent_Identity=26.3374485596708, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356223, Length=247, Percent_Identity=31.5789473684211, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI19923002, Length=254, Percent_Identity=32.2834645669291, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 27840; Mature: 27840

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLITGGAGFIGSHIAEYFAEAGHSVRILDNFATGFSKNIPQHKNVEFIQGDICDPSSV
CEEEEECCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCEEECCCCCHHHH
EKAISGMDCVFNEAALVSVPLSCEKPVEAFRINTLGTLNVLQACVREGVEKFVTASSAAV
HHHHCCHHHHHCCCEEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEE
YGNNPVLPKSEGMYPEPASPYAISKLDGEFLAKMFYEEHGLRTTCLRYFNVYGPRQDPKS
ECCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCC
PYAAVIPIFLEKAKAGKDLVIHGDGLQSRDFVHVRDVVRANVAALENGDGQVFNLLSAVK
CHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
FLNFIFFKLCKYFL
HHHHHHHHHHHHHC
>Mature Secondary Structure
MKVLITGGAGFIGSHIAEYFAEAGHSVRILDNFATGFSKNIPQHKNVEFIQGDICDPSSV
CEEEEECCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCEEECCCCCHHHH
EKAISGMDCVFNEAALVSVPLSCEKPVEAFRINTLGTLNVLQACVREGVEKFVTASSAAV
HHHHCCHHHHHCCCEEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEE
YGNNPVLPKSEGMYPEPASPYAISKLDGEFLAKMFYEEHGLRTTCLRYFNVYGPRQDPKS
ECCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCC
PYAAVIPIFLEKAKAGKDLVIHGDGLQSRDFVHVRDVVRANVAALENGDGQVFNLLSAVK
CHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
FLNFIFFKLCKYFL
HHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]