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The map label for this gene is wecB [H]

Identifier: 21227272

GI number: 21227272

Start: 1388406

End: 1389473

Strand: Direct

Name: wecB [H]

Synonym: MM_1170

Alternate gene names: 21227272

Gene position: 1388406-1389473 (Clockwise)

Preceding gene: 21227271

Following gene: 21227273

Centisome position: 33.89

GC content: 43.45

Gene sequence:

>1068_bases
ATGAAGATTGCAATTATTCTCGGTACAAGGCCTGAAATCATAAAAATGAGCCCTATAATAAGAGAATGTGAAAAACAGGG
CATAGAGTATTATATACTGCATACAGGCCAACACTACAGCTACGAAATGGATAAAATCTTTTTTGAGCAATTGAAACTCC
CGCAGGCAAAGTACAACCTCGATATTGGATCAGGCCTTCACGGCAAACAAACAGCAAAGATGCTTACCGGAATCGAAGAA
ATTCTGATAAAAGACAGACCAGATATTGTCCTGGTCCAGGGAGATACAAATACCGTTCTTGCAGGCGCCCTAGCAGCTTC
CAAACTTAATATAAAAATAGGCCATGTTGAGGCAGGTCTAAGGTCCTTCGACAGGACAATGCCCGAAGAAACAAACAGAA
TTATTGCAGACCATACTTCCGATTATCTGTTCGCCCCAACTGAGACCTCAAGAAAATATCTTTTAAATGAAGGCATACCC
CATAACAAAATCTTTGTTACAGGAAACACAGTTGTCGATGCAGCCTATCAGAACCTTGAGATCTCTAAAAACGGAGCCGA
TATCCTTGAAGAACTGGGCTTAACCGAAAAAGAATACTTCGCAGCTACAGCCCACCGTGCCGAAAACGTTGACAGCAAAG
AGCGTCTCGGTGGTATTCTGAACGGCTTTTCTCAGATATACAAAGAATTCGGTCTCCCAATCATCTTTCCAGCCCATCCC
AGGACCGTGAAAATGATCGGAGAGTTCGGCTTTAAAGTGCCTGAAGGCACAAGGCTGATCGAACCCCTCGGTTACCTCGA
GTTTTTACAGCTTGAAAACGGAGCCAAGCTTATCCTTACCGACAGTGGAGGCGTGCAGGAAGAAAGCTGCATCCTTAAAG
TGCCATGCGTGACACTGAGGAATAACACAGAAAGACCGGAAACTGTTGATGTGGGCGCGAATCTGATTGCGGGATGTGGG
GAGAACATTACAGAATGTGCAAGAAAAATGATGGAGTTAAATTCTGAGTGGGAAAACCCATATGGAAATGGGAATACCTC
AAAAATAATTGTCAAACAATTGATCTGA

Upstream 100 bases:

>100_bases
CGATTATATCAGTTTCATGGAAAAATAAGACATCCTAAGAATAGAATATAGATTCATAAGTTGATTAGAGAATGATTTCC
GGCAAGGACGCGGTAAAAAT

Downstream 100 bases:

>100_bases
TCCAACAATCAAAATGAACCCAAATAGGAATTTTTATGATAACTTCAAGAAAAAACAGGAAAAAAGATGTTTTTTATAGG
CTAAACATTTTAGATGGGTT

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MKIAIILGTRPEIIKMSPIIRECEKQGIEYYILHTGQHYSYEMDKIFFEQLKLPQAKYNLDIGSGLHGKQTAKMLTGIEE
ILIKDRPDIVLVQGDTNTVLAGALAASKLNIKIGHVEAGLRSFDRTMPEETNRIIADHTSDYLFAPTETSRKYLLNEGIP
HNKIFVTGNTVVDAAYQNLEISKNGADILEELGLTEKEYFAATAHRAENVDSKERLGGILNGFSQIYKEFGLPIIFPAHP
RTVKMIGEFGFKVPEGTRLIEPLGYLEFLQLENGAKLILTDSGGVQEESCILKVPCVTLRNNTERPETVDVGANLIAGCG
ENITECARKMMELNSEWENPYGNGNTSKIIVKQLI

Sequences:

>Translated_355_residues
MKIAIILGTRPEIIKMSPIIRECEKQGIEYYILHTGQHYSYEMDKIFFEQLKLPQAKYNLDIGSGLHGKQTAKMLTGIEE
ILIKDRPDIVLVQGDTNTVLAGALAASKLNIKIGHVEAGLRSFDRTMPEETNRIIADHTSDYLFAPTETSRKYLLNEGIP
HNKIFVTGNTVVDAAYQNLEISKNGADILEELGLTEKEYFAATAHRAENVDSKERLGGILNGFSQIYKEFGLPIIFPAHP
RTVKMIGEFGFKVPEGTRLIEPLGYLEFLQLENGAKLILTDSGGVQEESCILKVPCVTLRNNTERPETVDVGANLIAGCG
ENITECARKMMELNSEWENPYGNGNTSKIIVKQLI
>Mature_355_residues
MKIAIILGTRPEIIKMSPIIRECEKQGIEYYILHTGQHYSYEMDKIFFEQLKLPQAKYNLDIGSGLHGKQTAKMLTGIEE
ILIKDRPDIVLVQGDTNTVLAGALAASKLNIKIGHVEAGLRSFDRTMPEETNRIIADHTSDYLFAPTETSRKYLLNEGIP
HNKIFVTGNTVVDAAYQNLEISKNGADILEELGLTEKEYFAATAHRAENVDSKERLGGILNGFSQIYKEFGLPIIFPAHP
RTVKMIGEFGFKVPEGTRLIEPLGYLEFLQLENGAKLILTDSGGVQEESCILKVPCVTLRNNTERPETVDVGANLIAGCG
ENITECARKMMELNSEWENPYGNGNTSKIIVKQLI

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) to produce UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=376, Percent_Identity=35.6382978723404, Blast_Score=177, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 39515; Mature: 39515

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIILGTRPEIIKMSPIIRECEKQGIEYYILHTGQHYSYEMDKIFFEQLKLPQAKYNL
CEEEEEECCCCCEEECCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCCHHCCC
DIGSGLHGKQTAKMLTGIEEILIKDRPDIVLVQGDTNTVLAGALAASKLNIKIGHVEAGL
CCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEHHHEEEEEEEEEEHHHHHH
RSFDRTMPEETNRIIADHTSDYLFAPTETSRKYLLNEGIPHNKIFVTGNTVVDAAYQNLE
HHHHHCCCHHHCEEEEECCCCEEECCCCCCHHHHHCCCCCCCEEEEECCCEEEHHHHCCE
ISKNGADILEELGLTEKEYFAATAHRAENVDSKERLGGILNGFSQIYKEFGLPIIFPAHP
ECCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCC
RTVKMIGEFGFKVPEGTRLIEPLGYLEFLQLENGAKLILTDSGGVQEESCILKVPCVTLR
CHHHHHHHCCCCCCCCCHHHHHHCHHEEEEECCCCEEEEECCCCCCCCCEEEEECEEEEC
NNTERPETVDVGANLIAGCGENITECARKMMELNSEWENPYGNGNTSKIIVKQLI
CCCCCCCEEECCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MKIAIILGTRPEIIKMSPIIRECEKQGIEYYILHTGQHYSYEMDKIFFEQLKLPQAKYNL
CEEEEEECCCCCEEECCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCCHHCCC
DIGSGLHGKQTAKMLTGIEEILIKDRPDIVLVQGDTNTVLAGALAASKLNIKIGHVEAGL
CCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEHHHEEEEEEEEEEHHHHHH
RSFDRTMPEETNRIIADHTSDYLFAPTETSRKYLLNEGIPHNKIFVTGNTVVDAAYQNLE
HHHHHCCCHHHCEEEEECCCCEEECCCCCCHHHHHCCCCCCCEEEEECCCEEEHHHHCCE
ISKNGADILEELGLTEKEYFAATAHRAENVDSKERLGGILNGFSQIYKEFGLPIIFPAHP
ECCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCC
RTVKMIGEFGFKVPEGTRLIEPLGYLEFLQLENGAKLILTDSGGVQEESCILKVPCVTLR
CHHHHHHHCCCCCCCCCHHHHHHCHHEEEEECCCCEEEEECCCCCCCCCEEEEECEEEEC
NNTERPETVDVGANLIAGCGENITECARKMMELNSEWENPYGNGNTSKIIVKQLI
CCCCCCCEEECCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]