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The map label for this gene is acbA [H]

Identifier: 21227271

GI number: 21227271

Start: 1387902

End: 1388189

Strand: Direct

Name: acbA [H]

Synonym: MM_1169

Alternate gene names: 21227271

Gene position: 1387902-1388189 (Clockwise)

Preceding gene: 21227270

Following gene: 21227272

Centisome position: 33.88

GC content: 45.49

Gene sequence:

>288_bases
ATGAAAGAGGTTATACTTGCAGGCGGTACGGGCAGCAGACTGTATCCTCTAACCAAAGTAACTAACAAGCACCTTTTGCC
TGTCTATGACAAGCCAATGATCTACTACCCGATGGAGACTCTAATAAACGCCGGAATAAAAGAAATAATGATCGTTTCCG
GCAGAGGACATGCAGGACATTTTCTTGAACTTTTGGGTTCCGGGGTAGAGCATGAAGTGCATTTTACTTATGAAATTCAG
GAAAAAGCCGGGGGGATTGCCCAGGCACTCAGCCTTGCGGAAGATTGA

Upstream 100 bases:

>100_bases
AAGCAAAACGTCCAATGTATTCAGTTCTTGTGAATACTAAAACCGGACCCATGAGACACTGGAGAGAAGCACTTAAGGAC
TATTTGCAGGGGAGAAATAT

Downstream 100 bases:

>100_bases
GGGTTTCTGGAGTGATGCTGGGACTTTTGAGAGTTTGTTAAGAGCTGGAATGCTTGTAAAGCAAAGTATAGAAAAAAACT
TATAGGGCATCATACAATAA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 95; Mature: 95

Protein sequence:

>95_residues
MKEVILAGGTGSRLYPLTKVTNKHLLPVYDKPMIYYPMETLINAGIKEIMIVSGRGHAGHFLELLGSGVEHEVHFTYEIQ
EKAGGIAQALSLAED

Sequences:

>Translated_95_residues
MKEVILAGGTGSRLYPLTKVTNKHLLPVYDKPMIYYPMETLINAGIKEIMIVSGRGHAGHFLELLGSGVEHEVHFTYEIQ
EKAGGIAQALSLAED
>Mature_95_residues
MKEVILAGGTGSRLYPLTKVTNKHLLPVYDKPMIYYPMETLINAGIKEIMIVSGRGHAGHFLELLGSGVEHEVHFTYEIQ
EKAGGIAQALSLAED

Specific function: Probably involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=94, Percent_Identity=47.8723404255319, Blast_Score=100, Evalue=2e-23,
Organism=Escherichia coli, GI1790224, Length=94, Percent_Identity=48.936170212766, Blast_Score=99, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 10409; Mature: 10409

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEVILAGGTGSRLYPLTKVTNKHLLPVYDKPMIYYPMETLINAGIKEIMIVSGRGHAGH
CCCEEEECCCCCCEEEEECCCCCCCCEECCCCEEEECHHHHHHCCCCCEEEECCCCCCHH
FLELLGSGVEHEVHFTYEIQEKAGGIAQALSLAED
HHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHCCC
>Mature Secondary Structure
MKEVILAGGTGSRLYPLTKVTNKHLLPVYDKPMIYYPMETLINAGIKEIMIVSGRGHAGH
CCCEEEECCCCCCEEEEECCCCCCCCEECCCCEEEECHHHHHHCCCCCEEEECCCCCCHH
FLELLGSGVEHEVHFTYEIQEKAGGIAQALSLAED
HHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10196166 [H]