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The map label for this gene is yeiR [C]

Identifier: 21227174

GI number: 21227174

Start: 1259208

End: 1260365

Strand: Direct

Name: yeiR [C]

Synonym: MM_1072

Alternate gene names: 21227174

Gene position: 1259208-1260365 (Clockwise)

Preceding gene: 21227173

Following gene: 21227175

Centisome position: 30.74

GC content: 43.18

Gene sequence:

>1158_bases
GTGGAAGTCATTGTTGTTGGAGGTTTCCTGGGAAGCGGAAAGACCACTACCATTATCAATATGGGCAAATACCTCGCAGA
TAAAGGGAAAAAAGTTGCAATTATCGTAAACGAGATAGGGGAAATAGGGATTGACGGCGATGTGATTAAGAGATTCGGTT
TCGACACCAAGGAAATCACAAGCGGGTGCATCTGCTGTACATTGAAAGTCGGGCTGAGGGCAACAATGAGCACTCTTGTA
AAAGAGTATAAGCCCGATATCATAATGATCGAGCCCACAGGAATCGCTTTCCCGAATGTGATCAAAACCGAAGTTGAGCT
TATGAATCTTGGAGAGGAAGTGAAAGTTGCTCCACTTGTAACTCTGATTGACGGCAGCCGCTTCAAACACCTGATGAAAG
AGGTAAAAGAATTCGCTATGAGGCAGATTATAGATGCTGAAATCCTGGGAATAAATAAGGTAGATCTCATAGAGCCGATC
AGGATACCGATACTCGAAACTTCGGTCCAGCAGTTGAACCCTGAAGCAAAGGTGGTCTTGCTTTCGGGAAAGGACACCGG
CGAAAGATTTGAGAAATTCATGCAGGTAGTTCTTCCTGATATAAGAGAAGCACCGAAAAAAATCCAGGAAACAGCTACTG
CAGAAAATACATCCAGCATTACAGGGCCGCAGGAAACCGAAGACTCCATCAAAGCCTCGGGCGTTGGCAGCTATGCGGCA
GAGTTTGAAATTAAAGAAGGAGGAAACCTGAACACAGAAGAAGCCAGGAAACTCACCACCGAATTAATGAATATAATAAA
AGGAAAAGTTCTGGAGCTTAACCCTGAATTTGTAGGGCATATAAAACTCTTCCTGGACAATGGGACGGAGACCGTAAAAC
AGAGTGTCACCATCTATAATGAAGAGCCTCAGGAAGATGTGATTAAATCAAAAGATGGAGCTTTCCCGACATTCAAGATA
CTCTCTGCGGTTTCAAATGTTGACAAAGAAGCTCTGAAAGATGCTGTAAACAGCTCTGTGAAAGAAACATTTGAGAAAAA
AGGGATAAATGCGCACAAAACCGAGCATGGACATAAGCACGAAGGACACGCGCATAATGAACACAAACATGAGGGACATA
TACAGAGAATCGGGAGCATAAAAGGTATAAAAGAATAA

Upstream 100 bases:

>100_bases
TTGACATATATTCCTGAATAAAAAATATATTTACAATACTTTTAATAAAAAACGGAAAGAAAACAATAAGCAGAAAGCGG
CAGAAAACGGAGGAAAAAAA

Downstream 100 bases:

>100_bases
AAAGACGAAAAAGAAAATGAAGGGCGGGCCAGATAAAAACCTGACTCGTCAAACCCTATTTTAAAACATTTTTACTGAAA
TTACTGACCTGATGCCGCAG

Product: hypothetical protein

Products: NA

Alternate protein names: P47K [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MEVIVVGGFLGSGKTTTIINMGKYLADKGKKVAIIVNEIGEIGIDGDVIKRFGFDTKEITSGCICCTLKVGLRATMSTLV
KEYKPDIIMIEPTGIAFPNVIKTEVELMNLGEEVKVAPLVTLIDGSRFKHLMKEVKEFAMRQIIDAEILGINKVDLIEPI
RIPILETSVQQLNPEAKVVLLSGKDTGERFEKFMQVVLPDIREAPKKIQETATAENTSSITGPQETEDSIKASGVGSYAA
EFEIKEGGNLNTEEARKLTTELMNIIKGKVLELNPEFVGHIKLFLDNGTETVKQSVTIYNEEPQEDVIKSKDGAFPTFKI
LSAVSNVDKEALKDAVNSSVKETFEKKGINAHKTEHGHKHEGHAHNEHKHEGHIQRIGSIKGIKE

Sequences:

>Translated_385_residues
MEVIVVGGFLGSGKTTTIINMGKYLADKGKKVAIIVNEIGEIGIDGDVIKRFGFDTKEITSGCICCTLKVGLRATMSTLV
KEYKPDIIMIEPTGIAFPNVIKTEVELMNLGEEVKVAPLVTLIDGSRFKHLMKEVKEFAMRQIIDAEILGINKVDLIEPI
RIPILETSVQQLNPEAKVVLLSGKDTGERFEKFMQVVLPDIREAPKKIQETATAENTSSITGPQETEDSIKASGVGSYAA
EFEIKEGGNLNTEEARKLTTELMNIIKGKVLELNPEFVGHIKLFLDNGTETVKQSVTIYNEEPQEDVIKSKDGAFPTFKI
LSAVSNVDKEALKDAVNSSVKETFEKKGINAHKTEHGHKHEGHAHNEHKHEGHIQRIGSIKGIKE
>Mature_385_residues
MEVIVVGGFLGSGKTTTIINMGKYLADKGKKVAIIVNEIGEIGIDGDVIKRFGFDTKEITSGCICCTLKVGLRATMSTLV
KEYKPDIIMIEPTGIAFPNVIKTEVELMNLGEEVKVAPLVTLIDGSRFKHLMKEVKEFAMRQIIDAEILGINKVDLIEPI
RIPILETSVQQLNPEAKVVLLSGKDTGERFEKFMQVVLPDIREAPKKIQETATAENTSSITGPQETEDSIKASGVGSYAA
EFEIKEGGNLNTEEARKLTTELMNIIKGKVLELNPEFVGHIKLFLDNGTETVKQSVTIYNEEPQEDVIKSKDGAFPTFKI
LSAVSNVDKEALKDAVNSSVKETFEKKGINAHKTEHGHKHEGHAHNEHKHEGHIQRIGSIKGIKE

Specific function: The presence of P47K is critical for the expression of the nitrile hydratase genes. May stabilize or activate the nitrile hydratase proteins [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI126722884, Length=189, Percent_Identity=30.1587301587302, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI223941779, Length=189, Percent_Identity=30.1587301587302, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI148727351, Length=189, Percent_Identity=30.6878306878307, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI146231952, Length=189, Percent_Identity=30.6878306878307, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI33469141, Length=189, Percent_Identity=29.6296296296296, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI223941776, Length=182, Percent_Identity=30.2197802197802, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1788499, Length=167, Percent_Identity=32.3353293413174, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 42368; Mature: 42368

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVIVVGGFLGSGKTTTIINMGKYLADKGKKVAIIVNEIGEIGIDGDVIKRFGFDTKEIT
CEEEEEEEEECCCCEEEEEEHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCCHHHHC
SGCICCTLKVGLRATMSTLVKEYKPDIIMIEPTGIAFPNVIKTEVELMNLGEEVKVAPLV
CCEEEEEEHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEE
TLIDGSRFKHLMKEVKEFAMRQIIDAEILGINKVDLIEPIRIPILETSVQQLNPEAKVVL
EEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEE
LSGKDTGERFEKFMQVVLPDIREAPKKIQETATAENTSSITGPQETEDSIKASGVGSYAA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCE
EFEIKEGGNLNTEEARKLTTELMNIIKGKVLELNPEFVGHIKLFLDNGTETVKQSVTIYN
EEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEEEECCHHHHHHCEEEEC
EEPQEDVIKSKDGAFPTFKILSAVSNVDKEALKDAVNSSVKETFEKKGINAHKTEHGHKH
CCCHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
EGHAHNEHKHEGHIQRIGSIKGIKE
CCCCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEVIVVGGFLGSGKTTTIINMGKYLADKGKKVAIIVNEIGEIGIDGDVIKRFGFDTKEIT
CEEEEEEEEECCCCEEEEEEHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCCHHHHC
SGCICCTLKVGLRATMSTLVKEYKPDIIMIEPTGIAFPNVIKTEVELMNLGEEVKVAPLV
CCEEEEEEHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEE
TLIDGSRFKHLMKEVKEFAMRQIIDAEILGINKVDLIEPIRIPILETSVQQLNPEAKVVL
EEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEE
LSGKDTGERFEKFMQVVLPDIREAPKKIQETATAENTSSITGPQETEDSIKASGVGSYAA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCE
EFEIKEGGNLNTEEARKLTTELMNIIKGKVLELNPEFVGHIKLFLDNGTETVKQSVTIYN
EEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEEEECCHHHHHHCEEEEC
EEPQEDVIKSKDGAFPTFKILSAVSNVDKEALKDAVNSSVKETFEKKGINAHKTEHGHKH
CCCHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
EGHAHNEHKHEGHIQRIGSIKGIKE
CCCCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2013568 [H]