Click here to switch to the map view.

The map label for this gene is ziaR [H]

Identifier: 21227142

GI number: 21227142

Start: 1216520

End: 1216867

Strand: Direct

Name: ziaR [H]

Synonym: MM_1040

Alternate gene names: 21227142

Gene position: 1216520-1216867 (Clockwise)

Preceding gene: 21227141

Following gene: 21227143

Centisome position: 29.7

GC content: 45.69

Gene sequence:

>348_bases
ATGCAAAATAAGTGCAAGCGAGTAAGCACTGAACAGATAAAAACCCTGATGCAAAAGGTTCCCGACGCGGAAATCATCAC
ACGGATGTCTGCAATATTTCAGGCGCTCCAATCGGATACCCGCCTGAAAATACTTTTTTTACTCAGACATAAAGAGATGT
GCGTCTGTGAACTTGAAGAGGAACTTGAAGTCACACAGTCTGCCGTATCGCATGGGCTCAGGACCCTCAGGCAGCTCGAC
CTTGTAAGGGTCAGGAGGGAAGGAAAATTTACAGTTTACTATATTGCAGATGAACATGTACGCACACTTATCGAGATGTG
CCTTGAGCACGTGGAGGAAAAAGCTTGA

Upstream 100 bases:

>100_bases
TTTGATATCTTACATTAAATTTTGATATATCTTATCTTAAAATTCTGCATTTGAGAAGTTTTAAAAAAGGATTAATACAT
GAACATTTGTTCATATAATC

Downstream 100 bases:

>100_bases
GTACTGATATATTCAGTTCCATCCCGGAACTGATTTCGGGCATCCTCATATCTTCATGGGAAATCTTTGTAGAAGCTGCT
CCTTACCTTATTTTCGGATT

Product: putative transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 115; Mature: 115

Protein sequence:

>115_residues
MQNKCKRVSTEQIKTLMQKVPDAEIITRMSAIFQALQSDTRLKILFLLRHKEMCVCELEEELEVTQSAVSHGLRTLRQLD
LVRVRREGKFTVYYIADEHVRTLIEMCLEHVEEKA

Sequences:

>Translated_115_residues
MQNKCKRVSTEQIKTLMQKVPDAEIITRMSAIFQALQSDTRLKILFLLRHKEMCVCELEEELEVTQSAVSHGLRTLRQLD
LVRVRREGKFTVYYIADEHVRTLIEMCLEHVEEKA
>Mature_115_residues
MQNKCKRVSTEQIKTLMQKVPDAEIITRMSAIFQALQSDTRLKILFLLRHKEMCVCELEEELEVTQSAVSHGLRTLRQLD
LVRVRREGKFTVYYIADEHVRTLIEMCLEHVEEKA

Specific function: Transcriptional repressor of the expression of the ziaA gene. Controls zinc homeostasis by triggering ziaA-mediated efflux of excess zinc into the periplasm [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR018334
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 13519; Mature: 13519

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKCKRVSTEQIKTLMQKVPDAEIITRMSAIFQALQSDTRLKILFLLRHKEMCVCELEE
CCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHH
ELEVTQSAVSHGLRTLRQLDLVRVRREGKFTVYYIADEHVRTLIEMCLEHVEEKA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQNKCKRVSTEQIKTLMQKVPDAEIITRMSAIFQALQSDTRLKILFLLRHKEMCVCELEE
CCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHH
ELEVTQSAVSHGLRTLRQLDLVRVRREGKFTVYYIADEHVRTLIEMCLEHVEEKA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9724772 [H]