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The map label for this gene is tbp1 [H]

Identifier: 21227129

GI number: 21227129

Start: 1199798

End: 1200349

Strand: Reverse

Name: tbp1 [H]

Synonym: MM_1027

Alternate gene names: 21227129

Gene position: 1200349-1199798 (Counterclockwise)

Preceding gene: 21227130

Following gene: 21227128

Centisome position: 29.3

GC content: 44.75

Gene sequence:

>552_bases
ATGAGCGAATCTAGTATCAAGATCGAAAATGTGGTTGCATCCACCAAACTCGCTGAAGAATTCGACTTAACTGTTATCGA
ATCAGAGTTCGAAGGAGCAGAGTACAACAAGCAGAAGTTCCCCGGGCTCGTTTACAGGGTTTCAGATCCTAAAGCTGCAT
TCCTGGTCTTTACTTCTGGCAAGGTTGTCTGTACAGGGACGAAAAATGTTGCCGATGTACACACAGTTGTAGGTAATTTG
GCGAAAAAGCTGAACAGTATAGGGATTAAGACCATAGAGAACCCTCAGATTACTGTCCAGAACATTGTTGCTTCCGCAGA
CCTGCATACTATTTTGAACCTTAATGCAATTGCAATAGGGCTTGGACTTGAAAACATTGAATACGAGCCTGAGCAGTTTC
CTGGTCTTGTATACAGAATTGATGAGCCCAAAGTAGTTGTGCTTATCTTCAGCTCCGGAAAACTGGTAGTTGCAGGCGGT
AAGAGCCCTGAAGATTGCGAGAGGAGCGTGGAAGTAGTCCGCCAGCAGCTCGACAGTATGGGTCTTTTATAA

Upstream 100 bases:

>100_bases
GACAATATGGGGCTTTTATAAGAACCCTCAATCTATTAATTATATACCATTTTTCTGGAAATTAGGTAACTTACTTGCTT
TATATGCTAAGGGTGGACAA

Downstream 100 bases:

>100_bases
AATCCTCAAACTTTTTATCTATTATATCCATTTTAATCTGCCTCATAAAGTACATGGGGAATACTAAAATAAAAACGGAT
TCTGCGGTATTCGTAGAGGC

Product: transcription factor

Products: NA

Alternate protein names: Box A-binding protein 1; BAP 1; TATA sequence-binding protein 1; TBP 1; TATA-box factor 1 [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MSESSIKIENVVASTKLAEEFDLTVIESEFEGAEYNKQKFPGLVYRVSDPKAAFLVFTSGKVVCTGTKNVADVHTVVGNL
AKKLNSIGIKTIENPQITVQNIVASADLHTILNLNAIAIGLGLENIEYEPEQFPGLVYRIDEPKVVVLIFSSGKLVVAGG
KSPEDCERSVEVVRQQLDSMGLL

Sequences:

>Translated_183_residues
MSESSIKIENVVASTKLAEEFDLTVIESEFEGAEYNKQKFPGLVYRVSDPKAAFLVFTSGKVVCTGTKNVADVHTVVGNL
AKKLNSIGIKTIENPQITVQNIVASADLHTILNLNAIAIGLGLENIEYEPEQFPGLVYRIDEPKVVVLIFSSGKLVVAGG
KSPEDCERSVEVVRQQLDSMGLL
>Mature_182_residues
SESSIKIENVVASTKLAEEFDLTVIESEFEGAEYNKQKFPGLVYRVSDPKAAFLVFTSGKVVCTGTKNVADVHTVVGNLA
KKLNSIGIKTIENPQITVQNIVASADLHTILNLNAIAIGLGLENIEYEPEQFPGLVYRIDEPKVVVLIFSSGKLVVAGGK
SPEDCERSVEVVRQQLDSMGLL

Specific function: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation [H]

COG id: COG2101

COG function: function code K; TATA-box binding protein (TBP), component of TFIID and TFIIIB

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TBP family [H]

Homologues:

Organism=Homo sapiens, GI39930602, Length=155, Percent_Identity=34.1935483870968, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI285026520, Length=166, Percent_Identity=35.5421686746988, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI4507379, Length=165, Percent_Identity=34.5454545454545, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17555358, Length=162, Percent_Identity=34.5679012345679, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320996, Length=166, Percent_Identity=36.144578313253, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17136834, Length=172, Percent_Identity=34.3023255813954, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17647997, Length=160, Percent_Identity=35.625, Blast_Score=106, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012295
- InterPro:   IPR000814
- InterPro:   IPR012294 [H]

Pfam domain/function: PF00352 TBP [H]

EC number: NA

Molecular weight: Translated: 19837; Mature: 19706

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00351 TFIID

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESSIKIENVVASTKLAEEFDLTVIESEFEGAEYNKQKFPGLVYRVSDPKAAFLVFTSG
CCCCCEEHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEEEEECC
KVVCTGTKNVADVHTVVGNLAKKLNSIGIKTIENPQITVQNIVASADLHTILNLNAIAIG
EEEEECCCCHHHHHHHHHHHHHHHHHCCCEEECCCCEEHHHHHHHHHHHHHEECCEEEEE
LGLENIEYEPEQFPGLVYRIDEPKVVVLIFSSGKLVVAGGKSPEDCERSVEVVRQQLDSM
ECCCCCCCCCCCCCCEEEEECCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHC
GLL
CCC
>Mature Secondary Structure 
SESSIKIENVVASTKLAEEFDLTVIESEFEGAEYNKQKFPGLVYRVSDPKAAFLVFTSG
CCCCEEHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEEEEECC
KVVCTGTKNVADVHTVVGNLAKKLNSIGIKTIENPQITVQNIVASADLHTILNLNAIAIG
EEEEECCCCHHHHHHHHHHHHHHHHHCCCEEECCCCEEHHHHHHHHHHHHHEECCEEEEE
LGLENIEYEPEQFPGLVYRIDEPKVVVLIFSSGKLVVAGGKSPEDCERSVEVVRQQLDSM
ECCCCCCCCCCCCCCEEEEECCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHC
GLL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]