Click here to switch to the map view.

The map label for this gene is tbp1 [H]

Identifier: 21227130

GI number: 21227130

Start: 1200429

End: 1200980

Strand: Reverse

Name: tbp1 [H]

Synonym: MM_1028

Alternate gene names: 21227130

Gene position: 1200980-1200429 (Counterclockwise)

Preceding gene: 21227131

Following gene: 21227129

Centisome position: 29.32

GC content: 45.47

Gene sequence:

>552_bases
ATGAGCGAATCTAGCATCAAAATCGAAAACGTGGTTGCATCCACCAAACTCGCTGAAGAGTTTGATTTAACTGTGATAGA
ATCCCAGTTCGAAGGGGCTGAGTATAACAAACAGAAGTTCCCTGGACTCGTCTACAGAGTCTCTGACCCTAAAGCTGCTT
TTCTGGTATTTACTTCCGGAAAGGTTGTCTGCACAGGAGCAAAAAACGTTGCTGACGTGCACACAGTTATCGGCAACATG
GCAAAAAAGCTGAACAGCATCGGGATCAAAACAATGGAAAACCCGCAGATTACTGTTCAGAATATAGTCGCTTCAGCAGA
TCTGCACACCATTCTTAACCTCAATGCAATTGCAATAGGGCTTGGGCTTGAGAATATCGAATACGAACCCGAACAGTTTC
CGGGTCTTGTTTACAGGATCGATGAGCCCAAAGTAGTTGTCCTTATTTTCAGCTCCGGAAAACTTGTAGTTACAGGCGGC
AAGACGCCTGAAGATTGCGAGAGCGGCGTTGAAGTAGTCCGTCAGCAGCTCGACAATATGGGGCTTTTATAA

Upstream 100 bases:

>100_bases
CTTTATATATGGTATTTATATAGTATGCAGGGCATTTAACTATAGCTTTATATACTGGTTAGAGGATATTACTTTTGCTT
TATATACTGAGGGTTGACTA

Downstream 100 bases:

>100_bases
GAACCCTCAATCTATTAATTATATACCATTTTTCTGGAAATTAGGTAACTTACTTGCTTTATATGCTAAGGGTGGACAAA
TGAGCGAATCTAGTATCAAG

Product: transcription factor

Products: NA

Alternate protein names: Box A-binding protein 1; BAP 1; TATA sequence-binding protein 1; TBP 1; TATA-box factor 1 [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MSESSIKIENVVASTKLAEEFDLTVIESQFEGAEYNKQKFPGLVYRVSDPKAAFLVFTSGKVVCTGAKNVADVHTVIGNM
AKKLNSIGIKTMENPQITVQNIVASADLHTILNLNAIAIGLGLENIEYEPEQFPGLVYRIDEPKVVVLIFSSGKLVVTGG
KTPEDCESGVEVVRQQLDNMGLL

Sequences:

>Translated_183_residues
MSESSIKIENVVASTKLAEEFDLTVIESQFEGAEYNKQKFPGLVYRVSDPKAAFLVFTSGKVVCTGAKNVADVHTVIGNM
AKKLNSIGIKTMENPQITVQNIVASADLHTILNLNAIAIGLGLENIEYEPEQFPGLVYRIDEPKVVVLIFSSGKLVVTGG
KTPEDCESGVEVVRQQLDNMGLL
>Mature_182_residues
SESSIKIENVVASTKLAEEFDLTVIESQFEGAEYNKQKFPGLVYRVSDPKAAFLVFTSGKVVCTGAKNVADVHTVIGNMA
KKLNSIGIKTMENPQITVQNIVASADLHTILNLNAIAIGLGLENIEYEPEQFPGLVYRIDEPKVVVLIFSSGKLVVTGGK
TPEDCESGVEVVRQQLDNMGLL

Specific function: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation [H]

COG id: COG2101

COG function: function code K; TATA-box binding protein (TBP), component of TFIID and TFIIIB

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TBP family [H]

Homologues:

Organism=Homo sapiens, GI39930602, Length=155, Percent_Identity=35.4838709677419, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI285026520, Length=166, Percent_Identity=36.7469879518072, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI4507379, Length=165, Percent_Identity=35.7575757575758, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17555358, Length=160, Percent_Identity=36.875, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320996, Length=166, Percent_Identity=37.3493975903614, Blast_Score=117, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17136834, Length=174, Percent_Identity=36.2068965517241, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI17647997, Length=160, Percent_Identity=36.875, Blast_Score=109, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012295
- InterPro:   IPR000814
- InterPro:   IPR012294 [H]

Pfam domain/function: PF00352 TBP [H]

EC number: NA

Molecular weight: Translated: 19828; Mature: 19697

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00351 TFIID

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESSIKIENVVASTKLAEEFDLTVIESQFEGAEYNKQKFPGLVYRVSDPKAAFLVFTSG
CCCCCEEHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEEEEECC
KVVCTGAKNVADVHTVIGNMAKKLNSIGIKTMENPQITVQNIVASADLHTILNLNAIAIG
EEEEECCCCHHHHHHHHHHHHHHHHHCCCEEECCCCEEHHHHHHHHHHHHHEECCEEEEE
LGLENIEYEPEQFPGLVYRIDEPKVVVLIFSSGKLVVTGGKTPEDCESGVEVVRQQLDNM
ECCCCCCCCCCCCCCEEEEECCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHC
GLL
CCC
>Mature Secondary Structure 
SESSIKIENVVASTKLAEEFDLTVIESQFEGAEYNKQKFPGLVYRVSDPKAAFLVFTSG
CCCCEEHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEEEEECC
KVVCTGAKNVADVHTVIGNMAKKLNSIGIKTMENPQITVQNIVASADLHTILNLNAIAIG
EEEEECCCCHHHHHHHHHHHHHHHHHCCCEEECCCCEEHHHHHHHHHHHHHEECCEEEEE
LGLENIEYEPEQFPGLVYRIDEPKVVVLIFSSGKLVVTGGKTPEDCESGVEVVRQQLDNM
ECCCCCCCCCCCCCCEEEEECCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHC
GLL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]