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The map label for this gene is cbiT

Identifier: 21227102

GI number: 21227102

Start: 1174236

End: 1174790

Strand: Reverse

Name: cbiT

Synonym: MM_1000

Alternate gene names: 21227102

Gene position: 1174790-1174236 (Counterclockwise)

Preceding gene: 21227103

Following gene: 21227101

Centisome position: 28.68

GC content: 46.13

Gene sequence:

>555_bases
ATGTCCGAAATAGTAAGTGTTAGCGGCGGTCCGACTAAACCGGAAATAATTGCAGTTTCCCTTTCCAAACTCGGACTTAA
AGACGGGGACCGGTTTGCAGATGTCGGCTGCGGTACCGGGTCGGTCTCTATTGAAGCAGCCCGAATTGCTCGGAACCTGA
CTATCTATGCAATCGATGCCCGTAAAGAAGCTCTTCTCGCCACGGAAACAAATTTTAAGAATTTTGGGATTGAAAATGCC
AGGATTCTAGCCGGCGAAGCTTCGGATATCCTTGGTTCAGAAAAGACTATTGATTCCATAGACTGCGCTTTTGTTGGAGG
GACGAAAAACATTGGTTCCATACTTGCGAAGCTTGTTGAGAAAAAAGCCCGGAGCATTGTTGTAAACGCGGTCCGCATCG
AAACCGTTGTCAGGACGATTGAGGCTATGAAGAGTCTGGATATTTTTGATGAGGTCATTCATGTTGCAGTCTCAAGAAGC
TTCCCGATTGCCGGAGAGACAATGTTCAAACCCGAAAACCCGGTTTATATAGTTGTTGGAAAAAAGCAATCCTGA

Upstream 100 bases:

>100_bases
CAGCTTTAATTGCTGTGTTCAATTAATATATTTTCAAAATAATATCACCATCTATTTAATTTAATTTAATATATTTGCTT
TAATTTTCCCGAGGTAATAC

Downstream 100 bases:

>100_bases
GATTCATTCTTTAATTACCATCAGATTAAATCACCATCAAGTTCATTAATTTACTCTTAATATTTACCTGTAAATTTATG
GAGCGATAATATGTTAATAG

Product: precorrin-6Y C5,15-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MSEIVSVSGGPTKPEIIAVSLSKLGLKDGDRFADVGCGTGSVSIEAARIARNLTIYAIDARKEALLATETNFKNFGIENA
RILAGEASDILGSEKTIDSIDCAFVGGTKNIGSILAKLVEKKARSIVVNAVRIETVVRTIEAMKSLDIFDEVIHVAVSRS
FPIAGETMFKPENPVYIVVGKKQS

Sequences:

>Translated_184_residues
MSEIVSVSGGPTKPEIIAVSLSKLGLKDGDRFADVGCGTGSVSIEAARIARNLTIYAIDARKEALLATETNFKNFGIENA
RILAGEASDILGSEKTIDSIDCAFVGGTKNIGSILAKLVEKKARSIVVNAVRIETVVRTIEAMKSLDIFDEVIHVAVSRS
FPIAGETMFKPENPVYIVVGKKQS
>Mature_183_residues
SEIVSVSGGPTKPEIIAVSLSKLGLKDGDRFADVGCGTGSVSIEAARIARNLTIYAIDARKEALLATETNFKNFGIENAR
ILAGEASDILGSEKTIDSIDCAFVGGTKNIGSILAKLVEKKARSIVVNAVRIETVVRTIEAMKSLDIFDEVIHVAVSRSF
PIAGETMFKPENPVYIVVGKKQS

Specific function: Probably catalyzes the methylation of either C-15 or C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W. Methylation of C-15 would probably be followed by a spontaneous decarboxylation of C-12

COG id: COG2242

COG function: function code H; Precorrin-6B methylase 2

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CBIT_METMA (Q8PY64)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_633024.1
- ProteinModelPortal:   Q8PY64
- SMR:   Q8PY64
- GeneID:   1479342
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1000
- NMPDR:   fig|192952.1.peg.1000
- HOGENOM:   HBG553505
- OMA:   IRAVSIG
- ProtClustDB:   CLSK900531
- BioCyc:   MMAZ192952:MM1000-MONOMER
- HAMAP:   MF_00786
- InterPro:   IPR014008
- InterPro:   IPR007848
- TIGRFAMs:   TIGR02469

Pfam domain/function: PF05175 MTS

EC number: 1.-.-.-

Molecular weight: Translated: 19584; Mature: 19453

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: BINDING 12-12 BINDING 59-59 BINDING 87-87

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIVSVSGGPTKPEIIAVSLSKLGLKDGDRFADVGCGTGSVSIEAARIARNLTIYAIDA
CCCEEECCCCCCCCEEEEEEHHHCCCCCCCCEEECCCCCCCEEEEHHHHHCCEEEEEECC
RKEALLATETNFKNFGIENARILAGEASDILGSEKTIDSIDCAFVGGTKNIGSILAKLVE
CCCEEEEECCCCCCCCCCCCEEEECCCHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHH
KKARSIVVNAVRIETVVRTIEAMKSLDIFDEVIHVAVSRSFPIAGETMFKPENPVYIVVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEEE
KKQS
CCCC
>Mature Secondary Structure 
SEIVSVSGGPTKPEIIAVSLSKLGLKDGDRFADVGCGTGSVSIEAARIARNLTIYAIDA
CCEEECCCCCCCCEEEEEEHHHCCCCCCCCEEECCCCCCCEEEEHHHHHCCEEEEEECC
RKEALLATETNFKNFGIENARILAGEASDILGSEKTIDSIDCAFVGGTKNIGSILAKLVE
CCCEEEEECCCCCCCCCCCCEEEECCCHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHH
KKARSIVVNAVRIETVVRTIEAMKSLDIFDEVIHVAVSRSFPIAGETMFKPENPVYIVVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEEE
KKQS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824