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The map label for this gene is gor [H]

Identifier: 21226999

GI number: 21226999

Start: 1056604

End: 1057686

Strand: Reverse

Name: gor [H]

Synonym: MM_0897

Alternate gene names: 21226999

Gene position: 1057686-1056604 (Counterclockwise)

Preceding gene: 21227002

Following gene: 21226998

Centisome position: 25.82

GC content: 46.54

Gene sequence:

>1083_bases
ATGGAAAAGGAATATGATATTATAATTATCGGGACAGGGACTGCAGGCAGAACTCTGGCAGGCAGGGCAGAGTCTTCTGG
AATGAAATTTGCCATTATTGACTCAAGGGAGTACGGAGGCACCTGCCCTCTAAGGGGATGTGATCCCAAAAAAGTTCTTG
CAGGCGCATCGGAAGCTACAGACCTGAATAACCGGCTTATAGGCAAAGGTGCAGGGACAGAAGAGCCTTTAAAAATAGAC
TGGCCTTCGCTTATCAGATTCAAAAGGACGTTTACTGAAGTCTATCCCCGCGAAGCTGAGAAAATGTTTGCGGATATGGG
GATTGATATGTATCACGGTAGAGCCCGGTTTAAGAACGAAAACACCGTAATTGTCGGGAATGATGAACTCAAAGGAAAAT
TTATTTTTCTTGCAACAGGCTCAAAGCCGCGTAAACTGAAGATTCCTGGAGAGGAATACCTCACAACAAGTGAGGAATTT
ATGGAACTCATGGAGCTCCCTGAAAAGATTATTTTTGCAGGGGGAGGGTATATCTCCTTTGAATTTACACACATTGCCAG
GCGGGCAGGGGCTGAAGTCCTGATCCTGCACAGAAGTGAAAGGCCTCTGGGGACATTTGATCCTGATCTGGTGGACATGC
TTGTCCGGGCTTCCGAAGAGTCTGGAATAAAAATCCTTACAAATAGGCCGGTGGTAGCTGTTGAAAAAGCAGGTGACGGT
TTTCTTGTCAGGACTGAATATAAAACCGAAACAGGGTCGGAAGTCCAGGTTTTCAATGCGGACATGGTGGTAAACGGCGC
AGGGCGGGTTCCTGATATTGAAGACCTGCAGCTTGAGAATGCCGGAGTCAGGGCTGAAAAAAAAGGGATTATAGTCGATA
AGCATATGAGAACATCAAATCCCCGGGTTTATGCAGGGGGAGACTGTACTGCCGAAGGAATTCAGCTTACTCCGGTAGCA
ACTCTTCAGGGAGAAGTTGCAGCTGCTAATATTTTTGACAGAAACGGGGCTGAAGCCGATTATACAGGAATTCCAAGTGC
AGTATTTACCCATCCCTGTGCTTGCTTCCGTTGGAATAAGTGA

Upstream 100 bases:

>100_bases
TATTATTCTCACCTTAGCCTGTTCCATATTTTTAAGCTTTATTTATTATTTTGCTTTCAAGGTCTATTTTTAAGAAATAG
ATACAGGGGATGGGGATTCA

Downstream 100 bases:

>100_bases
GGAAAAAGAAAGTGATAAATACAGGGTTATTTTCCGTGACCGCAGTACATGGAGCACTACCAGGAGGGCAGGGATGGAAT
TTGCAGCTTCAAAGATAATT

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MEKEYDIIIIGTGTAGRTLAGRAESSGMKFAIIDSREYGGTCPLRGCDPKKVLAGASEATDLNNRLIGKGAGTEEPLKID
WPSLIRFKRTFTEVYPREAEKMFADMGIDMYHGRARFKNENTVIVGNDELKGKFIFLATGSKPRKLKIPGEEYLTTSEEF
MELMELPEKIIFAGGGYISFEFTHIARRAGAEVLILHRSERPLGTFDPDLVDMLVRASEESGIKILTNRPVVAVEKAGDG
FLVRTEYKTETGSEVQVFNADMVVNGAGRVPDIEDLQLENAGVRAEKKGIIVDKHMRTSNPRVYAGGDCTAEGIQLTPVA
TLQGEVAAANIFDRNGAEADYTGIPSAVFTHPCACFRWNK

Sequences:

>Translated_360_residues
MEKEYDIIIIGTGTAGRTLAGRAESSGMKFAIIDSREYGGTCPLRGCDPKKVLAGASEATDLNNRLIGKGAGTEEPLKID
WPSLIRFKRTFTEVYPREAEKMFADMGIDMYHGRARFKNENTVIVGNDELKGKFIFLATGSKPRKLKIPGEEYLTTSEEF
MELMELPEKIIFAGGGYISFEFTHIARRAGAEVLILHRSERPLGTFDPDLVDMLVRASEESGIKILTNRPVVAVEKAGDG
FLVRTEYKTETGSEVQVFNADMVVNGAGRVPDIEDLQLENAGVRAEKKGIIVDKHMRTSNPRVYAGGDCTAEGIQLTPVA
TLQGEVAAANIFDRNGAEADYTGIPSAVFTHPCACFRWNK
>Mature_360_residues
MEKEYDIIIIGTGTAGRTLAGRAESSGMKFAIIDSREYGGTCPLRGCDPKKVLAGASEATDLNNRLIGKGAGTEEPLKID
WPSLIRFKRTFTEVYPREAEKMFADMGIDMYHGRARFKNENTVIVGNDELKGKFIFLATGSKPRKLKIPGEEYLTTSEEF
MELMELPEKIIFAGGGYISFEFTHIARRAGAEVLILHRSERPLGTFDPDLVDMLVRASEESGIKILTNRPVVAVEKAGDG
FLVRTEYKTETGSEVQVFNADMVVNGAGRVPDIEDLQLENAGVRAEKKGIIVDKHMRTSNPRVYAGGDCTAEGIQLTPVA
TLQGEVAAANIFDRNGAEADYTGIPSAVFTHPCACFRWNK

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=358, Percent_Identity=29.0502793296089, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI22035672, Length=367, Percent_Identity=29.700272479564, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI148277065, Length=325, Percent_Identity=29.5384615384615, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI33519430, Length=325, Percent_Identity=29.5384615384615, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI33519428, Length=325, Percent_Identity=29.5384615384615, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI33519426, Length=325, Percent_Identity=29.5384615384615, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI148277071, Length=325, Percent_Identity=29.5384615384615, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI91199540, Length=360, Percent_Identity=25.8333333333333, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI291045266, Length=332, Percent_Identity=26.5060240963855, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI291045268, Length=314, Percent_Identity=26.1146496815287, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1789915, Length=355, Percent_Identity=34.0845070422535, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI1786307, Length=363, Percent_Identity=28.099173553719, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87081717, Length=365, Percent_Identity=28.4931506849315, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082354, Length=372, Percent_Identity=24.1935483870968, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17557007, Length=367, Percent_Identity=29.1553133514986, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71983419, Length=357, Percent_Identity=31.9327731092437, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71983429, Length=357, Percent_Identity=31.9327731092437, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32565766, Length=362, Percent_Identity=24.8618784530387, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71982272, Length=379, Percent_Identity=27.1767810026385, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6325166, Length=371, Percent_Identity=29.3800539083558, Blast_Score=122, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6321091, Length=370, Percent_Identity=24.3243243243243, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6325240, Length=339, Percent_Identity=25.6637168141593, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24640549, Length=363, Percent_Identity=30.3030303030303, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24640551, Length=363, Percent_Identity=30.3030303030303, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24640553, Length=363, Percent_Identity=30.3030303030303, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI17737741, Length=365, Percent_Identity=28.4931506849315, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21358499, Length=370, Percent_Identity=28.6486486486486, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 39511; Mature: 39511

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKEYDIIIIGTGTAGRTLAGRAESSGMKFAIIDSREYGGTCPLRGCDPKKVLAGASEAT
CCCCEEEEEEECCCCCCEEECCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHCCCCCCC
DLNNRLIGKGAGTEEPLKIDWPSLIRFKRTFTEVYPREAEKMFADMGIDMYHGRARFKNE
CCCCEEEECCCCCCCCEEECCHHHHHHHHHHHHHCCHHHHHHHHHCCCEEECCCEEECCC
NTVIVGNDELKGKFIFLATGSKPRKLKIPGEEYLTTSEEFMELMELPEKIIFAGGGYISF
CEEEECCCCCCEEEEEEEECCCCCEEECCCHHHCCCHHHHHHHHHCCCEEEEECCCEEEE
EFTHIARRAGAEVLILHRSERPLGTFDPDLVDMLVRASEESGIKILTNRPVVAVEKAGDG
EHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCC
FLVRTEYKTETGSEVQVFNADMVVNGAGRVPDIEDLQLENAGVRAEKKGIIVDKHMRTSN
EEEEEECCCCCCCEEEEEEEEEEEECCCCCCCHHHEEECCCCCCCCCCCEEEECCCCCCC
PRVYAGGDCTAEGIQLTPVATLQGEVAAANIFDRNGAEADYTGIPSAVFTHPCACFRWNK
CEEEECCCCCCCCEEEEEEEEECCCEEEEEEECCCCCCCCCCCCCHHHHHCCCEEEECCC
>Mature Secondary Structure
MEKEYDIIIIGTGTAGRTLAGRAESSGMKFAIIDSREYGGTCPLRGCDPKKVLAGASEAT
CCCCEEEEEEECCCCCCEEECCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHCCCCCCC
DLNNRLIGKGAGTEEPLKIDWPSLIRFKRTFTEVYPREAEKMFADMGIDMYHGRARFKNE
CCCCEEEECCCCCCCCEEECCHHHHHHHHHHHHHCCHHHHHHHHHCCCEEECCCEEECCC
NTVIVGNDELKGKFIFLATGSKPRKLKIPGEEYLTTSEEFMELMELPEKIIFAGGGYISF
CEEEECCCCCCEEEEEEEECCCCCEEECCCHHHCCCHHHHHHHHHCCCEEEEECCCEEEE
EFTHIARRAGAEVLILHRSERPLGTFDPDLVDMLVRASEESGIKILTNRPVVAVEKAGDG
EHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCC
FLVRTEYKTETGSEVQVFNADMVVNGAGRVPDIEDLQLENAGVRAEKKGIIVDKHMRTSN
EEEEEECCCCCCCEEEEEEEEEEEECCCCCCCHHHEEECCCCCCCCCCCEEEECCCCCCC
PRVYAGGDCTAEGIQLTPVATLQGEVAAANIFDRNGAEADYTGIPSAVFTHPCACFRWNK
CEEEECCCCCCCCEEEEEEEEECCCEEEEEEECCCCCCCCCCCCCHHHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]