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The map label for this gene is purC [H]

Identifier: 21226957

GI number: 21226957

Start: 1009614

End: 1010327

Strand: Direct

Name: purC [H]

Synonym: MM_0855

Alternate gene names: 21226957

Gene position: 1009614-1010327 (Clockwise)

Preceding gene: 21226951

Following gene: 21226961

Centisome position: 24.65

GC content: 44.82

Gene sequence:

>714_bases
ATGAAAAGAGAACAGCTCTATTCAGGGAAAGCAAAAACCATCTACAGGACAGATGATCCCGATACCCTTATCGCTGAGTT
CCGAAACAGCCTTACCGCATTTAATGGGGAAAAGAAAGGCGAGATGGAACTGAAGGGTTACTACAACGCCCAGATATCAA
AGAAGATTTTTGAGATGCTGGAAGCCAGCGGAGTCAAGACCCATTTTGTAAGTATGCTTACCGATATTGATATGCTTGTA
AGGGAAGTTGAAATCATCAAAATTGAGGTTATTGTAAGGAACATTGCCGCAGGCTCGATAACCAGAAAGTACCCTATAAA
AGAGGGAACTATTTTAAAGCCGCCTGTTCTCGTTTTTGATTTCAAAAGCGATGAATACGGAGACCCAATGCTGAATGATG
ATATTGCTCTTGCACTTGGCATTGCAACCCGCGAAGAACTTGCAGAACTTCGAAAACTGGCACTCAGGGTCAACGAGCTG
CTTGTTCCCTACCTTGATGAAAAAGGAATTCTGCTTCCCGATTTCAAGCTTGAGTTCGGTAGAAGGGAGGGGGAAATTGT
CCTTGCAGATGAGATTTCCTGCGACACCTGCCGTTTCTGGGACAAGAAAACCGGGCAGTCTATGGACAAAGACGTTTTCA
GGTTTGACAAGGGCGACATCTCCAAAGCCTATGAAGAAGTTGCCCGGCGCATAGTGCCCGAGATATTCGAATAA

Upstream 100 bases:

>100_bases
AAATAACTATTATATTAAAATTACTATTATTCCGGGAATTATTTCCGGAAATCTCTCTATCTAAGGAAAATCCAGAATTA
TCCCTAGAGAGGACCATTAC

Downstream 100 bases:

>100_bases
TCCAGAACAGGTCAAAAAGCAAGATCTTAAGCCTGAATAACCTGAAAAGGCTTTAAAGACCTGCTTATTAATTTTTAAAC
ATGAAGGCAGTTCATCTTAA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MKREQLYSGKAKTIYRTDDPDTLIAEFRNSLTAFNGEKKGEMELKGYYNAQISKKIFEMLEASGVKTHFVSMLTDIDMLV
REVEIIKIEVIVRNIAAGSITRKYPIKEGTILKPPVLVFDFKSDEYGDPMLNDDIALALGIATREELAELRKLALRVNEL
LVPYLDEKGILLPDFKLEFGRREGEIVLADEISCDTCRFWDKKTGQSMDKDVFRFDKGDISKAYEEVARRIVPEIFE

Sequences:

>Translated_237_residues
MKREQLYSGKAKTIYRTDDPDTLIAEFRNSLTAFNGEKKGEMELKGYYNAQISKKIFEMLEASGVKTHFVSMLTDIDMLV
REVEIIKIEVIVRNIAAGSITRKYPIKEGTILKPPVLVFDFKSDEYGDPMLNDDIALALGIATREELAELRKLALRVNEL
LVPYLDEKGILLPDFKLEFGRREGEIVLADEISCDTCRFWDKKTGQSMDKDVFRFDKGDISKAYEEVARRIVPEIFE
>Mature_237_residues
MKREQLYSGKAKTIYRTDDPDTLIAEFRNSLTAFNGEKKGEMELKGYYNAQISKKIFEMLEASGVKTHFVSMLTDIDMLV
REVEIIKIEVIVRNIAAGSITRKYPIKEGTILKPPVLVFDFKSDEYGDPMLNDDIALALGIATREELAELRKLALRVNEL
LVPYLDEKGILLPDFKLEFGRREGEIVLADEISCDTCRFWDKKTGQSMDKDVFRFDKGDISKAYEEVARRIVPEIFE

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=247, Percent_Identity=29.1497975708502, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI5453539, Length=247, Percent_Identity=29.1497975708502, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI119220559, Length=253, Percent_Identity=28.0632411067194, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788820, Length=230, Percent_Identity=40.8695652173913, Blast_Score=190, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17531275, Length=221, Percent_Identity=32.1266968325792, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6319326, Length=177, Percent_Identity=33.8983050847458, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583917, Length=218, Percent_Identity=30.7339449541284, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI18860083, Length=216, Percent_Identity=28.2407407407407, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27176; Mature: 27176

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKREQLYSGKAKTIYRTDDPDTLIAEFRNSLTAFNGEKKGEMELKGYYNAQISKKIFEML
CCCCHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEECEECCHHHHHHHHHHH
EASGVKTHFVSMLTDIDMLVREVEIIKIEVIVRNIAAGSITRKYPIKEGTILKPPVLVFD
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEECCCEEEEE
FKSDEYGDPMLNDDIALALGIATREELAELRKLALRVNELLVPYLDEKGILLPDFKLEFG
ECCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCC
RREGEIVLADEISCDTCRFWDKKTGQSMDKDVFRFDKGDISKAYEEVARRIVPEIFE
CCCCCEEEECCCCCCHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKREQLYSGKAKTIYRTDDPDTLIAEFRNSLTAFNGEKKGEMELKGYYNAQISKKIFEML
CCCCHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEECEECCHHHHHHHHHHH
EASGVKTHFVSMLTDIDMLVREVEIIKIEVIVRNIAAGSITRKYPIKEGTILKPPVLVFD
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEECCCEEEEE
FKSDEYGDPMLNDDIALALGIATREELAELRKLALRVNELLVPYLDEKGILLPDFKLEFG
ECCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCC
RREGEIVLADEISCDTCRFWDKKTGQSMDKDVFRFDKGDISKAYEEVARRIVPEIFE
CCCCCEEEECCCCCCHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]