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The map label for this gene is rpiA

Identifier: 21226175

GI number: 21226175

Start: 98569

End: 99273

Strand: Reverse

Name: rpiA

Synonym: MM_0073

Alternate gene names: 21226175

Gene position: 99273-98569 (Counterclockwise)

Preceding gene: 21226176

Following gene: 21226174

Centisome position: 2.42

GC content: 47.8

Gene sequence:

>705_bases
ATGACGGAAAGAAATACTTCTACTGATTCTCCGGAAAAACGGGCGGCAGGAATTGCTGCGGCAGGGCTTGTCAGCTCAGG
GATGGTTGTAGGGCTCGGTACGGGTTCGACAGTTGCATATACTATAAAAGAGCTGGGGCGCAGGGTAAAGGAGGAAGGCC
TCGACATCCTCGGGGTTGTTACCTCCTACCAGTCCGAAATGCTGGCAATAGATGCCGGGATAAGGCTTACCACCCTTTCT
CAGGACCCTGAACTGGATATTGCAATTGACGGAGCTGACCAGATAGACTCCAACCTTTATACCATCAAAGGAGGCGGGGC
TGCTCATACAAGGGAAAAGATCGTTTCCGTGTCTGCAAAAAGGTTTGTAGTAGTAGCCGACGACTCTAAAACCAGTACGC
AGCTTGATAAGCCTGTGCCTGTTGAAGTCCTTCCCTTTGCAAAAGAACCTGCAGTGAACAGGATCCGGAAACTTGGGGGA
GAACCCAGACTCAGGTCTGCCGTAAAAAAAGACGGTCCCGTTATAACGGATAATGGAAACTTTGTTCTTGATGTCGAATT
TGGCGTTATAAAAGATCCTGAGGCTCTTGCCCTTCAATTGTCTGCGGTTCCGGGAGTTGTTGAACACGGAATTTTTAGTA
ATGTTGATGAACTTTACATAGGGAAAAAAGACGGGTCCGTAAAAATTATATCCAGACAGAAGTGA

Upstream 100 bases:

>100_bases
TTTCATTTAAACTTGGAAGGACTTACTGTTTCTGAAAACATCTGTTGAATATGTTAACTTTTTCAGTTAACTTTTTTAGA
GCTGAAAGGCGGAAAACAAT

Downstream 100 bases:

>100_bases
AGGGTTTCGCGGGCAAACTAATAATTAATTTGCTGAATTATTCTGGTTAATTTGCTGAATTATTCTAGTTAATTTGCTGA
ATAATTCGTAATTAATTCGC

Product: ribose-5-phosphate isomerase A

Products: NA

Alternate protein names: Phosphoriboisomerase A; PRI

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MTERNTSTDSPEKRAAGIAAAGLVSSGMVVGLGTGSTVAYTIKELGRRVKEEGLDILGVVTSYQSEMLAIDAGIRLTTLS
QDPELDIAIDGADQIDSNLYTIKGGGAAHTREKIVSVSAKRFVVVADDSKTSTQLDKPVPVEVLPFAKEPAVNRIRKLGG
EPRLRSAVKKDGPVITDNGNFVLDVEFGVIKDPEALALQLSAVPGVVEHGIFSNVDELYIGKKDGSVKIISRQK

Sequences:

>Translated_234_residues
MTERNTSTDSPEKRAAGIAAAGLVSSGMVVGLGTGSTVAYTIKELGRRVKEEGLDILGVVTSYQSEMLAIDAGIRLTTLS
QDPELDIAIDGADQIDSNLYTIKGGGAAHTREKIVSVSAKRFVVVADDSKTSTQLDKPVPVEVLPFAKEPAVNRIRKLGG
EPRLRSAVKKDGPVITDNGNFVLDVEFGVIKDPEALALQLSAVPGVVEHGIFSNVDELYIGKKDGSVKIISRQK
>Mature_233_residues
TERNTSTDSPEKRAAGIAAAGLVSSGMVVGLGTGSTVAYTIKELGRRVKEEGLDILGVVTSYQSEMLAIDAGIRLTTLSQ
DPELDIAIDGADQIDSNLYTIKGGGAAHTREKIVSVSAKRFVVVADDSKTSTQLDKPVPVEVLPFAKEPAVNRIRKLGGE
PRLRSAVKKDGPVITDNGNFVLDVEFGVIKDPEALALQLSAVPGVVEHGIFSNVDELYIGKKDGSVKIISRQK

Specific function: Nonoxidative branch of the pentose phosphate pathway. [C]

COG id: COG0120

COG function: function code G; Ribose 5-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose 5-phosphate isomerase family

Homologues:

Organism=Homo sapiens, GI94536842, Length=224, Percent_Identity=42.4107142857143, Blast_Score=178, Evalue=4e-45,
Organism=Escherichia coli, GI1789280, Length=222, Percent_Identity=41.4414414414414, Blast_Score=141, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17551758, Length=232, Percent_Identity=42.6724137931034, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6324669, Length=218, Percent_Identity=38.0733944954128, Blast_Score=142, Evalue=5e-35,
Organism=Drosophila melanogaster, GI281364072, Length=214, Percent_Identity=41.1214953271028, Blast_Score=160, Evalue=5e-40,

Paralogues:

None

Copy number: 740 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): RPIA_METMA (Q8Q0R3)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_632097.1
- ProteinModelPortal:   Q8Q0R3
- SMR:   Q8Q0R3
- GeneID:   1478415
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_0073
- NMPDR:   fig|192952.1.peg.73
- HOGENOM:   HBG515603
- OMA:   HAREKIV
- ProtClustDB:   PRK00702
- BioCyc:   MMAZ192952:MM0073-MONOMER
- BRENDA:   5.3.1.6
- HAMAP:   MF_00170
- InterPro:   IPR004788
- InterPro:   IPR020672
- PANTHER:   PTHR11934
- TIGRFAMs:   TIGR00021

Pfam domain/function: PF06026 Rib_5-P_isom_A

EC number: =5.3.1.6

Molecular weight: Translated: 24814; Mature: 24682

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERNTSTDSPEKRAAGIAAAGLVSSGMVVGLGTGSTVAYTIKELGRRVKEEGLDILGVV
CCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCEEHHHHHHHHHHHHHCCCEEEEEH
TSYQSEMLAIDAGIRLTTLSQDPELDIAIDGADQIDSNLYTIKGGGAAHTREKIVSVSAK
HHCCCCEEEEECCEEEEEECCCCCEEEEECCHHHCCCCEEEEECCCCCHHHHHHHEECCE
RFVVVADDSKTSTQLDKPVPVEVLPFAKEPAVNRIRKLGGEPRLRSAVKKDGPVITDNGN
EEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHCCCEEECCCC
FVLDVEFGVIKDPEALALQLSAVPGVVEHGIFSNVDELYIGKKDGSVKIISRQK
EEEEEECCCCCCCHHHEEEEECCCCHHHHHHHCCCHHEEEECCCCCEEEEEECC
>Mature Secondary Structure 
TERNTSTDSPEKRAAGIAAAGLVSSGMVVGLGTGSTVAYTIKELGRRVKEEGLDILGVV
CCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCEEHHHHHHHHHHHHHCCCEEEEEH
TSYQSEMLAIDAGIRLTTLSQDPELDIAIDGADQIDSNLYTIKGGGAAHTREKIVSVSAK
HHCCCCEEEEECCEEEEEECCCCCEEEEECCHHHCCCCEEEEECCCCCHHHHHHHEECCE
RFVVVADDSKTSTQLDKPVPVEVLPFAKEPAVNRIRKLGGEPRLRSAVKKDGPVITDNGN
EEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHCCCEEECCCC
FVLDVEFGVIKDPEALALQLSAVPGVVEHGIFSNVDELYIGKKDGSVKIISRQK
EEEEEECCCCCCCHHHEEEEECCCCHHHHHHHCCCHHEEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824