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The map label for this gene is argG

Identifier: 161485685

GI number: 161485685

Start: 44603

End: 45787

Strand: Reverse

Name: argG

Synonym: MM_0037

Alternate gene names: 161485685

Gene position: 45787-44603 (Counterclockwise)

Preceding gene: 21226140

Following gene: 21226137

Centisome position: 1.12

GC content: 52.74

Gene sequence:

>1185_bases
ATGGTAAAAAAAGTTGCACTTGCATATTCCGGTGGGCTTGACACCTCTGTGTGTATCCCCATCCTCAAAGAAAAGTACGG
TTACGATGAAGTAATTACAATTTCGGTTGACGTCGGCCAGCCCGAAGAAGAAATCAGGAAGGCTGATGCGAAAGCCCAGA
AGATCAGCAACAAGCACTACACGATCGATGCAAAGGAAGAGTTCGTAAGGGACTACATCTTCCCCCTGATAAAAGCCAAC
GGAAACTACGAAGGCTATGTCATGGGCACGTCCGTAGCCCGCCCCCTGATTGCCAAAAAAGTAGTCGAAGCAGCCAAAAA
AGAAGGCGCAATTGCCCTTGCCCACGGCTGCACCGGAAAAGGAAACGACCAGCTCCGCTTTGAAGCCGTCTTCCGCCAGA
CCGATATGGACGTTATCGCCCCAATGCGTGAGATGAACCTGACCCGCGAGTGGGAAATCAATTACGCAAAGGAGCACGGC
ATCCCTGTCGAAGCCACAAAGTCCAAGCCCTGGAGCGTTGACGAAAATATCTGGAGCCGCAGCATCGAAGGCGGCAGGCT
TGAAGATCCCTCTTTTGTCCCGCCGGAAGAGATCTTCGAGTGGACAAAATCCGCAGAAGATGCCCCGAACGAGCCCAGGA
TTGTTGACATCGACTTTGAAGCCGGTGTCCCTGTTGCAATTGACGGCGAAAAACTTGGCGGCTATGCCCTTGTCAAGAAG
ATGAACGAAATTGCAGGCGAGAACGGCGTCGGCAGGACCGATATGATCGAAGACCGCGTGCTCGGCTTAAAAGCCCGTGA
GAACTACGAGCACCCGGCTGCAACCGTCCTCCTCGCAGCCCACGCCGACCTCGAGAAACTCGTCCTGACCCGCGGGGAAC
TGAAGTTCAAGAAAATCGTTGAAGAGCAGTGGTCCGAAATGGCATACGCAGGCCTTGTGGACGACCCTCTATTTGCCGAC
CTCAACGCTTTTATCGACAAGTCGCAGGAAAGGGTTACAGGTACAGTGAAAGTGAAGCTCTACAAAGGCGCACTTACTAT
CCTTGCCCGCAGTTCGCCAAATGCCCTGTATTCCGAAGACCTGGTCTCGTTTGACAGCCAGACCATTGACCAGAAGGATG
CAGAAGGATTTGCGAAGTATCACGGGTTCCAGGCGAGGATGTACAGGAAAGTCGTGGGAAAATAA

Upstream 100 bases:

>100_bases
TCAATGCATTAATATATTAATTTATTAGCGTGTCACTCGATTGACACATCAATTATTTTGGTTCTTATCACATATCTGCC
AAATAAGGGGTAGTAAAAGC

Downstream 100 bases:

>100_bases
AAGTGAAAATTTTCGACTTTTACCTGCCCTTTTTTTGAGGAGGGCAGGAGACTCCCATATTTTAAACTTAACTTTAATAG
TTCTAAGTCTTTGTTTTTTT

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MVKKVALAYSGGLDTSVCIPILKEKYGYDEVITISVDVGQPEEEIRKADAKAQKISNKHYTIDAKEEFVRDYIFPLIKAN
GNYEGYVMGTSVARPLIAKKVVEAAKKEGAIALAHGCTGKGNDQLRFEAVFRQTDMDVIAPMREMNLTREWEINYAKEHG
IPVEATKSKPWSVDENIWSRSIEGGRLEDPSFVPPEEIFEWTKSAEDAPNEPRIVDIDFEAGVPVAIDGEKLGGYALVKK
MNEIAGENGVGRTDMIEDRVLGLKARENYEHPAATVLLAAHADLEKLVLTRGELKFKKIVEEQWSEMAYAGLVDDPLFAD
LNAFIDKSQERVTGTVKVKLYKGALTILARSSPNALYSEDLVSFDSQTIDQKDAEGFAKYHGFQARMYRKVVGK

Sequences:

>Translated_394_residues
MVKKVALAYSGGLDTSVCIPILKEKYGYDEVITISVDVGQPEEEIRKADAKAQKISNKHYTIDAKEEFVRDYIFPLIKAN
GNYEGYVMGTSVARPLIAKKVVEAAKKEGAIALAHGCTGKGNDQLRFEAVFRQTDMDVIAPMREMNLTREWEINYAKEHG
IPVEATKSKPWSVDENIWSRSIEGGRLEDPSFVPPEEIFEWTKSAEDAPNEPRIVDIDFEAGVPVAIDGEKLGGYALVKK
MNEIAGENGVGRTDMIEDRVLGLKARENYEHPAATVLLAAHADLEKLVLTRGELKFKKIVEEQWSEMAYAGLVDDPLFAD
LNAFIDKSQERVTGTVKVKLYKGALTILARSSPNALYSEDLVSFDSQTIDQKDAEGFAKYHGFQARMYRKVVGK
>Mature_394_residues
MVKKVALAYSGGLDTSVCIPILKEKYGYDEVITISVDVGQPEEEIRKADAKAQKISNKHYTIDAKEEFVRDYIFPLIKAN
GNYEGYVMGTSVARPLIAKKVVEAAKKEGAIALAHGCTGKGNDQLRFEAVFRQTDMDVIAPMREMNLTREWEINYAKEHG
IPVEATKSKPWSVDENIWSRSIEGGRLEDPSFVPPEEIFEWTKSAEDAPNEPRIVDIDFEAGVPVAIDGEKLGGYALVKK
MNEIAGENGVGRTDMIEDRVLGLKARENYEHPAATVLLAAHADLEKLVLTRGELKFKKIVEEQWSEMAYAGLVDDPLFAD
LNAFIDKSQERVTGTVKVKLYKGALTILARSSPNALYSEDLVSFDSQTIDQKDAEGFAKYHGFQARMYRKVVGK

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI53759107, Length=404, Percent_Identity=40.0990099009901, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI16950633, Length=404, Percent_Identity=40.0990099009901, Blast_Score=273, Evalue=1e-73,
Organism=Escherichia coli, GI1789563, Length=387, Percent_Identity=24.031007751938, Blast_Score=82, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324514, Length=406, Percent_Identity=40.8866995073892, Blast_Score=267, Evalue=2e-72,
Organism=Drosophila melanogaster, GI21358151, Length=410, Percent_Identity=38.780487804878, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ASSY_METMA (Q8Q0U5)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_632061.2
- ProteinModelPortal:   Q8Q0U5
- SMR:   Q8Q0U5
- GeneID:   1478379
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_0037
- NMPDR:   fig|192952.1.peg.37
- HOGENOM:   HBG335267
- OMA:   VAVDVGQ
- ProtClustDB:   PRK13820
- BioCyc:   MMAZ192952:MM0037-MONOMER
- BRENDA:   6.3.4.5
- GO:   GO:0005737
- HAMAP:   MF_00005
- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11587
- TIGRFAMs:   TIGR00032

Pfam domain/function: PF00764 Arginosuc_synth

EC number: =6.3.4.5

Molecular weight: Translated: 43888; Mature: 43888

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1; PS00565 ARGININOSUCCIN_SYN_2

Important sites: BINDING 86-86 BINDING 91-91 BINDING 116-116 BINDING 118-118 BINDING 122-122 BINDING 122-122 BINDING 123-123 BINDING 126-126 BINDING 172-172 BINDING 181-181 BINDING 257-257 BINDING 269-269

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKKVALAYSGGLDTSVCIPILKEKYGYDEVITISVDVGQPEEEIRKADAKAQKISNKHY
CCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCE
TIDAKEEFVRDYIFPLIKANGNYEGYVMGTSVARPLIAKKVVEAAKKEGAIALAHGCTGK
EECCHHHHHHHHHHHHEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GNDQLRFEAVFRQTDMDVIAPMREMNLTREWEINYAKEHGIPVEATKSKPWSVDENIWSR
CCCCEEEEEHHHHCCHHHHCCHHHCCCCEEEEEEEHHHCCCCEEECCCCCCCCCHHHHHC
SIEGGRLEDPSFVPPEEIFEWTKSAEDAPNEPRIVDIDFEAGVPVAIDGEKLGGYALVKK
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEECCCCCCHHHHHHH
MNEIAGENGVGRTDMIEDRVLGLKARENYEHPAATVLLAAHADLEKLVLTRGELKFKKIV
HHHHHCCCCCCCCHHHHHHHHCEECCCCCCCCHHEEEEEHHCCHHHHHHHCCCHHHHHHH
EEQWSEMAYAGLVDDPLFADLNAFIDKSQERVTGTVKVKLYKGALTILARSSPNALYSED
HHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHEEEEEEEEEEECEEEEEEECCCCCHHHHH
LVSFDSQTIDQKDAEGFAKYHGFQARMYRKVVGK
HHHCCCHHCCHHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MVKKVALAYSGGLDTSVCIPILKEKYGYDEVITISVDVGQPEEEIRKADAKAQKISNKHY
CCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCE
TIDAKEEFVRDYIFPLIKANGNYEGYVMGTSVARPLIAKKVVEAAKKEGAIALAHGCTGK
EECCHHHHHHHHHHHHEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GNDQLRFEAVFRQTDMDVIAPMREMNLTREWEINYAKEHGIPVEATKSKPWSVDENIWSR
CCCCEEEEEHHHHCCHHHHCCHHHCCCCEEEEEEEHHHCCCCEEECCCCCCCCCHHHHHC
SIEGGRLEDPSFVPPEEIFEWTKSAEDAPNEPRIVDIDFEAGVPVAIDGEKLGGYALVKK
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEECCCCCCHHHHHHH
MNEIAGENGVGRTDMIEDRVLGLKARENYEHPAATVLLAAHADLEKLVLTRGELKFKKIV
HHHHHCCCCCCCCHHHHHHHHCEECCCCCCCCHHEEEEEHHCCHHHHHHHCCCHHHHHHH
EEQWSEMAYAGLVDDPLFADLNAFIDKSQERVTGTVKVKLYKGALTILARSSPNALYSED
HHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHEEEEEEEEEEECEEEEEEECCCCCHHHHH
LVSFDSQTIDQKDAEGFAKYHGFQARMYRKVVGK
HHHCCCHHCCHHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824