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The map label for this gene is HcaD3 [C]

Identifier: 20809045

GI number: 20809045

Start: 2597900

End: 2599255

Strand: Reverse

Name: HcaD3 [C]

Synonym: TTE2702

Alternate gene names: 20809045

Gene position: 2599255-2597900 (Counterclockwise)

Preceding gene: 20809046

Following gene: 20809044

Centisome position: 96.65

GC content: 44.69

Gene sequence:

>1356_bases
ATGCCTAAGCGCTATGTTATTATAGGTGGAGATGCGGCTGGGATGAGCGCAGCTTCCCAAATAAGGAGGATGGATAAAGA
GGGGGAAGTTCTGGTCTTTGAAAAGGAGGGAGTAATTTCTTATGCCCAGTGTGGCCTACCCTACTGGGTGGGAGGGGTTG
TGTCTGAGAAAAAAAAGCTTATTGCGCGCACAGCGGAAGAGTTCTTAAATCGCTACAATATTGACGTAAAGCTTTATCAC
GAAGTTGTGAAAATAGATCCTTCCAAAAAAGAAATCAAGGTTTTTCGCAGGGAAGAAAAAGACGAAATCGCTGTCCCTTA
TGATGTGCTTTTGATTGGGACAGGGAGTACTGCAATAGTACCTCCATGGGAGGGCAGGAATTTGCCGGGAGTGTTTACAT
TAAAGACCATGGGTGATGCGGAAAAACTTCTTGACTGGTTGAGCTCCCATACTCCCACTAAGGCGGTGGTTATAGGCGGA
GGTTATATAGGGCTTGAAACTGCCGAAGCGCTTCACAGCAGGGGCTTTAAGGTTACGGTTTTGGATTTAGCACCGCAGTT
AATACCTACTTTTGATAAGGAGATTGCCGAAATAGCTCAGGATGCTCTTACAAGACATGGAGTGGAAGTACATTTAAACG
AAGAAGTCGTCGGTTTGGAAGGGGATGAAAAAGGAGTAAAAGCCGTTGTAACGAAAAATGGCAAATTTGAAGCCGATTTA
GTTATAATATCTATAGGAGTAAGGCCTGTGAGCGAGCTGGCAAAGGAAGCGGGAATAGAGTTAGGGCCGAAGAATGCTAT
TTTAGTAAATGAAAGGCTTGAAACGAGTATTCCTGACATATACGCTGCTGGGGATTGCGCTACGCACTTTAACAGGATAA
AAAATGCACCGGATTACATACCACTGGGGACCACTGCTAATAAACAGGGAAGAATTGCAGGAATAAATATGGCAGGCGGA
GATGCGAAATTTGCAGGAGTGGTAGGAACGGCTATTGTCAAGGTTTTTGACAGGACTATAGCGAGAAGTGGTCTTGGAGA
AAGAGACTGCGAAGCTTTAGGCATACCTTATCAGGTAGTTTTAATAAAAGCAAGGCCTGTAAGCCATTACTATCCATGGG
AAGACGAAATTCTTACGATAAAGCTCTGCTACCACAAGGATAACAGAAAACTTCTGGGAGGACAAATAGCAGGGGGACTA
GGAGGAGTTGACAAGAGAATAGACGTTTTGGCTACTGCTTTGTTCCATGAAATGACTATTGACGAGTTGCAAGCTTTGGA
CCTTGCGTATGCTCCTCCATACAATTCTGTGTGGGATCCGTTGCAACAGGCATCAACTGTAGCGCAGAGGGGATAA

Upstream 100 bases:

>100_bases
CTCAATGGGATAAAATTACTCTAGAATGACTTGTTTGAAAAATTAAACAGGAAAAGGTATAATGTAGATGTGGACATAAG
TACAAAAAGGAGGAAGAAAA

Downstream 100 bases:

>100_bases
AAGAAAAGGTCTTACCGCTTTGGTAAGGCCTTTTTTGATAATAGGGTTAATTGAGGAGGTGTAGCTATGAAGTGGATAGA
GAAATATGTCTTTTTGACAA

Product: uncharacterized NAD(FAD)-dependent dehydrogenase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MPKRYVIIGGDAAGMSAASQIRRMDKEGEVLVFEKEGVISYAQCGLPYWVGGVVSEKKKLIARTAEEFLNRYNIDVKLYH
EVVKIDPSKKEIKVFRREEKDEIAVPYDVLLIGTGSTAIVPPWEGRNLPGVFTLKTMGDAEKLLDWLSSHTPTKAVVIGG
GYIGLETAEALHSRGFKVTVLDLAPQLIPTFDKEIAEIAQDALTRHGVEVHLNEEVVGLEGDEKGVKAVVTKNGKFEADL
VIISIGVRPVSELAKEAGIELGPKNAILVNERLETSIPDIYAAGDCATHFNRIKNAPDYIPLGTTANKQGRIAGINMAGG
DAKFAGVVGTAIVKVFDRTIARSGLGERDCEALGIPYQVVLIKARPVSHYYPWEDEILTIKLCYHKDNRKLLGGQIAGGL
GGVDKRIDVLATALFHEMTIDELQALDLAYAPPYNSVWDPLQQASTVAQRG

Sequences:

>Translated_451_residues
MPKRYVIIGGDAAGMSAASQIRRMDKEGEVLVFEKEGVISYAQCGLPYWVGGVVSEKKKLIARTAEEFLNRYNIDVKLYH
EVVKIDPSKKEIKVFRREEKDEIAVPYDVLLIGTGSTAIVPPWEGRNLPGVFTLKTMGDAEKLLDWLSSHTPTKAVVIGG
GYIGLETAEALHSRGFKVTVLDLAPQLIPTFDKEIAEIAQDALTRHGVEVHLNEEVVGLEGDEKGVKAVVTKNGKFEADL
VIISIGVRPVSELAKEAGIELGPKNAILVNERLETSIPDIYAAGDCATHFNRIKNAPDYIPLGTTANKQGRIAGINMAGG
DAKFAGVVGTAIVKVFDRTIARSGLGERDCEALGIPYQVVLIKARPVSHYYPWEDEILTIKLCYHKDNRKLLGGQIAGGL
GGVDKRIDVLATALFHEMTIDELQALDLAYAPPYNSVWDPLQQASTVAQRG
>Mature_450_residues
PKRYVIIGGDAAGMSAASQIRRMDKEGEVLVFEKEGVISYAQCGLPYWVGGVVSEKKKLIARTAEEFLNRYNIDVKLYHE
VVKIDPSKKEIKVFRREEKDEIAVPYDVLLIGTGSTAIVPPWEGRNLPGVFTLKTMGDAEKLLDWLSSHTPTKAVVIGGG
YIGLETAEALHSRGFKVTVLDLAPQLIPTFDKEIAEIAQDALTRHGVEVHLNEEVVGLEGDEKGVKAVVTKNGKFEADLV
IISIGVRPVSELAKEAGIELGPKNAILVNERLETSIPDIYAAGDCATHFNRIKNAPDYIPLGTTANKQGRIAGINMAGGD
AKFAGVVGTAIVKVFDRTIARSGLGERDCEALGIPYQVVLIKARPVSHYYPWEDEILTIKLCYHKDNRKLLGGQIAGGLG
GVDKRIDVLATALFHEMTIDELQALDLAYAPPYNSVWDPLQQASTVAQRG

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI65787454, Length=354, Percent_Identity=28.5310734463277, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI21389617, Length=354, Percent_Identity=28.5310734463277, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI226437568, Length=354, Percent_Identity=28.5310734463277, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI91199540, Length=309, Percent_Identity=27.1844660194175, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1789065, Length=291, Percent_Identity=29.2096219931272, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1789765, Length=377, Percent_Identity=27.5862068965517, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786307, Length=321, Percent_Identity=26.1682242990654, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87082354, Length=266, Percent_Identity=24.812030075188, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788892, Length=299, Percent_Identity=27.7591973244147, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787352, Length=246, Percent_Identity=29.6747967479675, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87081717, Length=201, Percent_Identity=31.3432835820896, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17559934, Length=289, Percent_Identity=28.3737024221453, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI32565766, Length=144, Percent_Identity=32.6388888888889, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325166, Length=198, Percent_Identity=28.7878787878788, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24639257, Length=333, Percent_Identity=27.3273273273273, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI281359715, Length=333, Percent_Identity=27.3273273273273, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI281359713, Length=333, Percent_Identity=27.3273273273273, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24639250, Length=333, Percent_Identity=27.3273273273273, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI18543267, Length=333, Percent_Identity=27.3273273273273, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24639252, Length=333, Percent_Identity=27.3273273273273, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24585130, Length=393, Percent_Identity=22.1374045801527, Blast_Score=105, Evalue=9e-23,
Organism=Drosophila melanogaster, GI21358499, Length=210, Percent_Identity=30.4761904761905, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 49124; Mature: 48993

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKRYVIIGGDAAGMSAASQIRRMDKEGEVLVFEKEGVISYAQCGLPYWVGGVVSEKKKL
CCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCEEHHHCCCCHHHHHHHHHHHHH
IARTAEEFLNRYNIDVKLYHEVVKIDPSKKEIKVFRREEKDEIAVPYDVLLIGTGSTAIV
HHHHHHHHHHHCCCCEEEEEEHHCCCCCHHHHHHHHCCCCCCEECCEEEEEEECCCCEEE
PPWEGRNLPGVFTLKTMGDAEKLLDWLSSHTPTKAVVIGGGYIGLETAEALHSRGFKVTV
CCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEECCEECHHHHHHHHHCCCEEEE
LDLAPQLIPTFDKEIAEIAQDALTRHGVEVHLNEEVVGLEGDEKGVKAVVTKNGKFEADL
EECCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEECCCCCCCCEEEEECCCCEEEEE
VIISIGVRPVSELAKEAGIELGPKNAILVNERLETSIPDIYAAGDCATHFNRIKNAPDYI
EEEEECCCCHHHHHHHCCCEECCCCEEEEECCHHCCCCCEEECCHHHHHHHHHCCCCCEE
PLGTTANKQGRIAGINMAGGDAKFAGVVGTAIVKVFDRTIARSGLGERDCEALGIPYQVV
ECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEE
LIKARPVSHYYPWEDEILTIKLCYHKDNRKLLGGQIAGGLGGVDKRIDVLATALFHEMTI
EEEECCCCCCCCCCCCEEEEEEEEECCCCEEECCEECCCCCCCHHHHHHHHHHHHHHHHH
DELQALDLAYAPPYNSVWDPLQQASTVAQRG
HHHHHHHEEECCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PKRYVIIGGDAAGMSAASQIRRMDKEGEVLVFEKEGVISYAQCGLPYWVGGVVSEKKKL
CCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCEEHHHCCCCHHHHHHHHHHHHH
IARTAEEFLNRYNIDVKLYHEVVKIDPSKKEIKVFRREEKDEIAVPYDVLLIGTGSTAIV
HHHHHHHHHHHCCCCEEEEEEHHCCCCCHHHHHHHHCCCCCCEECCEEEEEEECCCCEEE
PPWEGRNLPGVFTLKTMGDAEKLLDWLSSHTPTKAVVIGGGYIGLETAEALHSRGFKVTV
CCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEECCEECHHHHHHHHHCCCEEEE
LDLAPQLIPTFDKEIAEIAQDALTRHGVEVHLNEEVVGLEGDEKGVKAVVTKNGKFEADL
EECCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEECCCCCCCCEEEEECCCCEEEEE
VIISIGVRPVSELAKEAGIELGPKNAILVNERLETSIPDIYAAGDCATHFNRIKNAPDYI
EEEEECCCCHHHHHHHCCCEECCCCEEEEECCHHCCCCCEEECCHHHHHHHHHCCCCCEE
PLGTTANKQGRIAGINMAGGDAKFAGVVGTAIVKVFDRTIARSGLGERDCEALGIPYQVV
ECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEE
LIKARPVSHYYPWEDEILTIKLCYHKDNRKLLGGQIAGGLGGVDKRIDVLATALFHEMTI
EEEECCCCCCCCCCCCEEEEEEEEECCCCEEECCEECCCCCCCHHHHHHHHHHHHHHHHH
DELQALDLAYAPPYNSVWDPLQQASTVAQRG
HHHHHHHEEECCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]