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The map label for this gene is PgsA3 [H]

Identifier: 20809046

GI number: 20809046

Start: 2599327

End: 2600430

Strand: Reverse

Name: PgsA3 [H]

Synonym: TTE2703

Alternate gene names: 20809046

Gene position: 2600430-2599327 (Counterclockwise)

Preceding gene: 20809047

Following gene: 20809045

Centisome position: 96.69

GC content: 36.5

Gene sequence:

>1104_bases
ATGGGTAAAAGGATATTTATAAAGGCTTTACTTTTCTTTTTTGCGGTAGTATTTGTAATGGTATTTTTTGAAAATTCAGT
TGATAATAGTGCCATGAGAAAAGTTACTGTGGAGAAAGAAGAAAGTCTACTACCAGTTAAAGAGGGGCAAGACACGAAAG
ATGCAGAAAAAGTGTTAGATTACACTGAAATAGTGGTAAATGCTGTAGGGGACTGCACTCTGGGTTCAGATGAGAAATAC
TCTAAATATGGCACTTTTGATGAGGAACTGAAAAAGCAGAATTACGACTATTCCTATTTTTTTAGAAATGTAAAAGATAC
ATTTAAAAAGGGCGATTTGACTATAGCAAATTTAGAAGGTCCCTTGACTACTTCTACAAAAAGAGCAGAAAAGGAATACG
CCTTTAAAGGACATCCTTCGTATGCGAAGATTTTAAAAGAAGGGGGAGTTGATGCAGTAAATTTGGCTAATAACCACTCC
TTTGATTATGGGAAAGAAGGCTTTTATGAGACTGTGAATGCTTTAAAGAAAGAGGGTATAGGTTATTTTGGCTACGGGTA
CAGGTATATCACTGAGGTAAAGGGTGTGAAGATTGGCGTTTTGGGTTATACAGGTTATGATGATACAGAATGGACAAAAC
AAGAGATAAAAAAAGACATAGAAAAGCTAAGGCCAGAGGTCAATATATTGATTGTGAGCTTTCACTGGGGAGAAGAGAGT
AAGTATTATCCTAATAAAATACAAAGGAATCTGGGGCATTTTGCAATCGATGAGGGAGCAGACCTTGTTATAGGACACCA
TCCCCATGTGCTTCAGGGAATAGAAAAGTACAAAGCTAGATATATTGCATATTCTCTGGGTAATTTTGTGTTTGGAGGAA
ATAGAAATCCTAAGGACAAGGATTCGATGATTTTCCAGCAAATTTTCTTTGTAGATAAAGAGGGGAAAGTGGCAGAGACT
AAGGCGAATATAATACCTGTGTCTATATCTTCTCAAAAGGATAGAAATGACTACAGCCCTCGCCTTTTAGAAGGGGAAGA
GAGGGAGAAGGTTTTAGAAAAGATTGAAAAGCTATCTCAATGGGATAAAATTACTCTAGAATGA

Upstream 100 bases:

>100_bases
GAATATAGAGGAGGCTAAAAAGCTTTTAAAAAGAGCTAAGGAAGAGCTTGTAAAAGTGCTGGATTTGGAAGAATAATAAC
CCGGTTTGCGAGGGGAAAGA

Downstream 100 bases:

>100_bases
CTTGTTTGAAAAATTAAACAGGAAAAGGTATAATGTAGATGTGGACATAAGTACAAAAAGGAGGAAGAAAAATGCCTAAG
CGCTATGTTATTATAGGTGG

Product: putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MGKRIFIKALLFFFAVVFVMVFFENSVDNSAMRKVTVEKEESLLPVKEGQDTKDAEKVLDYTEIVVNAVGDCTLGSDEKY
SKYGTFDEELKKQNYDYSYFFRNVKDTFKKGDLTIANLEGPLTTSTKRAEKEYAFKGHPSYAKILKEGGVDAVNLANNHS
FDYGKEGFYETVNALKKEGIGYFGYGYRYITEVKGVKIGVLGYTGYDDTEWTKQEIKKDIEKLRPEVNILIVSFHWGEES
KYYPNKIQRNLGHFAIDEGADLVIGHHPHVLQGIEKYKARYIAYSLGNFVFGGNRNPKDKDSMIFQQIFFVDKEGKVAET
KANIIPVSISSQKDRNDYSPRLLEGEEREKVLEKIEKLSQWDKITLE

Sequences:

>Translated_367_residues
MGKRIFIKALLFFFAVVFVMVFFENSVDNSAMRKVTVEKEESLLPVKEGQDTKDAEKVLDYTEIVVNAVGDCTLGSDEKY
SKYGTFDEELKKQNYDYSYFFRNVKDTFKKGDLTIANLEGPLTTSTKRAEKEYAFKGHPSYAKILKEGGVDAVNLANNHS
FDYGKEGFYETVNALKKEGIGYFGYGYRYITEVKGVKIGVLGYTGYDDTEWTKQEIKKDIEKLRPEVNILIVSFHWGEES
KYYPNKIQRNLGHFAIDEGADLVIGHHPHVLQGIEKYKARYIAYSLGNFVFGGNRNPKDKDSMIFQQIFFVDKEGKVAET
KANIIPVSISSQKDRNDYSPRLLEGEEREKVLEKIEKLSQWDKITLE
>Mature_366_residues
GKRIFIKALLFFFAVVFVMVFFENSVDNSAMRKVTVEKEESLLPVKEGQDTKDAEKVLDYTEIVVNAVGDCTLGSDEKYS
KYGTFDEELKKQNYDYSYFFRNVKDTFKKGDLTIANLEGPLTTSTKRAEKEYAFKGHPSYAKILKEGGVDAVNLANNHSF
DYGKEGFYETVNALKKEGIGYFGYGYRYITEVKGVKIGVLGYTGYDDTEWTKQEIKKDIEKLRPEVNILIVSFHWGEESK
YYPNKIQRNLGHFAIDEGADLVIGHHPHVLQGIEKYKARYIAYSLGNFVFGGNRNPKDKDSMIFQQIFFVDKEGKVAETK
ANIIPVSISSQKDRNDYSPRLLEGEEREKVLEKIEKLSQWDKITLE

Specific function: Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapB and CapC [H]

COG id: COG2843

COG function: function code M; Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CapA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019079 [H]

Pfam domain/function: PF09587 PGA_cap [H]

EC number: NA

Molecular weight: Translated: 42095; Mature: 41964

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKRIFIKALLFFFAVVFVMVFFENSVDNSAMRKVTVEKEESLLPVKEGQDTKDAEKVLD
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEECCCCCCCCCCCCCCCHHHHHHHH
YTEIVVNAVGDCTLGSDEKYSKYGTFDEELKKQNYDYSYFFRNVKDTFKKGDLTIANLEG
HHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCC
PLTTSTKRAEKEYAFKGHPSYAKILKEGGVDAVNLANNHSFDYGKEGFYETVNALKKEGI
CCCCCHHHHHHHCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCC
GYFGYGYRYITEVKGVKIGVLGYTGYDDTEWTKQEIKKDIEKLRPEVNILIVSFHWGEES
CEECCCHHEEEEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCC
KYYPNKIQRNLGHFAIDEGADLVIGHHPHVLQGIEKYKARYIAYSLGNFVFGGNRNPKDK
CCCCHHHHHCCCCEEECCCCCEEECCCCHHHHHHHHHHHHHHHEECCCEEECCCCCCCHH
DSMIFQQIFFVDKEGKVAETKANIIPVSISSQKDRNDYSPRLLEGEEREKVLEKIEKLSQ
HHHHHHHHHEECCCCCEEECCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
WDKITLE
CCCEECC
>Mature Secondary Structure 
GKRIFIKALLFFFAVVFVMVFFENSVDNSAMRKVTVEKEESLLPVKEGQDTKDAEKVLD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEECCCCCCCCCCCCCCCHHHHHHHH
YTEIVVNAVGDCTLGSDEKYSKYGTFDEELKKQNYDYSYFFRNVKDTFKKGDLTIANLEG
HHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCC
PLTTSTKRAEKEYAFKGHPSYAKILKEGGVDAVNLANNHSFDYGKEGFYETVNALKKEGI
CCCCCHHHHHHHCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCC
GYFGYGYRYITEVKGVKIGVLGYTGYDDTEWTKQEIKKDIEKLRPEVNILIVSFHWGEES
CEECCCHHEEEEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCC
KYYPNKIQRNLGHFAIDEGADLVIGHHPHVLQGIEKYKARYIAYSLGNFVFGGNRNPKDK
CCCCHHHHHCCCCEEECCCCCEEECCCCHHHHHHHHHHHHHHHEECCCEEECCCCCCCHH
DSMIFQQIFFVDKEGKVAETKANIIPVSISSQKDRNDYSPRLLEGEEREKVLEKIEKLSQ
HHHHHHHHHEECCCCCEEECCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
WDKITLE
CCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2536679; 10475962; 12004073 [H]