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The map label for this gene is CsdB [H]

Identifier: 20809014

GI number: 20809014

Start: 2567800

End: 2569023

Strand: Reverse

Name: CsdB [H]

Synonym: TTE2670

Alternate gene names: 20809014

Gene position: 2569023-2567800 (Counterclockwise)

Preceding gene: 20809015

Following gene: 20809013

Centisome position: 95.52

GC content: 38.15

Gene sequence:

>1224_bases
ATGATGGATGTGAAGAAAATAAGAGAAGATTTTCCGATATTTAATGTAAAGCCTCATGGAAAGAGGCTTGTATACCTTGA
TAATGCTGCTACCACCCAGAAGCCTGAGTCGGTTATAAAAGCCATGGAAGAATATTATGAGAAAATGAATGCAAATGTGT
ACAGAAGCCCTCATTATTTAAGCGTTCTATCTACAGAGGCTTATGAAAAGGCGAGAGACAAAGTGAAAAAGTTTGTAAAT
GCAAAGAGTGAGGAGTCCATTATTTTTACAAGAAATACTACAGAATCAATAAATTTTATTGCCTACACATGGGGAATGAA
GCACATAAAAGAGGGGGACGAGATAGTTCTGACAATAGCGGAACATCACAGCAACATTCTTCCATGGCAGATGGTAGCAG
AAGCAAAAGGAGCAAAATTAAAATATGTGTATCTTGATGAAAATTTCAGACTTTCAATGAAAGATTTTGAAGAAAAAATG
TCTGATAGAGTAAAATTGGTGGCTGTACAGCACATGTCAAATGTCTTAGGGATAATAAATCCTGTGGAAGAAATTACACA
AATTGCTCATAAGTATGGGGCAAAAGTGCTGGTGGATGGGGCTCAGAGCGTACCTCATATGAAAGTGGACCTTAAGAAAA
TAAATTGCGACTTTTTCGCTTTTTCTGGCCACAAGATGTTGGGCCCTATGGGAATTGGAGTTTTGTATATAAAAGAAGAC
TTATTAGATGAAGTGCCTCCTTTTTTGAGGGGAGGAGAAATGATAGACGAGGTTTATGAAGAATATTCCACCTTTGCACC
TCCTCCTTTAAAATTTGAAGCAGGGACTCCCAATGTAGAGGGAGCTTATGTACTAATTTCTGCGATAGATTATCTTGAAA
GGATTGGACTTGAGAATATATATGAACATGAAGCTAAACTTTTGGAGTATGGACTTGAAAAAATTAATGCCCTCGAATAT
GTAAAAACTTATGGGCCTATGGATTCAAAAGACAGAGGAGGAATAATTTCTTTCAATGTGGAAGGAGTTCACCCACACGA
TGTTGCGACAATACTGGATGAAGAAGGAATTGCAGTAAGAAGCGGTCACCACTGCTGTCAGCCTCTGATGAGATATTTAG
GGGTTCCTGCCACTGTGAGAGCCAGCTTTTACCTTTACAATGACTTTGATGACATAGATGCCCTTGTGGAAGCACTTAAA
AAAGTCAGGAAGTGGTTTAAATGA

Upstream 100 bases:

>100_bases
TGGTGCAGGCAGTGTTAAATCCTGTCATAGATTTGATTCCGTATGACCCCATAAGAGAGATAATCTTAAGGGGTCATATA
GGGAGGAGGATTATAAAGTA

Downstream 100 bases:

>100_bases
GCGATTTAAATCAACTTTATTCAGAGATAATAATGGAACATTATGAAAATTCTCCTCACAGAAGAGAGTTGAAGGAAGCA
ACCCTCAAGGAAAGGGGACA

Product: selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MMDVKKIREDFPIFNVKPHGKRLVYLDNAATTQKPESVIKAMEEYYEKMNANVYRSPHYLSVLSTEAYEKARDKVKKFVN
AKSEESIIFTRNTTESINFIAYTWGMKHIKEGDEIVLTIAEHHSNILPWQMVAEAKGAKLKYVYLDENFRLSMKDFEEKM
SDRVKLVAVQHMSNVLGIINPVEEITQIAHKYGAKVLVDGAQSVPHMKVDLKKINCDFFAFSGHKMLGPMGIGVLYIKED
LLDEVPPFLRGGEMIDEVYEEYSTFAPPPLKFEAGTPNVEGAYVLISAIDYLERIGLENIYEHEAKLLEYGLEKINALEY
VKTYGPMDSKDRGGIISFNVEGVHPHDVATILDEEGIAVRSGHHCCQPLMRYLGVPATVRASFYLYNDFDDIDALVEALK
KVRKWFK

Sequences:

>Translated_407_residues
MMDVKKIREDFPIFNVKPHGKRLVYLDNAATTQKPESVIKAMEEYYEKMNANVYRSPHYLSVLSTEAYEKARDKVKKFVN
AKSEESIIFTRNTTESINFIAYTWGMKHIKEGDEIVLTIAEHHSNILPWQMVAEAKGAKLKYVYLDENFRLSMKDFEEKM
SDRVKLVAVQHMSNVLGIINPVEEITQIAHKYGAKVLVDGAQSVPHMKVDLKKINCDFFAFSGHKMLGPMGIGVLYIKED
LLDEVPPFLRGGEMIDEVYEEYSTFAPPPLKFEAGTPNVEGAYVLISAIDYLERIGLENIYEHEAKLLEYGLEKINALEY
VKTYGPMDSKDRGGIISFNVEGVHPHDVATILDEEGIAVRSGHHCCQPLMRYLGVPATVRASFYLYNDFDDIDALVEALK
KVRKWFK
>Mature_407_residues
MMDVKKIREDFPIFNVKPHGKRLVYLDNAATTQKPESVIKAMEEYYEKMNANVYRSPHYLSVLSTEAYEKARDKVKKFVN
AKSEESIIFTRNTTESINFIAYTWGMKHIKEGDEIVLTIAEHHSNILPWQMVAEAKGAKLKYVYLDENFRLSMKDFEEKM
SDRVKLVAVQHMSNVLGIINPVEEITQIAHKYGAKVLVDGAQSVPHMKVDLKKINCDFFAFSGHKMLGPMGIGVLYIKED
LLDEVPPFLRGGEMIDEVYEEYSTFAPPPLKFEAGTPNVEGAYVLISAIDYLERIGLENIYEHEAKLLEYGLEKINALEY
VKTYGPMDSKDRGGIISFNVEGVHPHDVATILDEEGIAVRSGHHCCQPLMRYLGVPATVRASFYLYNDFDDIDALVEALK
KVRKWFK

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=231, Percent_Identity=29.004329004329, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI156713448, Length=262, Percent_Identity=27.4809160305344, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1787970, Length=405, Percent_Identity=43.9506172839506, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1789175, Length=397, Percent_Identity=38.5390428211587, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI48994898, Length=231, Percent_Identity=29.004329004329, Blast_Score=105, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI25143064, Length=237, Percent_Identity=24.8945147679325, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI193211090, Length=393, Percent_Identity=24.1730279898219, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319831, Length=249, Percent_Identity=30.1204819277108, Blast_Score=115, Evalue=9e-27,
Organism=Drosophila melanogaster, GI20129463, Length=254, Percent_Identity=30.3149606299213, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 46451; Mature: 46451

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDVKKIREDFPIFNVKPHGKRLVYLDNAATTQKPESVIKAMEEYYEKMNANVYRSPHYL
CCCHHHHHHHCCEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCE
SVLSTEAYEKARDKVKKFVNAKSEESIIFTRNTTESINFIAYTWGMKHIKEGDEIVLTIA
EHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCHHHHCCCCEEEEEEE
EHHSNILPWQMVAEAKGAKLKYVYLDENFRLSMKDFEEKMSDRVKLVAVQHMSNVLGIIN
HHCCCCCCHHHHHHCCCCEEEEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PVEEITQIAHKYGAKVLVDGAQSVPHMKVDLKKINCDFFAFSGHKMLGPMGIGVLYIKED
CHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEECCEEEEECCCCEECCCCCEEEEEEHH
LLDEVPPFLRGGEMIDEVYEEYSTFAPPPLKFEAGTPNVEGAYVLISAIDYLERIGLENI
HHHHCCHHHCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCHHHH
YEHEAKLLEYGLEKINALEYVKTYGPMDSKDRGGIISFNVEGVHPHDVATILDEEGIAVR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCEEE
SGHHCCQPLMRYLGVPATVRASFYLYNDFDDIDALVEALKKVRKWFK
CCCHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMDVKKIREDFPIFNVKPHGKRLVYLDNAATTQKPESVIKAMEEYYEKMNANVYRSPHYL
CCCHHHHHHHCCEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCE
SVLSTEAYEKARDKVKKFVNAKSEESIIFTRNTTESINFIAYTWGMKHIKEGDEIVLTIA
EHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCHHHHCCCCEEEEEEE
EHHSNILPWQMVAEAKGAKLKYVYLDENFRLSMKDFEEKMSDRVKLVAVQHMSNVLGIIN
HHCCCCCCHHHHHHCCCCEEEEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PVEEITQIAHKYGAKVLVDGAQSVPHMKVDLKKINCDFFAFSGHKMLGPMGIGVLYIKED
CHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEECCEEEEECCCCEECCCCCEEEEEEHH
LLDEVPPFLRGGEMIDEVYEEYSTFAPPPLKFEAGTPNVEGAYVLISAIDYLERIGLENI
HHHHCCHHHCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCHHHH
YEHEAKLLEYGLEKINALEYVKTYGPMDSKDRGGIISFNVEGVHPHDVATILDEEGIAVR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCEEE
SGHHCCQPLMRYLGVPATVRASFYLYNDFDDIDALVEALKKVRKWFK
CCCHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]