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The map label for this gene is SerA2 [H]

Identifier: 20808958

GI number: 20808958

Start: 2499074

End: 2500675

Strand: Reverse

Name: SerA2 [H]

Synonym: TTE2613

Alternate gene names: 20808958

Gene position: 2500675-2499074 (Counterclockwise)

Preceding gene: 20808959

Following gene: 20808957

Centisome position: 92.98

GC content: 37.89

Gene sequence:

>1602_bases
TTGAAGATAATTGTCACAGAAAAAATCTCAGAAAATGGTATCGATTATCTTAAAAAATACGCTGATGTTGACGTAAAGAC
CAATATTTCTAGGGAAGAGCTTTTAGAGGTTATAAAAGATTACGACGCCATAATAGTTAGAAGTGCCACCAAAGTAGACA
GAGAACTTATAGAAAAGGGAGAGAAACTGAAAGTCATAGGCAGAGCTGGTAATGGTGTTGACAATATTGATGTTGAAGCG
GCGACTCAAAGAGGCATTCTAGTTGTAAATACTCCTGCAGGAAATACCATTGCCGCTGCTGAGCTCACTATTGGCCTTAT
GCTTGCCATTGCCAGAAATATACCACAGGCATACCATGCAGCTTTAAACGGCGATTTCAGAAGGGATAGGTTTAAAGGAG
TAGAGCTAAACGGTAAAACGGTTGGTATAATAGGATTAGGTAGAATTGGTTCTTTGGTTGCGTCTCGCCTTGCGGCTTTC
AATATGAGAGTGATTGCTTATGACCCCTACATGCCAGATGAGAGATTTGAAAAGTGCGGTGTCAAGAGAGTTACATTGGA
TGAGCTATTAGAGCAATCGGATTTCATCACTATTCACATTCCCAAGACTGAAGAGACAAAAAAGATGATAGGAGAAAAAG
AATTTAAAAAAATGAAAAAAGGTGTGAGAATAGTAAATGCTGCAAGAGGTGGCATTATAGACGAAAAAGCGCTTTACAAT
GCTATAAAAGAAGGTATAGTGGCAGCTGTAGGGCTGGATGTTTTAGAAGTAGAGCCAAAGTATAATGTGGAGCATCAGGA
TTTTCACAATCCTTTGTTAGAACTTCCCAATGTGGTTTTTACTCCTCACTTAGGAGCTTCTACTTATGAGGCGCAGGAAA
ATATTAGCATAGCAATTGCGCAGGAAGTCATATCAGCGTTAAATGGCAATCTCTATGGCAACATAGTAAATCTTCCCGGA
CTTAAATCAGATGAATTTTCTCGGTTAAAACCTTACATGAAATTGGCAGAAGTATTAGGAGCCCTTTATTACCAGATAAA
TGAAACACCTGCAAAATTAATTGAAGTCATATACAGAGGAGAAGTTGCAAAGAGCAATACAGAAATTGTTACCCTGTATG
CTATTAAAGGATTTTTAAAGCCTATATTAGAGGAAGATGTAAGTGTTGTGAATGCAAAGTTAAGAGCAAAAGAAATGGGC
ATAGAAATTGTAGAAGGAAAAATTGAAGAGATAGACCATTATTCCAGCCTTGTCATTTTAAAAATTACAGATACCAATGG
CAAAAGGACACAATTTGCTGGAACAACATACGGAGAAGAATTGAGAATTGTGGAGTATATGGGACATAAAGTGAATTTTG
AGCCTACAGAGTACATGCTTTTTGTCAAGAATAAAGACGTGCCGGGAGTTATAGGCCACATAGGAAATGTATTAGGAGAT
TTTGGTATAAACATCTCTACTATGCAGGTAAGCCCCAATAAAAATGACGGTACAGCCCTTATGCTTGTAAGCACCGATAA
AGAAATTCCAGAGGAGGCCGTGGAATCTTTAAACAAACTAAATAGCATAATTAAAGCAAAAGCGGTAAAAGGGTTGGTGT
GA

Upstream 100 bases:

>100_bases
ACATGGGTTATCTGACAGATGAAATGTTAGATAAAGCATTATATGCCCTAAAAGATGCCATATCCTCACTGTGAATTGAA
GAAATGGGAGGGAAAGGATT

Downstream 100 bases:

>100_bases
AAATACTTGTAGCCTTTTTGAAATATTGGAATAATGATATAATAAAAGTACAGGCTTAAAATAATCTTGGGTTAAGGTGA
TATCAATGAGCAATAGCTAC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MKIIVTEKISENGIDYLKKYADVDVKTNISREELLEVIKDYDAIIVRSATKVDRELIEKGEKLKVIGRAGNGVDNIDVEA
ATQRGILVVNTPAGNTIAAAELTIGLMLAIARNIPQAYHAALNGDFRRDRFKGVELNGKTVGIIGLGRIGSLVASRLAAF
NMRVIAYDPYMPDERFEKCGVKRVTLDELLEQSDFITIHIPKTEETKKMIGEKEFKKMKKGVRIVNAARGGIIDEKALYN
AIKEGIVAAVGLDVLEVEPKYNVEHQDFHNPLLELPNVVFTPHLGASTYEAQENISIAIAQEVISALNGNLYGNIVNLPG
LKSDEFSRLKPYMKLAEVLGALYYQINETPAKLIEVIYRGEVAKSNTEIVTLYAIKGFLKPILEEDVSVVNAKLRAKEMG
IEIVEGKIEEIDHYSSLVILKITDTNGKRTQFAGTTYGEELRIVEYMGHKVNFEPTEYMLFVKNKDVPGVIGHIGNVLGD
FGINISTMQVSPNKNDGTALMLVSTDKEIPEEAVESLNKLNSIIKAKAVKGLV

Sequences:

>Translated_533_residues
MKIIVTEKISENGIDYLKKYADVDVKTNISREELLEVIKDYDAIIVRSATKVDRELIEKGEKLKVIGRAGNGVDNIDVEA
ATQRGILVVNTPAGNTIAAAELTIGLMLAIARNIPQAYHAALNGDFRRDRFKGVELNGKTVGIIGLGRIGSLVASRLAAF
NMRVIAYDPYMPDERFEKCGVKRVTLDELLEQSDFITIHIPKTEETKKMIGEKEFKKMKKGVRIVNAARGGIIDEKALYN
AIKEGIVAAVGLDVLEVEPKYNVEHQDFHNPLLELPNVVFTPHLGASTYEAQENISIAIAQEVISALNGNLYGNIVNLPG
LKSDEFSRLKPYMKLAEVLGALYYQINETPAKLIEVIYRGEVAKSNTEIVTLYAIKGFLKPILEEDVSVVNAKLRAKEMG
IEIVEGKIEEIDHYSSLVILKITDTNGKRTQFAGTTYGEELRIVEYMGHKVNFEPTEYMLFVKNKDVPGVIGHIGNVLGD
FGINISTMQVSPNKNDGTALMLVSTDKEIPEEAVESLNKLNSIIKAKAVKGLV
>Mature_533_residues
MKIIVTEKISENGIDYLKKYADVDVKTNISREELLEVIKDYDAIIVRSATKVDRELIEKGEKLKVIGRAGNGVDNIDVEA
ATQRGILVVNTPAGNTIAAAELTIGLMLAIARNIPQAYHAALNGDFRRDRFKGVELNGKTVGIIGLGRIGSLVASRLAAF
NMRVIAYDPYMPDERFEKCGVKRVTLDELLEQSDFITIHIPKTEETKKMIGEKEFKKMKKGVRIVNAARGGIIDEKALYN
AIKEGIVAAVGLDVLEVEPKYNVEHQDFHNPLLELPNVVFTPHLGASTYEAQENISIAIAQEVISALNGNLYGNIVNLPG
LKSDEFSRLKPYMKLAEVLGALYYQINETPAKLIEVIYRGEVAKSNTEIVTLYAIKGFLKPILEEDVSVVNAKLRAKEMG
IEIVEGKIEEIDHYSSLVILKITDTNGKRTQFAGTTYGEELRIVEYMGHKVNFEPTEYMLFVKNKDVPGVIGHIGNVLGD
FGINISTMQVSPNKNDGTALMLVSTDKEIPEEAVESLNKLNSIIKAKAVKGLV

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=382, Percent_Identity=43.717277486911, Blast_Score=318, Evalue=9e-87,
Organism=Homo sapiens, GI145580578, Length=311, Percent_Identity=35.3697749196142, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI4557499, Length=311, Percent_Identity=35.3697749196142, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI61743967, Length=342, Percent_Identity=34.2105263157895, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI4557497, Length=342, Percent_Identity=34.2105263157895, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI145580575, Length=315, Percent_Identity=35.5555555555556, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI6912396, Length=319, Percent_Identity=32.2884012539185, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1789279, Length=323, Percent_Identity=34.3653250773994, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI87082289, Length=277, Percent_Identity=34.6570397111913, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1787645, Length=252, Percent_Identity=36.5079365079365, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1788660, Length=231, Percent_Identity=34.1991341991342, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87081824, Length=168, Percent_Identity=32.7380952380952, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=314, Percent_Identity=42.0382165605096, Blast_Score=251, Evalue=9e-67,
Organism=Caenorhabditis elegans, GI25147481, Length=316, Percent_Identity=31.9620253164557, Blast_Score=150, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320925, Length=341, Percent_Identity=35.4838709677419, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6322116, Length=341, Percent_Identity=34.8973607038123, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324055, Length=333, Percent_Identity=31.5315315315315, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=228, Percent_Identity=31.140350877193, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325144, Length=154, Percent_Identity=33.1168831168831, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324980, Length=140, Percent_Identity=32.1428571428571, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19921140, Length=323, Percent_Identity=40.2476780185758, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24646446, Length=290, Percent_Identity=36.551724137931, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24646448, Length=290, Percent_Identity=36.551724137931, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24646452, Length=290, Percent_Identity=36.551724137931, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24646450, Length=290, Percent_Identity=36.551724137931, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI62472511, Length=352, Percent_Identity=34.375, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI28571528, Length=319, Percent_Identity=35.7366771159875, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI28574286, Length=316, Percent_Identity=31.3291139240506, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24585514, Length=318, Percent_Identity=32.0754716981132, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI28574282, Length=318, Percent_Identity=32.0754716981132, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI45552429, Length=318, Percent_Identity=32.0754716981132, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI45551003, Length=318, Percent_Identity=32.0754716981132, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28574284, Length=318, Percent_Identity=32.0754716981132, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24585516, Length=289, Percent_Identity=29.4117647058824, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 58858; Mature: 58858

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIVTEKISENGIDYLKKYADVDVKTNISREELLEVIKDYDAIIVRSATKVDRELIEKG
CEEEEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHCC
EKLKVIGRAGNGVDNIDVEAATQRGILVVNTPAGNTIAAAELTIGLMLAIARNIPQAYHA
CEEEEEECCCCCCCCCEEEECCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHCCCHHHHH
ALNGDFRRDRFKGVELNGKTVGIIGLGRIGSLVASRLAAFNMRVIAYDPYMPDERFEKCG
HHCCCCCHHHCCCEEECCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHCC
VKRVTLDELLEQSDFITIHIPKTEETKKMIGEKEFKKMKKGVRIVNAARGGIIDEKALYN
CCEECHHHHHCCCCEEEEEECCCHHHHHHHCHHHHHHHHCCCEEEEHHCCCCCCHHHHHH
AIKEGIVAAVGLDVLEVEPKYNVEHQDFHNPLLELPNVVFTPHLGASTYEAQENISIAIA
HHHHHHHHHHCCEEEEECCCCCCCHHHHCCHHHHCCCEEECCCCCCCCCCCCCCCCHHHH
QEVISALNGNLYGNIVNLPGLKSDEFSRLKPYMKLAEVLGALYYQINETPAKLIEVIYRG
HHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
EVAKSNTEIVTLYAIKGFLKPILEEDVSVVNAKLRAKEMGIEIVEGKIEEIDHYSSLVIL
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHCCCCCCEEEE
KITDTNGKRTQFAGTTYGEELRIVEYMGHKVNFEPTEYMLFVKNKDVPGVIGHIGNVLGD
EEECCCCCEEEECCCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHH
FGINISTMQVSPNKNDGTALMLVSTDKEIPEEAVESLNKLNSIIKAKAVKGLV
CCCCEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIIVTEKISENGIDYLKKYADVDVKTNISREELLEVIKDYDAIIVRSATKVDRELIEKG
CEEEEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHCC
EKLKVIGRAGNGVDNIDVEAATQRGILVVNTPAGNTIAAAELTIGLMLAIARNIPQAYHA
CEEEEEECCCCCCCCCEEEECCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHCCCHHHHH
ALNGDFRRDRFKGVELNGKTVGIIGLGRIGSLVASRLAAFNMRVIAYDPYMPDERFEKCG
HHCCCCCHHHCCCEEECCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHCC
VKRVTLDELLEQSDFITIHIPKTEETKKMIGEKEFKKMKKGVRIVNAARGGIIDEKALYN
CCEECHHHHHCCCCEEEEEECCCHHHHHHHCHHHHHHHHCCCEEEEHHCCCCCCHHHHHH
AIKEGIVAAVGLDVLEVEPKYNVEHQDFHNPLLELPNVVFTPHLGASTYEAQENISIAIA
HHHHHHHHHHCCEEEEECCCCCCCHHHHCCHHHHCCCEEECCCCCCCCCCCCCCCCHHHH
QEVISALNGNLYGNIVNLPGLKSDEFSRLKPYMKLAEVLGALYYQINETPAKLIEVIYRG
HHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
EVAKSNTEIVTLYAIKGFLKPILEEDVSVVNAKLRAKEMGIEIVEGKIEEIDHYSSLVIL
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHCCCCCCEEEE
KITDTNGKRTQFAGTTYGEELRIVEYMGHKVNFEPTEYMLFVKNKDVPGVIGHIGNVLGD
EEECCCCCEEEECCCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHH
FGINISTMQVSPNKNDGTALMLVSTDKEIPEEAVESLNKLNSIIKAKAVKGLV
CCCCEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]